TWAS hub - MYO9B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.126	0.0430	2.3e-03	0.022	NA	0.041	NA	0.045	1.6e-02	NA	1.6e-03	NA	9.5e-04
2	GTEx	Nerve Tibial	0.294	0.0561	1.6e-07	0.160	NA	0.196	NA	0.161	2.1e-11	NA	6.7e-14	NA	1.7e-11
3	ROSMAP	Brain Pre-frontal Cortex	0.109	0.0254	2.0e-07	0.014	0.052	0.061	0.059	0.067	5.5e-03	2.5e-07	2.4e-08	4.3e-08	5.4e-09
4	TCGA	Colon Adenocarcinoma	0.104	0.0420	7.8e-04	0.011	0.050	0.063	NA	0.045	7.1e-02	7.4e-04	1.6e-04	NA	1.3e-03
5	TCGA	Prostate Adenocarcinoma	0.141	0.0380	7.7e-11	0.068	0.104	0.087	NA	0.072	1.2e-07	5.0e-11	2.3e-09	NA	5.5e-08
6	TCGA	Thyroid Carcinoma	0.054	0.0210	1.5e-04	0.010	0.035	0.008	NA	0.006	3.2e-02	2.0e-04	4.7e-02	NA	8.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Cardiovascular Disease	11.7	38.8	78.2	-8.8	5.4	-6.8	-3.0	-6.7	-4.9
Vascular/heart problems diagnosed by doctor	10.0	27.2	51.9	7.2	-4.1	5.5	3.2	5.8	4.5
High blood pressure	9.1	25.4	50.0	-7.1	3.7	-5.3	-3.2	-5.6	-4.4
Hypertension (Self-reported)	8.9	24.6	49.8	-7.1	3.9	-5.1	-3.3	-5.2	-4.3
Medication: Blood pressure	6.8	12.9	34.5	-5.9	3.1	-3.4	-1.0	-4.1	-2.1
Angina (self-reported)	5.7	7.5	11.0	-3.3	3.2	-2.7	-1.5	-3.0	-2.3
Eye problems/disorders: Glaucoma	5.6	6.6	11.7	-2.9	0.0	-3.4	-1.3	-3.3	-2.6
Medication: Bendroflumethiazide	5.5	8.3	23.5	-4.8	1.8	-2.6	-1.5	-3.0	-2.3
Number of self-reported non-cancer illnesses	5.4	9.4	19.4	-4.4	3.0	-2.6	-1.3	-3.6	-2.6
Impedance of whole body	5.4	27.3	60.5	-7.8	5.3	-5.6	-1.1	-5.4	-3.7
Medication: Atenolol	5.3	6.7	9.5	-3.0	0.8	-2.7	-2.4	-3.1	-2.8
Prostate Cancer	5.1	7.1	12.3	3.5	-1.9	2.7	1.5	3.4	2.4
Angina	4.9	6.4	10.0	-3.2	2.9	-2.6	-1.3	-2.7	-2.1
Medication: Simvastatin	4.9	7.1	11.8	-3.4	2.4	-2.3	-2.0	-3.2	-2.3
Impedance of arm (right)	4.8	22.2	46.2	-6.8	4.5	-5.6	-0.7	-4.8	-3.5
Impedance of arm (left)	4.6	21.5	41.9	-6.5	4.7	-5.4	-1.0	-4.6	-3.7
Impedance of leg (right)	4.5	21.8	56.6	-7.5	4.8	-4.5	-0.9	-4.7	-2.8
Systolic Blood Pressure	4.4	22.1	50.1	-7.1	5.1	-4.7	-1.5	-4.7	-3.2
Eye problems/disorders: Cataract	4.4	5.1	11.8	2.1	-0.6	2.2	3.4	1.5	2.6
Waist Hip Ratio (WHR)	4.3	19.4	37.5	-6.1	3.9	-4.7	-0.8	-5.7	-2.9
Impedance of leg (left)	4.3	20.8	54.2	-7.4	4.7	-4.5	-0.7	-4.6	-2.8
Diastolic blood pressure, automated reading	4.2	13.1	22.3	-4.7	2.4	-3.9	-2.8	-3.9	-3.5
Medication for cholesterol	4.0	6.1	13.6	3.7	-1.3	2.5	1.2	3.6	1.2
Breast cancer (self-reported)	3.9	4.7	11.0	2.3	-0.3	2.3	1.2	3.3	2.2
Trunk fat percentage	3.8	15.1	22.6	-4.3	2.7	-4.0	-2.9	-4.8	-4.2
Glaucoma (self-reported)	3.8	4.5	8.3	-2.4	0.3	-2.9	-0.8	-2.8	-2.1
Medication: Metformin	3.5	5.0	9.4	-1.7	2.0	-2.7	-1.5	-3.1	-1.9
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	12.7	3.6	-2.3	2.2	1.1	2.8	1.9
Body fat percentage	3.5	13.8	23.4	-4.2	2.4	-3.9	-2.7	-4.8	-3.8
Heart attack	3.4	4.4	7.0	-2.4	1.0	-2.3	-1.2	-2.6	-2.4
Medication: Seretide 50 evohaler	3.4	3.9	6.7	-1.6	0.9	-2.3	-1.8	-2.3	-2.6
Illnesses of father: None of the above (group 1)	3.4	4.2	8.9	3.0	-1.4	2.2	0.6	2.2	2.0
