Hub : Genes

CPEB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1200	0.0370	5.2e-05	0.118	NA	0.085	NA	0.099	2.8e-08	NA	2.5e-06	NA	3.9e-07
2	GTEx	Nerve Tibial	0.1157	0.0441	2.3e-03	0.027	NA	0.008	NA	0.028	5.2e-03	NA	8.1e-02	NA	4.6e-03
3	NTR	Blood	0.0329	0.0096	5.6e-07	0.031	0.010	0.025	0.009	0.003	2.0e-10	0.00019	1.4e-08	0.00041	2.3e-02
4	TCGA	Lung Adenocarcinoma	0.0301	0.0220	7.3e-03	0.022	0.012	0.014	NA	0.011	1.0e-03	0.01300	7.2e-03	NA	1.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.7	-0.3	0.5	1.3	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.2	2.6	0.1	0.3	1.4	-1.6
Depressed Affect (Nagel 2018)	1.2	2.4	8.2	-2.9	-1.0	-0.6	0.3
Depression (Nagel 2018)	4.5	6.8	11.3	-3.4	-2.7	-2.2	1.9
Intelligence (Savage-Jansen 2018)	0.9	2.9	9.4	3.1	0.9	0.7	-0.9
Neuroticism (Nagel 2018)	2.4	5.6	15.2	-3.9	-1.8	-1.8	1.0
Schizophrenia (2018)	0.2	0.5	1.3	0.4	0.0	0.7	-1.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.1	0.4	0.4	-0.7
Worry (Nagel 2018)	5.5	11.6	20.5	-4.5	-2.8	-3.6	2.3
Alzheimer’s Disease (in mother)	0.8	0.9	2.0	0.7	1.1	0.2	-1.4
Alzheimer’s Disease (in father)	6.1	6.6	7.9	2.2	2.8	2.8	-2.4
Alzheimer’s Disease (including proxy)	1.9	2.8	4.1	1.4	1.8	1.4	-2.0
Crohns Disease (2017)	0.3	0.8	2.7	0.2	-0.3	-0.5	1.6
Irritable Bowel Disease (IBD)	0.9	2.1	4.1	2.0	1.2	1.5	-0.7
Ulcerative Colitis (UC)	2.5	4.7	6.8	2.6	1.7	2.2	-2.1
Major Depression (MDD)	0.9	1.1	2.0	-1.4	-0.9	-0.7	1.0
Reaction Time	0.2	0.3	0.6	-0.7	-0.4	-0.8	0.1
Verbal and Numeric Reasoning (VNR)	1.6	3.8	8.8	3.0	1.3	1.6	-1.4
Breast Cancer	0.2	0.4	1.6	0.4	0.1	-1.2	0.0
Ovarian Cancer	0.2	0.3	0.6	-0.2	0.1	-0.7	0.8
Prostate Cancer	0.8	1.1	1.7	0.6	1.2	0.9	-1.3
Age at First Birth	0.9	1.3	2.2	1.5	1.1	0.5	1.2
Bipolar Disorder (2011)	0.2	0.2	0.6	0.2	0.1	0.7	-0.6
Body Mass Index (BMI) (2010)	0.5	0.6	0.9	-0.9	-0.9	-0.9	0.3
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.7	-0.2	-0.4	0.9
Crohns Disease (2012)	0.7	1.1	1.8	-0.9	-1.3	-0.7	1.2
Mean Putamen Volume	1.8	2.0	2.8	0.8	1.6	1.7	-1.5
Fasting Glucose	2.5	3.0	4.4	-1.4	-1.6	-1.7	2.1
HbA1C	0.2	0.2	0.4	-0.4	0.1	-0.6	-0.3
HDL Cholesterol	0.1	0.2	0.7	-0.3	-0.3	-0.0	-0.8
LDL Cholesterol	1.1	1.7	2.9	-1.7	-1.5	-0.9	0.9
Lupus	1.3	1.9	4.6	2.1	0.5	1.2	-1.2
Neuroticism (2016)	0.2	0.2	0.9	-0.9	-0.0	-0.2	0.2
Primary Biliary Cirrhosis	1.9	2.6	3.2	-1.8	-1.6	-1.8	1.4
Rheumatoid Arthritis	3.9	5.3	8.6	2.1	1.8	2.9	-2.2
Schizophrenia (2014)	0.3	0.7	1.3	0.7	0.7	0.9	-1.2
Triglycerides	0.1	0.2	0.3	0.5	0.2	-0.6	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1
Ulcerative Colitis	2.8	4.1	5.3	2.3	1.6	2.2	-1.9
