TWAS
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Models
Genes
Traits
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Traits
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Cardiovascular Disease
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chr3:26,563,909-28,211,713
Best TWAS P=1.33e-12 · Best GWAS P=5.34e-15 conditioned to 0.469
26.6M
26.8M
27M
27.2M
27.4M
27.6M
27.8M
28M
28.2M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Artery Aorta
SLC4A7
0.10
0.08
enet
15
0.08
5.4e-05
-7.8
-7.1
1.3e-12
0.92
0.00
0.99
TRUE
3
GTEx
Cells Transformed fibroblasts
SLC4A7
0.15
0.02
enet
21
0.04
4.0e-04
-7.8
-7.0
2.3e-12
0.80
0.00
0.99
TRUE
5
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
SLC4A7
0.08
0.02
lasso
4
0.04
1.4e-03
4.2
-6.4
1.5e-10
0.28
0.02
0.30
TRUE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
NEK10
0.02
0.02
lasso
4
0.02
1.3e-05
-5.4
5.4
8.2e-08
-0.69
0.14
0.86
FALSE
1
CommonMind
Brain Pre-frontal Cortex
NEK10
0.04
0.03
blup
450
0.03
9.5e-05
3.6
-5.1
2.8e-07
0.57
0.61
0.14
FALSE