TWAS hub - LIMA1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1998	0.0645	6.8e-05	0.037	NA	0.067	NA	0.082	6.5e-04	NA	6.4e-06	NA	5.7e-07
2	GTEx	Brain Caudate basal ganglia	0.1830	0.0720	1.5e-03	0.121	NA	0.012	NA	0.073	2.5e-04	NA	1.4e-01	NA	3.9e-03
3	GTEx	Cells Transformed fibroblasts	0.1680	0.0670	1.7e-03	0.013	NA	0.014	NA	0.022	3.2e-02	NA	2.7e-02	NA	8.8e-03
4	GTEx	Muscle Skeletal	0.1209	0.0615	6.5e-03	0.012	NA	-0.003	NA	0.002	1.9e-02	NA	8.2e-01	NA	1.7e-01
5	GTEx	Thyroid	0.0800	0.0380	1.4e-03	0.058	NA	0.062	NA	0.045	2.9e-05	NA	1.7e-05	NA	2.1e-04
6	YFS	Blood	0.0402	0.0113	0.0e+00	0.062	0.061	0.061	0.058	0.060	1.3e-19	3.9e-19	3.5e-19	2.9e-18	8.0e-19
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0783	0.0309	1.2e-10	0.098	0.101	0.099	NA	0.098	4.2e-11	1.8e-11	3.0e-11	NA	4.1e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Impedance of leg (right)	8.8	42.8	78.0	2.0	7.3	-6.8	-0.6	6.9	-8.3	-8.8
Impedance of leg (left)	8.7	42.5	76.0	2.6	7.1	-7.0	0.2	6.8	-8.7	-8.3
Blood White Count	8.2	61.1	112.4	-6.0	-9.0	7.1	-2.7	-8.0	10.6	8.8
Comparative body size at age 10	7.7	21.1	32.9	-2.4	-5.7	5.3	1.1	-5.4	5.0	5.0
Hair/balding pattern: Pattern 4	7.6	18.5	32.2	-2.9	-4.6	4.5	-1.5	-4.8	5.7	4.7
Impedance of whole body	7.3	37.1	66.3	1.6	6.9	-7.0	-0.2	5.9	-8.1	-7.8
Diastolic blood pressure, automated reading	6.8	21.2	46.4	3.1	4.5	-2.8	2.0	6.1	-4.7	-6.8
Blood Platelet Count	6.3	73.3	125.4	-5.8	-8.0	6.4	-3.9	-10.8	11.2	10.9
Systolic Blood Pressure	6.0	30.3	81.4	4.0	5.6	-2.4	1.2	7.8	-3.9	-9.0
Impedance of arm (right)	5.3	24.7	42.7	0.3	6.1	-5.8	-0.7	4.3	-6.4	-6.5
Crohns Disease (2012)	4.4	7.1	11.4	-2.5	-3.4	1.7	-1.1	-2.8	3.3	3.0
Alcohol usually taken with meals	4.2	6.8	11.2	-0.0	-3.3	2.9	-0.1	-2.7	3.2	3.3
High blood pressure	4.1	11.5	31.0	3.5	3.0	0.9	-1.1	4.5	-2.5	-5.6
Ever had prostate specific antigen (PSA) test	4.1	4.7	8.8	-1.5	-2.3	2.3	-1.7	-2.2	3.0	2.0
Hypertension (Self-reported)	4.0	11.2	31.0	3.0	3.1	0.5	-1.3	4.5	-2.5	-5.6
Average weekly beer plus cider intake	4.0	5.8	9.5	1.8	2.3	-2.6	-0.0	3.1	-3.1	-2.4
Systolic blood pressure, automated reading	3.9	11.2	28.3	2.0	3.0	-2.3	1.3	4.7	-2.8	-5.3
Impedance of arm (left)	3.9	18.0	31.7	0.3	4.8	-5.1	-0.9	3.7	-5.6	-5.6
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.6	10.2	0.7	2.8	-2.1	-0.7	1.8	-3.2	-2.3
Bilateral oophorectomy (both ovaries removed)	3.8	4.4	10.4	1.7	3.2	-1.7	0.7	1.8	-2.5	-2.2
Sitting height	3.8	26.6	43.0	3.8	6.3	-2.3	3.2	6.2	-5.9	-6.6
Cardiovascular Disease	3.7	12.3	33.9	3.0	4.0	0.6	-0.5	4.7	-2.4	-5.8
Crohns Disease (2017)	3.6	8.0	12.9	-2.9	-3.3	0.8	-1.7	-3.6	2.8	3.5
Schizophrenia (2014)	3.6	7.9	22.4	-0.9	3.2	-2.3	-0.3	2.5	-3.3	-4.7
Ever had hysterectomy (womb removed)	3.4	3.9	7.5	0.8	2.7	-2.4	1.4	1.7	-2.0	-2.0
Bipolar Disorder or Schizophrenia	3.3	8.1	21.6	0.3	3.2	-2.3	-0.6	2.9	-3.3	-4.6
Illnesses of siblings	3.3	4.7	10.2	-1.3	-3.0	1.2	1.2	-2.1	2.1	3.2
Hair/balding pattern: Pattern 3	3.3	4.9	9.7	-1.1	-1.2	2.0	-2.6	-2.6	3.1	2.3
Vascular/heart problems diagnosed by doctor	3.2	8.6	20.3	-3.7	-2.5	-1.3	0.8	-3.7	2.0	4.5
Schizophrenia (2018)	3.1	6.5	17.4	-0.4	3.1	-1.9	-0.3	2.5	-2.8	-4.2
Lung FVC	3.1	15.8	36.4	-0.4	-3.1	6.0	-1.8	-4.0	5.9	3.4
Illnesses of father: High blood pressure	3.1	3.8	6.8	2.2	2.6	-0.3	-0.2	2.6	-1.6	-2.3
