Best TWAS P=9.31e-19 · Best GWAS P=7.08e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HAUS8 | 0.11 | 0.09 | lasso | 3 | 0.08 | 5.4e-07 | 7.27 | -7.2 | 8.4e-13 | -0.62 | 0.30 | 0.70 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | HAUS8 | 0.15 | 0.12 | lasso | 2 | 0.12 | 7.0e-07 | 7.30 | -6.2 | 4.6e-10 | -0.61 | 0.48 | 0.48 | FALSE |
| 3 | GTEx | Artery Aorta | HAUS8 | 0.18 | 0.12 | lasso | 2 | 0.09 | 7.3e-06 | 7.30 | -7.3 | 2.5e-13 | -0.63 | 0.27 | 0.69 | FALSE |
| 4 | GTEx | Artery Tibial | HAUS8 | 0.16 | 0.02 | lasso | 7 | 0.02 | 4.7e-03 | 7.30 | -7.9 | 2.9e-15 | -0.62 | 0.25 | 0.66 | FALSE |
| 5 | GTEx | Artery Tibial | CTD-3032J10.3 | 0.14 | 0.01 | lasso | 5 | 0.01 | 6.4e-02 | 8.87 | -8.5 | 1.9e-17 | -0.96 | 0.00 | 0.95 | TRUE |
| 6 | GTEx | Brain Cerebellar Hemisphere | HAUS8 | 0.44 | 0.15 | lasso | 7 | 0.11 | 8.1e-04 | 7.27 | -6.9 | 3.7e-12 | -0.57 | 0.22 | 0.23 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | HAUS8 | 0.12 | 0.05 | enet | 19 | 0.05 | 1.0e-04 | 7.30 | -7.5 | 6.4e-14 | -0.53 | 0.56 | 0.26 | FALSE |
| 8 | GTEx | Colon Sigmoid | PLVAP | 0.29 | 0.01 | lasso | 10 | 0.00 | 3.8e-01 | 0.18 | 5.3 | 1.2e-07 | 0.36 | 0.04 | 0.36 | FALSE |
| 9 | GTEx | Esophagus Muscularis | MYO9B | 0.13 | 0.02 | lasso | 5 | 0.05 | 9.5e-04 | 6.41 | -8.8 | 9.3e-19 | -0.62 | 0.04 | 0.94 | TRUE |
| 10 | GTEx | Esophagus Muscularis | HAUS8 | 0.20 | 0.11 | lasso | 4 | 0.09 | 5.1e-06 | 7.27 | -6.9 | 5.9e-12 | -0.59 | 0.68 | 0.14 | FALSE |
| 11 | GTEx | Muscle Skeletal | HAUS8 | 0.15 | 0.10 | lasso | 4 | 0.08 | 1.6e-08 | 7.28 | -7.5 | 5.6e-14 | -0.62 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Nerve Tibial | MYO9B | 0.29 | 0.16 | enet | 30 | 0.20 | 6.7e-14 | 6.99 | 5.4 | 5.9e-08 | 0.52 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Stomach | PLVAP | 0.27 | 0.01 | lasso | 5 | 0.00 | 5.0e-01 | 8.14 | 7.6 | 2.3e-14 | 0.62 | 0.04 | 0.40 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | MYO9B | 0.11 | 0.01 | lasso | 8 | 0.07 | 5.4e-09 | 8.69 | -6.8 | 7.6e-12 | -0.65 | 0.02 | 0.98 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | HAUS8 | 0.05 | 0.05 | enet | 7 | 0.05 | 7.1e-07 | 7.28 | -7.3 | 2.7e-13 | -0.63 | 0.45 | 0.54 | FALSE |
| 16 | YFS | Blood | HAUS8 | 0.03 | 0.02 | lasso | 6 | 0.02 | 3.3e-07 | 7.09 | -6.3 | 2.8e-10 | -0.44 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HAUS8 | 0.05 | 0.06 | enet | 12 | 0.06 | 2.9e-12 | 7.28 | -7.3 | 2.0e-13 | -0.57 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | HAUS8 | 0.10 | 0.07 | blup | 55 | 0.07 | 3.2e-04 | 7.28 | -7.1 | 1.4e-12 | -0.74 | 0.05 | 0.90 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | HAUS8 | 0.12 | 0.06 | lasso | 5 | 0.06 | 1.8e-04 | 7.30 | -7.3 | 3.1e-13 | -0.58 | 0.28 | 0.52 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HAUS8 | 0.08 | 0.07 | blup | 55 | 0.07 | 6.7e-08 | 7.30 | -6.8 | 8.0e-12 | -0.53 | 0.99 | 0.01 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HAUS8 | 0.09 | 0.14 | lasso | 4 | 0.12 | 5.9e-14 | 7.27 | -7.6 | 3.6e-14 | -0.65 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HAUS8 | 0.06 | 0.03 | blup | 55 | 0.03 | 2.7e-04 | 7.28 | -5.5 | 4.5e-08 | -0.49 | 0.19 | 0.17 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | HAUS8 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.6e-04 | 7.30 | -6.9 | 3.9e-12 | -0.57 | 0.56 | 0.05 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HAUS8 | 0.06 | 0.04 | enet | 4 | 0.05 | 3.9e-06 | 6.41 | -7.3 | 2.2e-13 | -0.54 | 0.90 | 0.02 | FALSE |
| 25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HAUS8 | 0.20 | 0.13 | lasso | 2 | 0.11 | 2.4e-05 | 7.28 | -7.1 | 1.2e-12 | -0.61 | 0.32 | 0.39 | FALSE |
| 26 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HAUS8 | 0.21 | 0.11 | enet | 9 | 0.10 | 6.2e-05 | -5.75 | -7.1 | 9.5e-13 | -0.56 | 0.10 | 0.50 | FALSE |
| 27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HAUS8 | 0.13 | 0.10 | blup | 55 | 0.11 | 7.8e-12 | 7.30 | -7.4 | 1.8e-13 | -0.49 | 1.00 | 0.00 | FALSE |
| 28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO9B | 0.14 | 0.07 | blup | 103 | 0.10 | 5.0e-11 | 8.87 | -6.7 | 1.9e-11 | -0.59 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HAUS8 | 0.06 | 0.04 | blup | 55 | 0.04 | 1.0e-03 | 7.27 | -7.2 | 5.9e-13 | -0.64 | 0.04 | 0.37 | FALSE |
| 30 | The Cancer Genome Atlas | Thyroid Carcinoma | HAUS8 | 0.04 | 0.06 | lasso | 2 | 0.05 | 2.2e-05 | 7.28 | -7.7 | 1.1e-14 | -0.69 | 0.12 | 0.85 | FALSE |