TWAS hub - CHMP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.051	0.0280	8.4e-03	0.023	NA	0.019	NA	0.019	7.6e-03	NA	1.2e-02	NA	1.3e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.171	0.0429	4.0e-15	0.122	0.133	0.144	0.135	0.142	2.2e-15	8.7e-17	4.7e-18	4.9e-17	7.6e-18

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Neuroticism	7.8	18.7	31.9	-2.3	-5.7
Worry (Nagel 2018)	7.0	14.7	23.0	-2.5	-4.8
Neuroticism (Nagel 2018)	6.4	15.1	22.8	-2.7	-4.8
Heart disease (mother)	6.4	7.9	10.0	3.2	2.4
Bipolar Disorder (2018)	6.3	10.0	12.5	-3.5	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	5.8	6.2	8.4	2.9	2.0
Medication: Lisinopril	5.7	7.3	9.9	-3.1	-2.2
Tense / ‘highly strung’	5.3	8.7	10.3	-2.7	-3.2
Alcohol intake frequency.	5.3	12.2	23.9	0.7	4.9
Neuroticism score	4.8	10.1	17.7	-1.6	-4.2
Chronic bronchitis/emphysema (father)	4.7	5.5	10.9	3.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	4.7	7.2	12.4	-1.4	-3.5
Illness, injury, bereavement, stress in last 2 years	4.0	4.9	6.1	-2.5	-1.9
Irritability	3.8	6.4	8.3	-2.1	-2.9
Friendships satisfaction	3.7	4.6	4.8	2.1	2.2
Coronary Artery Disease (CAD)	3.6	4.3	4.8	-1.9	2.2
Exposure to tobacco smoke outside home	3.5	4.7	6.5	2.5	1.7
Tinnitus: Yes, now most or all of the time	3.4	4.0	7.7	0.6	2.8
Major Depression (MDD)	3.3	4.0	4.9	-1.8	-2.2
Worry too long after embarrassment	3.2	5.3	10.5	-0.4	-3.2
Number of live births	3.0	4.3	5.0	1.9	2.2
Average weekly red wine intake	3.0	4.4	7.4	-1.2	-2.7
Reaction Time	2.9	5.5	10.4	3.2	0.8
BMI	2.9	16.8	27.6	-2.4	5.2
Nervous feelings	2.9	5.4	7.7	-1.7	-2.8
Pain all over the body in last month	2.9	3.1	4.9	-2.2	1.2
Diabetes (mother)	2.8	3.6	5.1	1.5	2.3
Wheeze or whistling in the chest in last year	2.8	5.0	7.0	1.7	2.6
Osteoarthritis (self-reported)	2.8	3.6	6.5	-2.6	0.8
Guilty feelings	2.7	4.0	7.8	0.5	-2.8
Current tobacco smoking	2.6	4.3	8.2	2.9	0.7
Body mass index (BMI)	2.6	10.9	14.0	-2.8	3.7
Worrier / anxious feelings	2.6	4.8	9.6	0.2	-3.1
Sensitivity / hurt feelings	2.5	4.3	8.6	-0.0	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	6.3	-0.5	-2.5
Bipolar Disorder (2011)	2.4	2.4	4.7	-2.2	-0.0
Mean time to correctly identify matches	2.4	4.5	8.6	2.9	-0.6
Smoking status: Current	2.4	3.8	7.4	2.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	4.4	2.1	-1.7
Migraine (self-reported)	2.3	2.8	5.6	-2.4	-0.1
Number of full sisters	2.3	2.8	4.3	1.1	2.1
Ever had prostate specific antigen (PSA) test	2.3	2.7	4.2	-1.1	-2.0
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	5.3	0.7	2.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	2.9	-1.7	-1.5
Family relationship satisfaction	2.2	2.7	3.4	1.8	1.4
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	5.2	2.3	-0.2
Alcohol drinker status: Never	2.2	2.7	5.3	0.2	2.3
Bipolar Disorder or Schizophrenia	2.1	5.2	8.3	-2.9	-1.5
Medication: Cholesterol lowering	2.1	3.3	3.6	-1.9	1.7