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	10.1	-0.5	-0.9	1.8	-3.2	-2.3	1.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	12.0	1.4	3.0	-0.2	0.8	2.7	-3.1	-3.5
Lupus	2.7	4.1	8.9	-0.3	3.0	-2.0	0.6	2.3	-2.0	-2.5
High blood pressure (siblings)	2.7	3.9	8.8	2.5	1.8	0.2	-1.4	2.1	-1.4	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	10.3	-1.6	-2.0	3.0	0.5	-2.8	3.2	2.4
Medication: Blood pressure	2.6	4.9	13.2	2.5	1.8	0.0	-1.1	2.8	-1.6	-3.6
Alcohol drinker status: Previous	2.6	2.9	6.4	0.1	2.0	-2.1	-1.5	0.7	-2.5	-1.7
Current tobacco smoking	2.5	4.1	9.3	-0.7	-3.1	1.7	-1.1	-1.4	2.3	2.8
Standing height	2.4	23.6	47.1	3.0	6.8	-1.8	2.8	4.7	-5.5	-6.9
Blood clot in the leg (DVT)	2.4	3.1	6.2	-1.0	-1.9	0.4	1.9	-1.7	2.0	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	6.3	-1.7	-1.1	-0.2	-1.4	-2.5	1.0	2.4
Smoking status: Current	2.3	3.6	8.2	-0.7	-2.9	1.6	-0.9	-1.3	2.0	2.7
Height	2.2	42.6	92.6	5.3	7.9	-2.4	3.6	6.3	-7.6	-9.6
Peak expiratory flow (PEF)	2.2	5.1	10.6	1.6	2.4	2.1	3.3	1.9	-0.0	-3.0
Medication: Amlodipine	2.2	3.1	9.6	-0.5	2.0	-0.8	-2.0	0.4	-1.7	-3.1
Medication: Blood pressure	2.2	4.0	9.0	2.3	2.2	0.8	-1.0	2.2	-1.5	-3.0
Schizophrenia vs Biploar Disorder	2.0	2.6	4.6	0.8	1.9	-1.4	0.6	1.8	-2.1	-2.0
Chronotype (morning person)	2.0	4.7	10.0	0.9	2.2	-0.7	2.6	3.1	-0.5	-3.2
Medication: Omeprazole	2.0	2.4	9.8	-0.8	-3.1	1.1	0.4	-1.0	0.8	2.0
Leg pain on walking	2.0	2.5	4.8	-1.1	-1.3	0.8	-1.9	-2.2	1.6	1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	3.7	-0.2	-1.9	1.2	-0.5	-1.6	1.8	1.9
Hearing aid user	2.0	2.3	3.8	1.5	1.4	-1.9	-0.6	1.6	-1.9	-1.1
Heart attack/myocardial infarction (self-reported)	2.0	2.5	5.3	0.2	-2.0	1.2	0.7	-2.3	1.1	2.3
Irritable Bowel Disease (IBD)	1.9	4.5	8.8	-2.1	-2.3	0.4	-2.4	-3.0	2.1	1.6
HbA1C	1.9	2.1	8.0	-2.8	-0.3	-0.0	-0.8	-1.6	1.8	0.2
Blood Eosinophil Count	1.9	14.4	25.6	-4.5	-3.5	1.3	0.1	-5.1	4.3	4.7
Prospective memory result	1.9	2.3	5.6	-0.9	-1.9	2.4	-1.9	-0.7	1.3	0.5
Miserableness	1.9	3.2	12.2	-0.7	-3.5	1.6	0.1	-0.4	1.9	1.9
Mother’s age at death	1.9	2.4	4.5	2.0	0.7	-1.7	0.3	1.7	-2.1	-1.2
Medication: Bendroflumethiazide	1.9	2.9	8.4	1.8	-0.8	2.3	-2.9	0.3	1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	5.0	-1.0	-1.8	0.7	1.4	-1.6	1.9	2.2
Heel T-Score	1.8	14.4	43.4	2.7	3.0	-4.8	2.7	2.3	-6.6	-2.3
Heart attack	1.8	2.3	5.1	-0.2	-1.8	1.2	0.8	-2.2	1.0	2.2
Medication: Cholesterol lowering	1.8	2.8	7.1	-0.4	-1.7	2.7	0.1	-2.0	1.9	1.3
Tense / ‘highly strung’	1.8	3.0	8.5	1.3	1.5	-0.6	0.6	2.9	-1.9	-2.1
Qualifications: nursing, teaching	1.8	2.8	7.5	-1.5	-1.0	1.3	-1.7	-2.0	2.7	0.5
Medication: Aspirin	1.8	2.4	9.2	0.0	-0.6	3.0	-1.8	-0.7	1.8	0.4
High cholesterol (Self-reported)	1.8	3.2	14.4	1.4	-0.5	3.8	0.7	0.4	2.1	-0.6
Supplements: Calcium	1.8	2.0	4.8	0.1	1.7	-2.2	0.9	1.0	-1.8	-1.2
Heart disease (siblings)	1.8	2.2	6.2	-1.2	1.1	-2.5	-1.7	0.1	-1.3	-1.4
Primary Biliary Cirrhosis	1.7	2.4	5.8	-0.6	1.5	-2.4	-0.6	0.4	-2.1	-1.9
Medication for cholesterol	1.7	2.6	7.7	-1.2	-1.6	0.5	0.9	-1.9	1.3	2.8
Alzheimer’s Disease (including proxy)	1.6	2.3	4.4	-1.6	-2.1	-1.0	1.6	-0.9	0.6	2.1
Bipolar Disorder (2011)	1.6	1.5	4.6	0.1	1.5	-0.9	-0.9	1.1	-1.0	-2.1
Medication: Ramipril	1.6	2.0	6.5	1.4	-0.7	2.5	-1.9	0.1	1.0	-0.8
