Hub : Genes

RGS12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1720	0.0340	4.3e-12	0.116	0.111	0.140	0.123	0.143	5.5e-14	1.9e-13	1.1e-16	8.7e-15	5.0e-17
2	GTEx	Brain Caudate basal ganglia	0.2800	0.0890	3.6e-03	0.045	NA	0.158	NA	0.057	2.0e-02	NA	2.8e-05	NA	9.7e-03
3	GTEx	Lung	0.1821	0.0681	1.2e-03	0.082	NA	0.114	NA	0.090	6.9e-07	NA	4.7e-09	NA	2.2e-07
4	GTEx	Thyroid	0.0910	0.0420	9.3e-03	0.004	NA	0.016	NA	0.015	1.4e-01	NA	2.1e-02	NA	2.4e-02
5	METSIM	Adipose	0.0502	0.0232	2.6e-03	-0.001	0.005	-0.001	0.000	-0.001	4.5e-01	5.6e-02	6.2e-01	3.3e-01	6.0e-01
6	TCGA	Breast Invasive Carcinoma	0.0510	0.0226	5.3e-04	0.004	0.021	0.009	NA	0.005	3.6e-02	2.6e-05	4.0e-03	NA	3.2e-02
7	TCGA	Colon Adenocarcinoma	0.2100	0.0560	6.1e-12	0.238	0.244	0.269	NA	0.250	6.2e-14	2.7e-14	8.9e-16	NA	1.1e-14
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0480	0.0228	3.5e-03	0.018	0.017	0.004	NA	0.006	3.4e-03	4.8e-03	1.1e-01	NA	6.3e-02
9	TCGA	Brain Lower Grade Glioma	0.0482	0.0203	1.3e-03	0.025	0.028	0.028	NA	0.022	6.7e-04	3.2e-04	3.4e-04	NA	1.2e-03
10	TCGA	Rectum Adenocarcinoma	0.5840	0.1080	2.2e-05	0.098	0.181	0.240	NA	0.196	2.7e-03	4.9e-05	2.4e-06	NA	2.3e-05
11	TCGA	Thyroid Carcinoma	0.0820	0.0430	8.0e-03	0.007	0.011	0.011	NA	0.000	6.8e-02	2.4e-02	2.8e-02	NA	2.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.2	2.0	4.5	1.7	-2.1	-1.5	-1.1	-0.9	-1.2	-1.9	-0.8	0.7	-1.3	-1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	0.6	-1.7	-0.8	-1.2	-0.6	-0.7	-0.8	-0.1	0.9	-0.6	-0.8
Depressed Affect (Nagel 2018)	1.5	3.1	11.7	-1.3	0.4	-1.6	0.8	-3.4	-2.5	-0.5	-0.4	-2.0	-2.4	0.4
Depression (Nagel 2018)	2.3	3.4	12.8	-0.9	0.3	-1.8	2.1	-2.5	-0.1	-2.4	1.4	-0.7	-3.6	1.4
Intelligence (Savage-Jansen 2018)	1.7	5.4	17.0	4.1	1.2	0.8	-2.3	2.5	2.3	1.1	-1.0	3.5	2.4	-1.8
Neuroticism (Nagel 2018)	0.6	1.5	6.2	0.0	0.1	-1.3	-0.4	-1.8	-2.5	0.7	-0.8	-0.3	-1.4	-1.4
Schizophrenia (2018)	0.1	0.3	0.6	-0.6	-0.2	0.6	-0.8	-0.0	-0.1	0.6	0.6	0.7	0.3	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	-1.1	1.0	0.1	0.7	-0.1	0.4	1.1	1.4	-0.5	-1.2	1.2
Worry (Nagel 2018)	0.6	1.3	3.7	1.8	0.3	-1.9	0.4	-1.3	-0.7	-0.4	0.1	1.2	-1.6	-0.8
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	0.3	1.0	0.4	1.0	-0.5	0.4	-0.4	0.3	-0.0	-1.1	0.2
Alzheimer’s Disease (in father)	1.6	1.8	4.7	0.8	-1.5	-2.1	-0.1	-1.4	-0.3	-2.2	-0.9	0.4	-1.8	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	0.6	0.3	-0.8	1.2	-0.9	0.9	-1.2	1.0	1.2	-1.6	0.6
Crohns Disease (2017)	2.0	4.5	16.9	0.5	-1.8	-1.6	1.9	-2.7	-0.7	-2.7	-0.3	-0.7	-4.1	2.6
Irritable Bowel Disease (IBD)	1.9	4.5	11.8	-0.2	-3.1	0.0	1.8	-2.4	-1.4	-2.1	-1.2	-1.0	-3.1	3.4
Ulcerative Colitis (UC)	1.2	2.3	7.8	-0.6	-2.8	1.3	1.3	-1.2	-1.4	-0.8	-1.2	-0.6	-0.9	2.6
Major Depression (MDD)	0.0	0.0	0.1	0.2	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.3	2.4	5.9	-0.7	-1.4	-0.6	-1.7	1.6	-1.7	1.5	-2.4	-0.9	2.2	-1.1
Verbal and Numeric Reasoning (VNR)	1.5	3.5	7.4	2.7	0.5	1.3	-2.6	1.4	0.8	0.9	-1.4	2.7	1.6	-2.7
Breast Cancer	1.5	3.7	13.2	3.4	-0.0	2.1	-2.0	1.0	1.7	0.6	-0.3	3.6	1.5	-0.8
Ovarian Cancer	0.3	0.4	1.0	-0.0	-0.5	-0.6	-0.9	-1.0	0.6	-0.3	-0.1	-0.1	0.4	-1.0
Prostate Cancer	1.0	1.4	6.2	-2.5	0.8	-0.4	-0.3	1.0	-0.9	1.3	-0.2	-1.5	1.6	-0.8
Age at First Birth	1.2	1.7	4.5	0.7	-0.4	1.1	-0.3	1.7	-0.1	2.1	-1.6	0.9	1.3	-2.1
Bipolar Disorder (2011)	0.1	0.1	0.7	0.6	-0.8	0.0	-0.1	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.7	-1.6	0.8	-0.6	0.3	0.8	-0.7	0.7	1.0	-0.6	-0.8	-0.8
Coronary Artery Disease (CAD)	0.7	0.9	3.3	-0.4	-0.8	-0.4	1.8	-0.6	-0.5	-0.8	-0.0	0.2	-1.5	1.3
Crohns Disease (2012)	1.8	3.0	8.1	0.0	-2.0	-0.2	0.7	-2.0	-1.2	-1.9	-1.2	-1.7	-2.8	2.5
Mean Putamen Volume	2.5	2.8	9.0	0.7	-2.5	-1.4	-1.3	-1.9	-1.8	-0.8	-3.0	-0.4	1.1	-1.7
Fasting Glucose	1.1	1.3	3.6	1.7	0.8	0.5	-0.6	1.1	1.0	0.9	1.0	1.9	1.6	-0.5
HbA1C	0.3	0.4	1.0	-0.3	-0.4	1.0	-0.9	0.1	-0.1	-0.5	-0.7	-0.5	-1.0	0.5
HDL Cholesterol	1.4	2.3	6.0	-2.1	-0.3	1.1	-0.9	-0.4	-2.1	1.7	-1.4	-1.5	2.5	-1.3
LDL Cholesterol	3.3	5.3	15.8	2.0	0.5	-1.4	1.9	-0.8	3.3	-3.7	0.6	1.1	-2.3	4.0
Lupus	1.3	2.0	4.4	0.8	-0.5	-1.7	1.3	-1.8	-1.7	-2.0	-0.4	-0.5	-2.1	-0.9