Blood clot in the leg (DVT)	2.1	2.7	4.5	0.9	2.1
Neuroticism (2016)	2.0	2.8	5.3	-0.6	-2.3
Systolic Blood Pressure	2.0	10.2	12.9	-2.8	-3.6
Medication: Co-codamol	2.0	2.4	2.6	-1.6	-1.5
Arm fat percentage (right)	2.0	7.9	9.9	-2.4	3.1
Leg fat percentage (right)	2.0	7.1	7.3	-2.6	2.7
Overall health rating	2.0	4.3	7.2	1.2	2.7
Body Mass Index (BMI) (2010)	1.9	2.6	4.1	-1.1	2.0
Hip circumference	1.9	8.2	14.5	-1.4	3.8
Pulse wave peak to peak time	1.9	2.2	2.9	1.2	1.7
Medication: Ibuprofen	1.9	2.2	3.5	-1.9	1.0
Leg fat mass (right)	1.9	7.6	9.7	-2.3	3.1
Medication: Atorvastatin	1.9	2.4	4.2	-2.0	0.8
Depressed Affect (Nagel 2018)	1.8	3.8	5.9	-1.3	-2.4
Arm fat mass (right)	1.8	7.5	10.9	-2.0	3.3
Medication: Amlodipine	1.8	2.5	4.8	-2.2	-0.5
Medication: Allopurinol	1.8	2.4	4.5	-2.1	0.6
Pulse rate, automated reading	1.8	5.7	6.5	-2.5	2.2
Arm fat percentage (left)	1.8	7.0	7.6	-2.5	2.8
Arm fat mass (left)	1.8	7.5	10.6	-2.1	3.3
Leg fat percentage (left)	1.8	6.6	6.7	-2.5	2.6
Leg fat mass (left)	1.8	7.2	9.2	-2.3	3.0
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.8	0.6	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.3	2.1	0.4
Falls in the last year	1.7	2.2	4.2	-2.0	0.6
Gout (self-reported)	1.7	2.3	4.2	-2.1	0.6
Age at first live birth	1.7	3.0	4.7	-1.1	-2.2
Wears glasses or contact lenses	1.7	1.9	2.4	-1.6	-1.2
Smoking Status	1.6	3.9	7.9	2.8	0.1
Financial difficulties in last 2 years	1.6	2.1	3.1	1.8	1.0
Long-standing illness, disability or infirmity	1.6	2.5	4.5	-0.7	2.1
Medication: Paracetamol	1.6	2.5	4.8	-2.2	-0.3
Pain experienced in last month	1.6	2.7	4.6	-0.9	-2.1
Townsend deprivation index at recruitment	1.5	2.1	3.0	1.1	1.7
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.6	-0.7	-1.6
Waist circumference	1.5	5.4	8.0	-1.7	2.8
Medication: Lansoprazole	1.5	1.7	3.2	-1.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.7	1.9	0.4
Whole body fat mass	1.5	6.3	9.1	-1.9	3.0
Suffer from ‘nerves’	1.5	2.3	4.1	-0.7	-2.0
Supplements: Vitamin C	1.5	1.8	3.5	1.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.5	0.3	-1.9
Ever taken oral contraceptive pill	1.5	1.6	1.7	1.2	-1.3
Fractured/broken bones in last 5 years	1.5	2.0	3.9	-0.3	-2.0
Body fat percentage	1.4	5.5	5.9	-2.3	2.4
Health satisfaction	1.4	1.8	3.5	0.4	1.9
Illnesses of father: Heart disease	1.4	2.0	3.3	0.9	1.8
Alzheimer’s Disease (including proxy)	1.3	1.8	2.3	-1.2	1.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.4	1.0	-1.6
Weight	1.3	6.3	11.4	-1.1	3.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	3.9	2.0	-0.7
Medication for pain relief, constipation, heartburn	1.3	2.2	4.2	2.1	0.3
Knee pain experienced in last month	1.3	2.0	3.2	-0.9	1.8
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	0.8	1.6
Qualifications: nursing, teaching	1.3	2.0	4.0	-2.0	0.0
High cholesterol (Self-reported)	1.3	2.3	4.7	-2.2	0.0
Impedance of whole body	1.3	6.7	9.0	2.1	-3.0