Smoking status: Previous	1.6	2.3	5.8	1.4	1.2	-0.5	-1.3	1.6	-1.6	-2.4
Medication: Atorvastatin	1.6	2.0	9.3	-0.1	-0.3	3.0	-0.4	-1.4	1.5	0.6
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	5.1	-1.0	-2.3	1.1	-0.2	-1.4	0.8	1.9
Depressed Affect (Nagel 2018)	1.5	3.1	11.3	-0.7	-3.4	1.1	-0.6	-1.5	1.3	2.1
Body Mass Index (BMI) (2010)	1.5	2.1	10.0	1.0	-0.2	3.2	0.6	-0.6	1.6	0.4
Medication: Co-codamol	1.5	1.7	3.9	-0.7	-2.0	1.9	-0.3	-0.1	1.7	1.0
Trunk fat percentage	1.5	6.1	13.0	0.9	2.6	-1.2	1.7	2.6	-3.6	-3.3
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	11.5	1.8	1.1	-2.0	1.2	0.8	-3.4	-1.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.9	-1.1	-1.2	0.1	1.6	-1.7	1.6	0.9
Medication: Levothyroxine sodium	1.5	2.6	4.2	-1.8	-1.9	0.5	-1.7	-2.0	1.8	1.1
Medication: Lansoprazole	1.5	1.7	3.1	-1.6	-1.5	1.4	-0.7	-0.6	1.8	1.2
Birth weight of first child	1.5	2.7	10.5	-1.3	-1.6	0.4	0.9	-1.4	1.2	3.2
Medication for pain relief, constipation, heartburn	1.5	2.6	4.9	0.1	1.9	-2.2	2.2	1.4	-1.6	-0.6
Bipolar Disorder (2018)	1.4	2.2	5.0	0.9	1.2	-1.2	-0.8	1.6	-1.8	-2.2
Average weekly fortified wine intake	1.4	1.6	3.4	-0.9	-0.2	1.7	-1.9	-1.1	1.3	1.2
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.4	-1.4	-2.0	1.9	-0.9	-1.9	2.1	1.0
Health satisfaction	1.4	1.9	4.9	-2.2	-0.6	0.5	-1.1	-1.9	0.8	1.4
Emphysema/chronic bronchitis	1.4	1.6	5.0	1.0	-0.7	2.2	0.3	-1.7	0.8	1.1
Medication: Aspirin	1.4	1.9	8.9	0.3	0.1	3.0	-1.4	-0.3	1.4	-0.2
Osteoarthritis (self-reported)	1.4	1.9	3.5	-1.1	-1.0	1.7	0.4	-1.2	1.9	1.7
Medication: Gliclazide	1.4	1.6	3.5	-0.9	-1.9	0.7	0.1	-1.8	1.2	1.4
Hand grip strength (left)	1.3	3.3	11.2	1.1	-1.2	3.3	1.5	0.4	2.6	0.2
High blood pressure (mother)	1.3	1.8	3.7	0.9	1.5	-0.3	1.9	1.9	-0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	9.8	1.0	0.5	-2.8	1.3	0.6	-3.1	-0.6
Financial difficulties in last 2 years	1.3	1.7	5.1	1.0	0.2	-1.9	0.5	0.3	-2.3	-1.3
Father’s age at death	1.3	1.7	5.8	1.2	1.0	-2.4	0.7	-0.1	-1.8	0.3
Wheeze or whistling in the chest in last year	1.3	2.4	5.9	-0.9	-1.8	0.1	-1.5	-2.4	1.0	1.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	4.0	2.0	1.0	1.2	1.3	1.5	0.4	-0.6
Chronic bronchitis/emphysema (father)	1.2	1.4	4.7	-1.1	0.1	-2.2	0.3	0.5	-0.9	-1.5
Had menopause	1.2	1.5	2.8	1.1	-1.6	0.6	1.6	0.4	1.1	1.7
Falls in the last year	1.2	1.7	3.0	-1.0	-1.7	0.0	-1.5	-1.4	1.7	0.8
Happiness	1.2	1.5	3.0	-1.7	-0.9	0.0	-0.2	-1.6	0.9	1.7
Exposure to tobacco smoke at home	1.2	1.3	3.7	-0.4	-1.6	-0.2	1.0	-1.1	0.7	1.9
Friendships satisfaction	1.2	1.5	2.7	-1.5	-0.6	-0.4	-0.9	-1.5	1.4	1.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	6.6	-0.6	-2.6	0.1	0.3	-0.4	1.3	1.2
Ever smoked	1.2	2.2	4.8	2.0	0.7	0.0	-1.4	1.4	-1.4	-2.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	7.7	-1.7	-1.1	2.8	0.2	-0.4	1.7	0.3
Number of treatments/medications taken	1.1	1.9	6.2	0.1	-0.4	1.7	-2.5	0.3	0.2	-2.1
Average weekly spirits intake	1.1	1.3	3.6	1.2	-0.4	1.6	-1.9	0.0	0.7	1.0
Medication: Metformin	1.1	1.6	4.3	-1.1	-2.1	1.4	-0.7	-1.1	1.2	0.5
Trunk fat mass	1.1	4.7	8.1	1.1	2.4	0.0	2.3	2.3	-2.8	-2.9
Past tobacco smoking	1.1	2.1	4.9	-1.6	-0.6	-0.1	1.8	-1.4	1.2	2.2
Diabetes (self-reported)	1.1	1.7	4.8	-1.1	-2.0	2.2	-0.3	-0.4	1.4	0.1
Number of live births	1.1	1.6	5.0	-1.6	-2.2	-0.9	0.3	-0.9	-0.3	1.3