Cholesterol lowering medication	3.4	5.1	11.3	-2.7	1.2	-2.2	-1.6	-3.4	-1.8
Systolic blood pressure, automated reading	3.3	9.6	20.8	-4.6	1.8	-3.0	-1.7	-3.7	-2.9
Father’s age at death	3.3	4.5	9.2	0.8	-2.2	3.0	1.2	2.5	2.1
Medication: Ventolin 100micrograms inhaler	3.3	4.3	9.2	-0.1	0.3	-1.7	-2.6	-2.6	-3.0
Back pain experienced in last month	3.3	4.8	8.1	-1.8	0.4	-2.3	-2.6	-2.2	-2.8
Medication: Amlodipine	3.2	4.5	14.0	-3.7	2.3	-1.3	-0.6	-2.1	-1.1
Taking other prescription medications	3.1	4.8	9.7	-2.4	2.2	-1.4	-1.8	-3.1	-1.9
Leg fat percentage (right)	3.1	11.2	21.9	-3.8	2.0	-3.2	-2.7	-4.7	-2.9
Diabetes diagnosed by doctor	3.1	5.0	8.6	-2.9	2.1	-2.5	-0.7	-2.9	-1.3
Pain type(s) experienced in last month: Hip pain	3.1	3.8	6.2	-2.0	1.5	-1.1	-2.0	-2.4	-2.5
Age at First Birth	3.0	4.4	8.6	-2.5	2.9	-2.2	-0.6	-1.4	-2.0
Medication: Cholesterol lowering	3.0	4.7	11.8	-3.4	2.6	-1.8	-0.2	-2.1	-1.2
Breast Cancer	2.9	7.0	15.1	-3.6	3.9	-1.9	-0.2	-3.0	-1.2
Blood Platelet Count	2.9	33.6	89.3	-9.4	4.8	-6.3	0.9	-5.3	-4.5
Heart attack/myocardial infarction (self-reported)	2.8	3.6	5.7	-2.3	1.0	-2.0	-1.1	-2.4	-2.1
High blood pressure (siblings)	2.7	4.0	9.3	-2.2	0.5	-2.4	-1.3	-3.0	-1.5
Leg fat percentage (left)	2.7	9.9	19.7	-3.6	1.9	-3.1	-2.5	-4.4	-2.7
Number of treatments/medications taken	2.6	4.6	12.9	-3.6	1.9	-1.1	-0.7	-2.7	-1.4
High cholesterol (Self-reported)	2.6	4.5	12.5	-3.5	2.7	-1.5	0.3	-2.1	-0.8
Diabetes (self-reported)	2.5	3.9	9.0	-2.2	1.5	-2.3	-0.3	-3.0	-1.3
Medication: Blood pressure	2.5	4.4	10.4	-3.2	1.3	-1.8	-1.5	-2.3	-1.8
Medication: Allopurinol	2.5	3.3	11.3	-0.7	1.0	-1.2	-3.4	-1.5	-1.8
Type 2 Diabetes (T2D) (2012)	2.4	2.8	5.9	-1.6	0.0	-1.5	-2.4	-0.6	-2.4
Trunk fat-free mass	2.4	13.6	27.6	5.2	-1.7	4.7	0.2	5.1	1.7
Trunk predicted mass	2.4	13.8	28.1	5.3	-1.7	4.7	0.2	5.1	1.7
Average weekly champagne plus white wine intake	2.3	3.2	7.0	-2.0	1.8	-2.6	-1.3	-0.3	-1.8
Wears glasses or contact lenses	2.3	2.6	5.4	1.2	-1.6	2.3	1.8	1.6	0.9
Number of incorrect matches in round	2.2	3.7	11.7	-2.6	3.4	-1.3	1.1	-0.9	0.1
Severe depression (siblings)	2.1	2.3	4.4	1.6	0.3	1.7	1.0	2.1	1.8
Multivitamins +/- minerals	2.1	2.6	4.8	1.5	-0.7	1.6	1.6	1.8	2.2
Schizophrenia (2018)	2.0	4.1	6.3	1.7	-2.3	1.9	2.3	1.1	2.5
Arm fat percentage (right)	2.0	7.7	14.4	-2.7	1.1	-3.1	-2.2	-3.8	-3.0
Illnesses of mother	2.0	2.5	6.0	2.5	-2.2	1.1	-0.6	1.5	0.5
Commuting to job workplace: Car/motor vehicle	2.0	2.3	5.6	-1.3	-0.6	-2.4	-0.8	-1.8	-1.6
Whole body fat-free mass	2.0	11.2	25.1	5.0	-1.6	4.1	0.1	4.5	1.4
Arm fat percentage (left)	2.0	7.9	13.8	-2.6	1.3	-3.1	-2.4	-3.7	-3.1
Illnesses of father: High blood pressure	2.0	2.5	7.8	-2.8	1.5	-1.3	-0.1	-1.5	-1.0
Lupus	1.9	2.9	7.9	0.4	0.1	-1.5	-2.8	-2.0	-1.8
Primary Biliary Cirrhosis	1.9	2.8	14.4	-1.4	3.8	-0.3	0.1	-0.1	0.3
Mouth/teeth dental problems: Dentures	1.9	3.1	4.7	-1.9	0.9	-1.8	-1.5	-2.1	-2.2
Asthma	1.9	3.7	6.9	-1.9	-0.3	-1.9	-1.4	-2.6	-2.5
Asthma (self-reported)	1.9	3.9	7.5	-2.1	-0.2	-1.8	-1.2	-2.7	-2.6
Whole body water mass	1.9	10.9	25.1	5.0	-1.6	4.0	0.0	4.5	1.2