Blood Eosinophil Count	0.9	7.3	11.1	-2.6	-3.3	-2.5	2.4
Blood Platelet Count	1.0	11.9	15.4	-3.4	-3.9	-2.7	3.6
Blood Red Count	0.1	0.8	2.1	-1.4	-1.1	-0.3	0.2
Blood White Count	0.7	5.3	7.5	-2.7	-2.7	-1.6	2.0
Heel T-Score	7.0	55.4	78.1	7.8	8.8	6.7	-6.1
BMI	0.4	2.5	7.5	-2.7	-0.5	-1.1	1.1
Height	0.1	2.8	9.1	1.0	0.8	3.0	-0.8
Waist Hip Ratio (WHR)	0.8	3.8	6.4	2.5	1.7	2.2	-0.9
Systolic Blood Pressure	6.4	32.0	46.4	-4.6	-5.5	-6.8	5.5
Smoking Status	0.8	1.8	3.8	1.1	1.0	1.2	-2.0
Allergy or Eczema	0.2	0.4	1.4	-0.2	0.1	-1.2	0.6
Cardiovascular Disease	6.4	21.2	33.0	-5.7	-4.5	-4.4	3.5
Hypothyroidism (self reported)	0.1	0.1	0.5	-0.1	-0.3	-0.7	-0.1
Respiratory disease	3.0	6.6	7.7	-2.5	-2.8	-2.3	2.8
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.0	-1.7	-1.5	-0.2	1.1
Lung FEV1/FVC ratio	0.1	0.6	1.5	-0.6	1.2	-0.7	-0.3
Lung FVC	0.6	3.3	4.5	-0.9	-2.1	-1.9	2.1
Neuroticism	1.5	3.7	11.5	-3.4	-1.0	-1.0	1.0
Chronotype (morning person)	0.8	1.7	3.5	-1.9	-1.1	-0.9	1.2
Hair Pigment	0.2	6.5	8.8	2.0	2.7	2.5	-3.0
Tanning	0.3	3.6	5.7	-2.3	-1.7	-0.5	2.4
Hand grip strength (left)	0.0	0.1	0.3	0.6	0.1	0.1	0.3
Number of treatments/medications taken	5.3	9.5	15.4	-3.9	-2.8	-2.9	2.5
Average weekly spirits intake	0.7	0.8	1.3	0.6	0.8	1.2	-1.0
Sensitivity / hurt feelings	1.5	2.6	5.8	-2.4	-1.4	-1.4	0.7
Frequency of depressed mood in last 2 weeks	3.1	4.3	7.8	-2.8	-2.0	-1.5	1.7
Hearing difficulty/problems: Yes	0.9	1.4	2.0	-0.6	-1.2	-1.3	1.4
Relative age of first facial hair	0.6	1.3	3.3	-0.6	-1.1	-1.8	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.4	-0.3	-0.3	-1.2	0.4
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.3	-1.2	-1.5	-1.0	1.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.7	-1.2	-0.5	0.4
Systolic blood pressure, automated reading	5.8	16.8	26.2	-3.9	-3.6	-5.1	3.6
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.0	-0.2	0.2	0.3
Angina	0.2	0.3	0.6	-0.8	0.4	-0.6	-0.1
Medication for hormone replacement therapy	0.1	0.1	0.2	0.3	-0.5	0.1	0.3
Vitamin and mineral supplements	2.3	3.2	5.5	-1.7	-1.3	-1.6	2.3
Supplements: Zinc	0.8	0.8	3.1	-1.8	-0.2	-0.1	-0.5
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2
Medication: Metformin	0.6	0.9	1.9	-1.4	-0.7	0.0	1.0
Diabetes (father)	1.4	1.7	2.9	-1.4	-1.4	-1.7	0.5
Diabetes (mother)	0.2	0.3	0.4	-0.6	-0.6	-0.4	-0.6
Severe depression (siblings)	0.1	0.1	0.3	-0.2	-0.5	-0.1	0.4
Pack years adult smoking proportion	0.0	0.1	0.1	-0.1	0.4	0.1	-0.3
Impedance of leg (right)	0.2	0.8	2.2	-0.4	-1.5	-0.8	0.6
Leg fat-free mass (left)	0.1	0.6	2.4	-1.5	-0.1	0.1	0.1
Trunk fat percentage	1.7	6.8	16.1	-4.0	-2.3	-1.9	1.5