Neuroticism (2016)	1.2	1.7	6.6	-0.6	-1.0	-0.2	0.4	-0.6	-2.4	1.7	0.6	1.1	0.5	-2.6
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.6	-0.7	0.8	-0.2	-0.3	-0.9	0.1	0.4	-0.1	-0.3	0.9
Rheumatoid Arthritis	1.4	1.9	8.0	-2.3	0.3	-0.8	0.5	-1.4	-1.7	-0.5	-0.2	-2.8	-0.2	1.1
Schizophrenia (2014)	0.2	0.4	1.1	-0.6	-0.3	0.8	-0.5	-0.8	0.1	0.0	0.8	0.5	-1.0	0.9
Triglycerides	3.3	5.4	30.7	0.9	0.2	-1.3	1.3	-1.1	1.6	-3.0	1.2	-0.2	-3.2	5.5
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.2	0.2	-0.2	-0.7	2.0	-0.3	1.1	-0.7	0.8	0.2	-0.9	1.9
Ulcerative Colitis	1.2	1.8	6.2	-1.0	-2.4	1.3	-0.1	-0.9	-0.7	-0.4	-1.4	-0.9	-0.8	2.5
Blood Eosinophil Count	0.3	2.2	7.6	1.9	1.7	1.1	-0.8	-0.1	2.8	0.2	1.3	2.3	0.5	-1.3
Blood Platelet Count	2.5	29.3	95.8	3.1	-1.8	-2.4	6.3	-4.7	2.2	-8.2	1.7	2.3	-8.1	9.8
Blood Red Count	0.2	2.0	5.5	-1.8	2.3	-1.3	1.9	-2.1	-1.0	-0.4	0.9	-1.1	-0.0	-0.3
Blood White Count	2.1	15.4	52.4	1.3	-1.6	-2.2	4.0	-7.2	0.2	-6.5	0.4	-1.9	-5.8	3.6
Heel T-Score	0.6	4.9	14.4	-2.0	-1.6	1.4	-1.7	-0.8	-3.7	1.9	-1.3	-2.7	1.1	-3.8
BMI	1.3	7.5	17.7	0.4	1.7	0.4	3.6	-3.2	2.6	-2.5	4.2	0.7	-3.1	3.9
Height	1.1	22.0	118.8	-4.0	-1.0	0.6	-2.6	1.6	-5.1	3.6	-3.9	-2.1	6.1	-10.9
Waist Hip Ratio (WHR)	1.3	6.1	19.9	0.8	-1.6	-3.4	1.2	-3.7	-0.1	-4.5	-0.2	-1.7	-2.6	2.6
Systolic Blood Pressure	1.3	6.3	33.8	-0.2	-0.7	-1.9	2.7	-1.6	0.3	-2.5	-0.0	-1.6	-3.5	5.8
Smoking Status	1.0	2.4	8.3	-0.8	-1.2	-0.5	0.7	-2.9	-0.9	-1.1	-1.3	-2.6	-2.1	-0.0
Allergy or Eczema	0.5	1.3	3.1	1.7	-0.5	0.9	-0.3	-1.2	1.2	-0.1	1.1	1.6	0.1	-1.8
Cardiovascular Disease	4.6	15.2	36.0	1.1	1.1	-4.0	6.0	-4.0	2.0	-5.2	2.2	-1.5	-4.9	5.9
Hypothyroidism (self reported)	1.4	3.2	18.8	-1.9	0.4	-0.8	2.1	-1.9	0.0	-0.3	0.8	-1.6	0.5	4.3
Respiratory disease	1.2	2.7	7.2	-0.1	0.6	-1.0	1.0	-2.2	2.0	-2.3	2.7	0.9	-1.7	1.4
Type 2 Diabetes (T2D) (2018)	1.8	3.3	10.2	1.2	0.2	-1.0	2.2	-3.2	0.8	-2.9	0.8	-0.4	-2.0	2.2
Lung FEV1/FVC ratio	0.3	1.7	5.7	1.7	0.7	0.3	0.0	2.4	1.8	0.5	-0.5	1.4	-1.1	1.5
Lung FVC	1.0	5.0	19.4	-1.7	-0.7	-2.2	-0.0	2.2	-2.4	2.2	-0.2	0.6	3.5	-4.4
Neuroticism	0.9	2.3	8.7	-1.2	0.2	-1.4	0.9	-2.9	-3.0	0.7	-0.4	-1.4	-0.6	-0.7
Chronotype (morning person)	0.6	1.4	4.5	0.8	-0.8	0.4	2.0	-0.6	-0.2	-0.2	2.1	2.0	-0.4	0.9
Hair Pigment	0.2	4.8	16.1	0.9	-1.5	-3.6	0.6	-1.9	-0.7	-4.0	-1.5	-1.3	-2.6	2.4
Tanning	0.2	2.5	8.5	-1.4	-2.4	0.3	0.5	-2.5	-2.9	-0.2	-1.4	-1.6	-0.4	0.1
Hand grip strength (left)	0.3	0.7	1.9	-0.4	-0.1	1.2	0.8	0.4	-0.5	1.1	1.0	0.6	1.4	-0.7
Number of treatments/medications taken	2.3	4.1	10.5	1.8	1.3	-1.4	3.2	-1.5	3.0	-2.2	2.3	1.3	-1.3	1.5
Average weekly spirits intake	0.7	0.8	5.5	0.6	-0.9	-0.5	-2.4	0.5	0.2	0.6	0.5	0.4	0.9	-0.8
Sensitivity / hurt feelings	0.9	1.5	5.2	-1.3	0.2	1.5	0.7	-0.4	-1.2	2.3	0.7	0.8	1.6	-1.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	5.1	-0.8	1.2	-0.3	2.0	0.1	1.1	-0.2	2.3	0.8	-1.7	0.4
Hearing difficulty/problems: Yes	3.2	4.9	14.1	1.7	-1.8	-2.8	2.6	-2.5	0.8	-3.8	1.1	0.9	-3.2	0.4
Relative age of first facial hair	0.3	0.6	2.0	0.7	1.1	-0.5	-0.5	1.4	0.8	-0.1	0.2	1.4	-0.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.4	0.8	-0.4	-1.2	0.6	-1.5	0.7	-0.4	1.0	0.1	-0.6	1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	-1.0	0.3	1.5	0.6	0.2	0.4	0.9	0.2	-1.0	0.9	0.8
Ever had hysterectomy (womb removed)	1.2	1.3	5.6	-0.9	-1.0	-0.3	-0.6	-2.4	-1.2	-0.2	-1.3	-0.9	-0.1	1.6
Systolic blood pressure, automated reading	1.0	3.0	13.5	-1.1	-0.5	-0.8	1.4	-2.6	-0.5	-0.8	0.5	-1.3	-2.4	3.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.6	-0.3	-0.5	1.5	0.5	-1.6	0.1	-0.0	0.0	-0.8	0.1	0.0
Angina	1.5	1.9	7.6	-0.9	-1.2	0.3	1.0	-1.9	-0.1	-1.7	0.6	-1.0	-1.5	2.8
Medication for hormone replacement therapy	1.0	1.1	4.2	0.7	0.5	0.8	1.8	0.4	1.2	0.4	2.0	1.3	-0.4	0.3
Vitamin and mineral supplements	1.0	1.4	4.8	0.2	-0.8	-1.5	1.4	-0.9	-0.6	-1.7	0.7	0.0	-2.2	1.2
Supplements: Zinc	0.4	0.4	1.6	-0.6	0.5	0.0	-0.5	-0.5	-0.9	-0.4	-0.7	-1.2	-0.4	0.2
Medication: Co-codamol	0.2	0.2	1.3	0.2	0.6	-0.1	0.5	-1.1	0.4	-0.1	0.2	-0.5	0.3	0.3
Medication: Metformin	1.0	1.4	5.3	-0.1	0.1	-0.4	0.9	-2.3	-1.2	-1.6	-0.9	-1.4	-1.4	0.3
Diabetes (father)	0.9	1.2	2.7	-1.5	-1.1	1.6	0.1	-0.4	-1.3	1.5	0.0	-1.6	0.1	0.0