Pulse wave Arterial Stiffness index	1.1	1.3	2.6	0.0	1.1	-1.6	0.4	1.0	-1.2	-1.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.6	0.6	0.0	1.9	1.8	-1.0	1.5	1.3
Headache pain in last month	1.1	2.0	6.0	1.2	-2.4	1.4	-0.3	-0.6	1.5	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.9	-1.8	-1.2	-1.4	0.2	-1.2	0.8	2.0
Body fat percentage	1.1	4.3	8.9	0.9	2.0	-0.7	1.8	2.5	-3.0	-2.6
Illnesses of father: Heart disease	1.1	1.5	4.6	1.5	0.5	2.1	-0.8	-0.8	0.7	1.2
Financial situation satisfaction	1.1	1.3	4.5	-0.1	-0.9	-0.2	-2.1	-1.8	0.6	0.7
Worry (Nagel 2018)	1.0	2.1	4.3	0.6	1.6	-0.4	-0.4	2.1	-1.7	-2.1
Alzheimer’s Disease (in mother)	1.0	1.2	2.7	-1.4	-1.6	-0.2	1.1	-0.5	0.7	1.4
BMI	1.0	6.1	10.6	-0.7	-2.6	3.3	2.5	-2.2	2.6	2.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	4.9	-2.2	-0.4	-1.2	0.3	-1.2	0.1	-0.1
Fed-up feelings	1.0	1.9	9.1	-0.1	-3.0	0.8	0.1	0.5	1.1	1.4
Serious illness, injury or assault to yourself	1.0	1.2	2.5	-0.2	0.1	1.6	-1.5	-1.4	1.0	0.5
Medication: Atenolol	1.0	1.3	5.5	2.3	0.3	-0.6	0.2	0.7	-1.3	-0.9
Qualifications: None of the above	1.0	2.1	6.6	0.7	0.0	-2.6	-1.4	0.6	-2.2	-0.7
Pulse wave reflection index	1.0	1.2	4.9	-1.3	1.0	-2.2	0.0	-0.4	-0.6	-0.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.8	-0.4	-0.3	-0.5	-1.9	-1.9	-0.1	0.8
Number of full brothers	1.0	1.3	3.5	-1.9	1.5	-1.4	0.8	-0.4	-0.1	-0.4
Chest pain or discomfort	1.0	1.4	7.5	1.5	-0.0	2.7	-0.4	0.1	0.2	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.3	2.9	-0.0	1.0	-1.7	-0.0	1.4	-1.5	-0.6
Eye problems/disorders: Cataract	1.0	1.1	5.5	-0.3	-0.3	-1.0	2.3	1.0	0.1	0.2
Illnesses of father: None of the above (group 1)	1.0	1.2	5.5	-2.4	-0.4	-0.8	-0.8	-1.1	0.1	0.5
Age at First Birth	0.9	1.4	3.2	-0.2	1.8	-0.7	-1.7	-1.3	-0.5	-1.0
Triglycerides	0.9	1.5	5.3	-2.3	-0.2	0.9	-1.3	-0.7	1.5	0.2
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.6	0.3	-0.8	2.4	0.7	-1.3	1.3	1.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.9	-0.1	-1.2	0.9	-1.3	-1.1	1.4	0.8
Medication: Ibuprofen	0.9	1.1	3.3	1.7	0.2	1.1	-1.8	0.0	0.2	-0.4
Diabetes diagnosed by doctor	0.9	1.5	4.7	-1.1	-1.4	2.2	-1.0	0.1	1.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.8	0.2	-0.5	1.0	-0.9	-1.6	1.3	2.0
Average weekly champagne plus white wine intake	0.9	1.2	3.0	-0.2	-0.9	-0.3	1.3	-1.4	0.9	1.7
Guilty feelings	0.9	1.3	3.9	-2.0	-1.5	1.1	-0.8	-0.6	0.8	0.3
Wears glasses or contact lenses	0.9	1.0	3.2	0.6	1.2	-0.6	-1.8	0.4	-1.2	-0.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	1.7	0.4	-0.5	-1.3	0.2	-1.2	-0.9
Number of operations (self-reported)	0.9	1.4	3.1	0.9	1.8	0.1	1.3	1.3	-0.9	-1.2
Ulcerative Colitis (UC)	0.8	1.5	6.2	-0.8	-0.8	0.2	-2.5	-1.3	0.9	-0.6
LDL Cholesterol	0.8	1.3	2.8	-0.3	-0.9	0.6	-0.7	-1.5	1.5	1.7
Hypothyroidism (self reported)	0.8	1.9	3.5	-0.7	-1.9	1.9	-0.8	-1.2	1.9	0.6
Relative age of first facial hair	0.8	1.7	10.2	0.1	1.0	0.6	-3.2	-0.3	0.3	-0.4
Body mass index (BMI)	0.8	3.3	7.5	-0.1	-2.1	2.7	1.5	-1.1	1.9	2.1
Pain all over the body in last month	0.8	0.8	3.2	-0.3	0.9	0.6	-1.8	-0.4	-0.5	-1.0
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.2	-1.4	-0.5	0.0	2.0	0.3	0.3	0.1
Loud music exposure frequency	0.8	0.9	4.8	-2.2	0.6	-0.3	0.5	-0.8	0.5	0.1
Gout (self-reported)	0.8	1.1	3.0	-0.8	0.1	-1.7	0.8	0.3	-1.2	-1.4
