[Hub]/) : Traits : Cardiovascular Disease : ← →

chr1:112,312,154-113,941,737

Best TWAS P=4.84e-14 · Best GWAS P=5.69e-16 conditioned to 9.26e-10

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Thyroid Carcinoma	RHOC	0.04	0.03	enet	9	0.04	1.4e-04	-6.7	-7.5	4.8e-14	-0.30	0.01	0.98	TRUE
9	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WNT2B	0.05	0.02	blup	46	0.05	4.7e-04	-5.5	-7.0	3.1e-12	-0.30	0.06	0.10	FALSE
4	GTEx	Muscle Skeletal	WNT2B	0.06	0.02	lasso	7	0.03	9.4e-04	-5.4	-6.4	2.1e-10	-0.14	0.56	0.02	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTTNBP2NL	0.04	0.00	blup	53	0.02	2.1e-03	-5.9	-5.9	3.7e-09	-0.27	0.03	0.19	FALSE
6	GTEx	Skin Sun Exposed Lower leg	RHOC	0.07	0.02	lasso	3	0.02	1.5e-02	-5.4	-5.8	6.1e-09	-0.16	0.54	0.02	FALSE
3	GTEx	Breast Mammary Tissue (Male)	WNT2B	0.18	0.07	lasso	6	0.05	2.3e-02	-5.4	-5.7	1.2e-08	-0.16	0.08	0.05	FALSE
2	GTEx	Artery Aorta	WNT2B	0.15	0.01	enet	7	0.01	1.0e-01	-5.5	-5.6	1.9e-08	-0.16	0.24	0.04	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	CAPZA1	0.05	0.06	lasso	3	0.06	1.1e-07	-5.4	-5.4	7.1e-08	-0.16	1.00	0.00	FALSE
1	GTEx	Adipose Subcutaneous	WNT2B	0.10	0.10	enet	19	0.06	1.2e-05	-4.2	-5.3	1.3e-07	-0.12	1.00	0.00	FALSE
5	GTEx	Nerve Tibial	RP4-671G15.2	0.07	0.06	lasso	2	0.06	2.9e-05	-5.1	5.3	1.5e-07	0.17	0.94	0.00	FALSE