[Hub]/) : Traits : Cardiovascular Disease : ← →

chr12:47,671,905-49,444,545

Best TWAS P=1.13e-10 · Best GWAS P=1.82e-10 conditioned to 0.0761

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SENP1	0.05	0.02	blup	555	0.04	1.7e-05	6.4	-6.4	1.1e-10	-0.84	0.02	0.98	TRUE
24	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	6.4	6.3	3.2e-10	0.96	0.01	0.99	FALSE
10	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	6.0	6.2	6.5e-10	0.97	0.02	0.98	FALSE
26	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	6.0	6.1	8.8e-10	0.95	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	6.0	6.1	1.0e-09	0.95	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF641	0.11	0.12	enet	10	0.12	5.2e-12	6.4	6.0	2.1e-09	0.85	0.00	1.00	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP1-228P16.1	0.33	0.20	lasso	9	0.29	6.3e-10	5.7	-5.9	2.7e-09	-0.87	0.16	0.84	FALSE
29	GTEx	Pituitary	RP1-228P16.1	0.20	0.15	lasso	6	0.16	1.1e-04	5.1	-5.9	2.7e-09	-0.90	0.04	0.91	FALSE
3	GTEx	Adipose Subcutaneous	RP1-228P16.1	0.20	0.20	lasso	8	0.22	4.7e-18	5.3	-5.9	3.3e-09	-0.89	0.36	0.64	FALSE
25	GTEx	Lung	RP1-228P16.1	0.18	0.20	enet	21	0.21	7.0e-16	5.7	-5.9	4.8e-09	-0.90	0.22	0.78	FALSE
36	GTEx	Testis	RP1-228P16.1	0.38	0.28	lasso	6	0.31	4.0e-14	5.3	-5.8	5.0e-09	-0.78	0.83	0.17	FALSE
7	GTEx	Adrenal Gland	ZNF641	0.31	0.18	lasso	3	0.21	4.2e-08	6.4	5.7	1.0e-08	0.89	0.01	0.99	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	6.0	5.7	1.1e-08	0.90	0.02	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	RP1-228P16.1	0.09	0.03	lasso	3	0.04	8.1e-04	5.7	-5.7	1.2e-08	-0.90	0.07	0.91	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	RP1-228P16.1	0.17	0.10	enet	23	0.16	4.1e-09	6.4	-5.6	2.3e-08	-0.77	0.02	0.98	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	ASB8	0.20	0.04	lasso	4	0.02	7.7e-02	5.7	5.6	2.5e-08	0.84	0.08	0.52	FALSE
4	GTEx	Adipose Visceral Omentum	ZNF641	0.14	0.09	lasso	4	0.08	3.7e-05	6.0	5.6	2.7e-08	0.86	0.02	0.97	FALSE
11	GTEx	Artery Tibial	RP1-228P16.1	0.16	0.14	lasso	14	0.15	5.9e-12	5.2	-5.6	2.7e-08	-0.84	0.42	0.57	FALSE
6	GTEx	Adipose Visceral Omentum	RP1-228P16.1	0.18	0.13	lasso	4	0.15	2.3e-08	5.1	-5.5	4.1e-08	-0.83	0.22	0.78	FALSE
12	GTEx	Brain Caudate basal ganglia	RP1-228P16.1	0.14	0.12	lasso	4	0.11	5.7e-04	5.1	-5.5	4.2e-08	-0.85	0.10	0.65	FALSE
15	GTEx	Brain Frontal Cortex BA9	TMEM106C	0.35	0.01	lasso	8	-0.01	6.8e-01	-3.1	5.4	5.1e-08	0.66	0.09	0.22	FALSE
14	GTEx	Brain Cortex	ASB8	0.28	0.19	lasso	7	0.20	3.3e-06	5.3	5.4	5.2e-08	0.86	0.10	0.85	FALSE
23	GTEx	Esophagus Mucosa	RP1-228P16.1	0.19	0.18	lasso	4	0.21	8.7e-14	5.1	-5.4	5.2e-08	-0.79	0.70	0.30	FALSE
9	GTEx	Artery Coronary	RP1-228P16.1	0.12	0.06	lasso	2	0.03	2.6e-02	5.2	-5.4	5.7e-08	-0.85	0.07	0.87	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP1-228P16.1	0.30	0.21	lasso	7	0.28	6.5e-08	5.3	-5.4	6.0e-08	-0.82	0.29	0.70	FALSE
32	GTEx	Skin Sun Exposed Lower leg	RP1-228P16.1	0.29	0.24	enet	28	0.26	2.0e-21	5.2	-5.4	6.5e-08	-0.69	0.87	0.13	FALSE
18	GTEx	Breast Mammary Tissue (Female)	RP1-228P16.1	0.07	-0.01	enet	2	-0.01	5.9e-01	5.3	-5.4	7.2e-08	-0.80	0.04	0.36	FALSE
33	GTEx	Spleen	RP1-228P16.1	0.35	0.23	lasso	7	0.19	1.6e-05	5.3	-5.4	7.2e-08	-0.82	0.22	0.73	FALSE
38	METSIM	Adipose	ASB8	0.03	0.00	bslmm	526	0.01	3.8e-02	5.3	5.3	9.2e-08	0.64	0.16	0.15	FALSE
16	GTEx	Brain Frontal Cortex BA9	ASB8	0.24	0.16	lasso	6	0.07	7.1e-03	5.3	5.3	9.8e-08	0.76	0.21	0.44	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	RP1-228P16.1	0.23	0.25	enet	17	0.23	6.8e-09	5.1	-5.3	9.8e-08	-0.81	0.69	0.30	FALSE
21	GTEx	Colon Transverse	RP1-228P16.1	0.24	0.18	lasso	5	0.18	4.9e-09	5.1	-5.2	1.5e-07	-0.81	0.23	0.77	FALSE
35	GTEx	Testis	ASB8	0.17	0.15	lasso	3	0.13	1.8e-06	4.9	5.2	1.7e-07	0.72	0.25	0.65	FALSE
8	GTEx	Adrenal Gland	RP1-228P16.1	0.19	0.20	lasso	5	0.15	4.4e-06	5.2	-5.2	1.8e-07	-0.80	0.24	0.74	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	ASB8	0.04	0.03	lasso	3	0.03	2.3e-04	5.3	5.2	1.9e-07	0.76	0.24	0.59	FALSE
27	GTEx	Nerve Tibial	ASB8	0.09	0.08	lasso	4	0.07	1.8e-05	5.2	5.2	2.0e-07	0.79	0.55	0.34	FALSE
37	GTEx	Whole Blood	RP1-228P16.1	0.10	0.06	enet	20	0.09	4.7e-09	4.9	-5.2	2.0e-07	-0.75	0.22	0.78	FALSE
5	GTEx	Adipose Visceral Omentum	ASB8	0.10	0.00	lasso	6	0.00	6.8e-01	5.2	5.2	2.1e-07	0.77	0.02	0.93	FALSE
34	GTEx	Stomach	RP1-228P16.1	0.12	0.03	lasso	7	0.05	1.9e-03	5.1	-5.2	2.1e-07	-0.79	0.17	0.80	FALSE
28	GTEx	Nerve Tibial	RP1-228P16.1	0.18	0.21	enet	22	0.21	4.9e-15	5.3	-5.2	2.3e-07	-0.78	0.82	0.18	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	6.4	5.2	2.3e-07	0.75	0.01	0.98	FALSE