Hub : Genes

RNF103

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1010 0.0490 0.0004 0.040 NA 0.038 NA 0.052 0.0019 NA 0.0023 NA 0.00041
2 GTEx Nerve Tibial 0.0537 0.0281 0.0061 0.005 NA -0.004 NA 0.006 0.1300 NA 0.9000 NA 0.11000
3 GTEx Whole Blood 0.0670 0.0300 0.0027 -0.003 NA 0.001 NA -0.003 0.9400 NA 0.2400 NA 0.79000
4 ROSMAP Brain Pre-frontal Cortex 0.0372 0.0190 0.0026 0.001 0.018 0.000 0.019 -0.001 0.2700 0.0019 0.2800 0.0016 0.41000
5 TCGA Liver Hepatocellular Carcinoma 0.0590 0.0370 0.0075 0.018 0.025 -0.005 NA 0.010 0.0440 0.0240 0.7500 NA 0.10000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.3 2.1 3.8 -1.4 -1.9 -0.5 -1.5 1.5
Bipolar Disorder or Schizophrenia 0.9 2.3 5.2 -1.8 -1.0 -2.3 -0.4 1.5
Depressed Affect (Nagel 2018) 0.2 0.4 1.5 0.2 -0.7 0.0 -1.2 -0.4
Depression (Nagel 2018) 0.5 0.8 2.2 0.4 0.7 -0.2 -1.0 -1.5
Intelligence (Savage-Jansen 2018) 1.1 3.4 7.9 -2.1 -1.2 -2.8 -0.7 1.8
Neuroticism (Nagel 2018) 0.4 1.0 2.6 -0.0 -1.6 0.4 -1.6 -0.2
Schizophrenia (2018) 0.9 1.8 6.6 -1.1 0.3 -2.6 0.8 0.7
Schizophrenia vs Biploar Disorder 1.4 1.9 3.4 0.5 1.7 -1.3 1.9 -1.1
Worry (Nagel 2018) 0.5 1.0 3.1 -0.2 -1.8 0.3 -1.3 -0.1
Alzheimer’s Disease (in mother) 2.0 2.3 3.7 -1.9 -1.4 -0.9 -1.6 1.6
Alzheimer’s Disease (in father) 1.5 1.6 3.8 -1.9 -0.9 -0.6 -0.4 1.7
Alzheimer’s Disease (including proxy) 2.5 3.7 5.8 -2.4 -1.4 -1.6 -1.6 2.4
Crohns Disease (2017) 0.3 0.7 2.9 -0.6 -0.4 -1.7 0.1 0.4
Irritable Bowel Disease (IBD) 0.3 0.7 0.9 0.9 0.8 -0.4 0.9 -0.9
Ulcerative Colitis (UC) 0.7 1.3 2.6 1.6 0.9 0.7 0.9 -1.3
Major Depression (MDD) 1.1 1.3 2.2 -1.0 -1.5 0.6 -1.3 1.1
Reaction Time 5.3 10.0 14.8 3.8 2.9 2.8 2.7 -3.5
Verbal and Numeric Reasoning (VNR) 1.7 4.0 6.8 -2.3 -1.2 -2.6 -1.5 2.1
Breast Cancer 0.5 1.3 2.8 -1.7 -0.8 -0.9 -0.8 1.2
Ovarian Cancer 0.3 0.3 1.0 -1.0 0.6 -0.3 -0.6 0.2
Prostate Cancer 0.5 0.6 2.2 -0.7 -0.6 -0.2 0.3 1.5
Age at First Birth 0.2 0.2 0.6 0.0 0.8 0.5 0.4 -0.4
Bipolar Disorder (2011) 4.9 4.8 6.2 -1.7 -2.5 -2.3 -2.0 2.3
Body Mass Index (BMI) (2010) 3.1 4.3 6.1 -2.4 -1.7 -1.1 -2.3 2.5
Coronary Artery Disease (CAD) 9.0 10.7 19.0 -3.7 -2.0 -4.4 -2.2 3.4
Crohns Disease (2012) 0.7 1.1 1.7 -0.7 -1.3 -1.2 0.2 1.3
Mean Putamen Volume 3.0 3.4 6.8 -1.0 -2.6 -1.3 -1.6 2.3
Fasting Glucose 0.0 0.0 0.2 0.1 0.1 -0.4 0.1 0.2
HbA1C 0.3 0.3 0.9 -0.4 -0.0 0.6 -0.4 1.0
HDL Cholesterol 1.2 2.0 4.2 1.4 1.5 0.9 2.0 -0.9
LDL Cholesterol 0.4 0.7 1.7 -0.6 -0.9 0.2 -1.3 0.8
Lupus 0.2 0.3 0.8 0.5 -0.1 0.9 -0.4 0.1
Neuroticism (2016) 0.1 0.2 0.3 0.2 -0.3 0.5 -0.4 -0.6
Primary Biliary Cirrhosis 1.0 1.4 3.5 -1.2 -1.0 -0.9 -0.3 1.9
Rheumatoid Arthritis 0.3 0.4 1.0 0.6 -0.1 1.0 -0.6 -0.5
Schizophrenia (2014) 1.4 3.1 10.4 -1.7 -0.6 -3.2 0.1 1.3
Triglycerides 0.1 0.2 0.4 -0.5 -0.5 0.3 -0.6 -0.3
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 -1.7 -1.1 -1.1 -0.6 1.1