Schizophrenia vs Biploar Disorder	1.8	2.3	3.5	1.6	-0.7	1.9	1.7	1.2	1.8
Illnesses of siblings	1.8	2.5	6.1	2.5	-1.1	1.7	-0.4	2.2	0.3
Gout (self-reported)	1.8	2.5	8.5	-1.3	2.9	-0.8	-1.8	-0.8	-0.6
Hypothyroidism (self reported)	1.7	3.9	10.8	-3.0	3.3	-0.5	1.6	0.2	0.6
Hayfever, allergic rhinitis or eczema	1.7	3.6	11.8	2.7	-3.4	1.4	0.4	0.5	0.2
Trunk fat mass	1.7	7.4	11.2	-2.6	2.1	-2.5	-2.5	-3.0	-3.3
Arm fat-free mass (right)	1.7	8.9	20.2	4.5	-1.3	3.8	-0.2	4.0	1.2
Mineral and other dietary supplements	1.7	2.3	4.1	-1.3	0.6	-2.0	-1.4	-1.4	-1.9
Osteoporosis (self-reported)	1.7	2.0	5.2	0.7	-0.4	1.9	2.3	0.9	1.5
Hearing aid user	1.7	1.9	3.2	-1.2	1.5	-1.5	-1.2	-1.8	-1.0
Medication: Lisinopril	1.7	2.2	7.0	-1.3	0.8	-1.7	-0.6	-2.6	-0.9
Verbal and Numeric Reasoning (VNR)	1.6	3.9	8.7	1.6	-1.2	1.5	2.3	2.9	1.7
Vitamin and mineral supplements	1.6	2.2	3.9	-0.8	0.2	-1.6	-1.6	-1.9	-2.0
Arm predicted mass (right)	1.6	8.0	17.6	4.2	-1.4	3.5	-0.1	3.9	1.0
Bipolar Disorder (2018)	1.5	2.4	5.6	-1.3	-0.3	-1.6	-1.4	-2.4	-1.5
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.0	-2.3	1.5	-1.7	-0.0	-2.4	-0.8
Supplements: Zinc	1.5	1.6	4.0	1.0	0.5	1.2	2.0	1.0	1.5
Illnesses of father: Heart disease	1.5	2.1	3.7	-0.6	-1.9	-1.5	-0.4	-1.9	-1.5
Leg fat-free mass (right)	1.5	7.8	22.7	4.8	-1.6	2.9	-0.2	3.5	0.6
Leg predicted mass (right)	1.5	7.9	23.0	4.8	-1.7	2.9	-0.1	3.5	0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.8	0.2	-1.9	-0.3	-1.6	-1.8	-1.2
Rheumatoid Arthritis	1.4	1.9	6.5	-1.3	2.6	0.4	1.1	0.8	1.1
Hand grip strength (right)	1.4	3.8	11.1	3.0	-3.3	0.8	0.5	1.1	-0.2
High blood pressure (mother)	1.4	1.9	4.6	-1.8	2.1	-1.2	1.1	-1.1	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	9.0	2.4	-1.6	1.8	1.7	3.0	2.0
Medication: Aspirin	1.4	1.9	2.9	-1.4	1.7	-1.2	-1.2	-1.3	-1.3
Arm predicted mass (left)	1.4	7.3	16.2	4.0	-1.4	3.5	-0.2	3.5	1.1
Alzheimer’s Disease (including proxy)	1.3	1.9	8.6	0.6	-2.9	0.2	-0.9	-1.0	-0.6
Stomach or abdominal pain in last month	1.3	1.7	5.1	-1.2	0.3	-0.8	-0.5	-2.3	-1.6
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.8	1.4	-0.8	1.2	1.4	0.9	1.7
Shortness of breath walking on level ground	1.3	1.6	4.2	1.2	0.2	2.0	1.1	0.5	1.6
Whole body fat mass	1.3	5.6	8.2	-2.2	1.6	-2.2	-2.2	-2.9	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	4.2	-0.7	-0.3	-0.9	-1.3	-2.0	-1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.7	-0.3	0.0	1.3	2.2	0.8	1.8
Arm fat-free mass (left)	1.3	6.8	14.9	3.9	-1.1	3.4	-0.2	3.4	1.0
Risk taking	1.3	1.8	6.5	-0.8	2.6	-1.3	-1.0	-0.0	-1.1
Allergy or Eczema	1.2	3.3	9.6	2.7	-3.1	1.6	0.1	-0.3	0.4
Hand grip strength (left)	1.2	3.0	12.4	2.2	-3.5	0.3	0.9	0.4	-0.2
Hearing difficulty/problems: Yes	1.2	1.9	4.5	1.2	-0.0	2.1	0.6	0.7	2.1
Maternal smoking around birth	1.2	1.8	3.3	-1.8	1.1	-1.4	-0.2	-1.8	-1.1
Medication: Levothyroxine sodium	1.2	2.1	5.5	-1.4	2.4	-0.2	1.9	0.5	0.9
Past tobacco smoking	1.2	2.3	4.5	1.6	-2.1	1.1	0.5	1.2	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.8	0.2	0.9	1.1	1.2	1.7	1.4