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	-1.5	0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	2.4	-0.6	1.5
Age when periods started (menarche)	1.2	2.8	5.7	0.1	-2.4
Trunk fat mass	1.2	5.0	6.2	-1.9	2.5
Had menopause	1.2	1.5	2.2	-1.5	-0.9
Medication: Simvastatin	1.2	1.8	3.4	-1.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.2	-0.9	1.5
Pulse wave Arterial Stiffness index	1.2	1.4	2.1	-0.8	-1.4
Exposure to tobacco smoke at home	1.2	1.3	2.2	0.7	-1.5
Loud music exposure frequency	1.2	1.3	1.6	-1.0	-1.3
Number of children fathered	1.2	1.3	2.2	-1.5	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.1	0.8	-1.5
Smoking status: Previous	1.2	1.8	3.2	-0.6	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	2.9	-1.7	1.0
Illnesses of father: High blood pressure	1.2	1.4	2.8	-1.7	0.2
Average weekly beer plus cider intake	1.2	1.8	3.4	1.9	0.4
Mean Putamen Volume	1.1	1.2	2.1	-1.4	0.6
Impedance of leg (left)	1.1	5.3	7.1	1.9	-2.7
Heart attack	1.1	1.4	2.8	-1.7	0.1
Mood swings	1.1	2.0	3.9	-0.3	-2.0
Illnesses of father: None of the above (group 1)	1.1	1.4	1.4	-1.2	-1.2
Ever smoked	1.1	2.0	2.2	1.3	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.2	-1.5	-0.7
Primary Biliary Cirrhosis	1.0	1.5	1.5	-1.2	1.2
Hand grip strength (left)	1.0	2.5	3.2	-1.3	1.8
Trunk fat percentage	1.0	4.0	4.0	-2.0	2.0
Fed-up feelings	1.0	1.9	2.0	-1.4	-1.3
Taking other prescription medications	1.0	1.6	2.1	-1.0	1.5
High blood pressure (mother)	1.0	1.4	2.4	-1.6	-0.6
Number of incorrect matches in round	1.0	1.6	2.4	1.6	-0.9
Medication: Ramipril	1.0	1.3	1.5	1.0	1.2
Impedance of arm (left)	1.0	4.7	6.6	1.7	-2.6
Glaucoma (self-reported)	1.0	1.2	2.4	-1.5	-0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.5	-0.9	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	-0.7	1.4
Illnesses of siblings: Diabetes	1.0	1.2	2.0	1.4	0.7
Diabetes diagnosed by doctor	1.0	1.7	3.3	0.2	1.8
Medication for cholesterol	1.0	1.5	2.4	0.8	1.6
Back pain experienced in last month	1.0	1.5	2.9	1.7	-0.3
Chronotype (morning person)	0.9	2.2	3.1	-1.8	-1.1
Average weekly spirits intake	0.9	1.2	1.5	1.2	0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.1	-0.5	-1.5
Leg fat-free mass (left)	0.9	4.7	9.3	-0.3	3.0
Leg predicted mass (left)	0.9	4.9	9.7	-0.3	3.1
Hearing difficulty/problems with background noise	0.9	1.4	2.1	1.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.2	1.0	1.1
Medication: Paracetamol	0.9	1.6	2.0	-1.4	-1.0
Ever had bowel cancer screening	0.9	1.1	1.4	-1.2	-0.8
Commuting to job workplace: Public transport	0.9	1.1	1.7	0.7	-1.3
Basal metabolic rate	0.9	4.9	9.7	-0.0	3.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.0	-1.4	0.4
Blood Red Count	0.8	8.1	16.0	-4.0	-0.4
Systolic blood pressure, automated reading	0.8	2.2	3.1	-1.8	-1.1
Impedance of leg (right)	0.8	4.0	4.8	1.8	-2.2
Past tobacco smoking	0.8	1.4	2.3	-0.7	1.5
