TWAS hub - THADA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.190	0.0710	0.0062	-0.006	NA	-0.006	NA	-0.006	0.81	NA	0.97	NA	0.77
2	YFS	Blood	0.013	0.0074	0.0350	-0.001	0.004	-0.001	0.004	-0.001	0.67	0.011	0.77	0.02	0.85

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Cardiovascular Disease	6.0	20.0	33.3	-2.6	-5.8
Birth weight	5.3	11.6	19.5	1.9	4.4
LDL Cholesterol	4.7	7.5	14.7	-0.4	-3.8
Breastfed as a baby	4.1	5.1	8.9	-1.1	-3.0
High cholesterol (Self-reported)	4.0	7.1	13.9	-0.6	-3.7
Illnesses of father: None of the above (group 1)	3.7	4.5	5.0	2.0	2.2
Diastolic blood pressure, automated reading	3.6	11.3	11.8	-3.4	-3.3
Heel T-Score	3.4	26.8	38.3	-3.9	-6.2
Basal cell carcinoma (self-reported)	3.3	3.9	4.5	-1.8	2.1
Systolic Blood Pressure	3.2	15.8	20.5	-3.3	-4.5
Illnesses of father: Heart disease	3.2	4.4	7.3	-1.2	-2.7
Supplements: Zinc	3.1	3.4	4.2	-2.0	-1.6
Medication for cholesterol	3.0	4.5	5.0	2.0	2.2
Medication: Atorvastatin	3.0	3.8	7.3	-0.4	-2.7
Lung FEV1/FVC ratio	2.9	14.6	28.7	0.6	-5.4
Heart disease (mother)	2.9	3.6	6.2	-1.0	-2.5
Vascular/heart problems diagnosed by doctor	2.9	7.9	14.7	1.0	3.8
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.2	9.0	-3.0	-1.9
Leg pain on walking	2.8	3.5	5.7	-2.4	-1.1
Exposure to tobacco smoke outside home	2.7	3.6	5.9	1.1	2.4
Medication: Simvastatin	2.6	3.8	7.6	0.0	-2.8
Pulse wave reflection index	2.6	3.3	5.2	-2.3	-1.1
High blood pressure	2.5	6.9	12.0	-1.3	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	10.2	-3.2	-1.0
Allergy	2.5	5.7	9.2	1.4	3.0
Ever highly irritable/argumentative for 2 days	2.5	3.0	5.8	0.3	2.4
Lupus	2.4	3.7	6.9	-2.6	-0.7
Blood White Count	2.4	17.5	23.9	-3.3	-4.9
Allergy or Eczema	2.4	6.3	12.5	-0.1	-3.5
Number of treatments/medications taken	2.4	4.4	8.4	-0.6	-2.9
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	7.2	0.8	2.7
Breast cancer (self-reported)	2.4	2.8	5.6	-0.2	-2.4
Hearing difficulty/problems: Yes	2.3	3.5	6.6	-2.6	0.6
Medication: Ramipril	2.3	3.0	6.0	-0.2	-2.4
Illnesses of mother	2.3	2.8	3.7	1.9	1.4
Comparative body size at age 10	2.3	6.3	6.7	-2.4	2.6
Hypertension (Self-reported)	2.3	6.3	11.6	-1.0	-3.4
Illnesses of father: High blood pressure	2.3	2.9	5.7	-0.2	-2.4
Serious illness, injury or assault to yourself	2.2	2.7	5.1	-0.5	-2.3
Length of working week for main job	2.2	2.4	2.8	-1.7	1.4
Glaucoma (self-reported)	2.1	2.5	3.6	-1.2	-1.9
Alcohol intake frequency.	2.0	4.6	6.7	2.6	1.6
Average weekly beer plus cider intake	2.0	2.9	3.8	1.4	1.9
Vitamin and mineral supplements	1.9	2.5	4.1	1.0	2.0
Townsend deprivation index at recruitment	1.9	2.7	4.4	-2.1	-1.1
Hayfever, allergic rhinitis or eczema	1.9	4.1	7.5	-0.9	-2.7
Medication: Atenolol	1.9	2.4	2.4	-1.6	-1.6
Alcohol usually taken with meals	1.9	3.1	6.1	0.2	-2.5
Medication: Cholesterol lowering	1.9	2.9	5.8	0.1	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	4.0	2.0	0.0