Hand grip strength (right)	0.2	0.6	1.8	1.3	0.0	0.7	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.9	-1.0	-0.4	-0.1	-0.1
Current tobacco smoking	0.0	0.1	0.2	-0.0	-0.4	-0.2	-0.1
Average weekly fortified wine intake	0.7	0.8	1.8	0.7	1.3	0.5	-0.8
Maternal smoking around birth	1.7	2.5	3.7	-1.9	-1.7	-1.4	1.1
Fed-up feelings	1.1	2.0	6.9	-2.6	-0.9	-0.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	4.6	6.1	11.0	-3.3	-2.4	-2.0	1.9
Relative age voice broke	0.3	0.4	0.9	0.1	-0.6	-0.9	0.8
Taking other prescription medications	7.1	11.0	13.6	-3.7	-3.1	-3.3	3.2
Age when periods started (menarche)	1.8	4.3	6.0	-2.4	-1.7	-2.2	1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	0.0	-1.1	0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	9.1	2.4	3.0	2.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.7	1.3	0.0	0.6	-0.6
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.2	0.4	-0.2	-0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	-0.1	-0.1	0.2
High blood pressure	3.2	9.0	17.0	-4.1	-2.5	-3.1	1.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.1	0.2	-1.3	0.6
Multivitamins +/- minerals	1.2	1.5	3.7	1.1	0.7	0.8	-1.9
Stomach or abdominal pain in last month	0.4	0.6	1.1	1.1	0.7	0.7	-0.3
Supplements: Glucosamine	0.1	0.2	0.3	0.5	-0.2	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.1	-0.6	-1.3	1.1
Medication: Atenolol	0.2	0.3	0.9	-0.5	0.0	0.9	-0.0
Medication: Levothyroxine sodium	0.3	0.5	1.1	-0.2	-1.0	-0.7	0.6
Sitting height	0.1	0.8	3.0	-0.0	-0.5	1.7	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	-0.5	-0.9	-0.3	0.4
High blood pressure (mother)	1.0	1.4	4.5	-2.1	-1.0	-0.5	0.1
Body mass index (BMI)	0.6	2.6	8.4	-2.9	-0.6	-1.3	0.3
Impedance of leg (left)	0.1	0.4	1.2	0.2	-1.1	-0.2	0.3
Leg predicted mass (left)	0.1	0.6	2.3	-1.5	-0.1	0.1	0.1
Trunk fat mass	1.4	5.8	15.1	-3.9	-2.0	-1.5	1.3
Waist circumference	0.4	1.5	5.2	-2.3	-0.5	-0.4	0.6
Number of incorrect matches in round	2.3	3.8	5.0	2.0	1.7	2.2	-1.8
Past tobacco smoking	0.7	1.3	2.5	-1.1	-0.9	-0.8	1.6
Alcohol usually taken with meals	4.9	8.0	13.8	3.7	3.1	2.4	-1.7
Nervous feelings	5.3	9.9	15.2	-3.9	-2.1	-3.4	2.8
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	7.5	-2.7	-1.7	-2.1	2.0
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.0	-0.7	0.1	0.6
Hair/balding pattern: Pattern 2	32.9	41.8	49.4	6.2	6.5	6.1	-7.0
Had menopause	2.7	3.4	7.1	1.3	1.5	1.6	-2.7
Had other major operations	0.7	0.9	2.2	1.5	0.5	0.4	-0.9
Forced vital capacity (FVC)	0.1	0.3	0.5	0.7	-0.4	0.2	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	6.8	2.1	2.6	2.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.3	-0.1	0.5	-0.7