Lung cancer (father)	1.2	1.4	2.3	1.5	-1.2	1.2	1.1	1.0	1.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.8	1.9	-1.0	1.5	0.1	0.9	1.2
Qualifications: College or University degree	1.2	3.9	5.9	0.8	2.1	1.4	2.3	2.4	2.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.4	-1.1	1.5	-1.1	-1.1	-0.6	-1.4
Age at last live birth	1.2	1.7	3.6	-0.5	-1.4	-1.3	-0.9	-1.9	-1.4
Basal metabolic rate	1.2	6.6	15.7	4.0	-1.1	3.2	-0.3	3.5	0.7
Commuting to job workplace: Cycle	1.2	1.4	2.7	1.0	-1.2	1.6	0.3	1.5	1.0
Basal cell carcinoma (self-reported)	1.2	1.5	3.9	2.0	-1.1	1.0	0.3	1.3	0.9
Leg predicted mass (left)	1.1	5.9	17.1	4.1	-1.3	2.6	-0.5	3.1	0.3
Blood clot in the leg (DVT)	1.1	1.4	2.9	0.2	1.0	1.1	1.4	1.2	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.0	0.9	0.6	2.0	0.6	0.9	1.4
Number of full sisters	1.1	1.3	2.5	0.7	-0.0	0.8	1.6	1.4	1.5
Chest pain or discomfort	1.1	1.6	4.8	-1.1	1.0	-0.7	-0.9	-2.2	-1.1
Medication: Aspirin	1.1	1.4	2.3	-1.3	1.5	-0.9	-1.3	-1.1	-1.0
Supplements: Calcium	1.1	1.2	2.0	0.9	-0.8	1.2	0.9	1.4	1.1
Heart disease (siblings)	1.1	1.4	5.3	-1.0	0.8	0.0	2.3	0.2	1.1
Alzheimer’s Disease (in mother)	1.0	1.1	5.3	-0.5	-2.3	0.0	-0.7	-0.9	0.0
Diabetes (mother)	1.0	1.3	2.3	-1.5	1.1	-1.5	-0.6	-0.4	-1.3
Leg fat-free mass (left)	1.0	5.5	16.5	4.1	-1.2	2.5	-0.5	3.0	0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.1	2.0	-1.7	0.9	-0.4	0.0	-0.0
Medication: Ramipril	1.0	1.3	5.3	-2.3	0.4	-1.2	-0.3	-0.6	-0.9
Noisy workplace	1.0	1.3	3.2	0.1	-0.1	1.0	1.8	0.5	1.8
Peak expiratory flow (PEF)	1.0	2.3	3.8	2.0	-1.3	1.0	1.6	2.0	0.8
Forced vital capacity (FVC), Best measure	1.0	3.5	8.4	1.9	-0.4	1.8	1.7	2.9	1.6
Wheeze or whistling in the chest in last year	1.0	1.7	3.6	-1.9	-0.3	-0.5	-1.1	-1.6	-1.5
Overall health rating	1.0	2.2	4.9	-1.5	1.5	-1.3	-0.7	-2.2	-1.1
Smoking status: Previous	1.0	1.5	2.9	-1.7	1.7	-0.7	0.0	-1.0	-1.4
Ever had bowel cancer screening	1.0	1.1	3.5	0.5	0.6	1.9	0.2	1.2	1.2
Friendships satisfaction	1.0	1.2	2.2	-0.6	0.6	-1.0	-1.5	-1.4	-1.2
Pain experienced in last month	1.0	1.7	4.5	0.9	-0.3	1.2	1.3	1.4	2.1
Blood White Count	0.9	6.5	11.8	-3.4	3.4	-1.9	-1.9	-1.1	-2.7
Townsend deprivation index at recruitment	0.9	1.2	3.1	-1.0	0.7	-0.1	-1.8	-1.1	-1.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.1	1.5	0.4	1.2	0.5	0.7	1.3
Eye problems/disorders: None of the above	0.9	1.0	3.3	-0.9	0.5	-0.7	-1.8	-0.1	-1.1
Suffer from ‘nerves’	0.9	1.4	3.3	1.7	-1.8	0.1	-1.1	-0.7	-0.8
Leg pain on walking	0.9	1.1	5.0	-1.0	2.2	-0.2	-0.3	-0.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.6	0.1	-1.6	-0.9	-0.4	-1.4	-1.0
Commuting to job workplace: Walk	0.9	1.0	1.6	1.1	-0.4	1.2	0.9	0.9	1.3
Osteoarthritis (self-reported)	0.9	1.1	4.2	-1.0	2.0	-0.1	-0.6	-0.7	-0.7
Alcohol drinker status: Never	0.9	1.1	3.8	-1.6	2.0	0.5	0.3	-0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.4	0.3	0.7	1.0	1.3	1.1	1.5
Ovarian Cancer	0.8	1.1	2.0	-0.3	1.0	1.0	1.4	0.8	1.3
Ulcerative Colitis	0.8	1.2	1.9	0.4	-1.4	-0.8	-1.2	-1.1	-1.3
Respiratory disease	0.8	1.8	3.4	-1.2	-0.6	-1.2	-1.2	-1.5	-1.8