Cholesterol lowering medication	1.9	2.8	4.5	-1.1	-2.1
Financial difficulties in last 2 years	1.8	2.4	3.2	-1.8	-1.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.0	-2.0	-0.8
Schizophrenia vs Biploar Disorder	1.7	2.2	3.2	1.1	1.8
Father’s age at death	1.7	2.3	3.6	1.9	1.0
Angina (self-reported)	1.7	2.2	4.4	-0.3	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	4.3	-1.0	2.1
Financial situation satisfaction	1.7	2.2	4.3	0.3	2.1
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.1	-1.8	1.1
Diabetes (father)	1.6	1.9	3.5	-0.6	1.9
Stomach or abdominal pain in last month	1.6	2.0	2.8	-1.7	1.1
Falls in the last year	1.6	2.2	2.3	-1.5	1.4
Supplements: Calcium	1.6	1.8	3.6	0.1	-1.9
Alcohol drinker status: Previous	1.6	1.8	3.4	1.9	-0.4
Primary Biliary Cirrhosis	1.5	2.1	4.2	0.0	-2.0
Angina	1.5	1.9	3.8	-0.1	-2.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	1.9	-1.4	1.3
Qualifications: CSEs or equivalent	1.5	2.0	4.0	-2.0	0.1
Peak expiratory flow (PEF)	1.5	3.6	6.1	1.0	-2.5
Neck or shoulder pain in last month	1.5	2.2	2.5	1.6	1.4
Eye problems/disorders: Cataract	1.5	1.8	3.5	1.9	0.3
Ever taken oral contraceptive pill	1.5	1.6	2.9	-1.7	-0.6
Triglycerides	1.4	2.3	3.7	-1.9	-0.9
Ulcerative Colitis	1.4	2.0	3.7	-1.9	-0.5
High blood pressure (mother)	1.4	2.0	2.1	-1.5	-1.3
Loud music exposure frequency	1.4	1.5	3.1	-1.8	0.1
Medication: Blood pressure	1.4	2.6	4.4	-0.8	-2.1
Fractured/broken bones in last 5 years	1.4	1.8	1.8	1.3	1.3
Systolic blood pressure, automated reading	1.3	3.7	6.0	-1.2	-2.5
Medication for hormone replacement therapy	1.3	1.5	2.2	-1.5	-0.8
Multivitamins +/- minerals	1.3	1.6	2.6	-0.8	-1.6
Depression (self-reported)	1.3	1.6	1.8	-1.2	1.3
Medication: Allopurinol	1.3	1.7	3.3	0.1	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.1	0.1	1.7
Diabetes diagnosed by doctor	1.3	2.1	3.9	0.5	2.0
Guilty feelings	1.3	2.0	3.7	0.5	1.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.5	0.1	-1.9
Severe depression (siblings)	1.2	1.4	2.8	-1.7	-0.1
Mouth/teeth dental problems	1.2	1.8	3.3	1.8	-0.6
Heart attack	1.2	1.5	3.0	0.1	-1.7
Pulse wave peak to peak time	1.2	1.4	1.7	1.3	1.1
Wears glasses or contact lenses	1.2	1.4	1.8	-1.3	-1.0
Commuting to job workplace: Public transport	1.2	1.5	2.9	0.2	-1.7
Alzheimer’s Disease (in father)	1.1	1.1	2.1	0.4	1.4
Ulcerative Colitis (UC)	1.1	2.1	3.8	-1.9	-0.6
Major Depression (MDD)	1.1	1.3	2.6	0.1	1.6
Age at First Birth	1.1	1.7	3.3	1.8	-0.1
Coronary Artery Disease (CAD)	1.1	1.4	2.6	-0.4	-1.6
Mean Putamen Volume	1.1	1.3	1.3	-1.1	1.1
Hand grip strength (left)	1.1	2.9	3.9	-2.0	-1.3
Ever had hysterectomy (womb removed)	1.1	1.2	1.7	-1.3	0.8
Pain all over the body in last month	1.1	1.1	1.9	0.6	-1.4
Pulse wave Arterial Stiffness index	1.1	1.3	1.5	-1.0	-1.2
Birth weight of first child	1.1	2.0	3.0	0.9	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	-1.6	0.1