Qualifications: None of the above	4.5	9.6	17.9	-4.2	-3.1	-2.6	2.0
Financial difficulties in last 2 years	0.7	1.0	1.7	0.0	1.0	1.1	-1.3
Mouth/teeth dental problems	2.1	3.3	5.6	2.1	1.5	0.9	-2.4
Heart attack	0.2	0.3	0.4	-0.4	0.6	0.7	-0.4
Allergy	0.7	1.7	3.6	1.1	0.6	1.9	-1.2
Pain all over the body in last month	5.0	5.3	9.9	-3.1	-2.4	-2.2	1.0
Diabetes (self-reported)	0.6	1.0	1.9	-1.1	-0.8	-0.5	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.8	-0.5	-0.7	-0.9	0.8
Medication: Ramipril	0.2	0.2	0.8	-0.9	-0.0	0.1	-0.2
Medication: Simvastatin	4.1	6.0	9.9	-3.2	-2.2	-2.0	2.3
Fluid intelligence score	1.2	2.5	4.7	1.6	0.8	2.2	-1.3
Illnesses of siblings	1.7	2.4	6.3	2.5	1.7	0.5	-0.0
Neuroticism score	2.8	5.9	15.1	-3.9	-1.3	-2.0	1.6
Weight	0.5	2.4	7.8	-2.8	-1.0	-0.7	0.4
Impedance of arm (right)	1.4	6.3	8.4	-2.2	-2.9	-1.9	2.9
Arm fat percentage (right)	2.3	9.1	19.6	-4.4	-2.3	-2.5	2.2
Trunk fat-free mass	0.2	1.1	2.2	0.1	1.0	1.5	-1.1
Hip circumference	0.9	4.0	11.1	-3.3	-1.4	-1.2	1.2
Time employed in main current job	2.2	2.5	3.7	1.3	1.9	1.7	-1.3
Alcohol intake versus 10 years previously	0.7	1.0	3.1	-1.8	-0.2	-0.1	-1.0
Father’s age at death	0.5	0.7	1.8	1.4	-0.3	-0.8	0.5
Worrier / anxious feelings	6.4	12.0	21.1	-4.6	-2.4	-3.5	3.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.9	-2.4	-0.8	-0.9	1.4
Falls in the last year	0.3	0.4	0.7	-0.4	-0.2	-0.8	0.8
Hair/balding pattern: Pattern 3	1.6	2.3	4.3	-1.1	-1.3	-1.5	2.1
Number of live births	0.0	0.0	0.1	-0.1	0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.4	0.7	-0.1	0.0	0.4
Pulse rate	1.3	2.2	2.8	1.5	1.7	1.5	-1.2
Happiness	1.1	1.3	2.6	0.8	1.6	1.1	-0.9
Noisy workplace	0.7	0.8	1.8	-0.8	-1.3	-0.9	-0.3
Qualifications: A levels/AS levels or equivalent	1.1	2.4	6.8	2.6	1.1	1.0	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.3	1.0	1.0	0.9	-1.1
Mouth/teeth dental problems: Dentures	3.7	6.2	8.4	-2.4	-2.9	-2.3	2.4
Asthma	1.5	3.0	4.6	-2.1	-1.6	-1.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.1	-0.4	-0.2	0.3
Medication: Cholesterol lowering	1.8	2.8	5.0	-1.9	-1.0	-1.3	2.2
Depression (self-reported)	2.3	2.8	3.9	-1.4	-2.0	-1.6	1.6
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.4
Prospective memory result	0.9	1.1	1.7	-0.9	-1.3	-1.2	0.9
Lung cancer (father)	0.8	0.9	3.3	-1.8	-0.1	0.4	0.1
Illnesses of mother	2.0	2.5	6.7	2.6	1.8	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	0.6	-0.7	-0.6	1.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.1	0.3	-0.6	0.8
Impedance of arm (left)	1.1	5.1	7.8	-1.5	-2.8	-1.8	2.6
Arm fat mass (right)	1.2	5.1	13.8	-3.7	-1.7	-1.6	1.2