Diabetes (mother)	1.1	1.4	5.7	-0.4	-0.1	0.7	1.2	-2.4	-0.1	-1.8	-0.2	-1.3	-1.6	-0.0
Severe depression (siblings)	1.3	1.5	6.0	0.1	-2.4	-0.9	-1.5	-1.0	-0.5	-0.7	-2.1	-1.0	-0.1	0.6
Pack years adult smoking proportion	3.4	5.2	15.1	-3.1	1.2	-0.7	2.0	-3.9	-1.2	-1.4	1.8	-2.2	-1.3	3.6
Impedance of leg (right)	0.5	2.5	12.4	1.6	-0.9	0.3	-2.5	0.9	-1.4	0.6	-3.5	-0.4	1.5	0.5
Leg fat-free mass (left)	0.6	3.1	15.1	-2.2	1.6	0.6	2.6	-0.2	0.8	-0.1	3.9	0.6	-0.3	-1.9
Trunk fat percentage	1.1	4.6	19.6	0.9	0.1	-0.9	1.9	-4.4	0.8	-3.3	1.6	-0.1	-2.6	2.1
Hand grip strength (right)	0.1	0.4	1.1	-0.7	-0.1	0.4	0.8	-0.5	-1.0	0.1	0.2	-0.6	-0.0	-1.1
Townsend deprivation index at recruitment	1.6	2.3	10.4	-3.2	0.3	0.7	1.0	-1.1	-1.8	0.1	0.8	-2.8	0.5	0.6
Current tobacco smoking	1.4	2.3	5.6	0.4	-0.5	-2.2	2.1	-2.0	0.6	-1.9	0.8	-0.8	-2.4	0.5
Average weekly fortified wine intake	1.2	1.4	6.1	1.3	-1.7	0.1	-0.6	-1.2	0.4	-1.3	-2.5	-0.3	-0.8	-0.9
Maternal smoking around birth	1.2	1.7	6.4	-0.0	-0.3	-0.3	1.8	-2.5	-1.3	-0.9	0.8	-0.9	-1.9	-1.1
Fed-up feelings	1.1	2.1	5.7	-2.4	1.9	-0.8	1.0	-1.2	-1.1	0.6	1.4	-1.4	-1.6	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	5.2	-1.3	0.8	-1.1	2.1	-2.0	0.1	-1.9	1.4	-1.0	-2.3	1.7
Relative age voice broke	1.2	1.9	4.5	2.1	1.2	0.4	-1.1	1.7	1.4	1.5	-0.0	1.8	1.7	-0.4
Taking other prescription medications	1.2	1.8	4.3	-0.9	-0.0	0.4	2.0	-2.0	0.8	-1.0	2.1	-0.9	-1.5	1.3
Age when periods started (menarche)	1.2	3.0	15.4	1.9	-1.5	-0.1	-1.5	1.8	0.5	1.0	-3.9	-0.2	1.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.5	-0.8	0.3	-0.5	0.7	-1.2	-0.5	0.7	1.6	-0.2	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.7	0.5	1.6	0.8	-1.6	0.1	-0.1	1.0	0.5	1.2	0.9	-1.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	3.3	-0.5	-0.1	0.7	-1.7	0.1	-1.8	1.1	-1.0	-0.5	0.6	-1.6
Qualifications: CSEs or equivalent	0.7	0.9	3.9	-0.9	0.5	-0.7	0.6	-1.0	0.4	-0.1	2.0	0.9	-1.2	1.0
Serious illness, injury or assault to yourself	0.8	0.9	4.0	-0.5	-0.7	-0.1	0.9	-2.0	-1.1	-0.4	-0.6	-1.1	0.5	1.1
High blood pressure	1.9	5.4	15.3	0.3	0.9	-3.0	3.9	-3.0	1.0	-2.7	1.2	-0.9	-2.4	3.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.8	1.9	-0.4	0.1	-0.6	-0.7	1.9	-0.1	1.3	1.8	0.2	-1.1
Multivitamins +/- minerals	1.8	2.3	6.9	-1.5	0.9	1.7	-1.8	0.2	-0.8	2.4	-0.6	-1.2	2.6	-1.1
Stomach or abdominal pain in last month	2.5	3.1	9.0	0.9	2.0	-1.5	2.1	-1.0	1.6	-1.5	3.0	1.8	-1.1	1.9
Supplements: Glucosamine	2.8	3.7	11.2	0.2	0.4	2.0	-2.3	2.1	0.1	3.4	-0.3	1.2	1.8	-3.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.5	0.3	-0.7	-0.2	-0.1	-0.8	0.5	-1.6	0.8	0.8	-1.2	0.6
Medication: Atenolol	0.4	0.5	1.5	-1.2	-0.7	-1.2	0.6	-0.7	-0.2	-0.2	0.2	-0.6	-0.4	0.7
Medication: Levothyroxine sodium	0.8	1.4	3.9	-1.4	-0.2	-0.7	2.0	-1.6	-0.3	-0.4	1.1	-1.0	-0.3	1.9
Sitting height	0.9	6.3	22.8	-4.2	1.8	2.3	0.0	2.4	-1.7	2.5	0.7	-0.8	2.0	-4.8
Chronic bronchitis/emphysema (father)	0.9	1.0	3.2	-0.6	0.6	0.9	-1.6	-0.5	0.2	1.6	-0.2	-0.5	0.8	-1.8
High blood pressure (mother)	1.0	1.3	5.1	1.0	-0.6	-0.2	0.3	-1.8	-0.3	-2.3	-0.3	-0.3	-2.2	0.1
Body mass index (BMI)	2.0	8.5	20.1	-0.1	0.9	-0.2	3.7	-4.5	1.6	-3.4	4.4	0.4	-3.9	3.1
Impedance of leg (left)	0.6	2.8	12.4	2.7	-0.9	-0.2	-2.7	0.8	-0.6	-0.2	-3.5	0.5	1.3	0.8
Leg predicted mass (left)	0.6	3.0	14.3	-2.1	1.4	0.6	2.5	-0.2	0.8	-0.1	3.8	0.7	-0.3	-2.0
Trunk fat mass	0.8	3.5	13.1	0.1	0.7	-0.2	2.2	-3.6	0.9	-2.6	2.5	0.1	-2.2	1.1
Waist circumference	1.5	5.5	19.5	0.3	0.1	-1.1	3.1	-4.4	0.7	-3.2	2.8	0.0	-2.5	2.0
Number of incorrect matches in round	2.3	3.8	13.7	0.4	-3.7	-1.2	-1.9	-0.6	-3.0	-0.3	-3.0	-1.2	0.1	-1.7
Past tobacco smoking	2.0	3.7	10.3	-0.5	2.2	1.4	0.8	3.0	2.2	1.0	3.2	2.5	0.4	1.4
Alcohol usually taken with meals	1.0	1.7	5.8	1.6	1.1	0.4	-0.7	2.4	0.4	1.0	-0.8	0.9	1.7	-1.7
Nervous feelings	0.8	1.4	4.7	2.0	-0.5	-1.5	0.7	0.1	0.5	-0.6	-0.0	1.8	-0.3	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.4	0.5	0.4	-1.5	1.2	-1.3	1.5	-2.2	2.3	1.5	-0.9	1.5
Hearing difficulty/problems with background noise	1.2	1.9	4.7	0.1	0.8	-2.2	2.2	0.1	1.3	-0.9	1.7	1.3	-0.6	-1.8
