Best TWAS P=3.77e-25 · Best GWAS P=7.57e-24 conditioned to 0.428
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CELSR2 | 0.03 | 0.00 | lasso | 10 | 0.01 | 1.5e-02 | -7.61 | 7.1 | 1.0e-12 | -0.59 | 0.10 | 0.33 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PSRC1 | 0.20 | 0.04 | lasso | 8 | 0.13 | 4.8e-16 | 1.43 | -6.6 | 4.3e-11 | 0.63 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -9.96 | -9.9 | 3.7e-23 | 0.96 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -9.96 | -10.0 | 2.3e-23 | 1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Liver | ATXN7L2 | 0.39 | 0.04 | lasso | 12 | 0.21 | 1.3e-06 | 0.44 | -5.5 | 3.7e-08 | 0.70 | 0.07 | 0.80 | FALSE |
| 6 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -9.96 | -9.8 | 1.1e-22 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CELSR2 | 0.18 | 0.05 | lasso | 6 | 0.06 | 8.1e-06 | -8.30 | -7.1 | 1.1e-12 | 0.75 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -10.07 | -10.0 | 9.4e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | PSRC1 | 0.33 | 0.21 | bslmm | 430 | 0.26 | 1.2e-32 | -9.96 | -8.6 | 9.7e-18 | 0.82 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -9.96 | -9.6 | 9.6e-22 | 0.96 | 0.00 | 1.00 | FALSE |
| 11 | YFS | Blood | PSRC1 | 0.25 | 0.18 | enet | 32 | 0.24 | 1.6e-76 | -9.96 | -8.5 | 1.4e-17 | 0.86 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSRC1 | 0.03 | 0.00 | blup | 49 | 0.02 | 5.7e-05 | -8.30 | -8.3 | 7.7e-17 | 0.80 | 0.02 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PSRC1 | 0.14 | 0.04 | enet | 13 | 0.07 | 2.7e-04 | -9.76 | -6.3 | 3.8e-10 | 0.73 | 0.01 | 0.75 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | CELSR2 | 0.12 | 0.00 | enet | 21 | 0.04 | 3.0e-03 | -10.07 | -7.4 | 1.8e-13 | 0.58 | 0.00 | 0.79 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSRC1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 1.8e-03 | -8.30 | -8.3 | 1.0e-16 | 0.75 | 0.01 | 0.84 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSRC1 | 0.12 | 0.11 | lasso | 4 | 0.09 | 4.5e-06 | -9.51 | -9.3 | 1.1e-20 | 0.92 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSRC1 | 0.16 | 0.20 | lasso | 3 | 0.19 | 3.7e-09 | -9.70 | -9.8 | 8.0e-23 | 0.95 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SORT1 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.6e-08 | -10.07 | -10.4 | 3.8e-25 | 0.94 | 0.00 | 1.00 | TRUE |
| 19 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PSRC1 | 0.07 | 0.03 | enet | 8 | 0.05 | 3.4e-04 | -9.76 | -7.4 | 1.4e-13 | 0.77 | 0.01 | 0.92 | FALSE |
| 20 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PSRC1 | 0.09 | 0.00 | blup | 49 | 0.02 | 3.1e-02 | -7.13 | -7.5 | 4.6e-14 | 0.67 | 0.01 | 0.38 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PSRC1 | 0.12 | 0.03 | enet | 6 | 0.08 | 1.5e-06 | -9.96 | -5.8 | 5.4e-09 | 0.76 | 0.00 | 0.98 | FALSE |
| 22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SORT1 | 0.04 | 0.01 | blup | 60 | 0.03 | 4.4e-03 | -9.96 | -5.8 | 6.7e-09 | 0.64 | 0.00 | 0.81 | FALSE |