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chr2:26,223,547-29,792,216

Best TWAS P=2.87e-19 · Best GWAS P=4.58e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PPP1CB	0.12	0.08	blup	574	0.10	3.3e-12	6.0	-5.7	9.7e-09	0.00	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRMT61B	0.26	0.35	lasso	4	0.35	1.2e-43	5.2	5.1	2.8e-07	-0.01	0.93	0.07	FALSE
3	GTEx	Adipose Visceral Omentum	TRMT61B	0.31	0.33	lasso	13	0.31	1.1e-16	5.2	5.3	9.1e-08	0.00	0.34	0.66	FALSE
4	GTEx	Adrenal Gland	TRMT61B	0.30	0.27	enet	17	0.23	9.6e-09	5.2	5.1	2.9e-07	0.00	0.47	0.52	FALSE
5	GTEx	Adrenal Gland	PPP1CB	0.16	0.07	lasso	6	0.07	1.6e-03	5.2	-5.7	1.5e-08	0.01	0.04	0.87	FALSE
6	GTEx	Artery Coronary	TRMT61B	0.21	0.16	lasso	3	0.17	2.8e-06	5.3	6.0	2.1e-09	-0.01	0.05	0.94	FALSE
7	GTEx	Artery Tibial	TRMT61B	0.29	0.27	lasso	4	0.28	1.1e-21	5.0	5.2	2.5e-07	-0.01	0.94	0.06	FALSE
8	GTEx	Brain Caudate basal ganglia	TRMT61B	0.22	0.01	enet	5	0.04	2.5e-02	5.3	5.7	1.1e-08	0.00	0.05	0.86	FALSE
9	GTEx	Brain Frontal Cortex BA9	PPP1CB	0.27	0.14	lasso	5	0.12	4.3e-04	4.9	-5.2	1.5e-07	0.02	0.22	0.24	FALSE
10	GTEx	Brain Putamen basal ganglia	TRMT61B	0.27	0.12	enet	11	0.20	1.3e-05	5.2	6.0	1.7e-09	0.01	0.02	0.97	FALSE
11	GTEx	Breast Mammary Tissue	TRMT61B	0.32	0.17	lasso	7	0.20	8.2e-11	5.2	5.3	1.2e-07	0.00	0.51	0.49	FALSE
12	GTEx	Cells Transformed fibroblasts	TRMT61B	0.36	0.46	lasso	6	0.46	2.8e-38	5.2	5.2	2.1e-07	0.00	0.92	0.08	FALSE
13	GTEx	Colon Transverse	TRMT61B	0.15	0.12	lasso	5	0.10	1.1e-05	5.1	5.1	3.0e-07	-0.01	0.20	0.78	FALSE
14	GTEx	Esophagus Mucosa	TRMT61B	0.18	0.22	lasso	3	0.22	1.7e-14	5.2	5.2	1.5e-07	0.00	0.90	0.10	FALSE
15	GTEx	Esophagus Muscularis	TRMT61B	0.27	0.34	lasso	3	0.33	1.0e-20	5.2	5.2	1.7e-07	0.00	0.91	0.08	FALSE
16	GTEx	Heart Atrial Appendage	TRMT61B	0.38	0.27	lasso	4	0.24	5.5e-11	5.2	5.3	1.3e-07	0.00	0.24	0.76	FALSE
17	GTEx	Heart Left Ventricle	TRMT61B	0.21	0.17	lasso	3	0.15	1.9e-08	5.2	5.2	2.0e-07	0.00	0.57	0.43	FALSE
18	GTEx	Lung	TRMT61B	0.20	0.24	lasso	9	0.24	4.2e-18	5.2	5.3	8.6e-08	-0.01	0.93	0.07	FALSE
19	GTEx	Nerve Tibial	SLC35F6	0.10	0.02	enet	8	0.03	3.0e-03	4.5	5.5	3.2e-08	0.67	0.06	0.69	FALSE
20	GTEx	Pancreas	TRMT61B	0.17	0.14	lasso	2	0.12	7.5e-06	-5.2	5.3	1.1e-07	-0.03	0.50	0.44	FALSE
21	GTEx	Skin Sun Exposed Lower leg	TRMT61B	0.12	0.17	lasso	4	0.16	8.4e-13	5.0	5.2	1.7e-07	-0.01	0.90	0.10	FALSE
22	GTEx	Skin Sun Exposed Lower leg	SLC35F6	0.10	0.04	lasso	4	0.05	4.2e-05	-5.6	6.2	5.5e-10	0.76	0.39	0.20	FALSE
23	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	1.9	5.2	2.0e-07	0.06	0.18	0.10	FALSE
24	GTEx	Thyroid	TRMT61B	0.18	0.23	lasso	6	0.22	1.0e-16	5.2	5.2	2.0e-07	0.00	0.91	0.09	FALSE
25	GTEx	Thyroid	PPP1CB	0.07	0.00	enet	7	0.00	3.4e-01	5.3	-5.5	3.1e-08	0.02	0.12	0.65	FALSE
26	GTEx	Thyroid	AC097724.3	0.07	0.03	lasso	4	0.03	4.1e-03	-5.3	-5.1	3.0e-07	0.02	0.31	0.38	FALSE
27	METSIM	Adipose	PPP1CB	0.07	0.08	lasso	3	0.08	1.1e-11	-5.3	-5.2	2.3e-07	0.03	0.86	0.14	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	TRMT61B	0.15	0.11	lasso	8	0.10	3.7e-13	5.2	5.2	1.6e-07	-0.01	0.54	0.46	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	8.9	-9.0	2.9e-19	-0.99	0.00	1.00	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	SLC35F6	0.05	0.04	enet	11	0.04	8.0e-06	-5.6	6.4	1.4e-10	0.73	0.23	0.76	FALSE