Trunk predicted mass	0.2	1.1	2.2	0.2	1.0	1.5	-1.1
Standing height	0.1	0.6	2.2	0.3	-0.5	1.5	-0.2
Length of working week for main job	0.4	0.5	0.7	0.6	0.7	0.6	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	-0.3	-0.2	-0.6
Breastfed as a baby	2.4	3.0	5.4	2.3	1.2	1.2	-1.9
Tense / ‘highly strung’	3.3	5.4	12.6	-3.5	-2.2	-1.6	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.9	-1.3	-1.7	-1.0	2.0
Hair/balding pattern: Pattern 4	8.3	20.2	27.2	-4.0	-4.5	-4.2	5.2
Birth weight of first child	3.6	6.5	10.1	2.5	2.6	3.2	-1.7
Peak expiratory flow (PEF)	0.8	1.8	3.0	1.7	1.6	1.1	-0.4
Pulse wave reflection index	4.5	5.5	6.7	-2.3	-2.3	-2.2	2.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	-1.4	-0.1	0.6	0.1
Loud music exposure frequency	0.4	0.4	1.7	-0.2	-0.1	0.3	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	1.1	0.6	0.3	-1.4
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	3.9	-2.0	-1.2	-0.9	2.0
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.1	0.4	0.8	-1.0
Medication: Paracetamol	0.2	0.4	1.0	-0.5	-1.0	-0.5	0.3
Headache pain in last month	0.1	0.2	0.3	0.5	0.5	-0.1	-0.5
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	6.3	2.5	1.2	1.8	-2.2
Glaucoma (self-reported)	3.6	4.2	6.5	-2.5	-1.4	-2.5	1.4
Gout (self-reported)	1.6	2.2	3.2	-1.8	-1.2	-1.8	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.3	-0.3	-0.7	-0.6
Medication: Amlodipine	0.4	0.5	1.8	-0.3	1.3	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.1	-0.7	-1.0	-1.8	0.6
Birth weight	5.0	10.8	14.0	3.2	2.9	3.2	-3.7
Chronic bronchitis/emphysema (mother)	4.0	4.6	5.7	-2.4	-2.4	-1.3	2.4
High blood pressure (siblings)	0.6	0.9	1.9	-0.4	0.8	0.9	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.1	2.4	0.8	-1.0	-0.6	1.6
Body fat percentage	1.8	7.0	16.1	-4.0	-2.2	-2.2	1.6
Leg fat percentage (right)	1.5	5.3	13.3	-3.6	-1.6	-2.1	1.0
Arm fat-free mass (right)	0.2	1.1	2.0	-0.0	0.7	1.4	-1.4
Exposure to tobacco smoke outside home	1.5	2.1	5.6	-2.4	-1.6	-0.3	0.3
Comparative body size at age 10	1.0	2.9	5.4	2.3	1.2	1.6	-1.5
Number of full brothers	0.3	0.4	0.8	-0.4	-0.9	0.2	0.7
Worry too long after embarrassment	0.2	0.4	0.7	-0.6	0.6	0.5	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	5.7	7.3	8.9	-1.9	-2.9	-2.9	3.0
Wheeze or whistling in the chest in last year	1.4	2.5	5.7	-2.4	-1.5	-1.3	0.6
Number of children fathered	4.2	4.7	7.6	2.1	1.3	2.3	-2.8
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.8	0.7	1.1	2.2	-1.7
Age at first live birth	0.6	1.1	2.2	1.5	1.3	0.8	-0.2
Pulse wave peak to peak time	0.3	0.3	0.6	0.0	-0.3	0.8	-0.7
Health satisfaction	1.1	1.4	2.8	-1.5	-0.3	-0.7	1.7