Hair/balding pattern: Pattern 2	0.5	0.7	3.0	-1.3	-0.0	0.7	-0.7	-0.7	-0.4	0.8	0.3	-0.1	-0.4	1.7
Had menopause	0.2	0.3	0.7	-0.1	0.2	-0.2	-0.6	0.2	-0.3	0.8	-0.8	-0.8	0.7	-0.3
Had other major operations	1.3	1.6	4.6	-0.3	-0.6	0.7	-0.0	-1.5	-2.0	-0.4	-2.0	-2.1	0.3	-1.1
Forced vital capacity (FVC)	1.6	6.1	31.8	-2.2	-0.6	0.1	-0.8	2.7	-2.3	2.3	-0.6	0.7	3.3	-5.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	5.7	-0.2	0.8	0.6	-2.1	-0.3	-1.2	0.9	-0.0	0.1	0.5	-2.4
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	6.8	-0.3	-1.2	-2.0	1.4	-2.6	-0.5	-1.0	-0.7	-0.7	-2.2	0.0
Qualifications: None of the above	2.7	5.7	13.5	-1.9	0.8	-1.0	3.6	-3.7	-0.5	-2.6	1.9	-1.8	-2.8	3.0
Financial difficulties in last 2 years	2.2	2.9	7.3	-2.7	1.0	0.5	1.8	-1.8	0.8	-1.2	1.3	-2.4	-2.4	1.4
Mouth/teeth dental problems	3.4	5.2	19.4	-1.3	0.7	3.2	-1.1	3.6	1.0	4.4	-0.4	0.3	3.1	-1.0
Heart attack	2.1	2.6	7.1	0.3	-2.1	-0.6	2.1	-1.9	-0.3	-2.6	-0.1	-0.1	-2.7	1.5
Allergy	0.7	1.7	5.5	-1.7	-0.5	0.0	-0.0	1.4	-2.4	0.9	-1.8	-2.0	0.2	0.5
Pain all over the body in last month	0.5	0.5	2.8	0.5	-0.4	0.2	0.7	-1.7	0.1	-1.1	-0.1	-0.7	0.2	0.6
Diabetes (self-reported)	1.7	2.6	6.5	0.1	0.8	-0.7	2.2	-2.3	0.8	-2.5	1.8	-0.5	-2.2	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.0	0.6	0.2	1.4	-1.2	0.4	0.3	0.1	-0.1	0.1	-0.3	1.3
Medication: Ramipril	2.0	2.5	7.6	1.4	-1.3	-1.8	1.2	-2.8	-0.9	-2.3	-1.1	-1.0	-1.7	0.5
Medication: Simvastatin	3.1	4.5	11.5	-0.1	0.5	-2.6	3.4	-2.4	0.9	-2.6	1.3	-1.2	-2.4	2.9
Fluid intelligence score	1.1	2.2	6.2	1.8	0.1	1.2	-2.2	1.2	1.0	1.0	-1.1	2.5	1.8	-0.9
Illnesses of siblings	2.2	3.1	7.2	-0.4	0.6	2.2	-1.7	2.2	-0.9	2.6	-1.7	0.8	2.7	-1.4
Neuroticism score	1.0	2.0	8.7	-0.5	-0.6	-1.1	1.3	-3.0	-2.3	-0.1	-0.4	-0.7	-1.0	-1.6
Weight	0.6	3.0	12.5	-0.9	1.3	0.5	2.6	-2.3	0.8	-1.6	3.5	0.5	-1.5	-0.4
Impedance of arm (right)	1.3	6.0	22.0	1.7	-1.3	0.3	-3.9	1.9	-1.4	2.0	-4.7	-0.1	3.1	-2.0
Arm fat percentage (right)	1.3	5.2	18.9	0.4	0.6	-0.2	2.4	-4.3	1.2	-2.9	2.6	0.2	-2.9	2.6
Trunk fat-free mass	0.5	3.1	8.8	-2.5	1.8	1.2	1.5	1.3	0.4	1.2	3.0	0.7	1.0	-2.8
Hip circumference	0.4	1.7	6.4	-0.6	1.2	0.7	2.0	-1.8	0.7	-0.7	2.5	0.5	-1.0	-0.1
Time employed in main current job	0.8	0.9	3.4	1.2	0.2	-1.9	0.4	-0.9	0.7	-0.6	0.0	0.9	0.7	-1.4
Alcohol intake versus 10 years previously	1.0	1.5	4.4	-1.3	-0.5	-1.3	1.3	-0.6	-0.7	-1.1	1.4	-0.5	-2.1	1.6
Father’s age at death	2.9	3.9	10.7	0.2	0.7	2.0	-3.3	2.7	-0.8	2.9	-1.5	-0.1	2.0	-2.3
Worrier / anxious feelings	1.4	2.6	8.9	3.0	-0.3	-1.2	-0.0	-2.0	-1.3	-1.2	-0.7	1.5	-1.7	-2.2
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	12.0	-1.0	1.1	-3.2	3.4	-3.3	1.6	-3.5	3.2	-0.4	-2.4	2.4
Falls in the last year	1.4	1.9	8.1	-0.8	0.9	-2.0	2.0	-1.3	1.0	-0.4	2.8	-0.3	-0.9	0.1
Hair/balding pattern: Pattern 3	0.7	1.0	3.4	0.8	-1.6	-0.2	-0.2	-0.4	-0.8	-1.1	-0.7	-0.3	-1.8	-1.5
Number of live births	0.7	1.0	3.4	-1.3	-0.0	1.1	0.7	-0.2	-1.5	-0.2	-0.0	-1.8	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.9	20.7	-1.3	-0.3	-0.2	-0.4	2.9	-1.4	1.6	-0.2	1.4	2.3	-4.5
Pulse rate	0.3	0.5	1.5	-0.7	0.4	0.1	1.1	-0.8	0.8	0.5	0.7	0.5	1.2	0.2
Happiness	0.3	0.4	1.2	-1.1	0.7	0.6	-0.3	0.2	-0.0	1.0	0.3	0.1	-0.4	-0.6
Noisy workplace	1.3	1.6	7.6	-1.4	0.4	0.3	1.4	-2.8	0.5	-0.2	1.4	-1.0	-0.7	1.5
Qualifications: A levels/AS levels or equivalent	2.5	5.6	16.4	3.0	-0.7	1.6	-2.7	3.0	0.8	1.7	-2.2	2.3	1.8	-4.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	4.4	-0.5	-0.4	0.8	-1.7	-0.1	0.6	1.3	0.0	-0.3	2.1	-0.9
Mouth/teeth dental problems: Dentures	2.6	4.4	19.9	0.1	-1.4	-2.3	0.0	-4.5	-1.8	-3.1	-0.1	-1.3	-2.4	1.2
Asthma	1.7	3.4	9.0	0.7	0.8	-0.3	1.4	-2.0	2.0	-3.0	2.5	2.0	-2.0	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	5.6	-0.1	-0.4	-2.4	0.6	-0.2	1.0	0.0	1.0	0.2	-0.2	0.7
Medication: Cholesterol lowering	4.4	6.9	20.7	1.3	-0.7	-2.5	3.0	-2.6	1.2	-4.3	1.2	-0.9	-4.5	3.0
Depression (self-reported)	0.3	0.4	1.1	-0.4	1.1	0.1	-0.0	-0.0	0.8	0.8	1.0	0.7	-0.4	-0.2
Medication: Lansoprazole	0.7	0.8	4.2	1.8	0.2	-0.3	0.2	-0.2	0.3	-0.9	-0.0	0.6	0.4	-2.1
Prospective memory result	0.7	0.9	3.0	-1.7	0.9	0.8	1.2	-0.2	-0.8	0.5	-0.1	-1.4	0.9	-0.3
Lung cancer (father)	0.7	0.8	4.4	-0.7	1.3	0.0	0.5	0.0	0.4	0.4	-0.3	-0.5	2.1	1.0
