Best TWAS P=9.06e-11 · Best GWAS P=8.5e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP4-605O3.4 | 0.04 | 0.01 | lasso | 4 | 0.00 | 3.2e-01 | 6.4 | 5.4 | 5.1e-08 | 0.96 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP4-605O3.4 | 0.18 | 0.12 | enet | 14 | 0.10 | 1.5e-03 | 6.4 | 5.8 | 6.6e-09 | 0.91 | 0.02 | 0.90 | FALSE |
| 3 | GTEx | Nerve Tibial | RP4-605O3.4 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.7e-01 | 6.4 | 6.4 | 1.4e-10 | 0.83 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Prostate | CERS5 | 0.19 | 0.08 | lasso | 4 | 0.02 | 1.2e-01 | 6.5 | 6.2 | 4.7e-10 | 0.97 | 0.02 | 0.77 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | SMARCD1 | 0.07 | 0.02 | lasso | 2 | 0.03 | 1.4e-03 | -4.8 | -5.5 | 4.7e-08 | -0.70 | 0.06 | 0.80 | FALSE |
| 6 | GTEx | Testis | CERS5 | 0.12 | 0.06 | lasso | 6 | 0.07 | 4.0e-04 | 6.4 | 6.5 | 9.1e-11 | 0.97 | 0.01 | 0.94 | TRUE |
| 7 | GTEx | Whole Blood | RP4-605O3.4 | 0.04 | 0.04 | lasso | 4 | 0.01 | 1.5e-02 | 6.5 | 6.3 | 3.8e-10 | 0.99 | 0.01 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIMA1 | 0.08 | 0.10 | blup | 59 | 0.10 | 1.8e-11 | 6.0 | -5.8 | 5.9e-09 | -0.89 | 0.07 | 0.93 | FALSE |