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chr19:16,462,417-18,180,451

Best TWAS P=9.31e-19 · Best GWAS P=7.08e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Esophagus Muscularis	MYO9B	0.13	0.02	lasso	5	0.05	9.5e-04	6.41	-8.8	9.3e-19	-0.62	0.04	0.94	TRUE
5	GTEx	Artery Tibial	CTD-3032J10.3	0.14	0.01	lasso	5	0.01	6.4e-02	8.87	-8.5	1.9e-17	-0.96	0.00	0.95	TRUE
4	GTEx	Artery Tibial	HAUS8	0.16	0.02	lasso	7	0.02	4.7e-03	7.30	-7.9	2.9e-15	-0.62	0.25	0.66	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS8	0.04	0.06	lasso	2	0.05	2.2e-05	7.28	-7.7	1.1e-14	-0.69	0.12	0.85	FALSE
13	GTEx	Stomach	PLVAP	0.27	0.01	lasso	5	0.00	5.0e-01	8.14	7.6	2.3e-14	0.62	0.04	0.40	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAUS8	0.09	0.14	lasso	4	0.12	5.9e-14	7.27	-7.6	3.6e-14	-0.65	1.00	0.00	FALSE
11	GTEx	Muscle Skeletal	HAUS8	0.15	0.10	lasso	4	0.08	1.6e-08	7.28	-7.5	5.6e-14	-0.62	1.00	0.00	FALSE
7	GTEx	Cells Transformed fibroblasts	HAUS8	0.12	0.05	enet	19	0.05	1.0e-04	7.30	-7.5	6.4e-14	-0.53	0.56	0.26	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS8	0.13	0.10	blup	55	0.11	7.8e-12	7.30	-7.4	1.8e-13	-0.49	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS8	0.05	0.06	enet	12	0.06	2.9e-12	7.28	-7.3	2.0e-13	-0.57	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HAUS8	0.06	0.04	enet	4	0.05	3.9e-06	6.41	-7.3	2.2e-13	-0.54	0.90	0.02	FALSE
3	GTEx	Artery Aorta	HAUS8	0.18	0.12	lasso	2	0.09	7.3e-06	7.30	-7.3	2.5e-13	-0.63	0.27	0.69	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	HAUS8	0.05	0.05	enet	7	0.05	7.1e-07	7.28	-7.3	2.7e-13	-0.63	0.45	0.54	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	HAUS8	0.12	0.06	lasso	5	0.06	1.8e-04	7.30	-7.3	3.1e-13	-0.58	0.28	0.52	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAUS8	0.06	0.04	blup	55	0.04	1.0e-03	7.27	-7.2	5.9e-13	-0.64	0.04	0.37	FALSE
1	GTEx	Adipose Subcutaneous	HAUS8	0.11	0.09	lasso	3	0.08	5.4e-07	7.27	-7.2	8.4e-13	-0.62	0.30	0.70	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS8	0.21	0.11	enet	9	0.10	6.2e-05	-5.75	-7.1	9.5e-13	-0.56	0.10	0.50	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS8	0.20	0.13	lasso	2	0.11	2.4e-05	7.28	-7.1	1.2e-12	-0.61	0.32	0.39	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HAUS8	0.10	0.07	blup	55	0.07	3.2e-04	7.28	-7.1	1.4e-12	-0.74	0.05	0.90	FALSE
6	GTEx	Brain Cerebellar Hemisphere	HAUS8	0.44	0.15	lasso	7	0.11	8.1e-04	7.27	-6.9	3.7e-12	-0.57	0.22	0.23	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	HAUS8	0.04	0.04	lasso	2	0.03	1.6e-04	7.30	-6.9	3.9e-12	-0.57	0.56	0.05	FALSE
10	GTEx	Esophagus Muscularis	HAUS8	0.20	0.11	lasso	4	0.09	5.1e-06	7.27	-6.9	5.9e-12	-0.59	0.68	0.14	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	MYO9B	0.11	0.01	lasso	8	0.07	5.4e-09	8.69	-6.8	7.6e-12	-0.65	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS8	0.08	0.07	blup	55	0.07	6.7e-08	7.30	-6.8	8.0e-12	-0.53	0.99	0.01	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYO9B	0.14	0.07	blup	103	0.10	5.0e-11	8.87	-6.7	1.9e-11	-0.59	0.00	1.00	FALSE
16	YFS	Blood	HAUS8	0.03	0.02	lasso	6	0.02	3.3e-07	7.09	-6.3	2.8e-10	-0.44	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	HAUS8	0.15	0.12	lasso	2	0.12	7.0e-07	7.30	-6.2	4.6e-10	-0.61	0.48	0.48	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	HAUS8	0.06	0.03	blup	55	0.03	2.7e-04	7.28	-5.5	4.5e-08	-0.49	0.19	0.17	FALSE
12	GTEx	Nerve Tibial	MYO9B	0.29	0.16	enet	30	0.20	6.7e-14	6.99	5.4	5.9e-08	0.52	1.00	0.00	FALSE
8	GTEx	Colon Sigmoid	PLVAP	0.29	0.01	lasso	10	0.00	3.8e-01	0.18	5.3	1.2e-07	0.36	0.04	0.36	FALSE