Best TWAS P=1.33e-12 · Best GWAS P=5.34e-15 conditioned to 0.469
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEK10 | 0.04 | 0.03 | blup | 450 | 0.03 | 9.5e-05 | 3.6 | -5.1 | 2.8e-07 | 0.57 | 0.61 | 0.14 | FALSE |
| 2 | GTEx | Artery Aorta | SLC4A7 | 0.10 | 0.08 | enet | 15 | 0.08 | 5.4e-05 | -7.8 | -7.1 | 1.3e-12 | 0.92 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | -7.8 | -7.0 | 2.3e-12 | 0.80 | 0.00 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | -5.4 | 5.4 | 8.2e-08 | -0.69 | 0.14 | 0.86 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC4A7 | 0.08 | 0.02 | lasso | 4 | 0.04 | 1.4e-03 | 4.2 | -6.4 | 1.5e-10 | 0.28 | 0.02 | 0.30 | TRUE |