[Hub]/) : Traits : Cardiovascular Disease : ← →

chr1:109,098,737-110,733,794

Best TWAS P=3.77e-25 · Best GWAS P=7.57e-24 conditioned to 0.428

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-10.07	-10.4	3.8e-25	0.94	0.00	1.00	TRUE
8	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-10.07	-10.0	9.4e-24	1.00	0.00	1.00	FALSE
4	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-9.96	-10.0	2.3e-23	1.00	0.00	1.00	FALSE
3	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-9.96	-9.9	3.7e-23	0.96	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-9.70	-9.8	8.0e-23	0.95	0.01	0.99	FALSE
6	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-9.96	-9.8	1.1e-22	0.99	0.01	0.99	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-9.96	-9.6	9.6e-22	0.96	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-9.51	-9.3	1.1e-20	0.92	0.01	0.99	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-9.96	-8.6	9.7e-18	0.82	0.00	1.00	FALSE
11	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-9.96	-8.5	1.4e-17	0.86	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-8.30	-8.3	7.7e-17	0.80	0.02	0.91	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-8.30	-8.3	1.0e-16	0.75	0.01	0.84	FALSE
20	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-7.13	-7.5	4.6e-14	0.67	0.01	0.38	FALSE
19	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-9.76	-7.4	1.4e-13	0.77	0.01	0.92	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-10.07	-7.4	1.8e-13	0.58	0.00	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-7.61	7.1	1.0e-12	-0.59	0.10	0.33	FALSE
7	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-8.30	-7.1	1.1e-12	0.75	0.01	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	1.43	-6.6	4.3e-11	0.63	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-9.76	-6.3	3.8e-10	0.73	0.01	0.75	FALSE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-9.96	-5.8	5.4e-09	0.76	0.00	0.98	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-9.96	-5.8	6.7e-09	0.64	0.00	0.81	FALSE
5	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	0.44	-5.5	3.7e-08	0.70	0.07	0.80	FALSE