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	0.1	0.6	0.3
Qualifications: College or University degree	3.2	10.0	23.6	4.9	3.1	2.3	-1.4
Eye problems/disorders: None of the above	0.4	0.5	1.3	0.5	-1.1	0.1	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.1	-0.3	-0.3	-0.3	1.8
Emphysema/chronic bronchitis	0.8	0.9	1.0	-0.8	-1.0	-0.8	1.0
Medication for pain relief, constipation, heartburn	1.5	2.6	4.9	2.2	1.6	1.5	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.4	0.2	-0.6	0.2
Medication: Blood pressure	0.3	0.5	1.2	-1.1	0.6	-0.1	0.6
Angina (self-reported)	0.3	0.4	1.0	-1.0	0.2	-0.6	0.2
Migraine (self-reported)	0.5	0.6	1.7	0.5	1.3	0.7	0.0
Medication: Ibuprofen	0.0	0.0	0.1	0.1	-0.3	0.0	0.3
Medication: Allopurinol	1.5	2.0	2.5	-1.6	-1.3	-1.5	1.3
Medication: Omeprazole	2.0	2.4	3.1	-1.8	-1.6	-1.5	1.2
Medication: Seretide 50 evohaler	2.1	2.4	3.3	-1.8	-1.8	-1.7	-0.5
Mean time to correctly identify matches	0.1	0.2	0.5	-0.6	0.1	-0.7	-0.2
Heart disease (mother)	1.1	1.3	2.8	-1.5	-1.7	0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.4	0.5	-0.2	-0.3	-1.2
Whole body fat mass	1.3	5.4	14.5	-3.8	-1.8	-1.5	1.3
Leg fat mass (right)	1.2	4.6	12.9	-3.6	-1.5	-1.5	0.9
Arm predicted mass (right)	0.3	1.4	2.4	0.0	0.8	1.5	-1.5
Pulse rate, automated reading	0.1	0.2	0.5	-0.7	-0.6	-0.2	-0.0
Alcohol intake frequency.	0.6	1.3	4.2	-2.0	-0.6	-0.8	0.4
Comparative height size at age 10	0.2	1.2	4.2	0.6	0.2	2.1	-0.4
Number of full sisters	0.9	1.1	3.3	-1.8	-0.4	0.5	-0.7
Suffer from ‘nerves’	4.5	7.1	10.6	-2.5	-2.3	-3.3	2.5
Overall health rating	4.0	8.6	12.2	-3.5	-2.6	-2.8	2.7
Chest pain or discomfort	0.5	0.7	2.2	-1.5	-0.2	-0.5	0.5
Had major operations	2.2	2.6	4.2	1.8	1.5	2.0	-0.8
Age at last live birth	0.3	0.4	0.9	0.0	0.0	-0.7	1.0
Family relationship satisfaction	0.3	0.4	1.2	0.2	0.4	1.1	0.3
Leg pain on walking	0.3	0.3	1.0	-1.0	-0.3	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	0.6	0.5	0.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.9	2.2	6.1	1.1	0.7	1.0	-2.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	1.7	-1.1	-0.6	-1.3	1.3
Medication: Aspirin	1.3	1.7	2.9	-1.7	-1.1	-1.1	1.3
Supplements: Vitamin C	1.4	1.6	2.6	0.9	0.9	1.6	-1.5
Knee pain experienced in last month	1.7	2.7	4.1	-1.4	-1.5	-1.5	2.0
Hypertension (Self-reported)	3.1	8.7	17.1	-4.1	-2.5	-3.0	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.3	-0.8	-0.4	0.3
Illnesses of father: Heart disease	0.3	0.4	1.1	-1.1	-0.3	-0.7	-0.1
Illnesses of siblings: Diabetes	0.6	0.7	2.6	-1.6	-0.5	0.3	0.1
Smoking status: Previous	1.3	2.0	3.2	1.2	1.3	1.2	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.3	-1.4	-2.1	-0.4	1.6