Illnesses of mother	0.8	1.0	4.9	0.0	0.1	-0.3	-0.5	2.2	0.2	1.1	1.1	1.2	1.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	20.5	-1.3	0.2	0.4	-0.3	2.3	-1.3	2.6	-0.7	0.8	2.3	-4.5
Pulse wave Arterial Stiffness index	2.2	2.6	8.4	-1.4	-1.0	-2.6	1.0	-2.9	-1.5	-1.4	-0.5	-1.8	-1.3	-0.2
Impedance of arm (left)	1.1	5.0	23.3	1.7	-1.9	-0.2	-3.3	1.1	-1.6	1.0	-4.8	-0.6	2.6	-1.5
Arm fat mass (right)	1.2	5.0	13.9	-0.2	1.0	0.3	2.8	-3.7	1.2	-2.8	3.4	0.5	-2.7	2.0
Trunk predicted mass	0.5	3.0	8.0	-2.4	1.8	1.1	1.5	1.2	0.4	1.1	2.8	0.6	1.1	-2.8
Standing height	1.1	11.2	53.0	-1.9	0.7	1.8	-2.2	4.3	-1.6	3.5	-1.5	0.5	4.6	-7.3
Length of working week for main job	0.7	0.8	3.1	-1.2	1.8	1.1	-0.7	-0.0	0.3	0.4	0.5	-0.8	0.7	-0.6
Exposure to tobacco smoke at home	0.2	0.3	0.8	-0.2	0.4	-0.4	0.4	-0.6	0.4	-0.6	0.4	-0.5	-0.6	0.9
Breastfed as a baby	1.7	2.1	6.3	2.0	-1.7	-0.1	-2.2	0.2	0.3	-0.0	-2.5	0.5	1.2	-1.7
Tense / ‘highly strung’	1.1	1.8	4.7	-0.2	0.3	-1.7	2.2	-1.7	0.0	-1.2	1.6	0.6	-1.9	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	8.2	-0.1	-0.0	-1.4	1.7	-2.9	-0.1	-1.3	1.3	-0.9	-2.8	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	4.8	0.5	0.5	-2.2	1.7	0.3	-0.1	-0.7	0.8	0.3	-1.0	1.8
Birth weight of first child	0.6	1.1	4.2	2.0	-0.7	-0.5	-0.6	0.6	1.2	-1.6	-0.2	1.3	-0.2	-0.5
Peak expiratory flow (PEF)	1.8	4.2	11.2	-1.3	0.5	1.5	-1.4	3.0	0.0	3.3	1.0	1.4	3.2	-2.6
Pulse wave reflection index	0.5	0.6	2.7	-0.3	0.3	-0.9	0.2	-1.3	0.3	-0.4	-0.1	-0.7	-1.6	-0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-0.1	0.6	-0.5	1.1	-1.3	-0.1	-0.7	1.1	0.1	-1.4	0.9
Loud music exposure frequency	1.5	1.7	5.3	-0.2	-0.1	2.3	-0.1	2.0	0.9	1.6	2.3	0.3	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	2.0	3.3	7.9	1.9	-0.7	0.3	-2.4	2.8	0.7	1.2	-0.9	2.5	2.0	-2.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	8.5	-0.2	-0.1	-2.1	1.9	-1.9	0.5	-2.9	0.6	-0.6	-1.7	1.4
Blood clot in the leg (DVT)	0.5	0.6	3.9	0.2	-0.8	0.2	1.3	-2.0	-0.5	0.1	-0.2	-0.0	0.5	-0.0
Medication: Paracetamol	1.0	1.7	5.2	2.1	0.5	-1.2	0.8	-0.6	2.3	-0.5	1.3	1.7	-1.0	-0.0
Headache pain in last month	0.9	1.5	4.6	0.9	1.5	-0.5	1.0	-0.8	1.9	-0.8	2.1	1.7	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	3.7	6.2	15.8	-0.9	0.4	3.0	-2.7	2.5	-1.2	3.8	-0.9	1.0	4.0	-3.3
Glaucoma (self-reported)	0.9	1.0	3.5	-1.9	1.2	-0.2	-0.6	-0.1	-0.6	0.6	-0.6	-1.6	1.4	-0.3
Gout (self-reported)	0.7	0.9	1.9	1.4	-1.0	-0.1	1.2	-1.2	0.6	-1.0	-0.7	0.4	-1.0	1.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	9.3	-1.9	0.3	-0.9	2.1	-1.1	-0.4	-0.3	0.9	-1.5	0.6	3.0
Medication: Amlodipine	2.8	3.9	9.1	1.5	-1.1	-2.9	2.3	-1.9	0.4	-2.8	0.9	0.8	-2.0	3.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.8	-0.4	-0.9	0.2	-0.7	0.1	-0.1	-0.2	-0.3	-0.2	0.6	0.5
Birth weight	0.2	0.5	3.1	-0.1	0.6	0.6	0.0	-0.3	-1.0	0.1	-0.2	0.6	0.1	-1.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.3	-0.4	0.8	0.6	-0.4	-1.5	-0.4	-0.2	0.4	-0.6	-0.2	-0.5
High blood pressure (siblings)	1.6	2.3	6.9	0.4	0.0	-1.6	2.0	-1.0	1.4	-2.5	1.2	-0.4	-2.6	1.2
Forced vital capacity (FVC), Best measure	1.7	6.3	33.5	-2.0	0.1	0.6	-0.8	2.3	-2.0	3.2	-1.0	0.3	3.2	-5.8
Body fat percentage	1.5	5.9	22.8	0.7	0.4	-0.7	2.5	-4.8	1.0	-3.6	2.1	-0.1	-3.1	2.6
Leg fat percentage (right)	2.2	7.9	23.7	0.5	0.9	-0.1	3.1	-4.9	0.9	-4.1	3.0	-0.4	-4.1	3.1
Arm fat-free mass (right)	0.5	2.8	15.2	-1.8	1.6	0.4	2.4	-0.2	0.6	-0.1	3.9	0.7	-0.2	-1.6
Exposure to tobacco smoke outside home	1.1	1.5	6.1	0.0	0.8	-0.8	0.8	-2.5	-0.6	-1.5	1.5	-0.8	-1.5	0.7
Comparative body size at age 10	0.9	2.5	6.2	-1.5	0.5	1.1	1.1	-2.5	-1.5	-0.3	1.7	-1.5	-2.0	2.3
Number of full brothers	2.7	3.4	11.3	-3.4	-0.4	-0.9	0.8	-1.6	-1.8	-0.8	-1.0	-3.0	0.7	2.8
Worry too long after embarrassment	3.5	5.9	22.7	-0.7	-1.1	0.9	-3.2	0.9	-2.7	3.0	-2.8	-0.5	2.0	-4.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	12.1	1.5	-0.9	-2.1	1.3	-2.9	-0.2	-2.7	-0.3	0.4	-3.5	0.7
Wheeze or whistling in the chest in last year	1.9	3.4	8.7	1.1	1.3	-0.9	1.4	-1.1	2.9	-1.9	2.9	2.2	-1.4	1.5
Number of children fathered	0.4	0.5	1.4	-0.3	-0.2	0.9	-1.2	0.2	-0.7	0.8	-0.6	-0.4	0.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	5.2	1.2	0.3	0.8	-2.3	0.1	0.6	0.3	-0.4	0.7	-0.3	0.6