Number of self-reported non-cancer illnesses	1.1	1.9	3.8	-0.2	-2.0
Bipolar Disorder (2018)	1.0	1.6	3.2	0.1	-1.8
Prostate Cancer	1.0	1.4	2.6	-1.6	0.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	-0.1	1.7
Blood Red Count	1.0	9.6	14.6	-3.8	2.2
Average weekly spirits intake	1.0	1.3	1.6	-1.0	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.6	-0.1	1.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.8	-1.3	-0.8
Had other major operations	1.0	1.2	1.9	1.4	0.7
Leg fat percentage (right)	1.0	3.7	7.2	-2.7	-0.5
Medication: Seretide 50 evohaler	1.0	1.1	1.3	1.1	-1.0
Comparative height size at age 10	1.0	5.7	11.4	0.2	-3.4
Age at last live birth	1.0	1.5	1.7	1.3	-1.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.6	1.2	0.9
Osteoarthritis (self-reported)	1.0	1.3	1.5	1.0	-1.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.1	1.4	-0.5
Alzheimer’s Disease (in mother)	0.9	1.0	2.0	-0.3	1.4
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.6	0.8	1.9
Rheumatoid Arthritis	0.9	1.2	2.2	-0.4	-1.5
Medication: Co-codamol	0.9	1.0	1.8	1.3	0.4
Diabetes (self-reported)	0.9	1.5	2.8	0.4	1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.9	0.7	-1.4
Illnesses of siblings	0.9	1.3	2.6	1.6	-0.1
Pulse rate	0.9	1.5	2.0	-1.4	0.9
Impedance of arm (left)	0.9	4.0	7.9	0.4	2.8
Health satisfaction	0.9	1.2	2.3	1.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.7	0.0	-1.9
Medication: Aspirin	0.9	1.1	1.2	-1.0	-1.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.0	-0.5	-1.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.7	-0.8	-1.3
Leg fat percentage (left)	0.9	3.2	5.8	-2.4	-0.7
Arm predicted mass (left)	0.9	4.3	8.6	-0.1	-2.9
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.5	0.5	1.2
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.8	-0.2	1.7
Fluid intelligence score	0.8	1.7	2.0	1.4	1.2
Medication: Lansoprazole	0.8	1.0	1.1	-0.9	1.1
Lung cancer (father)	0.8	0.9	1.1	0.9	1.1
Gout (self-reported)	0.8	1.1	1.5	0.8	-1.2
Medication for pain relief, constipation, heartburn	0.8	1.3	2.5	0.2	1.6
Smoking status: Previous	0.8	1.2	1.3	1.1	-1.1
Asthma (self-reported)	0.8	1.7	1.9	-1.4	-1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.3	0.7	1.1
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.0	-1.0	-1.0
Depression (Nagel 2018)	0.7	1.1	2.1	0.3	1.5
Fasting Glucose	0.7	0.8	1.2	-1.1	-0.7
HbA1C	0.7	0.8	0.9	-1.0	0.8
Medication: Metformin	0.7	1.0	1.7	0.6	1.3
Impedance of leg (right)	0.7	3.2	6.5	-2.5	-0.2
Average weekly fortified wine intake	0.7	0.9	1.6	-0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.5	-0.8	1.2
Medication: Amlodipine	0.7	1.0	1.6	0.6	-1.3
High blood pressure (siblings)	0.7	1.0	1.1	-1.1	-0.9
Age at first live birth	0.7	1.2	2.2	1.5	-0.4
Emphysema/chronic bronchitis	0.7	0.8	1.6	-0.1	-1.3
Had major operations	0.7	0.8	1.0	-0.8	-1.0
Long-standing illness, disability or infirmity	0.7	1.1	2.2	0.1	-1.5
