Best TWAS P=9.47e-09 · Best GWAS P=4.26e-09 conditioned to 1.6e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 5.2 | 5.6 | 2.3e-08 | 0.02 | 0.10 | 0.79 | FALSE |
2 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 5.2 | -5.2 | 2.1e-07 | -0.03 | 0.16 | 0.78 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | CRIM1 | 0.36 | 0.21 | lasso | 5 | 0.16 | 5.4e-05 | 5.7 | 5.7 | 9.9e-09 | -0.01 | 0.04 | 0.89 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | FEZ2 | 0.41 | 0.30 | lasso | 6 | 0.28 | 8.6e-08 | 5.4 | 5.5 | 4.7e-08 | -0.03 | 0.05 | 0.94 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | AC007401.1 | 0.40 | 0.26 | lasso | 4 | 0.22 | 2.3e-06 | 5.7 | 5.6 | 2.2e-08 | -0.02 | 0.04 | 0.95 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | RP11-490M8.1 | 0.37 | 0.18 | lasso | 4 | 0.15 | 1.2e-04 | 5.3 | 5.4 | 7.4e-08 | -0.02 | 0.06 | 0.78 | FALSE |
7 | GTEx | Brain Cerebellum | FEZ2 | 0.44 | 0.26 | lasso | 6 | 0.23 | 2.6e-07 | 5.5 | 5.7 | 9.5e-09 | -0.03 | 0.03 | 0.96 | TRUE |
8 | GTEx | Brain Cerebellum | AC007401.1 | 0.27 | 0.21 | enet | 5 | 0.20 | 1.5e-06 | 5.7 | 5.6 | 1.7e-08 | -0.02 | 0.03 | 0.96 | FALSE |
9 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 4.7 | 5.7 | 1.4e-08 | -0.01 | 0.09 | 0.74 | FALSE |
10 | GTEx | Whole Blood | FEZ2 | 0.11 | 0.09 | enet | 25 | 0.10 | 8.4e-10 | 5.4 | 5.3 | 1.1e-07 | -0.02 | 0.08 | 0.92 | FALSE |
11 | GTEx | Whole Blood | AC006369.2 | 0.07 | 0.04 | lasso | 6 | 0.04 | 7.7e-05 | -3.9 | 5.4 | 8.4e-08 | 0.07 | 0.01 | 0.19 | TRUE |
12 | GTEx | Whole Blood | AC007401.1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.6e-05 | 5.4 | 5.6 | 1.7e-08 | -0.01 | 0.06 | 0.92 | FALSE |
13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 5.2 | -5.2 | 2.3e-07 | 0.00 | 0.04 | 0.88 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | FEZ2 | 0.11 | 0.03 | blup | 84 | 0.07 | 6.1e-05 | 5.0 | -5.2 | 2.3e-07 | 0.03 | 0.03 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FEZ2 | 0.06 | 0.05 | blup | 87 | 0.08 | 1.4e-08 | 5.3 | -5.7 | 1.5e-08 | 0.01 | 0.03 | 0.97 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | FEZ2 | 0.07 | 0.06 | blup | 87 | 0.06 | 2.4e-06 | 5.3 | -5.6 | 2.7e-08 | 0.02 | 0.03 | 0.97 | FALSE |