Age at first live birth	2.8	5.0	14.7	2.7	-1.5	1.3	-3.8	2.1	-0.5	1.2	-3.4	1.2	1.6	-2.8
Pulse wave peak to peak time	2.7	3.2	11.8	1.1	1.1	2.9	-1.1	3.4	1.4	1.8	0.5	1.9	1.5	-0.3
Health satisfaction	0.4	0.6	2.4	-1.5	0.8	0.8	-0.3	-0.9	0.5	0.5	0.4	-0.8	-0.6	0.4
Shortness of breath walking on level ground	1.3	1.6	7.4	0.8	0.4	0.1	1.0	-1.9	0.2	-1.9	0.6	0.0	-2.7	0.4
Qualifications: College or University degree	3.8	12.0	23.0	4.4	-0.0	2.5	-4.6	4.7	1.3	3.0	-2.4	3.4	3.4	-4.8
Eye problems/disorders: None of the above	0.4	0.4	1.6	0.7	-0.7	-0.2	-1.3	0.7	-0.6	0.5	-0.8	-0.1	-0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.5	-0.3	0.0	-1.2	0.0	-0.7	-1.9	-0.6	-0.9	-1.2	0.2	0.7
Emphysema/chronic bronchitis	2.0	2.2	5.2	1.1	0.8	1.3	-1.3	2.3	2.1	0.9	1.2	2.2	1.2	-0.9
Medication for pain relief, constipation, heartburn	1.0	1.8	4.2	-1.4	-0.2	2.0	-1.9	0.7	-1.9	1.0	-1.9	-0.6	0.8	-0.3
Neck or shoulder pain in last month	1.5	2.1	8.5	-2.9	0.6	-0.9	2.0	-1.6	-0.3	-0.4	1.5	-1.3	-0.3	1.5
Medication: Blood pressure	1.7	3.0	7.9	1.0	0.2	-2.8	2.5	-0.6	1.3	-2.3	1.0	0.3	-2.6	1.7
Angina (self-reported)	1.6	2.1	9.8	-1.0	-1.1	0.4	1.4	-1.6	-0.1	-1.6	0.9	-0.9	-1.5	3.1
Migraine (self-reported)	0.5	0.6	2.2	0.5	-0.8	-1.0	1.2	-1.5	0.0	-0.7	0.2	0.9	0.1	-0.3
Medication: Ibuprofen	0.5	0.6	2.9	0.3	-0.8	-1.7	0.8	-0.7	0.7	-0.3	0.5	0.5	-0.2	0.7
Medication: Allopurinol	1.4	1.9	5.5	2.4	-1.3	-1.4	0.6	-1.5	0.9	-1.5	-1.0	0.9	-1.9	-0.8
Medication: Omeprazole	1.7	2.0	6.8	0.4	-0.6	-0.8	1.7	-0.9	1.6	-2.0	1.9	0.3	-2.6	0.7
Medication: Seretide 50 evohaler	0.7	0.8	4.2	-0.5	2.0	-1.1	-0.3	0.5	1.3	-0.0	0.6	0.3	-0.1	-0.7
Mean time to correctly identify matches	1.7	3.1	6.0	-0.6	-0.8	-0.4	-2.4	2.3	-1.5	2.1	-2.3	-0.5	2.4	-2.2
Heart disease (mother)	0.5	0.6	2.1	0.9	-0.3	0.0	-1.0	-0.1	-0.4	-0.2	-1.2	0.1	-0.9	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.4	-0.3	-1.9	0.4	-1.6	-0.0	-0.7	-0.7	-0.9	-0.1	-0.4	1.2
Whole body fat mass	1.1	4.8	15.4	-0.1	1.0	-0.1	2.7	-3.9	1.1	-2.9	3.1	0.2	-2.7	1.5
Leg fat mass (right)	1.7	6.6	16.6	-0.4	1.2	0.3	3.5	-4.1	1.0	-3.1	3.9	0.1	-3.4	2.0
Arm predicted mass (right)	0.6	2.9	16.3	-1.9	1.5	0.3	2.6	-0.3	0.9	-0.2	4.0	0.8	-0.3	-1.1
Pulse rate, automated reading	1.7	5.4	13.0	1.2	0.5	-2.6	3.2	-3.1	2.0	-3.6	2.2	0.7	-1.8	2.5
Alcohol intake frequency.	4.8	11.3	25.2	-1.5	2.5	-0.4	4.7	-2.7	1.6	-3.5	4.9	-0.3	-4.7	5.0
Comparative height size at age 10	0.8	4.3	20.3	-2.5	-1.6	0.1	-1.6	-0.0	-3.1	0.7	-1.4	-1.5	1.4	-4.5
Number of full sisters	1.5	1.9	4.8	-0.8	1.3	1.2	-0.4	1.6	2.2	0.4	2.1	0.4	0.8	2.0
Suffer from ‘nerves’	0.8	1.2	4.5	0.9	-0.6	-2.0	0.1	-0.6	-0.3	0.2	0.5	1.3	-1.0	-2.1
Overall health rating	2.8	6.0	15.3	-2.3	0.7	-0.3	3.0	-3.9	1.2	-2.1	2.5	-1.9	-2.5	3.8
Chest pain or discomfort	2.9	4.1	7.2	-0.0	1.1	-1.7	2.6	-2.5	2.2	-2.0	2.5	0.6	-2.4	2.7
Had major operations	0.4	0.5	1.9	1.2	0.4	-1.4	0.2	-0.2	0.1	-0.5	-0.7	0.0	0.7	0.5
Age at last live birth	2.0	2.9	7.8	1.5	-0.5	0.4	-2.8	2.5	0.1	0.8	-2.4	0.7	0.9	-2.7
Family relationship satisfaction	0.3	0.4	1.2	-0.1	-0.9	-0.0	-0.3	1.1	0.3	0.5	-0.6	0.9	-0.6	0.6
Leg pain on walking	0.8	1.0	3.9	0.2	-0.2	1.0	0.9	-2.0	-0.7	-0.8	0.8	0.7	-1.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.3	-0.2	-1.3	0.3	0.0	-0.6	-0.0	-1.0	1.2	-0.4	-1.5	1.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.6	0.8	-0.3	1.6	0.2	-1.5	-0.1	-0.3	-0.9	0.1	-0.2	-0.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.3	5.9	2.1	0.9	0.8	-1.3	2.3	0.7	1.8	-0.5	2.4	0.5	-1.4
Medication: Aspirin	1.4	1.9	5.2	1.6	-1.9	-1.5	1.4	-1.5	0.5	-2.3	0.1	-0.2	-1.5	0.3
Supplements: Vitamin C	0.9	1.1	6.5	0.5	0.7	0.2	-0.8	0.7	0.9	0.6	-1.4	0.3	2.6	0.4
Knee pain experienced in last month	0.9	1.4	3.3	0.1	1.6	-0.4	1.3	-1.8	1.4	0.3	1.7	0.0	0.6	-1.5
Hypertension (Self-reported)	2.1	5.7	15.4	0.5	0.7	-3.2	3.9	-3.0	1.0	-3.2	0.8	-0.9	-2.4	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.2	-0.6	1.2	0.9	1.1	-0.5	0.7	-0.8	0.4	-0.7	0.0	-2.1
Illnesses of father: Heart disease	1.9	2.6	7.7	1.9	-1.1	-2.8	-0.3	-1.4	1.1	-2.4	-1.0	-0.4	-2.5	0.8