Ever smoked	0.7	1.2	2.3	-0.0	-1.5
Arm fat-free mass (left)	0.7	3.8	7.5	0.0	-2.7
Age started oral contraceptive pill	0.7	0.9	1.1	1.0	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.0	0.8	1.7
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	-0.2	1.3
Ovarian Cancer	0.6	0.7	1.3	-0.4	1.1
Blood Eosinophil Count	0.6	4.5	8.8	3.0	0.5
Hand grip strength (right)	0.6	1.8	1.9	-1.4	-1.3
Number of incorrect matches in round	0.6	0.9	1.5	-0.6	-1.2
Hearing difficulty/problems with background noise	0.6	1.0	2.0	-1.4	0.0
Asthma	0.6	1.3	1.4	-1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.5	1.2	0.0
Trunk predicted mass	0.6	3.2	6.1	0.6	-2.5
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.6	1.3	-0.5
Medication: Paracetamol	0.6	0.9	1.8	-0.2	-1.4
Chronic bronchitis/emphysema (mother)	0.6	0.6	0.9	-1.0	-0.6
Arm fat-free mass (right)	0.6	3.2	6.5	-0.0	-2.5
Chest pain or discomfort	0.6	0.9	1.5	-0.6	-1.2
Ever had bowel cancer screening	0.6	0.7	1.4	0.2	1.2
Friendships satisfaction	0.6	0.7	1.2	0.5	1.1
Medication: Gliclazide	0.6	0.7	1.2	1.1	-0.5
Worry (Nagel 2018)	0.5	1.0	1.4	-0.8	-1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.5	0.7	0.7
Fed-up feelings	0.5	0.9	1.8	0.1	1.4
Relative age voice broke	0.5	0.7	1.0	-0.7	-1.0
Impedance of leg (left)	0.5	2.6	4.9	-2.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	1.0	-0.5
Impedance of arm (right)	0.5	2.5	4.5	0.7	2.1
Trunk fat-free mass	0.5	3.1	6.0	0.6	-2.4
Worrier / anxious feelings	0.5	0.9	1.7	0.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.1	-1.0	0.6
Hair/balding pattern: Pattern 4	0.5	1.1	2.2	0.1	-1.5
Wheeze or whistling in the chest in last year	0.5	0.9	1.2	-0.8	-1.1
Shortness of breath walking on level ground	0.5	0.6	1.0	-1.0	-0.3
Arm predicted mass (right)	0.5	2.6	5.2	0.2	-2.3
Suffer from ‘nerves’	0.5	0.8	1.5	-1.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	0.9	-1.0	0.6
Medication: Aspirin	0.5	0.7	0.7	-0.8	-0.9
Back pain experienced in last month	0.5	0.7	1.0	1.0	0.6
Whole body water mass	0.5	2.7	4.7	0.9	-2.2
Average weekly champagne plus white wine intake	0.5	0.7	1.1	1.0	0.5
Medication: Blood pressure	0.5	0.9	1.1	-0.9	-1.0
Medication: Paracetamol	0.5	0.7	1.5	-0.1	-1.2
Alcohol drinker status: Never	0.5	0.6	1.0	1.0	0.3
Number of operations (self-reported)	0.5	0.7	1.0	1.0	0.7
Ever depressed for a whole week	0.5	0.6	1.3	0.1	-1.1
Pack years of smoking	0.5	0.7	1.2	-1.1	0.3
Smoking Status	0.4	1.0	1.7	-0.5	-1.3
Chronotype (morning person)	0.4	0.8	1.5	1.2	-0.3
Diabetes (mother)	0.4	0.5	0.7	-0.8	-0.5
Pack years adult smoking proportion	0.4	0.6	1.1	-1.1	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	0.8	0.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	0.5
Noisy workplace	0.4	0.5	1.0	-1.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	0.4	1.2
Body fat percentage	0.4	1.6	3.2	-1.8	-0.2
