TWAS
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Traits
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Cardiovascular Disease
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chr4:14,310,407-16,125,136
Best TWAS P=9.18e-09 · Best GWAS P=2.47e-09 conditioned to 1
14.5M
15M
15.5M
16M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Mucosa
CPEB2
0.12
0.12
lasso
3
0.10
3.9e-07
5.6
-5.7
9.2e-09
-0.99
0.01
0.99
TRUE
2
GTEx
Skin Sun Exposed Lower leg
RP11-665G4.1
0.09
0.11
lasso
1
0.09
5.0e-08
5.3
-5.3
1.1e-07
-0.93
0.08
0.92
FALSE