Heart disease (mother)	0.8	0.9	2.7	0.7	1.1	1.3	-1.6	0.2	-0.0	-0.6
Comparative height size at age 10	0.8	4.2	13.4	1.6	2.4	0.1	1.0	1.4	-2.3	-3.7
Number of full sisters	0.8	1.0	3.0	0.7	-0.9	1.1	1.7	-0.5	1.1	0.5
Family relationship satisfaction	0.8	1.0	2.7	-0.7	-0.5	0.2	-1.6	-0.6	1.6	0.3
Leg fat-free mass (right)	0.8	4.2	14.1	0.4	-1.0	3.8	2.5	-1.1	2.1	1.4
Leg predicted mass (right)	0.8	4.1	13.7	0.4	-1.0	3.7	2.5	-1.1	2.1	1.4
Leg fat percentage (left)	0.8	2.8	5.2	1.4	1.1	-0.1	2.0	2.2	-2.3	-1.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.3	0.5	0.4	2.3	-1.4	-1.1	2.1	1.1
Alzheimer’s Disease (in father)	0.7	0.8	1.8	-0.4	-1.3	-0.3	0.9	-0.9	0.5	1.3
Coronary Artery Disease (CAD)	0.7	0.8	1.9	-1.3	0.6	0.9	0.8	-0.5	1.4	0.0
Lung FEV1/FVC ratio	0.7	3.4	13.0	-1.0	-2.6	0.5	3.6	0.2	0.5	1.6
Hearing difficulty/problems: Yes	0.7	1.0	2.8	0.9	1.0	-1.7	-0.7	-0.1	-1.0	-1.1
Leg fat-free mass (left)	0.7	3.7	13.8	0.2	-0.8	3.7	2.2	-1.0	2.1	1.0
Hand grip strength (right)	0.7	1.9	7.4	1.1	-0.8	2.7	1.1	-0.0	1.6	-0.2
Supplements: Glucosamine	0.7	0.9	2.2	1.2	-1.5	0.9	0.8	-0.0	0.6	0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.7	-1.9	-0.8	-0.5	-0.4	-0.6	0.7	-0.1
Leg predicted mass (left)	0.7	3.6	13.3	0.2	-0.8	3.6	2.3	-0.9	2.1	1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	8.4	0.3	1.1	2.2	2.9	0.5	1.0	-1.3
Pulse rate	0.7	1.2	4.5	1.2	0.7	0.6	0.9	2.1	0.5	-0.8
Illnesses of mother	0.7	0.9	2.0	0.3	-0.6	1.3	0.7	-0.6	1.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.1	-0.5	0.2	-0.4	0.3	1.0	-1.6	-1.8
Leg fat percentage (right)	0.7	2.6	5.6	0.9	1.3	-0.1	1.4	2.4	-2.1	-2.0
Arm fat-free mass (right)	0.7	3.7	11.9	1.6	-0.4	3.5	3.0	0.1	1.2	0.8
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-0.1	-1.0	-1.0	-0.9	-1.4	-0.7	1.1
Worry too long after embarrassment	0.7	1.2	3.5	-1.0	-0.6	1.9	0.1	-1.3	0.9	0.9
Neck or shoulder pain in last month	0.7	1.0	3.1	0.8	-0.7	1.4	-0.4	1.8	0.4	-0.9
Medication: Allopurinol	0.7	0.9	2.9	-0.5	0.4	-1.1	0.6	1.1	-0.6	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.2	-0.9	-0.5	-1.8	0.7	-0.6	-1.0	0.2
Whole body fat mass	0.7	3.0	5.6	0.8	1.7	0.5	2.4	1.9	-1.9	-2.1
Arm predicted mass (right)	0.7	3.5	10.5	1.4	-0.4	3.2	3.2	0.1	1.1	0.5
Long-standing illness, disability or infirmity	0.7	1.0	2.7	-1.1	-1.6	0.7	-1.1	-1.2	0.5	-0.2
Mineral and other dietary supplements	0.7	0.9	3.2	-0.5	-0.1	0.4	-1.0	-1.1	0.9	1.8
Number of self-reported non-cancer illnesses	0.7	1.2	3.3	1.4	0.3	1.8	-0.6	1.1	0.0	-1.2
Ever taken oral contraceptive pill	0.7	0.7	1.6	-0.1	0.5	0.0	-1.1	1.1	-0.9	-1.3
Alcohol drinker status: Never	0.7	0.9	3.2	1.2	-0.2	1.8	-0.0	-0.0	0.8	0.8
Reaction Time	0.6	1.1	5.1	-0.7	0.9	-2.3	-0.1	-0.6	-1.0	-0.3
Ovarian Cancer	0.6	0.8	2.4	0.6	1.5	-0.3	0.2	0.9	-1.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.2	0.7	0.3	-1.5	0.6	0.8	-1.4	-0.1
Diabetes (mother)	0.6	0.8	2.7	-0.8	-1.6	0.2	0.3	-0.8	0.4	1.1
Taking other prescription medications	0.6	0.9	2.0	-0.6	-1.1	1.3	-1.4	-0.5	0.8	0.1
Multivitamins +/- minerals	0.6	0.7	1.9	1.0	0.1	-0.8	0.4	0.8	-1.4	-0.9
Trunk fat-free mass	0.6	3.4	12.8	1.5	0.1	3.6	2.6	-0.1	1.3	0.3
Worrier / anxious feelings	0.6	1.1	4.1	-0.2	1.2	0.1	0.3	2.0	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.5	1.9	-0.1	1.0	-0.9	0.5	0.1	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.0	-0.6	-0.2	2.2	2.1	-0.3	1.7	-0.4
