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chr19:48,464,978-50,108,983

Best TWAS P=4.7e-19 · Best GWAS P=4.69e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	RASIP1	0.20	0.11	lasso	4	0.10	2.4e-04	-5.3	5.8	4.9e-09	0.67	0.21	0.56	FALSE
2	GTEx	Brain Caudate basal ganglia	MAMSTR	0.47	0.01	enet	24	0.17	1.3e-05	-4.8	5.1	2.6e-07	0.38	0.05	0.55	FALSE
3	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	8.9	8.7	2.3e-18	0.96	0.00	1.00	FALSE
4	GTEx	Esophagus Mucosa	RASIP1	0.13	0.13	lasso	4	0.13	9.0e-09	-6.1	7.2	5.0e-13	0.75	0.83	0.17	FALSE
5	GTEx	Esophagus Mucosa	NTN5	0.15	0.01	lasso	9	0.03	6.0e-03	2.7	5.5	4.8e-08	0.39	0.09	0.32	FALSE
6	GTEx	Esophagus Muscularis	NTN5	0.14	0.00	enet	12	0.01	6.5e-02	-8.0	5.4	8.4e-08	0.65	0.02	0.68	FALSE
7	GTEx	Heart Atrial Appendage	MAMSTR	0.24	0.13	lasso	2	0.13	1.3e-06	-6.5	7.1	1.3e-12	0.72	0.34	0.60	FALSE
8	GTEx	Heart Atrial Appendage	NUCB1-AS1	0.16	0.04	lasso	3	0.07	5.3e-04	-8.0	-6.0	1.6e-09	-0.65	0.04	0.62	FALSE
9	GTEx	Heart Left Ventricle	MAMSTR	0.26	0.18	lasso	6	0.21	3.4e-11	-6.2	7.5	9.2e-14	0.77	0.11	0.89	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	RASIP1	0.15	0.04	lasso	6	0.08	2.9e-05	7.4	5.9	2.8e-09	0.70	0.28	0.54	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	NTN5	0.19	0.07	lasso	5	0.08	2.5e-05	8.5	8.3	7.3e-17	0.91	0.02	0.98	FALSE
12	GTEx	Skin Sun Exposed Lower leg	RASIP1	0.21	0.13	enet	19	0.17	1.1e-13	-6.2	6.2	4.6e-10	0.70	0.99	0.01	FALSE
13	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	8.9	7.8	6.8e-15	0.90	0.00	1.00	FALSE
14	GTEx	Testis	RASIP1	0.29	0.20	lasso	8	0.30	7.5e-14	-6.4	7.1	1.0e-12	0.76	0.73	0.27	FALSE
15	GTEx	Thyroid	NTN5	0.14	0.02	enet	26	0.04	4.4e-04	8.5	5.7	1.2e-08	0.65	0.01	0.99	FALSE
16	METSIM	Adipose	NTN5	0.13	0.10	bslmm	450	0.14	3.2e-20	8.9	6.9	5.4e-12	0.75	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FUT2	0.05	0.01	blup	52	0.01	6.1e-02	7.3	-7.3	2.0e-13	-0.80	0.02	0.36	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUT2	0.03	0.05	blup	54	0.05	1.9e-10	8.9	-8.1	4.5e-16	-0.88	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	8.3	7.1	1.3e-12	0.80	0.01	0.91	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	RASIP1	0.02	0.02	blup	56	0.03	3.8e-07	8.5	8.1	5.0e-16	0.89	0.02	0.98	FALSE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FUT2	0.10	0.02	blup	55	0.06	6.8e-04	8.3	-8.2	3.0e-16	-0.90	0.01	0.98	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	FUT2	0.18	0.22	enet	12	0.18	6.8e-11	8.5	-8.7	2.7e-18	-0.96	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC1	0.05	0.04	enet	11	0.01	8.5e-02	8.6	-8.1	5.0e-16	-0.87	0.02	0.82	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	FUT2	0.33	0.27	lasso	3	0.24	3.9e-08	-8.0	-8.2	1.8e-16	-0.87	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FUT2	0.11	0.22	blup	52	0.22	6.3e-24	8.9	-8.1	5.8e-16	-0.92	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RASIP1	0.04	0.01	enet	10	0.02	2.3e-03	-6.5	5.8	5.4e-09	0.63	0.17	0.54	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FUT2	0.10	0.01	blup	51	0.05	9.8e-04	8.6	-7.9	3.3e-15	-0.86	0.03	0.84	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NTN5	0.11	0.02	blup	41	0.07	1.2e-04	-6.5	6.2	5.1e-10	0.77	0.02	0.79	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM83E	0.06	0.04	lasso	4	0.06	6.1e-07	-4.8	5.4	5.4e-08	0.61	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	FUT2	0.02	0.04	lasso	1	0.03	1.8e-04	-6.5	-6.5	9.0e-11	-0.65	0.15	0.11	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAMSTR	0.04	0.04	blup	47	0.06	3.9e-07	-5.3	7.3	2.3e-13	0.78	0.48	0.52	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	NTN5	0.05	0.04	lasso	2	0.02	6.7e-04	8.5	8.5	2.5e-17	0.92	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT2	0.09	0.12	blup	52	0.12	4.2e-14	8.3	-8.4	5.4e-17	-0.92	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FUT2	0.05	0.08	lasso	2	0.08	6.7e-09	8.6	-8.7	4.5e-18	-0.95	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FUT2	0.06	0.00	blup	53	0.05	3.5e-04	7.3	-8.2	3.5e-16	-0.88	0.02	0.83	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FUT2	0.08	0.12	lasso	4	0.11	2.5e-05	8.9	-8.9	4.7e-19	-1.00	0.00	0.99	TRUE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	IZUMO1	0.16	0.17	lasso	7	0.15	1.4e-06	-6.1	6.3	3.6e-10	0.65	0.55	0.39	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUT2	0.05	0.06	blup	52	0.06	8.6e-07	8.9	-8.4	4.3e-17	-0.93	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	NTN5	0.06	0.03	blup	41	0.03	2.1e-04	8.3	6.1	7.9e-10	0.76	0.02	0.74	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	FUT2	0.26	0.28	lasso	10	0.22	5.2e-06	8.5	-8.4	4.1e-17	-0.91	0.02	0.97	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	RASIP1	0.05	0.06	blup	54	0.04	1.4e-03	-8.0	7.3	2.5e-13	0.78	0.03	0.66	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	FUT2	0.14	0.16	lasso	8	0.14	4.9e-10	8.9	-8.9	4.8e-19	-0.99	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FUT2	0.22	0.09	lasso	8	0.13	3.0e-05	-4.8	-7.1	1.4e-12	-0.81	0.01	0.98	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	FUT2	0.06	0.04	blup	54	0.06	1.1e-06	-8.0	-8.1	4.6e-16	-0.87	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	NTN5	0.11	0.07	blup	43	0.09	2.6e-09	8.3	8.2	3.4e-16	0.88	0.06	0.94	FALSE