TWAS
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Traits
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Cardiovascular Disease
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chr4:2,616,202-4,082,936
Best TWAS P=1.95e-09 · Best GWAS P=2.21e-09 conditioned to 0.000727
2.6M
2.8M
3M
3.2M
3.4M
3.6M
3.8M
4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Thyroid
RGS12
0.09
0.00
enet
21
0.02
2.1e-02
4.9
6.0
2.0e-09
0.40
0.06
0.55
TRUE
5
The Cancer Genome Atlas
Thyroid Carcinoma
RGS12
0.08
0.01
blup
108
0.01
2.4e-02
3.6
5.9
4.8e-09
0.28
0.03
0.06
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
C4orf44
0.03
0.02
blup
42
0.02
8.0e-04
-4.6
5.3
1.3e-07
0.47
0.27
0.24
FALSE
2
The Cancer Genome Atlas
Colon Adenocarcinoma
RGS12
0.21
0.24
enet
9
0.27
8.9e-16
-5.3
-5.2
1.6e-07
-0.57
0.03
0.97
FALSE
4
The Cancer Genome Atlas
Lung Adenocarcinoma
C4orf44
0.03
0.04
lasso
4
0.05
2.9e-06
-4.7
5.2
2.4e-07
0.45
0.55
0.37
FALSE