Illnesses of siblings: Diabetes	2.7	3.4	10.0	-2.5	-1.3	-0.5	1.1	-2.1	-2.6	-1.2	-0.0	-3.2	-2.2	-0.1
Smoking status: Previous	2.1	3.1	9.0	-0.1	-1.8	-0.5	-1.8	-2.3	-2.3	-0.2	-3.0	-2.5	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.7	-1.4	0.1	1.9	0.4	1.3	-0.1	0.5	0.6	0.4	0.4	-1.0
Whole body fat-free mass	0.5	3.0	11.8	-2.3	1.8	0.9	2.1	0.5	0.7	0.5	3.4	0.7	0.4	-2.5
Leg fat-free mass (right)	0.5	2.7	12.9	-1.7	1.4	0.5	2.3	0.0	1.0	-0.1	3.6	1.0	-0.1	-2.1
Arm fat percentage (left)	1.6	6.3	21.6	0.6	0.2	-0.6	2.9	-4.7	1.3	-3.5	2.6	0.1	-3.3	2.6
Average weekly red wine intake	1.7	2.5	12.0	-0.0	-0.2	0.3	-1.9	1.3	-1.1	1.8	-1.4	-1.1	1.3	-3.5
Handedness (chirality/laterality): Left-handed	3.8	4.5	9.4	-1.6	-0.7	2.6	-2.6	1.3	-2.6	2.7	-2.4	-1.1	3.1	-1.2
Mood swings	1.3	2.4	7.5	-1.4	0.2	-1.7	2.7	-2.7	-1.0	-0.6	1.1	-1.3	-1.4	-0.2
Loneliness, isolation	1.0	1.3	5.3	-1.0	0.0	-0.1	0.7	-1.8	-0.3	-1.7	0.8	-0.5	-2.3	0.9
Long-standing illness, disability or infirmity	1.3	1.9	6.1	-1.4	1.6	0.5	1.6	-0.1	1.5	0.2	2.5	-0.3	-1.3	2.0
Ever had bowel cancer screening	0.5	0.6	1.6	0.5	-1.1	1.2	-0.9	1.3	-0.7	0.2	-0.9	-0.1	-0.2	0.1
Diabetes diagnosed by doctor	1.2	1.9	7.3	0.4	0.4	-0.5	1.7	-2.7	0.5	-2.4	0.7	-0.6	-1.6	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.9	-0.4	0.7	-0.9	0.6	0.5	0.4	0.1	-0.2	-0.3	0.1	-0.5
Friendships satisfaction	1.6	1.9	7.2	-2.0	-0.9	2.7	-1.3	1.5	-1.0	1.9	0.8	-0.5	-0.2	0.4
Qualifications: nursing, teaching	1.2	1.9	5.9	2.4	0.4	-0.5	-1.0	1.3	1.7	0.6	-0.4	2.1	1.6	-1.0
Commuting to job workplace: Walk	0.2	0.3	1.6	-1.3	0.1	-0.3	-0.1	0.1	-0.0	-0.4	-0.4	-0.9	-0.1	0.2
Eye problems/disorders: Cataract	0.7	0.9	2.0	-1.1	0.6	-0.2	1.2	0.9	1.4	-0.1	1.4	0.5	0.4	1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.9	1.2	-1.1	-1.2	-0.7	0.4	-0.5	-1.7	-0.8	0.5	-1.1	1.1
Medication for cholesterol	1.5	2.3	5.0	-1.7	-0.6	0.3	-2.1	1.1	-2.2	2.2	-0.5	-1.2	-0.6	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	1.2	-0.0	-0.6	-0.8	-0.4	0.5	-0.9	-0.1	0.5	-0.7	-1.0
Back pain experienced in last month	0.9	1.3	5.8	0.1	0.5	-1.1	2.4	-1.1	1.2	-1.0	1.5	0.9	-0.2	0.7
Mineral and other dietary supplements	3.6	4.8	14.5	0.5	-1.8	-3.2	1.6	-2.8	-0.7	-3.8	-1.1	-1.5	-2.2	2.3
Breast cancer (self-reported)	0.3	0.3	1.3	-0.2	-0.2	-0.0	-0.8	0.1	-0.7	0.6	-1.1	0.4	0.5	-0.2
Asthma (self-reported)	1.4	2.9	8.0	0.5	0.4	-0.3	1.0	-1.8	1.9	-2.8	2.4	1.9	-1.7	1.8
Osteoporosis (self-reported)	0.7	0.9	4.3	2.1	0.3	0.4	-0.3	1.0	0.9	1.3	0.0	0.9	0.7	-0.6
Osteoarthritis (self-reported)	0.9	1.2	6.3	-0.3	-0.6	-0.5	2.5	-1.5	1.1	-0.5	0.7	-0.6	-0.7	1.2
Medication: Aspirin	2.2	2.9	8.9	1.6	-1.7	-2.0	1.8	-2.1	0.4	-3.0	0.4	-0.3	-2.3	0.1
Medication: Gliclazide	1.6	1.8	8.2	1.6	0.5	0.6	1.0	-1.2	1.2	-1.4	0.5	0.1	-1.4	2.9
Illnesses of father: None of the above (group 1)	0.7	0.9	3.5	-1.1	0.0	1.2	0.3	1.2	-0.3	1.0	0.5	0.4	1.9	0.3
Smoking status: Current	0.9	1.4	3.2	0.2	-0.6	-1.6	1.8	-1.7	0.3	-1.5	0.3	-0.8	-1.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	11.0	-0.7	0.1	-0.1	-0.3	2.0	-1.4	1.5	0.4	1.0	0.8	-3.3
Whole body water mass	0.5	3.0	12.2	-2.3	1.7	0.8	2.0	0.5	0.6	0.5	3.5	0.8	0.5	-2.4
Leg predicted mass (right)	0.5	2.6	12.8	-1.7	1.3	0.4	2.3	-0.1	0.9	-0.2	3.6	1.0	-0.2	-2.1
Arm fat mass (left)	1.3	5.3	15.7	-0.1	0.8	-0.2	2.9	-4.0	1.2	-3.0	3.4	0.5	-2.8	1.7
Number of self-reported non-cancer illnesses	2.3	3.9	13.0	-1.4	1.2	0.1	2.2	-3.6	0.9	-1.9	1.1	-1.9	-1.1	3.4
Average weekly champagne plus white wine intake	1.5	2.1	4.6	2.1	-0.9	-0.5	-1.1	1.8	0.2	0.8	-2.1	1.2	1.4	-2.0
Miserableness	1.2	2.2	7.2	-1.2	0.4	-1.1	1.4	-2.7	-1.6	-0.7	-0.2	-1.4	-2.6	0.4
Guilty feelings	0.7	1.0	3.4	0.3	0.6	0.0	-1.2	1.0	-1.0	1.4	-0.2	0.9	1.0	-1.8
Wears glasses or contact lenses	0.7	0.8	2.2	1.3	-0.3	-1.1	0.3	0.9	0.1	0.7	-0.8	0.2	1.2	-1.5
Ever taken oral contraceptive pill	0.9	1.0	4.6	0.9	0.2	-1.8	1.0	0.9	0.0	0.0	-0.1	0.9	-0.0	-2.1
Hearing aid user	0.8	1.0	2.8	-0.7	-1.0	0.1	1.1	-1.7	-0.2	-1.6	0.9	-0.0	-0.8	-0.8
Mother’s age at death	3.0	3.7	9.3	2.9	-0.9	0.4	-3.1	1.3	-0.4	0.2	-2.7	0.6	2.1	-2.9
Financial situation satisfaction	0.9	1.1	4.1	-1.2	0.4	-0.3	1.3	-2.0	-0.3	-0.7	0.6	-1.6	-0.5	1.0