Number of full brothers	0.4	0.4	0.8	0.9	-0.2
Number of children fathered	0.4	0.4	0.8	-0.2	-0.9
Leg fat mass (right)	0.4	1.6	2.8	-1.7	-0.6
Supplements: Vitamin C	0.4	0.5	0.8	-0.9	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.2	1.0
Whole body fat-free mass	0.4	2.5	4.1	0.9	-2.0
Leg fat-free mass (right)	0.4	1.9	2.6	1.6	-1.1
Mineral and other dietary supplements	0.4	0.5	1.0	0.1	1.0
Leg predicted mass (right)	0.4	2.0	3.0	1.7	-1.1
Miserableness	0.4	0.7	1.1	1.0	0.6
Hearing aid user	0.4	0.5	1.0	-0.1	-1.0
Basal metabolic rate	0.4	1.9	3.6	0.5	-1.9
Pain experienced in last month	0.4	0.7	0.7	-0.8	-0.9
Heart disease (siblings)	0.4	0.5	0.7	-0.8	-0.6
Leg fat mass (left)	0.4	1.7	2.8	-1.7	-0.8
Crohns Disease (2017)	0.3	0.6	1.3	1.1	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	0.7	-0.8	-0.9
Blood Platelet Count	0.3	3.9	7.9	0.0	2.8
Sensitivity / hurt feelings	0.3	0.4	0.5	0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	-0.7	0.5
Supplements: Glucosamine	0.3	0.4	0.8	0.2	-0.9
Past tobacco smoking	0.3	0.5	0.7	-0.6	0.8
Qualifications: None of the above	0.3	0.5	0.8	-0.9	-0.6
Weight	0.3	1.3	2.2	-0.7	-1.5
Hip circumference	0.3	1.1	1.3	-1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.9	0.7	-0.9
Standing height	0.3	2.7	4.5	1.0	-2.1
Tense / ‘highly strung’	0.3	0.5	0.7	-0.6	-0.8
Headache pain in last month	0.3	0.5	0.9	0.9	-0.4
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.8	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	-0.5	0.7
Migraine (self-reported)	0.3	0.3	0.4	0.6	0.5
Whole body fat mass	0.3	1.1	1.6	-1.3	-0.8
Pulse rate, automated reading	0.3	1.0	2.0	-1.4	-0.2
Average weekly red wine intake	0.3	0.5	0.9	1.0	0.0
Mood swings	0.3	0.6	0.8	-0.9	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.1	-0.8
Osteoporosis (self-reported)	0.3	0.3	0.6	0.8	-0.3
Smoking status: Current	0.3	0.5	0.9	-1.0	0.1
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.9	-0.3
Risk taking	0.3	0.4	0.8	-0.1	0.9
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.2	-0.6
HDL Cholesterol	0.2	0.3	0.5	0.7	0.3
Neuroticism (2016)	0.2	0.3	0.3	-0.4	-0.6
Waist Hip Ratio (WHR)	0.2	1.1	1.7	0.7	-1.3
Respiratory disease	0.2	0.5	0.8	-0.4	-0.9
Lung FVC	0.2	1.0	2.0	-1.4	0.2
Neuroticism	0.2	0.4	0.6	0.8	0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.8	0.1
Leg fat-free mass (left)	0.2	1.2	1.5	1.2	-0.9
Body mass index (BMI)	0.2	0.9	1.3	-1.1	-0.7
Leg predicted mass (left)	0.2	1.2	1.5	1.2	-0.9
Waist circumference	0.2	0.7	1.3	-0.2	-1.1
Arm fat percentage (right)	0.2	0.8	1.6	-1.3	-0.2
Time employed in main current job	0.2	0.3	0.3	-0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.6	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	0.1	-1.0
Happiness	0.2	0.2	0.4	0.6	0.3
Arm fat mass (right)	0.2	0.9	1.0	-1.0	-0.9
Medication: Omeprazole	0.2	0.2	0.4	0.6	-0.0
Arm fat percentage (left)	0.2	0.8	1.6	-1.3	0.3
