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chr1:10,435,170-12,600,396

Best TWAS P=1.56e-36 · Best GWAS P=6.52e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	-8.87	-12.6	1.6e-36	0.75	0.22	0.78	TRUE
11	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-7.56	-9.1	1.3e-19	0.86	0.04	0.72	TRUE
14	GTEx	Testis	CLCN6	0.39	0.17	lasso	10	0.19	1.1e-08	-4.73	6.1	9.6e-10	-0.34	0.99	0.00	TRUE
12	GTEx	Stomach	RP4-635E18.7	0.13	0.06	enet	25	0.03	8.8e-03	-1.35	-5.8	6.1e-09	0.13	0.12	0.58	TRUE
19	METSIM	Adipose	NPPA	0.12	0.09	lasso	11	0.10	3.0e-14	-5.31	5.3	1.2e-07	-0.18	1.00	0.00	TRUE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	-12.69	-12.4	4.2e-35	0.91	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	-9.81	-12.2	3.0e-34	0.59	0.20	0.79	FALSE
5	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	-12.69	-11.1	9.1e-29	0.75	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	-12.29	-11.0	2.7e-28	0.94	0.01	0.98	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	-7.66	-11.0	4.5e-28	0.83	0.02	0.93	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	-7.25	-10.4	1.7e-25	0.64	0.15	0.84	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	-8.87	-10.2	3.2e-24	0.69	0.10	0.89	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCN6	0.14	0.05	blup	104	0.09	1.2e-05	-12.29	-9.7	4.7e-22	0.81	0.01	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	-8.20	-8.7	5.1e-18	0.57	0.04	0.93	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPPA	0.06	0.03	enet	4	0.04	7.6e-04	-9.81	8.4	5.1e-17	-0.45	0.11	0.15	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	-2.33	-8.2	3.2e-16	0.76	0.04	0.47	FALSE
22	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-4.14	-7.8	5.1e-15	0.66	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	NPPA	0.06	0.01	lasso	5	0.01	1.3e-01	-5.31	7.8	5.3e-15	-0.34	0.04	0.24	FALSE
17	METSIM	Adipose	CLCN6	0.09	0.04	blup	480	0.06	1.6e-09	-6.96	-7.8	5.5e-15	0.65	0.06	0.94	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	3.15	-7.7	1.9e-14	0.60	0.06	0.29	FALSE
10	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	-4.40	-7.6	2.3e-14	0.67	0.03	0.73	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	-4.40	-7.5	6.2e-14	0.51	0.49	0.48	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	-7.49	-7.5	6.6e-14	0.80	0.34	0.27	FALSE
20	NTR	Blood	AGTRAP	0.02	0.00	bslmm	484	0.00	5.2e-02	-0.61	7.0	2.6e-12	-0.38	0.05	0.06	FALSE
21	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	-7.85	-6.9	6.0e-12	0.78	0.38	0.54	FALSE
15	GTEx	Testis	NPPA	0.36	0.23	lasso	9	0.24	5.0e-11	-4.46	6.8	1.5e-11	-0.36	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	NPPA-AS1	0.38	0.41	lasso	12	0.50	4.6e-73	-4.45	6.6	3.3e-11	-0.40	1.00	0.00	FALSE
1	GTEx	Artery Tibial	CLCN6	0.14	0.04	lasso	6	0.04	5.0e-04	-7.85	-6.4	2.0e-10	0.66	0.10	0.88	FALSE
25	YFS	Blood	MTHFR	0.50	0.49	enet	40	0.62	5.5e-264	-4.14	-6.3	3.0e-10	0.52	1.00	0.00	FALSE
8	GTEx	Nerve Tibial	NPPA-AS1	0.11	0.07	lasso	7	0.06	3.4e-05	-4.75	6.2	6.2e-10	-0.32	0.90	0.01	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPPA	0.10	0.07	lasso	7	0.07	6.5e-08	-5.31	6.0	1.5e-09	-0.22	0.98	0.00	FALSE
18	METSIM	Adipose	DRAXIN	0.09	0.01	enet	21	0.04	1.6e-06	0.44	6.0	2.7e-09	-0.51	0.03	0.92	FALSE
7	GTEx	Esophagus Mucosa	NPPA-AS1	0.14	0.05	enet	13	0.04	7.5e-04	-4.45	5.8	4.8e-09	-0.25	0.84	0.02	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	MTHFR	0.05	0.02	blup	92	0.02	2.5e-03	-4.14	-5.8	5.9e-09	0.44	0.16	0.06	FALSE
3	GTEx	Brain Cerebellum	NPPA-AS1	0.75	0.06	lasso	17	0.13	1.2e-04	-4.73	5.8	7.7e-09	-0.27	0.70	0.03	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	C1orf167	0.07	0.01	blup	475	0.03	1.4e-04	-7.25	-5.7	1.6e-08	0.43	0.36	0.04	FALSE
16	GTEx	Testis	NPPA-AS1	0.62	0.35	lasso	10	0.41	1.8e-19	-4.73	5.6	2.1e-08	-0.28	1.00	0.00	FALSE
13	GTEx	Stomach	NPPA-AS1	0.25	0.20	lasso	6	0.23	2.8e-11	-4.45	5.6	2.3e-08	-0.24	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NPPA	0.07	0.00	blup	79	0.04	9.7e-04	-5.31	5.5	3.9e-08	-0.35	0.10	0.07	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPPA	0.11	0.07	enet	12	0.11	1.0e-11	-4.45	5.4	7.6e-08	-0.46	0.99	0.01	FALSE
2	GTEx	Brain Cerebellar Hemisphere	NPPA-AS1	0.50	0.17	lasso	5	0.31	1.1e-08	-4.73	5.3	1.4e-07	-0.26	0.86	0.03	FALSE