Whole body fat-free mass	0.1	0.7	1.3	-0.4	0.7	1.1	-0.8
Leg fat-free mass (right)	0.1	0.4	0.8	-0.9	0.3	0.7	-0.3
Arm fat percentage (left)	2.1	8.5	17.2	-4.2	-2.4	-2.5	2.1
Average weekly red wine intake	4.7	7.0	10.3	2.6	3.2	2.5	-2.3
Handedness (chirality/laterality): Left-handed	5.3	6.4	8.8	-1.7	-2.5	-3.0	2.8
Mood swings	2.1	3.8	11.3	-3.4	-1.1	-1.3	1.0
Loneliness, isolation	1.8	2.5	5.8	-2.4	-1.6	-1.2	0.6
Long-standing illness, disability or infirmity	1.6	2.5	3.0	-1.5	-1.3	-1.7	1.7
Ever had bowel cancer screening	0.3	0.4	0.7	0.1	-0.8	-0.6	0.7
Diabetes diagnosed by doctor	0.8	1.3	1.9	-1.4	-1.1	-0.6	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.0	0.3	-0.2	0.1
Friendships satisfaction	1.9	2.3	3.6	1.9	1.6	1.3	-1.1
Qualifications: nursing, teaching	2.7	4.1	5.4	2.3	1.8	2.0	-2.0
Commuting to job workplace: Walk	2.6	2.8	7.0	-0.7	-1.5	-1.2	2.6
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.6	1.0	0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	2.5	1.5	1.1	1.6	0.1
Medication for cholesterol	2.4	3.6	6.6	2.6	1.8	1.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	-0.6	0.5	-0.0	0.1
Back pain experienced in last month	0.4	0.6	0.9	-0.8	-0.8	-0.9	-0.4
Mineral and other dietary supplements	0.4	0.5	1.2	-0.4	-0.6	-1.1	0.7
Breast cancer (self-reported)	0.5	0.6	2.3	-0.5	-1.5	-0.2	-0.0
Asthma (self-reported)	1.6	3.3	4.7	-2.2	-1.7	-1.8	1.5
Osteoporosis (self-reported)	0.2	0.2	0.6	0.0	0.3	0.3	-0.8
Osteoarthritis (self-reported)	0.3	0.3	1.0	-1.0	0.0	-0.3	0.5
Medication: Aspirin	1.4	1.8	3.3	-1.8	-1.0	-1.1	1.4
Medication: Gliclazide	1.9	2.1	3.0	-1.7	-1.5	-0.7	1.6
Illnesses of father: None of the above (group 1)	4.3	5.4	7.7	2.8	2.5	2.3	-1.5
Smoking status: Current	0.0	0.1	0.1	-0.1	-0.4	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-0.9	-0.4	-1.1	0.6
Whole body water mass	0.1	0.5	1.0	-0.5	0.6	1.0	-0.7
Leg predicted mass (right)	0.1	0.3	1.0	-1.0	0.2	0.5	-0.2
Arm fat mass (left)	1.4	5.6	13.8	-3.7	-1.8	-1.7	1.5
Number of self-reported non-cancer illnesses	7.1	12.4	21.4	-4.6	-3.2	-3.0	3.0
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.5	-0.6	-0.8	0.9
Miserableness	0.7	1.1	3.9	-2.0	-0.6	-0.6	0.1
Guilty feelings	3.4	5.1	8.6	-2.9	-2.0	-1.6	2.2
Wears glasses or contact lenses	2.3	2.7	3.9	1.9	1.5	1.0	-2.0
Ever taken oral contraceptive pill	0.7	0.7	1.2	1.1	-0.3	-0.8	1.0
Hearing aid user	0.4	0.5	1.2	0.1	-0.5	-0.6	1.1
Mother’s age at death	1.3	1.6	4.1	2.0	1.1	-0.2	0.9
Financial situation satisfaction	0.1	0.1	0.4	-0.2	-0.6	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.2	0.1	1.0	0.0	-1.1
