Best TWAS P=1.53e-09 · Best GWAS P=4.42e-19 conditioned to 3.33e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | DYNC2LI1 | 0.11 | 0.02 | enet | 14 | 0.05 | 1.3e-03 | -0.2 | 5.4 | 6.7e-08 | 0.05 | 0.17 | 0.04 | TRUE |
| 2 | GTEx | Colon Sigmoid | LRPPRC | 0.18 | 0.06 | lasso | 3 | 0.04 | 1.3e-02 | -5.5 | -5.1 | 2.9e-07 | 0.00 | 0.18 | 0.04 | TRUE |
| 3 | GTEx | Vagina | ZFP36L2 | 0.32 | 0.08 | enet | 27 | 0.14 | 4.7e-04 | -6.0 | 5.4 | 5.9e-08 | 0.00 | 0.06 | 0.29 | TRUE |
| 4 | METSIM | Adipose | LRPPRC | 0.08 | 0.05 | enet | 26 | 0.05 | 1.5e-08 | -3.5 | -5.2 | 2.3e-07 | -0.03 | 1.00 | 0.00 | TRUE |
| 5 | YFS | Blood | THADA | 0.01 | 0.00 | blup | 724 | 0.00 | 1.1e-02 | -5.9 | -5.8 | 8.0e-09 | -0.09 | 0.08 | 0.02 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LRPPRC | 0.02 | 0.02 | lasso | 2 | 0.02 | 9.7e-05 | -5.8 | -5.8 | 5.6e-09 | -0.03 | 0.55 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | LRPPRC | 0.18 | 0.05 | blup | 109 | 0.01 | 1.3e-01 | -5.2 | -5.1 | 2.8e-07 | -0.06 | 0.12 | 0.05 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LRPPRC | 0.07 | 0.07 | blup | 109 | 0.06 | 6.4e-07 | -3.7 | -5.2 | 1.6e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LRPPRC | 0.10 | 0.02 | blup | 109 | 0.05 | 6.8e-04 | -2.8 | -6.0 | 1.5e-09 | -0.22 | 0.08 | 0.22 | TRUE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRPPRC | 0.12 | 0.13 | lasso | 2 | 0.11 | 4.9e-05 | -5.3 | -5.3 | 1.2e-07 | -0.03 | 0.34 | 0.08 | FALSE |
| 11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LRPPRC | 0.27 | 0.12 | blup | 109 | 0.13 | 7.3e-04 | -1.7 | -5.4 | 8.4e-08 | -0.15 | 0.22 | 0.05 | FALSE |