Fluid intelligence score	0.8	1.7	3.3	-0.2	1.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.4	0.4	-1.5
Medication: Gliclazide	0.8	0.9	1.6	-0.5	1.3
Hearing aid user	0.8	0.9	1.6	-1.3	-0.4
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.2	1.4
Depression (Nagel 2018)	0.7	1.0	1.6	0.7	-1.3
LDL Cholesterol	0.7	1.1	1.7	-1.3	-0.6
Schizophrenia (2014)	0.7	1.5	3.0	-1.7	0.2
Blood Eosinophil Count	0.7	5.6	10.6	3.2	0.8
Waist Hip Ratio (WHR)	0.7	3.3	6.6	-0.4	-2.6
Cardiovascular Disease	0.7	2.2	3.5	-1.9	1.0
Medication for hormone replacement therapy	0.7	0.7	1.0	-0.7	-1.0
Medication: Metformin	0.7	0.9	1.7	-1.3	0.3
Maternal smoking around birth	0.7	1.0	2.1	1.4	0.1
Relative age voice broke	0.7	1.1	1.5	-0.8	-1.2
Serious illness, injury or assault to yourself	0.7	0.9	1.5	0.5	1.2
Diabetes (self-reported)	0.7	1.1	1.7	0.7	1.3
Trunk fat-free mass	0.7	3.9	7.6	0.5	2.8
Lung cancer (father)	0.7	0.8	1.4	1.2	-0.4
Trunk predicted mass	0.7	4.1	8.0	0.5	2.8
Headache pain in last month	0.7	1.2	1.2	1.1	1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.5	-0.3	-1.2
Medication: Blood pressure	0.7	1.3	2.3	-1.5	0.6
Medication: Omeprazole	0.7	0.8	1.7	-1.3	0.0
Whole body fat-free mass	0.7	4.2	8.4	0.1	2.9
Leg fat-free mass (right)	0.7	4.0	7.9	-0.1	2.8
Whole body water mass	0.7	4.0	8.0	0.1	2.8
Leg predicted mass (right)	0.7	3.9	7.8	-0.2	2.8
Arm fat-free mass (left)	0.7	3.4	6.8	-0.2	2.6
Age started oral contraceptive pill	0.7	0.9	1.7	-1.3	0.2
Commuting to job workplace: Cycle	0.7	0.8	1.6	0.2	-1.2
Basal cell carcinoma (self-reported)	0.7	0.8	0.9	-0.8	-0.9
Arm predicted mass (left)	0.7	3.8	7.4	-0.4	2.7
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	1.1	0.7
Alzheimer’s Disease (in father)	0.6	0.6	1.2	-1.1	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	-1.1	0.5
Blood White Count	0.6	4.4	8.6	0.5	2.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	1.1	-0.4
Hand grip strength (right)	0.6	1.7	3.1	-1.8	0.6
Medication: Atenolol	0.6	0.7	1.5	-1.2	0.1
Alcohol usually taken with meals	0.6	0.9	1.4	-0.7	-1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	1.7	1.3	0.2
Impedance of arm (right)	0.6	3.0	3.1	1.8	-1.7
Alcohol intake versus 10 years previously	0.6	0.8	0.8	0.9	0.9
Happiness	0.6	0.7	1.0	-1.0	0.6
Illnesses of mother	0.6	0.7	0.9	0.7	-0.9
Standing height	0.6	5.6	11.0	3.3	-0.5
Shortness of breath walking on level ground	0.6	0.7	1.3	-1.1	0.4
Neck or shoulder pain in last month	0.6	0.9	1.8	0.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.3	-1.1	0.5
Number of self-reported non-cancer illnesses	0.6	1.1	2.2	-0.2	1.5
Financial situation satisfaction	0.6	0.8	1.6	1.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.1	-1.4	0.3
Ovarian Cancer	0.5	0.6	1.2	0.2	1.1
Crohns Disease (2012)	0.5	0.8	1.0	-1.0	0.8
Fasting Glucose	0.5	0.7	1.2	0.3	1.1
Height	0.5	9.0	17.6	4.2	-0.6
Lung FVC	0.5	2.8	4.7	-0.9	-2.2