Trunk predicted mass	0.6	3.3	12.4	1.4	0.2	3.5	2.6	-0.1	1.3	0.3
Breastfed as a baby	0.6	0.8	2.2	-0.2	1.5	-0.9	-0.3	0.2	-1.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.5	-0.7	0.6	-1.6	-0.9	-0.3	-0.9	0.5
Birth weight	0.6	1.3	2.4	-0.4	-1.6	0.8	0.6	-1.5	1.2	1.4
Angina (self-reported)	0.6	0.8	3.0	1.1	-0.2	1.7	-0.2	-0.7	0.4	0.8
Age at last live birth	0.6	0.8	1.7	0.3	1.3	0.1	0.5	1.3	-0.8	-1.1
Whole body fat-free mass	0.6	3.5	13.1	1.0	-0.2	3.6	2.7	-0.4	1.5	0.6
Average weekly red wine intake	0.6	0.9	2.6	-1.0	1.1	-0.4	-1.6	-1.2	-0.3	0.1
Whole body water mass	0.6	3.7	13.9	1.2	-0.3	3.7	2.7	-0.4	1.6	0.7
Commuting to job workplace: Public transport	0.6	0.7	1.9	1.4	-0.8	1.1	0.5	0.9	0.3	0.5
Arm fat-free mass (left)	0.6	3.0	10.4	1.6	0.5	2.7	3.2	0.3	0.3	0.0
Risk taking	0.6	0.9	3.3	1.8	0.9	-0.6	-0.5	-0.5	-1.0	-0.3
Pack years of smoking	0.6	0.9	2.4	1.5	0.9	-0.6	1.3	0.6	-0.8	0.1
Arm predicted mass (left)	0.6	2.9	9.1	1.7	0.5	2.8	3.0	0.5	0.4	-0.1
Prostate Cancer	0.5	0.7	5.2	0.0	0.0	0.0	0.0	0.0	0.0	2.3
Mean Putamen Volume	0.5	0.6	1.9	0.6	1.4	-1.0	-0.7	0.2	-0.5	-0.1
HDL Cholesterol	0.5	0.9	2.5	-0.1	-1.6	-0.1	0.4	-0.3	1.1	1.5
Rheumatoid Arthritis	0.5	0.6	1.3	-1.1	-1.1	-0.8	0.1	-0.6	0.6	0.9
Ulcerative Colitis	0.5	0.8	2.6	0.1	-0.7	0.8	-1.6	-0.1	0.8	-0.9
Neuroticism	0.5	1.2	4.5	-1.1	-2.1	1.0	-0.0	0.1	1.0	0.7
Sensitivity / hurt feelings	0.5	0.8	1.9	-0.9	-1.4	-0.3	1.3	0.4	0.3	1.1
Angina	0.5	0.7	2.9	1.0	-0.0	1.7	-0.3	-0.5	0.4	0.6
Medication for hormone replacement therapy	0.5	0.6	2.3	-0.0	0.2	-0.9	-0.6	-1.5	-0.5	0.4
Vitamin and mineral supplements	0.5	0.6	1.7	-0.9	-0.1	0.2	0.1	-0.9	1.3	1.0
Supplements: Zinc	0.5	0.5	1.9	-0.9	-0.5	-0.4	1.4	-0.1	0.6	0.1
Townsend deprivation index at recruitment	0.5	0.7	1.8	-0.3	0.4	-1.2	-1.3	-0.6	-1.1	-0.1
Relative age voice broke	0.5	0.7	1.9	0.8	0.1	1.4	-0.3	0.8	1.3	0.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.5	-0.3	1.9	0.6	-0.9	-0.6	0.1	-1.4
Number of incorrect matches in round	0.5	0.8	1.4	-1.2	1.1	-0.7	-1.2	-0.2	-0.7	-0.8
Forced vital capacity (FVC)	0.5	1.8	3.6	0.4	1.9	1.9	1.4	0.2	0.9	-1.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	3.2	-1.8	-0.5	0.4	-0.7	-0.6	0.0	0.4
Mouth/teeth dental problems	0.5	0.8	1.5	-1.0	-0.7	0.3	1.2	0.1	1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.9	-0.7	0.1	1.4	-0.6	0.4	1.2	-0.5
Medication: Simvastatin	0.5	0.8	2.4	0.2	-1.5	1.6	-0.1	-0.1	0.8	0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.2	0.3	-0.6	-0.9	0.9	1.0	-1.1	-0.7
Depression (self-reported)	0.5	0.6	1.8	0.2	-0.8	0.5	1.4	0.2	-0.8	-0.7
Pulse wave peak to peak time	0.5	0.6	2.0	0.3	-0.5	1.4	-0.1	-0.6	0.7	1.1
Qualifications: College or University degree	0.5	1.5	4.6	-0.9	0.9	2.1	-1.2	-1.0	1.4	-0.3
Migraine (self-reported)	0.5	0.6	2.6	1.6	-0.6	-0.1	-0.2	0.5	-0.8	-0.4
Leg fat mass (right)	0.5	1.9	5.2	0.6	0.9	1.0	2.3	1.7	-1.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.6	0.0	-0.8	-0.8	1.6	0.1	-0.3	0.5
Supplements: Vitamin C	0.5	0.6	1.2	-1.0	-0.6	0.2	-1.0	-1.1	0.6	0.1
Mood swings	0.5	1.0	4.9	0.8	-2.2	0.3	0.1	0.3	-0.2	0.9
Loneliness, isolation	0.5	0.7	1.9	-0.7	-1.4	-0.5	1.3	0.2	-0.6	0.6
