[Hub]/) : Traits : Cardiovascular Disease : ← →

chr1:15,314,120-17,490,832

Best TWAS P=7.89e-10 · Best GWAS P=1.66e-07 conditioned to 0.582

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSPB7 0.18 0.16 lasso 11 0.15 3.1e-18 -4.7 -5.4 6.8e-08 0.94 0.02 0.98 FALSE
2 GTEx Esophagus Mucosa PLEKHM2 0.10 0.01 enet 20 0.02 1.2e-02 -3.9 5.2 1.8e-07 -0.37 0.35 0.10 FALSE
3 GTEx Pancreas RP4-798A10.2 0.18 0.01 lasso 6 0.06 1.8e-03 -5.2 -5.5 3.2e-08 0.87 0.01 0.90 TRUE
4 GTEx Skin Not Sun Exposed Suprapubic RP11-169K16.9 0.19 0.06 lasso 8 0.06 4.7e-04 -4.5 5.6 2.2e-08 -0.66 0.07 0.88 FALSE
5 GTEx Thyroid HSPB7 0.17 0.12 lasso 6 0.15 9.8e-12 -4.7 -5.2 1.6e-07 0.95 0.02 0.98 FALSE
6 ROSMAP Brain Pre-frontal Cortex PLEKHM2 0.06 0.01 blup 488 0.03 4.7e-05 -2.8 -6.2 7.9e-10 0.31 0.26 0.09 TRUE
7 ROSMAP Brain Pre-frontal Cortex HSPB7 0.18 0.18 lasso 9 0.20 2.2e-25 -5.2 -5.4 5.9e-08 0.96 0.01 0.99 FALSE
8 ROSMAP Brain Pre-frontal Cortex CLCNKA 0.16 0.18 enet 15 0.21 1.4e-26 4.7 -5.2 2.2e-07 0.93 0.06 0.93 FALSE
9 The Cancer Genome Atlas Lung Adenocarcinoma HSPB7 0.08 0.04 lasso 3 0.06 8.0e-08 4.9 -5.2 1.5e-07 0.77 0.02 0.97 FALSE
10 The Cancer Genome Atlas Skin Cutaneous Melanoma SPEN 0.18 0.03 blup 71 0.00 3.7e-01 5.0 -5.3 1.4e-07 0.80 0.01 0.53 FALSE