Ulcerative Colitis 0.1 0.2 0.3 0.5 0.2 0.5 0.0 -0.5
Blood Eosinophil Count 1.0 7.3 10.5 2.2 3.2 2.2 2.8 -3.0
Blood Platelet Count 0.5 5.6 12.2 -2.6 -2.1 -1.7 -3.5 1.1
Blood Red Count 0.9 9.0 16.0 -2.5 -4.0 -1.1 -3.5 3.1
Blood White Count 0.5 3.4 4.9 -1.2 -2.2 -2.0 -1.8 1.8
Heel T-Score 0.3 2.3 4.3 -2.0 -0.8 -1.2 -1.1 2.1
BMI 4.1 24.0 51.7 -4.9 -4.2 -3.9 -3.5 7.2
Height 0.7 13.9 28.8 4.9 2.3 2.5 2.3 -5.4
Waist Hip Ratio (WHR) 0.1 0.5 1.3 0.5 0.1 1.1 0.1 -1.1
Systolic Blood Pressure 0.7 3.7 9.9 -3.1 -1.2 -1.8 -1.8 0.8
Smoking Status 3.8 9.0 17.6 4.2 1.7 2.5 2.8 -3.3
Allergy or Eczema 0.4 1.0 2.5 -1.6 -0.4 -0.2 -1.2 0.9
Cardiovascular Disease 3.3 10.8 13.8 -3.7 -2.9 -3.2 -3.5 3.0
Hypothyroidism (self reported) 0.3 0.6 2.6 1.6 -0.1 0.4 0.5 0.0
Respiratory disease 0.3 0.7 1.5 0.8 1.2 0.6 -0.0 -0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.3 -0.9 -0.1 -0.3 -0.5 1.1
Lung FEV1/FVC ratio 0.2 1.3 4.5 0.5 -0.2 -2.1 0.9 -0.8
Lung FVC 0.0 0.2 0.6 -0.1 -0.6 0.1 -0.8 0.2
Neuroticism 0.5 1.3 2.2 0.5 -1.5 1.5 -0.9 -1.0
Chronotype (morning person) 0.6 1.3 2.4 -1.4 -0.9 -0.7 -0.9 1.6
Hair Pigment 0.1 2.0 3.0 -1.6 -1.7 -0.8 -1.1 1.7
Tanning 0.1 0.6 1.0 1.0 -0.9 0.7 -1.0 -0.1
Hand grip strength (left) 2.0 5.3 8.0 -2.0 -2.3 -2.1 -2.1 2.8
Number of treatments/medications taken 0.2 0.4 1.2 -0.5 -0.2 -1.1 -0.4 0.7
Average weekly spirits intake 0.4 0.4 1.2 0.7 -0.1 1.1 -0.6 -0.3
Sensitivity / hurt feelings 0.8 1.4 5.1 0.7 0.4 2.2 0.4 -1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.6 0.8 0.4 -0.3 -0.8 -1.6
Hearing difficulty/problems: Yes 0.2 0.3 0.8 0.2 -0.4 0.9 -0.4 -0.3
Relative age of first facial hair 1.0 2.2 3.1 1.5 1.7 -0.1 1.8 -1.6
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 0.3 -0.5 0.5 -1.2 0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 0.2 -0.4 0.6 1.2 0.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.4 0.5 0.6 1.2 0.9 -0.8
Systolic blood pressure, automated reading 1.1 3.1 9.7 -3.1 -0.7 -1.3 -1.3 1.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.3 -1.0 -1.1 -0.0 -1.3 1.5
Angina 0.8 1.0 1.6 -0.6 -1.3 -1.1 -1.1 0.9
Medication for hormone replacement therapy 0.6 0.7 1.9 1.4 -1.1 0.5 0.0 0.2
Vitamin and mineral supplements 1.4 1.9 4.7 -1.5 -0.4 -1.4 -2.2 0.6
Supplements: Zinc 0.1 0.1 0.3 -0.5 -0.0 -0.1 -0.1 0.3
Medication: Co-codamol 0.5 0.6 1.7 -0.8 -0.4 0.6 -1.3 0.0
Medication: Metformin 0.5 0.7 1.2 -0.7 -1.1 -0.3 -0.9 1.1
Diabetes (father) 0.4 0.5 1.5 -0.6 1.2 -0.5 0.1 -0.4
Diabetes (mother) 0.2 0.3 1.2 1.1 -0.0 0.2 0.6 -0.1
Severe depression (siblings) 1.1 1.2 3.2 0.1 -1.8 -0.8 -1.2 0.9
Pack years adult smoking proportion 0.6 1.0 4.3 -0.2 -0.7 2.1 0.1 -0.0
Impedance of leg (right) 1.5 7.3 12.2 2.4 2.3 1.3 3.5 -3.4
Leg fat-free mass (left) 0.7 3.5 6.5 -1.5 -1.9 -0.9 -2.1 2.5
