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Cardiovascular Disease
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chr19:44,614,208-46,098,885
Best TWAS P=7.87e-13 · Best GWAS P=4.87e-64 conditioned to 9.93e-38
44.6M
44.8M
45M
45.2M
45.4M
45.6M
45.8M
46M
0
10
20
30
40
50
60
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Thyroid Carcinoma
PVRL2
0.09
0.05
blup
55
0.03
4.6e-04
2.8
-7.2
7.9e-13
0.31
0.46
0.09
TRUE
2
GTEx
Stomach
BCAM
0.33
0.00
enet
3
0.01
9.6e-02
3.3
-6.7
1.5e-11
0.27
0.07
0.08
TRUE
3
YFS
Blood
TOMM40
0.04
0.00
bslmm
371
0.01
2.6e-04
-5.7
5.6
2.2e-08
-0.08
0.05
0.02
TRUE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
APOC4
0.06
0.03
blup
34
0.04
8.4e-06
1.9
5.4
8.0e-08
-0.19
0.66
0.06
TRUE
1
GTEx
Esophagus Mucosa
PVRL2
0.15
0.01
enet
10
0.02
1.7e-02
-6.8
5.4
7.1e-08
-0.16
0.14
0.04
FALSE