Tinnitus: Yes, now most or all of the time	1.5	1.8	6.9	-0.2	-2.3	-1.0	-1.1	-2.6	-1.2	-1.2	-1.1	-0.9	-0.5	-0.5
Commuting to job workplace: Public transport	1.7	2.0	6.4	2.5	1.5	-0.8	-0.8	1.9	1.9	0.2	0.6	2.2	-0.0	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	5.3	-1.7	2.3	-0.1	1.0	-0.9	0.5	-0.1	0.8	-0.9	0.9	0.4
Medication: Blood pressure	1.2	2.3	7.1	1.5	0.4	-1.7	2.1	-2.3	1.0	-2.7	0.4	0.3	0.0	1.4
Pain type(s) experienced in last month: Hip pain	1.7	2.1	7.6	-1.1	0.0	-1.4	2.7	-1.8	-0.7	-1.4	1.5	-0.5	-0.5	1.9
Supplements: Fish oil (including cod liver oil)	3.1	4.1	10.8	-0.8	0.8	2.9	-2.8	1.8	-0.4	3.3	-0.6	0.4	2.9	-2.2
High cholesterol (Self-reported)	4.5	8.0	29.2	0.3	0.3	-1.6	3.6	-2.9	1.3	-4.1	0.9	-1.9	-3.4	5.4
Medication: Bendroflumethiazide	1.3	2.0	6.8	2.2	1.6	-0.1	1.3	-0.3	2.6	-0.6	1.0	1.9	0.4	1.1
Medication: Paracetamol	1.5	2.3	9.1	3.0	-0.0	-0.9	1.3	-1.0	2.5	-1.3	0.3	1.8	-1.2	0.2
Medication: Lisinopril	0.7	1.0	3.2	0.7	1.3	-0.5	1.8	-1.5	-0.1	-1.3	0.8	0.3	0.2	-0.3
Medication: Atorvastatin	2.1	2.6	9.5	0.3	-0.5	-1.3	1.1	-0.8	1.1	-2.9	0.0	-0.2	-2.3	3.1
Illnesses of father: High blood pressure	0.9	1.1	4.5	-0.8	2.1	0.4	1.4	0.4	0.4	0.8	0.3	-0.5	1.3	1.5
Alcohol drinker status: Never	1.8	2.1	6.6	0.7	2.6	0.0	2.2	-0.3	1.5	-0.3	2.3	1.0	-1.6	0.7
Ever smoked	2.2	3.9	8.9	1.6	-2.6	-3.0	-0.3	-2.5	-1.5	-1.1	-2.8	-1.2	-0.5	-2.3
Basal metabolic rate	0.5	2.8	13.0	-2.0	1.8	0.8	2.3	-0.2	0.8	-0.1	3.6	0.8	-0.1	-1.9
Leg fat percentage (left)	2.4	8.7	24.6	1.1	0.9	-0.6	3.1	-5.0	1.4	-4.5	3.0	0.2	-4.2	3.2
Arm fat-free mass (left)	0.6	2.9	15.7	-2.0	1.8	0.5	2.3	-0.6	0.7	-0.1	4.0	0.8	-0.3	-1.3
Number of operations (self-reported)	0.7	1.0	2.9	-0.4	1.6	1.3	-0.6	-0.8	0.2	1.7	0.7	0.3	1.5	-0.7
Average weekly beer plus cider intake	0.6	0.9	5.7	-2.4	0.1	0.3	0.3	0.1	-0.5	1.3	-0.4	-0.9	0.5	0.6
Irritability	0.2	0.4	1.4	-0.1	0.2	-0.6	0.6	-1.2	-0.9	0.6	0.6	-0.3	-0.6	0.6
Risk taking	0.3	0.5	2.1	-0.5	-0.7	-0.8	1.4	-0.5	0.8	-0.3	0.7	0.3	0.4	0.6
Ever had prostate specific antigen (PSA) test	1.5	1.8	6.5	0.2	-0.9	-2.3	-0.3	0.3	-1.6	0.7	-2.6	-1.2	0.5	-1.4
Fractured/broken bones in last 5 years	0.5	0.6	4.0	-0.3	1.1	0.8	0.3	0.5	-0.5	0.2	2.0	0.2	0.3	0.3
Age started oral contraceptive pill	1.1	1.3	6.7	0.1	-1.0	1.5	-0.9	-0.6	-1.3	0.3	-2.6	-1.1	0.7	0.3
Diastolic blood pressure, automated reading	1.4	4.4	10.3	-0.9	2.5	-1.2	3.2	-1.7	1.8	-1.2	3.0	-0.1	-3.0	2.1
Ever depressed for a whole week	0.6	0.7	1.9	-0.1	-0.9	-1.4	1.4	-0.8	-0.5	-0.5	-0.4	-0.5	-1.3	0.5
Unable to work because of sickness or disability	1.9	2.5	4.7	-1.3	1.3	-1.3	2.2	-2.2	1.0	-1.0	2.2	-0.6	-1.7	1.7
Commuting to job workplace: Cycle	3.4	4.1	9.1	0.5	-1.2	3.0	-2.8	2.5	-0.1	2.8	-0.4	0.4	2.4	-2.4
Myopia	0.6	0.9	5.6	0.9	0.2	1.1	0.2	2.4	0.9	0.9	-0.3	0.5	0.5	-0.2
Vascular/heart problems diagnosed by doctor	2.2	6.0	12.8	-0.7	-0.1	2.7	-3.6	3.5	-0.9	3.2	-0.8	0.9	3.0	-3.4
Cholesterol lowering medication	0.5	0.7	3.8	0.7	0.0	-0.7	0.8	-0.3	0.9	-1.1	-0.4	0.1	0.3	1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.6	0.3	-1.4	-1.0	1.2	-1.8	0.5	-1.6	1.4	-0.3	-2.4	0.3
Pain experienced in last month	1.5	2.5	8.9	2.5	-1.2	0.9	-3.0	1.5	-0.2	-0.3	-2.0	1.1	-1.3	-0.7
Supplements: Calcium	0.7	0.7	1.7	-0.9	1.2	-0.4	0.9	1.3	0.1	0.8	0.6	-0.4	0.4	1.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.5	0.4	-1.2	0.1	-0.0	0.3	-0.5	-0.0	-0.3	-0.4	-0.6	-0.1
Heart attack/myocardial infarction (self-reported)	2.1	2.7	7.2	0.3	-2.2	-0.6	2.1	-1.9	-0.2	-2.7	-0.1	0.1	-2.4	1.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.5	-0.2	-0.7	0.3	0.9	-1.9	-0.7	0.5	-0.6	-0.5	0.7	-0.3
Heart disease (siblings)	1.2	1.5	5.7	-0.3	-1.8	-1.3	-0.3	-2.4	-0.9	-1.0	-0.7	-1.4	-1.1	-0.0
Alcohol drinker status: Previous	3.1	3.6	9.2	-0.4	0.4	-0.7	3.0	-3.0	0.2	-3.0	1.1	-1.0	-2.9	0.9
Pack years of smoking	3.1	4.5	12.3	-3.1	1.1	-0.7	1.6	-3.5	-1.4	-1.3	1.7	-2.1	-1.2	3.3
Impedance of whole body	0.8	4.3	21.0	2.3	-1.5	-0.3	-3.2	1.0	-1.2	0.5	-4.6	-0.1	2.2	-0.5
Leg fat mass (left)	1.8	7.0	16.7	0.1	1.3	0.1	3.5	-4.1	1.4	-3.4	4.0	0.6	-3.4	2.1
Arm predicted mass (left)	0.6	3.1	16.6	-1.6	2.1	0.6	2.3	-0.4	1.1	-0.1	4.1	1.1	-0.0	-1.3