Trunk fat percentage 1.9 7.8 15.3 -2.9 -2.7 -1.9 -2.0 3.9
Hand grip strength (right) 1.4 3.9 5.9 -1.8 -2.2 -0.6 -2.4 2.2
Townsend deprivation index at recruitment 0.1 0.2 0.4 0.7 -0.6 -0.4 0.0 0.2
Current tobacco smoking 4.5 7.3 13.4 3.7 1.5 2.3 2.5 -3.1
Average weekly fortified wine intake 0.7 0.8 1.7 -1.3 0.6 -1.1 0.9 0.4
Maternal smoking around birth 0.6 0.8 1.7 1.2 -0.2 1.3 0.5 -0.9
Fed-up feelings 0.4 0.7 1.9 -0.4 -1.1 -0.4 -1.4 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.4 0.4 1.5 -0.5 0.1 -1.3
Relative age voice broke 0.1 0.2 0.4 0.0 0.7 0.3 0.6 0.1
Taking other prescription medications 1.3 2.1 2.7 -1.0 -1.4 -1.6 -1.6 1.5
Age when periods started (menarche) 1.0 2.3 4.6 1.4 1.0 2.1 0.9 -1.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.9 -0.8 -1.4 0.9 -0.9 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.5 0.5 -0.1 1.6 0.5 1.0
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.3 1.1 -0.2 1.2 0.2 -0.4
Qualifications: CSEs or equivalent 0.1 0.1 0.1 0.1 -0.4 0.1 -0.3 0.3
Serious illness, injury or assault to yourself 0.5 0.6 1.6 1.3 0.4 0.9 0.6 -0.5
High blood pressure 0.9 2.4 4.1 -2.0 -0.5 -1.7 -1.8 1.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 -1.2 -0.1 0.3 -1.1 0.6
Multivitamins +/- minerals 0.5 0.6 1.8 -0.5 -1.0 0.3 0.1 1.3
Stomach or abdominal pain in last month 0.8 1.0 1.9 -0.6 -1.1 -1.4 -1.0 0.6
Supplements: Glucosamine 0.3 0.4 0.9 -0.6 -0.4 -0.7 0.2 0.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.5 -0.9 -0.2 -0.7 0.9
Medication: Atenolol 0.3 0.4 0.7 -0.8 -0.3 0.5 -0.8 0.6
Medication: Levothyroxine sodium 0.3 0.5 1.2 1.1 -0.5 0.8 0.8 -0.0
Sitting height 0.5 3.7 8.1 2.8 0.3 1.9 -0.1 -2.6
Chronic bronchitis/emphysema (father) 4.8 5.6 9.2 2.8 2.5 1.6 1.5 -3.0
High blood pressure (mother) 0.8 1.2 2.6 -0.2 -1.2 -1.6 0.3 1.3
Body mass index (BMI) 4.1 17.6 36.8 -4.3 -3.6 -3.0 -3.2 6.1
Impedance of leg (left) 1.9 9.2 15.8 3.1 2.5 1.6 3.4 -4.0
Leg predicted mass (left) 0.7 3.8 7.0 -1.6 -1.9 -1.0 -2.2 2.6
Trunk fat mass 2.1 8.9 17.4 -2.9 -3.0 -2.2 -2.2 4.2
Waist circumference 2.5 9.3 17.6 -3.2 -2.8 -2.2 -2.4 4.2
Number of incorrect matches in round 2.1 3.4 6.0 2.1 1.8 1.0 2.4 -1.7
Past tobacco smoking 1.0 1.9 4.0 -2.0 -0.8 -1.0 -1.2 1.5
Alcohol usually taken with meals 1.0 1.7 4.0 -2.0 -0.8 -1.0 -0.3 1.6
Nervous feelings 1.0 1.9 4.5 -0.7 -2.1 0.7 -1.9 0.6
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.3 9.7 2.9 1.1 0.7 1.3 -3.1
Hearing difficulty/problems with background noise 0.7 1.0 1.5 0.8 1.1 0.7 1.1 -1.2
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 -0.3 0.0 0.2 0.4 1.0
Had menopause 0.5 0.6 0.8 -0.7 -0.9 0.9 -0.3 0.8
Had other major operations 0.4 0.4 1.4 0.0 1.2 0.8 -0.3 -0.4
Forced vital capacity (FVC) 0.1 0.2 0.4 0.5 -0.0 -0.1 -0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.5 -0.1 -0.5 0.5 0.2 1.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.1 0.9 -0.8 1.4 0.1 -0.1
