Best TWAS P=2.41e-08 · Best GWAS P=9.35e-08 conditioned to 0.146
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | PDE5A | 0.13 | 0.02 | enet | 12 | 0.06 | 6.4e-03 | 5.0 | -5.1 | 3.0e-07 | -0.58 | 0.09 | 0.72 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | RP11-33B1.4 | 0.12 | 0.16 | lasso | 4 | 0.15 | 5.7e-05 | 5.0 | -5.3 | 1.5e-07 | -0.68 | 0.08 | 0.86 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | RP11-33B1.1 | 0.23 | 0.44 | lasso | 11 | 0.45 | 1.8e-37 | 5.1 | -5.1 | 2.7e-07 | -0.72 | 0.10 | 0.89 | FALSE |
4 | GTEx | Liver | RP11-33B1.1 | 0.18 | 0.12 | enet | 31 | 0.17 | 1.6e-05 | 5.0 | -5.2 | 1.7e-07 | -0.63 | 0.11 | 0.88 | FALSE |
5 | GTEx | Liver | RP11-33B1.4 | 0.18 | 0.14 | lasso | 6 | 0.12 | 3.2e-04 | 5.2 | -5.2 | 2.4e-07 | -0.70 | 0.07 | 0.90 | FALSE |
6 | GTEx | Pancreas | RP11-33B1.4 | 0.20 | 0.05 | lasso | 16 | 0.05 | 3.8e-03 | 5.2 | -5.5 | 3.8e-08 | -0.69 | 0.05 | 0.93 | FALSE |
7 | GTEx | Testis | RP11-33B1.4 | 0.23 | 0.31 | enet | 16 | 0.37 | 1.5e-17 | 5.0 | -5.6 | 2.4e-08 | -0.80 | 0.07 | 0.93 | TRUE |
8 | GTEx | Thyroid | RP11-33B1.4 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.8e-04 | 5.2 | -5.3 | 1.1e-07 | -0.69 | 0.05 | 0.93 | FALSE |
9 | GTEx | Whole Blood | C4orf3 | 0.11 | 0.16 | lasso | 6 | 0.16 | 3.0e-14 | 5.0 | 5.1 | 2.9e-07 | 0.67 | 0.11 | 0.89 | FALSE |
10 | NTR | Blood | PDE5A | 0.03 | 0.05 | lasso | 6 | 0.04 | 2.0e-13 | 5.0 | -5.5 | 3.6e-08 | -0.69 | 0.11 | 0.88 | FALSE |