Best TWAS P=1.75e-08 · Best GWAS P=5.84e-09 conditioned to 0.00533
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | DCUN1D4 | 0.08 | 0.02 | enet | 11 | 0.04 | 2.4e-03 | 5.5 | 5.6 | 1.8e-08 | 0.89 | 0.05 | 0.86 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | DCUN1D4 | 0.02 | 0.03 | lasso | 1 | 0.02 | 8.2e-02 | 5.5 | 5.5 | 4.6e-08 | 0.96 | 0.02 | 0.16 | FALSE |
| 3 | GTEx | Nerve Tibial | DCUN1D4 | 0.10 | 0.09 | lasso | 3 | 0.10 | 6.8e-08 | 5.1 | 5.4 | 6.5e-08 | 0.93 | 0.09 | 0.91 | FALSE |
| 4 | GTEx | Nerve Tibial | RASL11B | 0.13 | 0.06 | lasso | 5 | 0.08 | 2.0e-06 | 4.7 | -5.1 | 3.1e-07 | 0.16 | 0.74 | 0.20 | FALSE |
| 5 | GTEx | Thyroid | DCUN1D4 | 0.03 | 0.05 | lasso | 1 | 0.04 | 2.4e-04 | 5.5 | 5.5 | 4.6e-08 | 0.96 | 0.06 | 0.88 | FALSE |
| 6 | GTEx | Whole Blood | SNORA26 | 0.04 | 0.00 | enet | 4 | 0.01 | 9.9e-02 | 3.5 | 5.2 | 1.5e-07 | -0.08 | 0.04 | 0.73 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | SGCB | 0.03 | 0.03 | enet | 9 | 0.03 | 7.0e-05 | 5.1 | 5.4 | 5.2e-08 | 0.87 | 0.11 | 0.88 | FALSE |