Osteoporosis (self-reported)	0.5	0.7	2.4	0.3	0.2	0.3	1.6	-0.2	1.2	0.8
Eye problems/disorders: Glaucoma	0.5	0.5	1.5	0.7	0.9	0.7	-0.4	0.4	0.3	-1.2
Basal metabolic rate	0.5	2.9	10.4	1.2	0.1	3.2	2.8	-0.0	1.0	0.1
Fractured/broken bones in last 5 years	0.5	0.7	2.8	1.0	0.3	1.7	-0.5	0.1	0.8	0.2
Unable to work because of sickness or disability	0.5	0.6	1.3	-1.0	0.5	-1.0	0.1	0.4	-0.8	-1.2
Myopia	0.5	0.8	3.2	0.8	1.8	0.4	-0.1	0.9	0.4	-0.6
Leg fat mass (left)	0.5	2.0	6.3	0.9	0.7	1.1	2.5	1.6	-1.1	-1.2
Depression (Nagel 2018)	0.4	0.5	1.3	-1.0	-1.2	-0.4	-0.8	-0.4	-0.6	-0.3
Major Depression (MDD)	0.4	0.5	1.3	0.2	0.8	-0.1	-0.6	0.2	-1.2	-0.9
Blood Red Count	0.4	4.1	11.7	0.9	0.5	-3.4	1.8	0.9	-3.2	-1.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	-1.0	-1.3	-0.1	-0.1	0.7	-1.0	-0.2
Severe depression (siblings)	0.4	0.4	1.3	-0.2	0.0	1.1	-1.1	-0.3	-0.1	-0.5
Pack years adult smoking proportion	0.4	0.6	1.1	1.1	0.9	-0.6	1.0	0.4	-0.8	-0.1
Maternal smoking around birth	0.4	0.5	1.9	0.5	-0.5	-0.8	1.4	0.6	-0.1	0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.4	-0.4	-0.7	-0.4	-1.2	0.9	-0.6	-0.5
Hearing difficulty/problems with background noise	0.4	0.7	2.1	1.4	-0.2	1.2	-0.0	0.0	1.0	-0.2
Allergy	0.4	1.0	1.7	0.3	-1.3	-0.9	1.2	0.9	-0.9	1.1
Weight	0.4	2.2	6.4	1.4	0.9	2.0	2.5	0.8	-0.6	-1.0
Hip circumference	0.4	1.9	3.6	0.9	1.9	1.3	1.3	0.9	-1.1	-1.8
Time employed in main current job	0.4	0.4	1.5	-0.8	0.9	0.3	1.2	0.0	0.2	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	-0.3	-0.5	-1.2	-0.3	0.8	-1.3	-0.3
Medication: Paracetamol	0.4	0.7	3.8	0.1	-2.0	0.3	-0.7	-0.6	0.6	-0.0
Forced vital capacity (FVC), Best measure	0.4	1.5	4.4	-0.1	1.1	2.1	1.4	-0.2	1.2	-1.3
Number of children fathered	0.4	0.5	1.2	0.3	-0.7	-0.2	-1.1	-0.3	-0.6	-0.9
Shortness of breath walking on level ground	0.4	0.5	2.1	-0.7	-0.2	-0.1	-0.5	-1.4	0.5	0.6
Mean time to correctly identify matches	0.4	0.8	3.3	-0.4	0.4	-1.8	-0.6	-1.1	-0.7	0.4
Pulse rate, automated reading	0.4	1.2	4.2	0.1	-0.4	0.7	1.8	2.0	0.4	-0.6
Ever had bowel cancer screening	0.4	0.4	1.1	-0.4	-0.5	-0.7	-0.7	-1.0	0.4	0.7
Commuting to job workplace: Walk	0.4	0.5	1.6	-1.3	0.4	-0.6	-0.1	0.3	-0.8	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	-1.0	-0.5	-0.1	-0.4	-0.6	-0.4	-1.2
Irritability	0.4	0.6	1.4	1.0	0.3	0.2	-0.4	1.2	-0.8	-1.0
Age started oral contraceptive pill	0.4	0.5	0.8	-0.7	-0.8	0.3	0.5	-0.3	0.9	0.9
Ever depressed for a whole week	0.4	0.5	2.6	-1.6	0.1	-0.1	-0.9	-0.1	-0.6	-0.1
Cholesterol lowering medication	0.4	0.7	2.1	0.0	-0.7	1.4	-0.9	-0.1	1.1	0.4
Neuroticism (Nagel 2018)	0.3	0.7	2.5	-0.7	-1.6	0.7	-0.6	-0.4	0.4	0.6
Fasting Glucose	0.3	0.3	0.5	0.7	-0.3	0.4	0.7	0.6	0.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.7	-0.7	0.2	-0.9	0.0	0.4	-0.4
Allergy or Eczema	0.3	0.9	1.8	-0.9	1.0	0.7	-1.3	-0.7	0.6	-1.3
Respiratory disease	0.3	0.6	2.0	-0.0	1.0	-0.7	-1.4	-0.0	-0.2	-0.9
Hair Pigment	0.3	8.0	14.2	1.4	1.9	-3.8	2.7	3.0	-3.3	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	-0.6	-1.2	-0.4	-0.6	-0.2	-0.4	0.0
Waist circumference	0.3	1.0	4.9	-0.0	0.1	2.2	1.2	0.0	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.5	-0.7	-0.2	-0.5	-0.4	1.2	-0.7	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.7	-0.1	-1.2	0.5	0.1	-0.7	0.2