Relative age of first facial hair	0.8	1.6	3.4	1.6	-1.2	1.0	0.6	1.8	0.8
Supplements: Glucosamine	0.8	1.0	2.4	1.5	-0.8	1.3	0.5	0.9	0.6
Waist circumference	0.8	2.9	5.7	-1.6	0.9	-1.6	-1.4	-2.4	-1.9
Hearing difficulty/problems with background noise	0.8	1.3	3.0	0.5	0.2	1.7	1.3	0.4	1.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	4.4	-1.6	2.1	-0.4	1.3	0.1	0.5
Birth weight	0.8	1.8	5.1	2.3	-1.6	0.7	-1.1	1.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.1	-1.3	0.6	-0.8	-0.5	-1.4	-0.7
Medication: Omeprazole	0.8	0.9	2.3	0.2	-1.5	0.0	-0.7	-1.5	-0.7
Leg fat mass (right)	0.8	3.2	5.8	-1.4	1.0	-1.5	-2.1	-2.4	-2.0
Long-standing illness, disability or infirmity	0.8	1.2	2.4	-1.0	1.6	-1.2	-0.3	-1.2	-0.9
Financial situation satisfaction	0.8	1.0	3.1	-1.0	1.8	-0.7	-0.5	-0.6	-0.7
Commuting to job workplace: Public transport	0.8	0.9	3.1	-0.7	0.8	0.0	1.8	0.9	0.7
Leg fat mass (left)	0.8	3.0	5.3	-1.4	0.9	-1.5	-1.9	-2.3	-1.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.6	-0.4	1.9	-0.8	0.7	-0.8	0.2
Forced vital capacity (FVC)	0.7	2.8	6.6	2.0	-0.2	2.0	0.8	2.6	1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.3	2.0	-1.0	1.5	0.7	2.3	1.1
Happiness	0.7	0.8	1.7	0.9	-0.7	1.3	0.1	1.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	4.4	0.2	0.6	0.4	2.1	0.1	0.8
Exposure to tobacco smoke at home	0.7	0.8	1.7	-0.5	1.2	-0.9	-1.3	-0.7	-0.4
Loud music exposure frequency	0.7	0.7	2.2	1.5	-0.9	1.0	0.1	-0.0	0.6
Number of full brothers	0.7	0.8	1.6	0.3	0.7	1.3	0.7	1.0	1.1
Pulse wave peak to peak time	0.7	0.8	2.0	1.4	-1.0	0.8	-0.9	0.4	-0.5
Pulse rate, automated reading	0.7	2.4	5.3	-1.6	0.6	-2.3	-1.4	-1.0	-1.8
Guilty feelings	0.7	1.0	2.6	-0.6	1.6	0.3	1.5	0.5	0.5
Mother’s age at death	0.7	0.9	2.5	0.3	-1.6	1.2	1.0	0.7	0.2
Number of operations (self-reported)	0.7	1.0	2.6	0.2	0.1	1.6	0.1	1.4	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.7	-0.6	1.9	0.0	-0.4	0.5	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.7	0.7	-0.6	0.8	0.9	1.7	0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	7.1	0.5	0.0	0.6	1.6	2.7	1.1
Schizophrenia (2014)	0.6	1.3	2.7	0.7	-1.6	0.8	1.4	0.0	1.3
Lung FVC	0.6	3.0	9.1	3.0	-2.6	1.1	-0.1	1.0	0.3
Average weekly spirits intake	0.6	0.7	1.6	-1.1	1.3	-0.1	1.1	0.4	0.3
Diabetes (father)	0.6	0.7	1.9	-1.0	1.4	-0.9	-0.3	-0.4	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	2.6	1.6	-1.0	-0.1	-0.8	-0.8	-0.3
Nervous feelings	0.6	1.1	2.2	-1.5	1.5	-0.4	-0.9	-1.1	-0.4
Pulse rate	0.6	1.0	1.9	-1.1	1.4	-1.4	-0.3	-0.6	-0.7
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-1.2	1.2	-0.9	0.8	-0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	-0.0	1.4	0.9	1.0	0.5	1.1
Health satisfaction	0.6	0.8	1.5	-1.2	1.2	-0.4	-1.0	-0.6	-0.5
Illnesses of siblings: Diabetes	0.6	0.7	2.2	-1.5	1.3	-0.7	0.2	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.7	-0.1	0.5	-0.7	-1.1	-1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	1.4	-1.3	0.5	0.2	0.2	0.2
Arm fat mass (left)	0.6	2.4	4.2	-1.0	0.6	-1.3	-1.9	-1.8	-2.0