Hearing difficulty/problems: Yes	0.5	0.7	1.2	1.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	-0.1	1.1
Severe depression (siblings)	0.5	0.5	0.6	-0.7	-0.8
Pulse rate	0.5	0.9	1.6	-1.3	0.5
Noisy workplace	0.5	0.6	1.1	-0.4	1.0
Depression (self-reported)	0.5	0.6	0.9	-0.4	-1.0
Pulse wave reflection index	0.5	0.7	0.7	-0.8	-0.8
Birth weight	0.5	1.1	1.2	-1.0	-1.1
Number of full brothers	0.5	0.7	1.3	0.3	1.1
Comparative height size at age 10	0.5	2.5	3.9	2.0	1.1
Age at last live birth	0.5	0.7	0.9	-0.7	-0.9
Mineral and other dietary supplements	0.5	0.6	0.9	1.0	0.6
Osteoporosis (self-reported)	0.5	0.6	0.8	0.9	-0.6
Average weekly champagne plus white wine intake	0.5	0.8	1.0	-0.7	-1.0
Miserableness	0.5	0.8	1.7	-0.0	-1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.9	-0.7	-1.0
Unable to work because of sickness or disability	0.5	0.7	1.4	0.2	1.2
Breast Cancer	0.4	1.0	1.2	-1.1	-0.9
Lupus	0.4	0.6	0.8	-0.9	-0.6
Respiratory disease	0.4	0.9	1.4	1.2	0.6
Relative age of first facial hair	0.4	0.9	1.2	1.1	-0.8
Vitamin and mineral supplements	0.4	0.6	1.1	-1.1	0.0
Allergy	0.4	0.8	1.7	-0.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	-1.3	-0.5
Asthma	0.4	0.7	1.1	1.0	0.6
Angina (self-reported)	0.4	0.5	0.6	-0.8	0.7
Medication: Seretide 50 evohaler	0.4	0.5	0.5	0.7	-0.7
Medication: Aspirin	0.4	0.5	0.9	0.5	0.9
Hypertension (Self-reported)	0.4	1.1	2.0	-0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	0.9	0.9	1.0
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	-0.9	0.3
Number of operations (self-reported)	0.4	0.7	1.3	-1.1	-0.2
Diastolic blood pressure, automated reading	0.4	1.3	2.5	-1.6	-0.1
Myopia	0.4	0.6	0.6	-0.8	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.3	0.1	-1.5
Supplements: Calcium	0.4	0.5	0.8	-0.9	-0.4
Prostate Cancer	0.3	0.5	0.9	-0.9	-0.1
HbA1C	0.3	0.3	0.5	-0.7	0.3
HDL Cholesterol	0.3	0.4	0.8	0.9	0.3
Hypothyroidism (self reported)	0.3	0.6	0.8	0.7	0.9
Number of treatments/medications taken	0.3	0.5	0.9	-0.9	0.3
Angina	0.3	0.4	0.4	-0.6	0.6
High blood pressure	0.3	0.9	1.9	-0.1	1.4
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	-1.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.2	-0.8
Qualifications: None of the above	0.3	0.6	1.0	-0.3	1.0
Birth weight of first child	0.3	0.6	1.1	-1.0	-0.1
Arm fat-free mass (right)	0.3	1.7	3.3	-0.2	1.8
Arm predicted mass (right)	0.3	1.7	3.3	-0.2	1.8
Commuting to job workplace: Walk	0.3	0.3	0.3	0.5	0.5
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.7	-0.3
Medication: Aspirin	0.3	0.4	0.9	0.2	0.9
Cholesterol lowering medication	0.3	0.4	0.8	-0.9	-0.0
Pack years of smoking	0.3	0.5	0.8	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.8	-0.9	0.8
Schizophrenia (2018)	0.2	0.4	0.7	-0.8	0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.8	0.4
Blood Platelet Count	0.2	2.8	4.6	-2.1	-1.0
Heel T-Score	0.2	1.4	2.1	-1.4	-0.8
Allergy or Eczema	0.2	0.7	1.0	-1.0	0.6