Qualifications: None of the above 0.1 0.1 0.4 -0.2 -0.0 -0.7 -0.1 0.3
Financial difficulties in last 2 years 1.0 1.3 2.7 0.8 1.6 0.9 1.3 -0.8
Mouth/teeth dental problems 1.2 1.8 3.2 1.8 1.1 -0.2 1.3 -1.7
Heart attack 0.2 0.3 0.7 0.1 -0.4 -0.8 -0.0 0.8
Allergy 0.2 0.4 1.5 0.5 0.3 -0.3 1.2 -0.3
Pain all over the body in last month 4.7 5.0 7.7 -2.6 -1.9 -1.8 -1.9 2.8
Diabetes (self-reported) 0.1 0.2 0.5 -0.7 0.1 0.2 -0.6 0.3
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 4.8 0.5 2.2 0.7 0.7 -2.1
Medication: Ramipril 0.5 0.6 1.4 0.9 0.7 0.5 1.2 -0.3
Medication: Simvastatin 2.4 3.5 6.8 -2.6 -0.9 -1.3 -1.8 2.2
Fluid intelligence score 1.8 3.8 6.0 -2.3 -0.4 -2.3 -1.5 2.4
Illnesses of siblings 1.1 1.6 4.5 -0.1 -2.1 0.5 -1.8 0.4
Neuroticism score 0.3 0.6 1.3 0.3 -1.1 0.8 -0.8 -0.7
Weight 1.4 6.8 13.8 -2.4 -2.5 -1.9 -2.1 3.7
Impedance of arm (right) 1.0 4.6 10.6 1.5 2.3 1.4 1.6 -3.3
Arm fat percentage (right) 3.4 13.3 27.2 -4.0 -3.2 -2.4 -2.7 5.2
Trunk fat-free mass 0.2 1.0 1.3 -0.2 -1.2 -1.0 -1.0 1.1
Hip circumference 2.3 10.0 17.3 -3.2 -2.9 -2.2 -3.0 4.2
Time employed in main current job 0.3 0.3 1.3 -0.2 -0.3 -1.1 -0.2 0.3
Alcohol intake versus 10 years previously 0.2 0.4 1.1 0.6 0.0 1.1 -0.6 -0.1
Father’s age at death 0.3 0.3 0.6 0.6 0.5 0.4 0.7 -0.6
Worrier / anxious feelings 0.6 1.1 2.5 0.8 -0.3 1.6 0.1 -1.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 0.6 -0.3 -0.5 -0.3 0.5
Falls in the last year 2.7 3.6 5.7 -1.8 -2.2 -0.6 -2.0 2.4
Hair/balding pattern: Pattern 3 0.4 0.6 2.2 0.0 0.6 1.5 -0.4 -0.1
Number of live births 0.7 0.9 2.0 0.8 1.0 -0.6 1.4 -0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.8 0.2 0.1 -0.9 -0.4 -0.4
Pulse rate 1.4 2.3 3.6 -0.9 -1.9 -1.5 -1.6 1.6
Happiness 1.9 2.3 3.8 -1.6 -1.7 -0.6 -1.4 1.9
Noisy workplace 0.7 0.8 1.5 1.2 -1.0 0.5 0.7 0.8
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.4 -2.3 -0.4 -0.7 -1.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.3 -0.0 1.2 0.3 0.0 0.0
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 -0.9 0.5 0.1 -0.3 0.7
Asthma 0.4 0.8 1.7 1.3 1.0 0.6 0.7 -0.7
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 5.1 -0.8 -2.3 0.1 -1.2 2.2
Medication: Cholesterol lowering 4.0 6.2 10.4 -3.2 -1.3 -1.8 -2.8 2.8
Depression (self-reported) 0.3 0.4 1.3 -0.4 -0.4 -1.1 -0.2 0.6
Medication: Lansoprazole 1.1 1.3 1.9 -0.7 -1.1 -1.0 -1.4 1.3
Prospective memory result 0.2 0.2 0.4 0.7 -0.2 -0.3 0.5 -0.3
Lung cancer (father) 1.1 1.2 2.1 1.4 0.6 1.4 1.0 -1.0
Illnesses of mother 0.5 0.6 1.3 0.9 0.8 0.5 0.3 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.7 0.1 0.3 -0.8 -0.5 -0.4
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 0.2 -0.6 0.7 -0.1 -0.6
Impedance of arm (left) 1.4 6.5 13.9 2.4 2.1 2.2 1.9 -3.7