Commuting to job workplace: Public transport	0.5	0.6	1.1	0.3	1.1	0.0	-1.0
Eye problems/disorders: Glaucoma	2.0	2.4	5.2	-1.9	-0.7	-2.3	0.5
Medication: Blood pressure	3.5	6.7	14.4	-3.8	-2.3	-2.4	1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.5	0.9	0.4	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.1	0.1	0.7	-0.6
High cholesterol (Self-reported)	3.1	5.4	10.8	-3.3	-2.0	-1.9	1.9
Medication: Bendroflumethiazide	0.4	0.6	1.3	-0.8	-0.4	-0.5	-1.1
Medication: Paracetamol	0.1	0.2	0.5	-0.3	-0.7	-0.6	-0.1
Medication: Lisinopril	2.2	2.9	6.2	-2.5	-1.9	-1.2	0.7
Medication: Atorvastatin	1.3	1.6	3.0	-1.7	-1.1	-1.1	1.0
Illnesses of father: High blood pressure	2.8	3.5	4.7	-2.2	-2.2	-1.6	1.4
Alcohol drinker status: Never	3.0	3.6	4.6	-1.8	-2.1	-2.2	1.5
Ever smoked	0.8	1.5	3.7	1.9	1.0	0.7	-0.8
Basal metabolic rate	0.1	0.4	1.3	-1.1	0.2	0.5	-0.3
Leg fat percentage (left)	1.1	3.8	10.0	-3.2	-1.3	-1.7	0.8
Arm fat-free mass (left)	0.1	0.7	1.4	-0.7	0.4	1.2	-0.9
Number of operations (self-reported)	0.2	0.3	0.8	0.9	-0.3	0.6	0.2
Average weekly beer plus cider intake	0.5	0.7	1.4	-1.1	-1.2	0.2	0.1
Irritability	0.7	1.1	3.3	-1.8	-0.7	-0.4	0.7
Risk taking	1.8	2.6	3.2	1.6	1.5	1.8	-1.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.3	-1.5	-0.8	-0.8	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.6	-0.9	0.2	0.2
Age started oral contraceptive pill	0.3	0.4	0.9	0.4	0.7	0.2	-0.9
Diastolic blood pressure, automated reading	3.5	10.7	13.0	-2.8	-3.1	-3.6	3.5
Ever depressed for a whole week	0.3	0.4	0.6	-0.4	-0.8	-0.4	0.8
Unable to work because of sickness or disability	1.3	1.7	2.8	-1.7	-1.4	-1.0	1.1
Commuting to job workplace: Cycle	0.8	0.9	1.4	1.2	1.0	1.2	0.3
Myopia	0.3	0.4	1.0	1.0	-0.7	0.0	0.3
Vascular/heart problems diagnosed by doctor	4.3	11.7	20.4	4.5	3.0	3.4	-2.5
Cholesterol lowering medication	2.6	3.8	6.8	-2.6	-1.9	-2.0	1.0
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	3.6	-1.7	-1.9	-1.6	1.4
Pain experienced in last month	0.6	1.0	3.5	1.9	0.6	0.6	0.3
Supplements: Calcium	0.2	0.2	0.3	0.2	0.6	0.5	-0.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.7	-1.6	-1.3	-0.4	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.3	0.7	0.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	-0.4	0.2	0.7	-0.8
Heart disease (siblings)	1.5	1.9	4.8	-2.2	-1.5	-0.6	0.2
Alcohol drinker status: Previous	0.7	0.8	2.9	-1.7	-0.5	-0.1	-0.1
Pack years of smoking	0.0	0.0	0.1	-0.3	0.1	-0.3	-0.1
Impedance of whole body	0.6	3.1	6.3	-1.0	-2.5	-1.2	1.9
Leg fat mass (left)	1.0	3.9	11.2	-3.4	-1.4	-1.4	0.8
Arm predicted mass (left)	0.2	1.2	2.0	-0.4	1.0	1.4	-1.4