Qualifications: nursing, teaching	0.2	0.3	0.3	-0.6	-0.6
Arm fat mass (left)	0.2	0.9	1.1	-1.0	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.3	-0.6	0.1
Myopia	0.2	0.3	0.6	0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	0.2	-0.7
Impedance of whole body	0.2	0.9	1.1	-0.8	1.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.2	-0.6
Neuroticism (Nagel 2018)	0.1	0.1	0.1	-0.4	-0.3
Schizophrenia (2018)	0.1	0.3	0.4	-0.4	0.6
Reaction Time	0.1	0.3	0.5	0.7	0.0
Breast Cancer	0.1	0.3	0.5	0.7	0.3
Crohns Disease (2012)	0.1	0.2	0.3	0.5	-0.2
Schizophrenia (2014)	0.1	0.3	0.6	-0.8	-0.2
BMI	0.1	0.5	1.0	-0.2	-1.0
Height	0.1	1.7	3.0	0.7	-1.7
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.3	0.7
Tanning	0.1	0.7	0.9	0.7	-0.9
Relative age of first facial hair	0.1	0.3	0.5	-0.3	0.7
Trunk fat percentage	0.1	0.5	1.1	-1.0	-0.0
Current tobacco smoking	0.1	0.2	0.3	-0.5	-0.3
Maternal smoking around birth	0.1	0.1	0.1	-0.4	0.3
Taking other prescription medications	0.1	0.1	0.1	0.3	-0.3
Age when periods started (menarche)	0.1	0.3	0.6	0.1	-0.8
Sitting height	0.1	0.4	0.6	-0.5	-0.8
Trunk fat mass	0.1	0.6	0.7	-0.8	-0.7
Nervous feelings	0.1	0.2	0.4	-0.7	0.2
Had menopause	0.1	0.1	0.2	-0.3	0.4
Neuroticism score	0.1	0.2	0.4	0.6	0.1
Prospective memory result	0.1	0.2	0.2	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.4	-0.7
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.9	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.4	-0.3
Qualifications: College or University degree	0.1	0.4	0.6	0.4	0.7
Medication: Ibuprofen	0.1	0.2	0.3	0.5	0.2
Family relationship satisfaction	0.1	0.1	0.3	0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.3	-0.4
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.3	0.2
Loneliness, isolation	0.1	0.1	0.2	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.2	-0.4	-0.4
Mother’s age at death	0.1	0.1	0.3	0.2	0.5
Medication: Lisinopril	0.1	0.1	0.1	-0.4	0.1
Irritability	0.1	0.2	0.4	0.6	0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	-0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.4	-0.1
Hair Pigment	0.0	0.4	0.5	-0.7	-0.6
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.0	0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.3	0.1
Forced vital capacity (FVC)	0.0	0.2	0.2	-0.5	0.3
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.3	0.1
Number of live births	0.0	0.1	0.1	-0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.2	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.3	0.2
Worry too long after embarrassment	0.0	0.0	0.0	-0.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.0	0.1
Mean time to correctly identify matches	0.0	0.0	0.0	0.1	-0.2
Number of full sisters	0.0	0.0	0.1	-0.1	0.3
Overall health rating	0.0	0.0	0.1	0.2	0.0
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.0	0.2

Hub : Genes

THADA

Models

Trait associations