Fluid intelligence score	0.3	0.6	2.6	-0.5	-0.4	-0.0	0.2	-0.5	0.9	1.6
Neuroticism score	0.3	0.7	2.9	-0.1	-1.7	0.9	0.7	0.9	0.2	0.2
Noisy workplace	0.3	0.3	1.0	-0.8	0.3	0.3	-0.7	-1.0	0.0	0.1
Asthma	0.3	0.5	1.4	0.8	-0.7	0.4	-1.2	-0.3	0.7	-0.6
Lung cancer (father)	0.3	0.3	1.3	-0.6	-0.4	-0.3	-1.2	-0.6	0.2	0.0
Glaucoma (self-reported)	0.3	0.4	0.8	-0.2	0.8	0.3	-0.4	-0.3	0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.5	0.8	-0.2	-0.4	0.1	-0.6	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-1.1	0.2	-0.2	-0.5	-0.8	-0.8	-0.1
Eye problems/disorders: None of the above	0.3	0.4	0.9	0.9	-0.5	0.7	-0.7	-0.4	0.0	0.3
Suffer from ‘nerves’	0.3	0.4	1.5	0.1	-0.7	0.7	1.2	0.4	0.1	0.4
Had major operations	0.3	0.3	1.0	-0.7	0.3	0.6	1.0	-0.0	0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	1.1	0.6	-0.4	-0.3	-0.4	-0.3	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.2	0.7	0.7	-1.0	-0.5	0.0	0.7
Medication: Paracetamol	0.3	0.4	1.5	0.2	-1.2	0.5	-0.6	-0.2	0.7	-0.6
Medication: Lisinopril	0.3	0.4	1.5	0.4	0.0	0.7	-1.2	-0.2	-0.1	-0.9
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-1.2	0.3	-0.2	0.2	-0.7	0.0	0.7
Neuroticism (2016)	0.2	0.3	0.7	-0.3	-0.7	0.8	-0.0	0.4	0.1	-0.6
Smoking Status	0.2	0.4	1.5	0.0	-1.2	0.5	-1.1	0.1	0.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.5	0.3	0.5	0.4	0.8	-0.8	-0.3
Age when periods started (menarche)	0.2	0.6	1.9	-0.7	0.2	-1.4	0.1	-0.8	-0.9	0.4
Nervous feelings	0.2	0.3	1.6	-0.1	0.3	-0.1	0.1	1.3	-0.6	-0.6
Arm fat percentage (right)	0.2	0.7	1.3	0.1	0.7	0.5	1.2	0.8	-0.9	-1.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.3	0.1	-0.5	-0.5	0.4	-1.0	0.9
Arm fat mass (right)	0.2	1.0	4.0	0.2	0.5	1.3	2.0	0.5	-0.4	-0.5
Length of working week for main job	0.2	0.2	0.5	0.2	0.1	-0.7	0.0	-0.4	-0.2	0.7
Age at first live birth	0.2	0.4	1.4	-0.0	1.2	0.6	0.3	0.2	-0.7	-0.6
Alcohol intake frequency.	0.2	0.5	2.0	1.4	-0.7	0.4	-0.5	-0.5	-0.5	0.4
Overall health rating	0.2	0.4	0.9	0.9	0.1	0.9	-0.6	0.6	-0.3	-0.4
Knee pain experienced in last month	0.2	0.3	0.7	0.9	-0.1	0.5	0.7	0.3	-0.1	0.4
Back pain experienced in last month	0.2	0.3	1.4	0.4	-0.4	-0.3	-1.2	0.6	0.2	-0.0
Breast cancer (self-reported)	0.2	0.2	0.6	0.2	0.1	-0.2	0.7	-0.8	0.3	-0.1
Asthma (self-reported)	0.2	0.3	0.7	0.9	-0.2	0.2	-0.8	-0.1	0.6	-0.7
Arm fat mass (left)	0.2	0.9	3.3	0.1	0.2	1.6	1.8	0.3	-0.2	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	0.5	0.7	1.0	0.1	0.1	0.5	0.5
Waist Hip Ratio (WHR)	0.1	0.5	2.2	-1.0	0.2	0.2	0.1	0.6	0.4	1.5
Tanning	0.1	1.6	4.0	0.2	0.1	2.0	0.7	-0.8	1.9	1.7
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.6	-0.0	0.1	0.5	0.3	0.5	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.3	0.0	0.1	0.1	0.6	0.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	-0.3	-0.4	0.8	0.0	0.2	0.1	0.0
Arm fat percentage (left)	0.1	0.4	1.3	-0.2	-0.0	1.0	1.2	0.4	-0.4	-0.4
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.5	0.5	-0.2	-0.1	-0.1	-0.5	-0.7
Pain experienced in last month	0.1	0.2	0.6	-0.6	0.5	-0.3	0.6	-0.8	-0.1	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Diabetes (father)	0.0	0.0	0.2	-0.0	0.1	0.1	0.1	0.2	-0.2	-0.4
Had other major operations	0.0	0.1	0.2	0.1	0.5	-0.3	0.2	-0.2	-0.2	0.0

Hub : Genes

LIMA1

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Trait associations