Ever taken oral contraceptive pill	0.6	0.6	1.9	1.1	-0.1	0.7	0.4	1.4	0.3
Ever smoked	0.6	1.0	3.4	-0.8	1.8	-0.5	-0.3	-0.4	-1.2
Age started oral contraceptive pill	0.6	0.8	1.7	0.8	-1.0	1.3	-0.3	0.9	0.8
Bipolar Disorder or Schizophrenia	0.5	1.1	3.8	0.5	-2.0	0.5	0.9	-0.7	1.0
Ulcerative Colitis (UC)	0.5	1.0	2.0	-0.4	0.3	-1.1	-1.4	-0.6	-1.4
Sitting height	0.5	3.5	13.1	-0.9	3.6	-0.3	-1.7	1.0	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.8	-0.3	1.9	0.4	0.4	-0.3	0.5
Financial difficulties in last 2 years	0.5	0.7	1.4	0.1	0.6	0.9	1.2	0.9	0.7
Fluid intelligence score	0.5	1.0	3.6	0.4	0.5	0.2	1.2	1.9	0.5
Arm fat mass (right)	0.5	2.1	3.9	-1.0	0.5	-1.2	-1.7	-1.7	-2.0
Birth weight of first child	0.5	0.8	1.6	0.7	-0.7	1.2	1.2	0.8	0.5
Pulse wave reflection index	0.5	0.7	2.7	-1.6	0.7	-0.6	0.6	-0.0	0.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.5	-0.1	0.6	-0.2	0.8	1.9	0.4
Comparative body size at age 10	0.5	1.4	4.0	1.9	-2.0	0.3	0.4	0.6	0.4
Number of children fathered	0.5	0.6	2.8	-0.6	1.7	-0.0	0.1	0.2	0.5
Mean time to correctly identify matches	0.5	1.0	2.0	-1.4	1.4	1.1	0.1	-0.4	0.9
Heart disease (mother)	0.5	0.6	2.2	-1.0	1.5	-0.2	-0.5	-0.5	-0.3
Supplements: Vitamin C	0.5	0.5	1.7	0.3	0.1	0.8	0.8	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.1	0.9	1.2	0.4	-0.1	2.0	-0.2
Mood swings	0.5	0.9	2.7	-1.0	0.8	0.1	-1.6	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	1.1	-1.3	0.5	1.1	1.1	1.1
Medication: Paracetamol	0.5	0.8	2.0	-1.1	0.4	-0.4	0.3	-1.4	-1.2
Alcohol drinker status: Previous	0.5	0.6	1.7	-1.3	0.9	-0.8	0.5	-0.2	-0.3
Reaction Time	0.4	0.7	1.3	-0.9	0.8	1.1	0.4	-0.3	1.1
Crohns Disease (2012)	0.4	0.7	1.2	0.6	0.7	0.8	1.1	0.9	0.9
Triglycerides	0.4	0.7	1.5	-1.1	0.8	0.6	1.2	-0.7	0.4
Blood Eosinophil Count	0.4	2.9	12.1	-3.5	0.4	-0.9	-0.2	-1.3	-1.6
Hair Pigment	0.4	11.4	26.1	3.0	-1.1	5.1	1.3	3.6	4.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	0.5	-0.6	0.9	0.8	0.9	0.4
Medication: Co-codamol	0.4	0.5	0.8	-0.7	0.8	-0.9	0.1	-0.8	-0.5
Pack years adult smoking proportion	0.4	0.5	1.0	1.0	-1.0	0.7	-0.7	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.4	0.8	-1.6	0.1	0.0	-0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	0.4	-0.1	-1.1	-0.2	-1.1	-0.6
Serious illness, injury or assault to yourself	0.4	0.4	2.1	-0.3	1.4	0.1	-0.1	0.6	0.3
Alcohol usually taken with meals	0.4	0.7	1.9	-1.0	1.4	-0.8	-0.3	-0.7	-0.4
Had menopause	0.4	0.5	1.2	-0.7	-0.4	1.1	0.2	0.7	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-1.1	-0.3	-1.0	-0.8	-1.5	-0.7
Pain all over the body in last month	0.4	0.4	1.0	-0.3	1.0	-0.6	-0.8	-0.2	-0.5
Number of live births	0.4	0.6	1.5	0.7	-1.2	-0.1	-0.9	-0.3	-0.8
Standing height	0.4	3.5	9.5	1.1	2.5	1.9	0.1	3.1	-0.5
Length of working week for main job	0.4	0.4	1.1	-0.1	0.8	-1.1	-0.5	-0.3	-0.6
Exposure to tobacco smoke outside home	0.4	0.6	1.4	-0.1	0.1	1.0	0.5	0.9	1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	1.3	-0.8	0.1	0.2	1.2	0.8
Medication: Ibuprofen	0.4	0.5	2.2	0.3	0.4	0.2	1.5	-0.4	0.2