Arm fat mass (right) 2.9 12.0 24.0 -3.4 -3.2 -2.5 -2.8 4.9
Trunk predicted mass 0.2 1.1 1.5 -0.3 -1.2 -1.0 -1.1 1.2
Standing height 0.9 9.1 19.4 3.8 2.1 2.0 1.8 -4.4
Length of working week for main job 1.0 1.2 4.9 0.8 -0.1 2.2 -0.1 -0.5
Exposure to tobacco smoke at home 3.7 4.1 6.4 2.5 1.5 1.6 2.2 -2.1
Breastfed as a baby 0.2 0.2 0.4 -0.6 -0.2 -0.3 0.4 0.6
Tense / ‘highly strung’ 2.9 4.8 10.8 -1.7 -3.3 -1.1 -2.6 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.0 -0.5 -1.2 1.2 -1.7 -0.1
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 0.0 -0.6 0.6 -0.4 0.1
Birth weight of first child 1.9 3.4 16.1 -0.8 0.1 -4.0 0.7 0.2
Peak expiratory flow (PEF) 0.2 0.5 1.7 -1.0 0.2 -1.3 -0.2 0.3
Pulse wave reflection index 0.2 0.3 1.2 -1.1 -0.0 0.4 -0.1 0.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 -0.3 -0.5 -0.4 -0.3 0.6
Loud music exposure frequency 0.8 0.9 3.4 -1.0 0.4 1.9 -0.3 0.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.2 0.5 0.3 0.7 -0.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.2 -1.1 -1.5 -0.9 -0.4 1.2
Blood clot in the leg (DVT) 0.2 0.3 1.0 1.0 -0.3 0.4 -0.3 -0.2
Medication: Paracetamol 0.3 0.4 1.4 -0.4 -0.4 0.6 0.2 1.2
Headache pain in last month 1.4 2.5 4.8 1.8 1.4 2.2 1.3 -0.8
Medication for cholesterol, blood pressure or diabetes 3.5 5.8 6.9 2.6 1.7 2.6 2.6 -2.5
Glaucoma (self-reported) 0.8 1.0 1.7 -1.0 -1.0 -1.1 -0.4 1.3
Gout (self-reported) 3.8 5.1 10.6 -1.7 -3.3 -0.7 -2.0 2.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.5 1.2 -0.2 0.7 0.7 0.1
Medication: Amlodipine 3.5 5.0 7.6 -2.1 -2.1 -1.4 -2.8 2.5
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.5 1.9 0.9 -0.4 0.1 -1.4
Birth weight 0.1 0.3 0.7 0.8 -0.3 -0.5 0.4 -0.0
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.0 0.1 0.1 1.0 0.5 -0.2
High blood pressure (siblings) 0.7 1.0 1.7 -0.8 1.1 -1.3 1.0 0.0
Forced vital capacity (FVC), Best measure 0.1 0.3 1.0 0.4 0.4 -0.0 -1.0 -0.5
Body fat percentage 2.6 10.2 20.8 -3.5 -2.9 -2.4 -2.0 4.6
Leg fat percentage (right) 3.8 13.7 28.8 -4.2 -3.0 -3.2 -1.6 5.4
Arm fat-free mass (right) 0.2 1.3 2.8 -0.2 -1.6 -0.7 -0.8 1.7
Exposure to tobacco smoke outside home 1.4 1.9 2.5 1.5 1.3 1.6 1.1 -1.2
Comparative body size at age 10 0.7 2.1 3.0 -1.7 -0.5 -1.5 -1.5 1.6
Number of full brothers 0.2 0.3 0.8 0.9 -0.2 0.2 0.7 0.1
Worry too long after embarrassment 0.8 1.4 3.8 1.7 0.2 0.1 0.7 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 0.8 -0.4 1.0 -0.1 -1.0
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 0.4 -0.1 0.2 -0.8 0.1
Number of children fathered 1.7 1.9 3.7 -1.0 -1.6 0.6 -1.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 2.7 1.6 0.6 1.2 0.5 -1.6
Age at first live birth 0.7 1.2 3.5 -1.6 0.1 0.3 -1.9 -0.0
Pulse wave peak to peak time 0.2 0.3 0.9 0.2 0.9 -0.7 0.3 0.2