31	YFS	Blood	PPP1CB	0.07	0.10	enet	17	0.12	9.2e-36	-5.3	-5.4	8.5e-08	0.01	0.84	0.16	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRMT61B	0.14	0.17	lasso	2	0.16	1.9e-13	5.2	5.2	1.5e-07	0.00	0.03	0.97	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1CB	0.04	0.02	blup	39	0.02	1.6e-04	6.0	-5.5	4.7e-08	0.03	0.02	0.89	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRMT61B	0.10	0.17	lasso	2	0.17	1.2e-33	5.2	5.2	1.8e-07	0.00	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	PPP1CB	0.05	0.02	blup	39	0.03	4.7e-03	6.5	-6.4	1.8e-10	0.01	0.01	0.96	TRUE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	TRMT61B	0.20	0.23	lasso	7	0.22	6.1e-13	5.3	5.2	2.5e-07	0.00	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf18	0.20	0.02	blup	30	0.06	6.7e-03	4.9	6.2	5.7e-10	0.75	0.01	0.37	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	TRMT61B	0.35	0.22	lasso	3	0.22	2.1e-07	5.3	5.4	5.2e-08	-0.01	0.03	0.97	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRMT61B	0.12	0.15	lasso	4	0.16	1.7e-17	5.1	5.3	8.8e-08	-0.01	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP1CB	0.04	0.04	lasso	1	0.03	9.8e-05	-5.3	-5.3	1.1e-07	0.03	0.27	0.50	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	5.0	5.7	1.1e-08	0.10	0.00	0.97	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRMT61B	0.17	0.29	enet	17	0.32	9.9e-37	5.3	5.2	2.1e-07	-0.01	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-5.5	5.8	6.2e-09	0.09	0.00	0.94	TRUE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRMT61B	0.12	0.18	lasso	4	0.18	1.8e-10	5.2	5.4	6.1e-08	-0.01	0.03	0.97	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRMT61B	0.08	0.09	lasso	1	0.07	3.4e-04	5.2	5.2	2.3e-07	0.00	0.03	0.90	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61B	0.10	0.17	lasso	3	0.16	1.6e-17	5.2	5.2	2.6e-07	-0.01	0.04	0.96	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRMT61B	0.14	0.14	lasso	6	0.13	3.7e-09	5.2	5.2	2.2e-07	0.00	0.03	0.96	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRMT61B	0.20	0.12	enet	12	0.18	3.2e-08	5.3	5.3	9.9e-08	-0.02	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPDYA	0.05	0.03	blup	49	0.05	6.0e-03	4.9	5.8	5.1e-09	-0.01	0.02	0.54	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRMT61B	0.30	0.30	enet	18	0.30	2.6e-12	5.2	5.4	6.0e-08	-0.01	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	CENPA	0.04	0.00	enet	4	0.00	1.0e-01	4.5	5.2	2.4e-07	0.59	0.01	0.21	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPP1CB	0.09	0.13	lasso	4	0.12	9.7e-13	5.2	-5.2	1.6e-07	0.01	0.90	0.10	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61B	0.20	0.31	lasso	4	0.31	4.8e-33	5.2	5.2	2.1e-07	-0.01	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Rectum Adenocarcinoma	PPP1CB	0.14	0.05	lasso	2	0.05	2.8e-02	4.9	-5.3	1.1e-07	-0.01	0.01	0.48	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRMT61B	0.13	0.12	enet	14	0.13	2.7e-08	5.2	5.5	3.8e-08	-0.03	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRMT61B	0.13	0.14	enet	11	0.15	5.5e-11	5.1	5.2	1.7e-07	-0.01	0.03	0.96	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	4.6	5.3	9.1e-08	0.04	0.12	0.86	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1CB	0.11	0.06	lasso	7	0.10	2.4e-10	-5.3	-5.2	2.1e-07	0.03	0.55	0.45	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	TRMT61B	0.29	0.37	lasso	4	0.38	1.5e-38	5.2	5.2	2.4e-07	0.00	0.04	0.96	FALSE
60	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRMT61B	0.26	0.15	lasso	7	0.14	1.0e-04	5.3	5.3	1.4e-07	-0.01	0.02	0.85	FALSE