Had major operations	0.4	0.4	0.8	0.5	-0.4	0.7	-0.7	0.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.2	-0.6	-0.8	1.0	-0.9	0.4
Average weekly red wine intake	0.4	0.5	1.4	1.0	1.2	0.6	-0.0	0.4	0.6
Medication: Gliclazide	0.4	0.4	1.0	-0.7	0.5	-0.2	1.0	-0.2	0.8
Ever depressed for a whole week	0.4	0.5	2.1	-0.2	1.4	0.4	-0.3	-0.9	-0.0
Myopia	0.4	0.5	1.6	1.3	0.1	0.8	0.5	0.8	0.1
Crohns Disease (2017)	0.3	0.6	2.8	-0.5	1.7	-0.4	-0.6	0.1	-0.6
Fasting Glucose	0.3	0.4	0.9	-0.9	0.5	-0.5	0.8	-0.7	0.1
HbA1C	0.3	0.4	1.3	-0.6	1.2	0.2	0.5	-0.2	0.4
Neuroticism (2016)	0.3	0.4	1.1	-1.1	0.6	0.7	-0.5	0.0	0.3
Blood Red Count	0.3	3.1	5.8	1.5	-0.2	2.0	1.8	1.8	2.4
BMI	0.3	1.7	4.6	0.6	-2.1	-0.2	-1.6	-1.4	-1.0
Height	0.3	5.6	11.5	2.1	2.5	3.4	0.0	3.1	-1.3
Smoking Status	0.3	0.8	2.4	-1.3	1.5	-0.6	-0.1	-0.2	-0.6
Chronotype (morning person)	0.3	0.7	2.3	-1.1	0.1	-1.5	0.4	-0.4	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.1	0.4	-0.8	-0.5	-1.1	-1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.8	-0.1	-0.4	-0.7	-0.7	-0.5
Average weekly fortified wine intake	0.3	0.4	1.0	-0.6	-1.0	-0.1	0.1	-1.0	0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.0	0.4	1.0	0.8	0.4	0.7
Body mass index (BMI)	0.3	1.1	2.2	0.5	-1.2	-0.5	-1.5	-1.2	-1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-1.1	-0.0	-0.2	0.0	1.1	-0.1
Had other major operations	0.3	0.4	1.3	0.7	-0.4	1.1	0.3	0.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	0.2	1.0	0.9	-0.6	-0.4	0.2
Qualifications: None of the above	0.3	0.7	1.2	-1.1	-1.1	0.1	-0.6	-0.9	-0.7
Allergy	0.3	0.7	3.0	-0.5	1.7	-0.5	-0.4	0.4	0.6
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.9	0.8	0.5	0.7	-0.3	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.0	0.4	-0.2	-0.8	-0.2	-1.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	0.4	0.2	-0.8	0.4	1.5	-0.3
Medication: Lansoprazole	0.3	0.3	1.4	-0.6	0.0	-0.2	-0.3	-1.2	-0.1
Headache pain in last month	0.3	0.6	2.5	0.0	-0.1	-0.7	-0.3	-0.7	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.1	0.8	0.5	-0.5	-0.6	-0.6
Worry too long after embarrassment	0.3	0.4	0.8	0.3	-0.5	0.1	-0.9	-0.8	-0.9
Alcohol intake frequency.	0.3	0.7	3.4	-1.9	0.5	0.6	0.4	0.0	0.4
Family relationship satisfaction	0.3	0.4	0.9	0.8	-0.3	0.8	-0.9	-0.1	0.4
Loneliness, isolation	0.3	0.4	1.4	-0.3	-1.2	0.5	0.4	-0.4	-0.3
Miserableness	0.3	0.6	1.2	1.0	0.3	0.9	-1.1	0.5	-0.2
Average weekly beer plus cider intake	0.3	0.4	1.2	-0.3	0.5	0.3	1.1	0.5	0.7
Irritability	0.3	0.6	1.8	-1.3	1.2	-0.2	-0.3	0.4	0.2
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-0.6	1.2	0.5	-0.2	-0.5	-0.1
Worry (Nagel 2018)	0.2	0.5	2.5	-0.3	1.6	0.5	-0.3	-0.5	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.4	0.3	0.4	-0.4	0.1	-0.6
Irritable Bowel Disease (IBD)	0.2	0.6	1.4	-0.1	0.4	-0.7	-1.2	-0.2	-1.1
Mean Putamen Volume	0.2	0.2	0.4	-0.6	0.3	-0.4	0.6	0.4	0.2
HDL Cholesterol	0.2	0.4	1.0	0.3	1.0	-0.4	-0.5	0.8	0.3
Tanning	0.2	1.9	6.7	1.8	-2.6	1.0	-0.6	-0.7	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.2	-0.7	0.7	0.5	0.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.4	0.7	-0.5	0.4	-0.1	0.4