Health satisfaction 0.5 0.6 1.9 -0.9 -0.6 -0.2 -0.3 1.4
Shortness of breath walking on level ground 1.3 1.5 3.2 -1.2 -1.1 -1.3 -0.3 1.8
Qualifications: College or University degree 0.4 1.4 3.0 -1.4 1.0 -1.7 -0.8 0.5
Eye problems/disorders: None of the above 0.5 0.6 2.2 -0.5 0.5 -1.5 0.1 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 -0.6 -1.1 0.9 -0.9 0.2
Emphysema/chronic bronchitis 1.3 1.4 2.3 1.0 1.0 -1.1 1.5 -1.3
Medication for pain relief, constipation, heartburn 1.3 2.3 4.4 0.9 2.1 -0.4 1.3 -2.1
Neck or shoulder pain in last month 0.5 0.7 2.3 -0.2 -0.7 1.5 -0.0 1.0
Medication: Blood pressure 1.8 3.2 4.4 -1.7 -1.5 -1.9 -2.1 1.8
Angina (self-reported) 1.1 1.5 2.3 -0.8 -1.5 -1.3 -1.2 1.1
Migraine (self-reported) 1.3 1.6 3.0 -0.9 -1.5 0.1 -1.4 1.7
Medication: Ibuprofen 3.3 3.9 8.0 -1.6 -2.8 -0.4 -1.6 2.6
Medication: Allopurinol 4.2 5.6 8.9 -1.9 -3.0 -1.4 -2.7 2.5
Medication: Omeprazole 1.9 2.2 4.9 -0.8 -2.2 0.5 -1.3 1.9
Medication: Seretide 50 evohaler 1.2 1.4 4.8 2.2 0.5 0.9 0.6 -1.0
Mean time to correctly identify matches 6.5 12.4 16.4 3.8 3.3 3.2 3.2 -4.0
Heart disease (mother) 2.3 2.9 5.2 1.4 2.0 1.6 0.7 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 1.9 -1.2 -1.1 -0.7 -1.4 1.3
Whole body fat mass 2.5 10.3 20.8 -3.2 -3.1 -2.5 -2.2 4.6
Leg fat mass (right) 3.3 12.7 25.9 -3.9 -3.0 -2.9 -2.2 5.1
Arm predicted mass (right) 0.2 1.2 2.4 -0.4 -1.3 -0.9 -0.9 1.6
Pulse rate, automated reading 4.2 13.6 17.3 -3.2 -3.8 -3.5 -3.8 4.2
Alcohol intake frequency. 0.8 1.8 5.6 -0.4 -0.3 -1.8 -0.1 2.4
Comparative height size at age 10 0.5 2.6 4.6 2.1 1.3 1.3 1.3 -1.9
Number of full sisters 0.1 0.1 0.4 0.7 -0.1 0.0 -0.3 -0.1
Suffer from ‘nerves’ 0.1 0.2 0.6 -0.1 -0.7 0.3 -0.8 -0.0
Overall health rating 0.1 0.2 0.5 0.7 0.3 0.3 -0.3 0.5
Chest pain or discomfort 0.7 1.0 3.1 -0.9 -1.0 0.1 -1.8 0.4
Had major operations 0.1 0.1 0.3 0.5 -0.2 0.5 0.1 -0.2
Age at last live birth 0.7 1.0 2.7 -1.5 -0.2 -0.3 -1.6 -0.0
Family relationship satisfaction 0.3 0.4 1.1 0.3 1.1 0.2 0.3 -0.6
Leg pain on walking 0.1 0.1 0.1 0.2 -0.0 0.2 0.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 6.7 2.6 0.2 1.6 1.8 -1.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.3 -0.2 -0.2 -1.1 0.5 0.7
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 3.4 -1.9 -1.7 -1.5 -1.4 0.8
Medication: Aspirin 0.1 0.2 0.9 0.1 -0.0 0.9 -0.3 0.1
Supplements: Vitamin C 2.1 2.5 3.9 1.1 1.6 1.0 1.9 -2.0
Knee pain experienced in last month 1.7 2.6 4.7 -1.8 -1.0 -0.5 -1.9 2.2
Hypertension (Self-reported) 1.1 3.2 5.2 -2.1 -0.8 -1.7 -2.3 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 1.8 -0.9 -0.9 -0.9 -1.4 1.2
Illnesses of father: Heart disease 0.1 0.1 0.4 -0.0 0.4 0.3 -0.1 0.7
Illnesses of siblings: Diabetes 2.6 3.2 7.3 1.5 2.2 0.8 2.7 -1.1
Smoking status: Previous 0.1 0.1 0.3 0.3 0.3 0.6 0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.3 1.1 0.1 0.1 -0.6 -0.9
