Best TWAS P=7.29e-14 · Best GWAS P=1.65e-38 conditioned to 5.11e-31
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FLJ20021 | 0.05 | 0.04 | lasso | 6 | 0.04 | 2.3e-05 | 5.5 | -5.5 | 4.1e-08 | -0.05 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AP001816.1 | 0.20 | 0.20 | enet | 12 | 0.22 | 7.9e-18 | 5.3 | -5.6 | 1.9e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | UBE2D3 | 0.07 | 0.00 | enet | 23 | 0.02 | 3.2e-02 | -3.8 | 6.0 | 2.2e-09 | 0.21 | 0.18 | 0.07 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | PPP3CA | 0.15 | 0.00 | enet | 11 | 0.00 | 3.5e-01 | 5.8 | -5.9 | 4.5e-09 | -0.13 | 0.37 | 0.03 | FALSE |
| 5 | GTEx | Adipose Visceral Omentum | AP001816.1 | 0.07 | 0.07 | lasso | 8 | 0.06 | 3.5e-04 | 5.6 | -6.9 | 5.2e-12 | -0.07 | 0.65 | 0.08 | FALSE |
| 6 | GTEx | Artery Aorta | AP001816.1 | 0.10 | 0.10 | lasso | 3 | 0.09 | 7.2e-06 | 5.6 | -5.5 | 4.6e-08 | -0.05 | 0.90 | 0.00 | FALSE |
| 7 | GTEx | Artery Tibial | AP001816.1 | 0.13 | 0.09 | lasso | 6 | 0.06 | 3.1e-05 | 5.8 | -5.6 | 2.7e-08 | -0.06 | 0.99 | 0.00 | FALSE |
| 8 | GTEx | Brain Cortex | AP001816.1 | 0.12 | 0.11 | enet | 9 | 0.14 | 1.4e-04 | 5.6 | -6.6 | 4.5e-11 | -0.06 | 0.25 | 0.05 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | AP001816.1 | 0.11 | 0.05 | lasso | 7 | 0.04 | 4.2e-03 | 7.1 | -7.5 | 7.3e-14 | -0.12 | 0.31 | 0.04 | TRUE |
| 10 | GTEx | Breast Mammary Tissue (Male) | AP001816.1 | 0.06 | -0.01 | lasso | 3 | -0.01 | 4.7e-01 | 5.8 | -5.8 | 8.4e-09 | -0.04 | 0.04 | 0.06 | FALSE |
| 11 | GTEx | Breast Mammary Tissue (Female) | AP001816.1 | 0.20 | -0.01 | enet | 32 | -0.01 | 5.8e-01 | 3.6 | -5.9 | 4.5e-09 | -0.23 | 0.09 | 0.07 | FALSE |
| 12 | GTEx | Cells Transformed fibroblasts | AP001816.1 | 0.24 | 0.23 | lasso | 3 | 0.22 | 2.4e-16 | 5.6 | -5.5 | 4.4e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | AP001816.1 | 0.10 | 0.05 | enet | 10 | 0.09 | 3.6e-04 | 5.3 | -5.2 | 2.3e-07 | -0.06 | 0.51 | 0.05 | FALSE |
| 14 | GTEx | Esophagus Mucosa | AP001816.1 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.5e-03 | 5.9 | -5.7 | 1.2e-08 | -0.04 | 0.21 | 0.04 | FALSE |
| 15 | GTEx | Esophagus Muscularis | AP001816.1 | 0.13 | 0.14 | enet | 9 | 0.14 | 1.3e-08 | 5.8 | -5.4 | 6.2e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Heart Atrial Appendage | AP001816.1 | 0.18 | 0.10 | lasso | 2 | 0.06 | 1.6e-03 | 5.8 | -5.2 | 1.5e-07 | -0.03 | 0.22 | 0.04 | FALSE |
| 17 | GTEx | Lung | AP001816.1 | 0.12 | 0.10 | lasso | 1 | 0.09 | 1.2e-07 | 5.6 | -5.6 | 2.5e-08 | -0.04 | 0.99 | 0.00 | FALSE |
| 18 | GTEx | Nerve Tibial | AP001816.1 | 0.23 | 0.22 | lasso | 5 | 0.20 | 2.8e-14 | 5.6 | -5.7 | 1.5e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Whole Blood | AP001816.1 | 0.15 | 0.12 | lasso | 6 | 0.12 | 3.6e-11 | 5.6 | -5.5 | 4.2e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 20 | NTR | Blood | MANBA | 0.01 | 0.00 | bslmm | 390 | 0.01 | 3.1e-03 | -4.3 | -6.1 | 1.0e-09 | -0.11 | 0.10 | 0.03 | TRUE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | AP001816.1 | 0.12 | 0.08 | lasso | 4 | 0.07 | 8.9e-10 | 5.5 | -5.2 | 2.2e-07 | -0.06 | 1.00 | 0.00 | FALSE |