Hair Pigment	0.2	4.6	6.2	-2.5	-1.8
Supplements: Zinc	0.2	0.3	0.4	-0.3	0.6
Diabetes (father)	0.2	0.3	0.5	0.7	-0.3
Average weekly fortified wine intake	0.2	0.2	0.4	-0.7	-0.1
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.4	-0.5	0.7
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	-0.3
Sitting height	0.2	1.3	2.6	1.6	-0.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.1	0.8
Mouth/teeth dental problems	0.2	0.4	0.7	0.8	-0.1
Prospective memory result	0.2	0.2	0.3	-0.3	-0.6
Breastfed as a baby	0.2	0.3	0.5	-0.7	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.7	-0.2
Comparative body size at age 10	0.2	0.6	0.7	-0.7	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.3
Had major operations	0.2	0.3	0.4	-0.7	-0.3
Medication: Blood pressure	0.2	0.3	0.5	-0.4	-0.7
Medication: Bendroflumethiazide	0.2	0.3	0.3	-0.5	-0.5
Ever depressed for a whole week	0.2	0.3	0.3	0.5	0.5
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.7	-0.0
Age at First Birth	0.1	0.2	0.4	0.6	-0.1
Rheumatoid Arthritis	0.1	0.1	0.1	0.4	-0.3
Triglycerides	0.1	0.1	0.2	-0.4	-0.1
Lung FEV1/FVC ratio	0.1	0.3	0.4	-0.3	-0.7
Tanning	0.1	1.2	1.5	0.9	1.2
Pack years adult smoking proportion	0.1	0.2	0.2	-0.4	-0.5
Multivitamins +/- minerals	0.1	0.1	0.2	-0.5	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.5	0.1
Forced vital capacity (FVC)	0.1	0.4	0.7	-0.1	-0.9
Illnesses of siblings	0.1	0.2	0.3	-0.6	-0.3
Father’s age at death	0.1	0.2	0.4	0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.1	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.3	0.3	-0.5	-0.5
Length of working week for main job	0.1	0.1	0.3	-0.1	-0.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.2	0.5
High blood pressure (siblings)	0.1	0.1	0.2	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.1	0.5
Loneliness, isolation	0.1	0.2	0.3	0.6	0.0
Breast cancer (self-reported)	0.1	0.1	0.2	-0.5	-0.2
Asthma (self-reported)	0.1	0.2	0.2	0.5	0.5
Mother’s age at death	0.1	0.2	0.2	-0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	-0.2
Risk taking	0.1	0.1	0.2	0.4	-0.3
Heart disease (siblings)	0.1	0.2	0.2	0.5	0.4
Crohns Disease (2017)	0.0	0.0	0.1	-0.2	0.1
Ulcerative Colitis	0.0	0.1	0.1	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.4	0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	-0.1
Had other major operations	0.0	0.0	0.0	-0.0	-0.0
Time employed in main current job	0.0	0.0	0.0	-0.2	0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.1	-0.3
Peak expiratory flow (PEF)	0.0	0.1	0.1	0.3	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	0.5	0.1
Qualifications: College or University degree	0.0	0.1	0.3	0.0	0.5
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.1	-0.1
Chest pain or discomfort	0.0	0.0	0.1	0.1	0.2
Leg pain on walking	0.0	0.0	0.0	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

CHMP3

Models

Trait associations