Whole body fat-free mass 0.3 1.9 3.2 -0.7 -1.5 -1.0 -1.5 1.8
Leg fat-free mass (right) 0.5 2.7 5.0 -1.0 -1.6 -0.7 -2.2 2.1
Arm fat percentage (left) 3.2 12.7 26.4 -3.7 -3.3 -2.0 -2.8 5.1
Average weekly red wine intake 0.2 0.3 0.7 -0.9 -0.4 0.1 -0.5 0.5
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.2 0.5 -0.4 -1.1 -0.3 0.0
Mood swings 0.6 1.1 1.9 1.2 0.3 1.4 -0.3 -1.4
Loneliness, isolation 0.1 0.2 0.4 0.3 -0.6 0.1 -0.5 -0.3
Long-standing illness, disability or infirmity 0.6 0.9 2.3 -0.4 -0.5 -0.7 -1.1 1.5
Ever had bowel cancer screening 0.4 0.4 1.5 1.2 -0.3 -0.7 0.1 0.2
Diabetes diagnosed by doctor 0.4 0.6 1.3 -1.0 -0.4 0.1 -0.7 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.8 0.8 0.8 -0.4 0.7 -1.4
Friendships satisfaction 0.2 0.2 0.9 -0.4 1.0 -0.3 0.2 0.2
Qualifications: nursing, teaching 2.1 3.2 4.4 -2.1 -1.8 -0.0 -2.1 2.1
Commuting to job workplace: Walk 0.3 0.3 0.7 0.6 -0.0 -0.0 0.7 -0.8
Eye problems/disorders: Cataract 0.4 0.5 1.1 -0.8 -0.1 1.1 -0.3 0.7
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 6.4 -1.8 -2.3 -0.5 -1.2 2.5
Medication for cholesterol 0.1 0.2 0.3 0.5 0.6 0.5 -0.0 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 3.3 1.3 1.2 1.8 0.7 -1.7
Back pain experienced in last month 2.4 3.5 5.5 2.4 1.6 1.8 1.4 -2.0
Mineral and other dietary supplements 0.6 0.7 1.6 0.3 1.3 1.1 -0.3 -0.8
Breast cancer (self-reported) 0.0 0.1 0.2 -0.3 -0.0 0.1 -0.2 -0.4
Asthma (self-reported) 0.1 0.3 0.7 0.8 0.7 0.3 0.3 -0.3
Osteoporosis (self-reported) 1.2 1.5 3.0 0.7 1.4 -0.0 1.4 -1.7
Osteoarthritis (self-reported) 2.4 3.1 7.3 -1.1 -1.7 -0.6 -2.0 2.7
Medication: Aspirin 0.3 0.3 0.5 -0.7 -0.2 0.6 -0.7 0.6
Medication: Gliclazide 0.2 0.3 0.4 -0.1 -0.7 -0.6 0.4 0.6
Illnesses of father: None of the above (group 1) 0.5 0.7 2.3 0.7 -1.5 0.7 -0.3 -0.0
Smoking status: Current 4.8 7.6 14.8 3.9 1.4 2.0 2.5 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.3 -0.2 -0.2 -1.1 -0.5 -0.3
Whole body water mass 0.3 2.0 3.5 -0.7 -1.6 -0.9 -1.6 1.9
Leg predicted mass (right) 0.5 2.9 5.2 -1.1 -1.7 -0.7 -2.3 2.2
Arm fat mass (left) 2.8 11.5 23.3 -3.3 -3.4 -2.2 -2.8 4.8
Number of self-reported non-cancer illnesses 0.3 0.5 1.5 -0.4 0.8 -1.2 -0.5 0.1
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.7 -0.3 -0.7 0.3 0.6
Miserableness 0.4 0.6 1.6 1.3 -0.6 0.3 -0.2 -1.0
Guilty feelings 1.2 1.8 5.1 1.6 0.8 0.6 0.6 -2.3
Wears glasses or contact lenses 1.2 1.3 4.0 0.1 -1.3 2.0 -0.8 0.6
Ever taken oral contraceptive pill 0.3 0.3 1.1 0.7 -0.1 -0.1 0.0 -1.1
Hearing aid user 2.3 2.6 4.8 -1.4 -2.2 -0.3 -1.8 1.8
Mother’s age at death 0.6 0.7 1.9 -1.4 -0.4 -0.6 -0.4 1.1
Financial situation satisfaction 1.0 1.3 2.7 1.6 0.2 0.9 1.2 -1.2
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.8 0.1 -0.2 -0.1 -0.5 0.9
