Best TWAS P=6.05e-14 · Best GWAS P=1.29e-15 conditioned to 0.00386
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KDM3A | 0.03 | 0.04 | lasso | 2 | 0.04 | 2.0e-05 | 5.7 | 5.8 | 8.3e-09 | 0.70 | 0.37 | 0.49 | FALSE |
| 2 | GTEx | Esophagus Muscularis | AC015971.2 | 0.09 | 0.03 | lasso | 6 | 0.05 | 9.1e-04 | 7.8 | -7.5 | 6.0e-14 | -0.89 | 0.02 | 0.92 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | KDM3A | 0.05 | 0.00 | enet | 13 | 0.03 | 1.9e-04 | 7.1 | 5.6 | 1.7e-08 | 0.76 | 0.06 | 0.92 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CHMP3 | 0.17 | 0.12 | enet | 20 | 0.14 | 4.7e-18 | -3.3 | 5.2 | 1.5e-07 | 0.61 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VPS24 | 0.03 | 0.01 | blup | 103 | 0.01 | 6.4e-04 | 5.8 | -6.1 | 1.4e-09 | -0.66 | 0.22 | 0.58 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VPS24 | 0.05 | 0.02 | enet | 12 | 0.03 | 2.9e-04 | 7.8 | -6.1 | 1.0e-09 | -0.65 | 0.01 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RNF103 | 0.06 | 0.02 | blup | 42 | 0.02 | 2.4e-02 | -5.3 | 7.2 | 6.4e-13 | 0.86 | 0.02 | 0.44 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS24 | 0.05 | 0.02 | blup | 101 | 0.04 | 1.0e-04 | -3.1 | -6.6 | 4.3e-11 | -0.67 | 0.08 | 0.74 | FALSE |