Age when periods started (menarche)	0.2	0.5	1.4	0.8	0.2	-0.4	-0.7	-0.3	-1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.8	0.5	0.4	-0.3	0.7	-0.1
Mouth/teeth dental problems	0.2	0.2	0.5	-0.1	-0.5	0.1	0.7	0.4	0.7
Weight	0.2	0.8	2.0	1.1	0.1	0.4	-1.4	0.1	-1.1
Hip circumference	0.2	0.7	2.1	1.4	-0.4	0.5	-0.7	0.7	-0.7
Worrier / anxious feelings	0.2	0.5	1.1	-1.1	1.1	0.1	0.1	-0.7	0.3
Falls in the last year	0.2	0.3	1.0	1.0	0.0	0.3	-0.5	0.1	-0.4
Depression (self-reported)	0.2	0.2	0.7	-0.8	0.5	0.3	-0.3	0.2	0.0
Breastfed as a baby	0.2	0.2	1.0	1.0	-0.2	0.5	-0.1	0.4	0.2
Medication: Paracetamol	0.2	0.4	0.8	-0.9	0.4	0.1	0.8	-0.7	-0.4
Age at first live birth	0.2	0.3	1.0	-1.0	0.4	-0.6	0.7	-0.0	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.4	0.0	-0.2	-0.6	-0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.6	-0.5	-0.7	-0.0	0.5	0.0
Comparative height size at age 10	0.2	0.9	2.1	0.6	1.5	0.4	-0.7	1.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	-0.2	1.1	-0.1	-0.3	0.2	-0.5
Medication: Atorvastatin	0.2	0.3	1.2	-1.1	-0.2	-0.3	0.3	-0.6	0.1
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.3	0.7	0.5	-0.3	-0.7	-0.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.4	0.7	0.7	-0.5	-0.3	-0.4
Depression (Nagel 2018)	0.1	0.2	0.7	0.1	-0.8	0.3	0.6	-0.2	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.3	0.5	-0.0	0.3	0.1	0.1
LDL Cholesterol	0.1	0.2	0.5	0.3	-0.5	0.4	0.7	-0.1	0.0
Lung FEV1/FVC ratio	0.1	0.7	1.8	1.1	-1.4	0.4	0.5	-0.1	1.0
Neuroticism	0.1	0.4	1.2	-0.2	1.1	0.9	-0.3	0.1	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.4	-0.6	-0.4	0.2	-0.3	-0.0
Current tobacco smoking	0.1	0.2	0.5	-0.1	0.7	0.2	0.2	0.7	0.4
Fed-up feelings	0.1	0.2	0.7	-0.0	0.6	0.0	0.8	-0.0	0.2
Relative age voice broke	0.1	0.1	0.5	-0.1	-0.2	0.7	-0.2	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.4	-0.6	-0.5	-0.4	-0.7	0.1
Neuroticism score	0.1	0.2	0.6	-0.4	0.8	0.5	-0.2	-0.1	-0.2
Time employed in main current job	0.1	0.1	0.3	-0.0	-0.5	0.2	-0.2	0.1	0.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	-0.3	-0.3
Prospective memory result	0.1	0.1	0.6	-0.8	0.0	-0.4	-0.0	-0.0	0.1
Tense / ‘highly strung’	0.1	0.2	0.9	0.2	1.0	0.3	-0.0	-0.4	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.3	-0.6	-0.5	-0.2	-0.4	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.1	0.1	0.0	0.5	-0.6	-0.2
Migraine (self-reported)	0.1	0.1	0.3	0.1	0.3	0.3	0.3	-0.5	-0.5
Knee pain experienced in last month	0.1	0.2	0.5	0.6	0.2	0.4	-0.1	-0.7	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.7	-0.1	-0.4	0.2	-0.1	0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.4	0.2	-0.7	-0.7	-0.1	-0.3
Smoking status: Current	0.1	0.2	0.6	-0.2	0.8	0.1	-0.2	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.8	-0.1	-0.9	0.0	0.1	-0.2	0.1
Pack years of smoking	0.1	0.2	0.5	0.3	-0.5	0.4	-0.7	0.2	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.3	0.8	-0.3	-0.7	-0.3	0.9	0.3	0.7

Hub : Genes

MYO9B

Models

Trait associations