Commuting to job workplace: Public transport 1.9 2.3 5.3 1.3 0.9 2.3 -0.0 -1.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.4 -0.2 -1.1 -1.0 -0.0 1.2
Medication: Blood pressure 0.3 0.7 2.0 -1.4 -0.2 0.1 -0.9 0.6
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.9 0.5 -0.0 0.8 -0.9 -0.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 0.3 -1.0 -0.8 0.0 0.2
High cholesterol (Self-reported) 2.3 4.1 7.7 -2.8 -1.5 -1.4 -2.2 1.9
Medication: Bendroflumethiazide 0.8 1.3 2.0 -1.1 -1.2 -0.6 -1.4 1.1
Medication: Paracetamol 0.9 1.4 4.1 -1.2 -1.0 0.3 -0.6 2.0
Medication: Lisinopril 4.5 5.8 9.3 -2.4 -3.0 -0.9 -2.8 2.4
Medication: Atorvastatin 2.3 2.9 6.0 -2.5 -1.1 -1.1 -1.4 2.0
Illnesses of father: High blood pressure 2.2 2.8 4.0 -1.5 -1.6 -1.8 -1.4 2.0
Alcohol drinker status: Never 1.5 1.8 6.3 -0.9 0.7 -2.5 0.9 0.9
Ever smoked 2.7 4.7 8.6 2.9 1.4 1.6 2.0 -2.5
Basal metabolic rate 0.5 2.8 5.1 -1.1 -1.7 -1.3 -1.7 2.3
Leg fat percentage (left) 3.3 12.0 25.6 -3.7 -2.9 -3.1 -1.7 5.1
Arm fat-free mass (left) 0.4 2.3 4.2 -1.0 -1.7 -1.3 -1.3 2.0
Number of operations (self-reported) 0.1 0.1 0.4 -0.1 -0.3 -0.3 -0.3 0.6
Average weekly beer plus cider intake 1.3 1.9 6.8 2.6 0.2 0.8 0.5 -1.4
Irritability 0.5 0.8 2.9 -0.2 -1.7 -0.7 -0.9 0.1
Risk taking 0.6 0.9 2.5 1.6 -0.2 0.1 1.0 -0.9
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.7 0.2 0.6 -0.3 0.8 -0.8
Fractured/broken bones in last 5 years 1.3 1.6 2.9 0.8 1.7 1.3 1.1 -1.3
Age started oral contraceptive pill 2.2 2.8 5.1 -2.3 -1.1 -1.5 -1.4 1.9
Diastolic blood pressure, automated reading 0.8 2.5 5.3 -2.3 -1.3 -1.2 -0.2 2.0
Ever depressed for a whole week 0.9 1.1 2.7 1.3 0.1 1.6 1.2 0.0
Unable to work because of sickness or disability 0.3 0.4 0.8 0.6 0.3 -0.9 0.9 0.4
Commuting to job workplace: Cycle 0.4 0.5 1.7 0.6 0.3 0.6 -0.2 -1.3
Myopia 1.8 2.6 3.3 -1.6 -1.3 -1.8 -1.4 1.8
Vascular/heart problems diagnosed by doctor 0.8 2.2 3.5 1.6 0.6 1.8 1.9 -1.2
Cholesterol lowering medication 0.6 0.8 2.3 -1.5 -0.4 -0.4 -0.6 1.1
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 4.0 -0.5 -2.0 0.1 -0.9 1.5
Pain experienced in last month 0.6 1.0 4.4 -0.7 0.1 -2.1 0.4 -0.5
Supplements: Calcium 0.3 0.3 1.4 -0.3 -0.1 -1.2 0.2 0.4
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 0.1 -0.4 -0.2 -0.7 -0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.7 -0.0 -0.2 -0.6 0.0 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 0.7 -0.7 0.2 -0.6 0.2
Heart disease (siblings) 0.6 0.8 1.6 1.1 0.7 0.8 1.2 -0.1
Alcohol drinker status: Previous 0.3 0.4 1.6 -0.3 -0.3 -0.1 -0.1 1.3
Pack years of smoking 0.5 0.8 3.4 -0.3 -0.6 1.8 0.1 -0.2
Impedance of whole body 1.8 9.4 18.6 3.0 2.6 2.2 2.8 -4.3
Leg fat mass (left) 2.9 11.4 24.0 -3.4 -3.0 -2.7 -2.2 4.9
Arm predicted mass (left) 0.5 2.7 5.1 -1.0 -1.9 -1.3 -1.5 2.2