TWAS hub - HSPB7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.185	0.0450	1.3e-15	0.156	0.136	0.145	0.144	0.153	1.4e-18	2.9e-16	2.9e-17	4.0e-17	3.1e-18
2	GTEx	Artery Tibial	0.168	0.0484	3.2e-05	0.105	NA	0.061	NA	0.069	1.4e-08	NA	1.4e-05	NA	4.2e-06
3	GTEx	Cells Transformed fibroblasts	0.099	0.0390	4.1e-04	0.098	NA	0.075	NA	0.075	8.5e-08	NA	2.9e-06	NA	2.9e-06
4	GTEx	Thyroid	0.170	0.0430	2.1e-09	0.122	NA	0.133	NA	0.152	1.5e-09	NA	2.3e-10	NA	9.8e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.182	0.0359	0.0e+00	0.183	0.180	0.202	0.189	0.202	6.6e-23	1.3e-22	2.4e-25	1.1e-23	2.2e-25
6	TCGA	Lung Adenocarcinoma	0.079	0.0301	1.2e-07	0.043	0.050	0.041	NA	0.063	7.2e-06	1.7e-06	1.2e-05	NA	8.1e-08
7	TCGA	Thyroid Carcinoma	0.344	0.0690	0.0e+00	0.420	0.440	0.455	NA	0.447	3.6e-44	8.5e-47	6.7e-49	NA	9.0e-48

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Cardiovascular Disease	7.0	23.0	29.4	-5.4	-0.4	-5.1	-5.2	-5.4	-5.2	-4.6
Ovarian Cancer	6.5	8.5	11.9	3.3	-0.7	2.2	3.4	3.0	3.2	3.5
Multivitamins +/- minerals	6.1	7.7	10.1	3.2	0.2	2.8	3.1	3.2	2.9	2.9
High blood pressure	5.7	15.8	21.5	-4.2	0.2	-3.9	-4.3	-4.6	-4.6	-4.1
Blood Red Count	5.6	53.7	97.6	-7.4	-2.4	-9.3	-7.1	-7.1	-9.9	-5.5
Hypertension (Self-reported)	5.6	15.4	20.3	-4.2	0.2	-3.9	-4.3	-4.5	-4.5	-4.0
Systolic Blood Pressure	5.3	26.6	44.1	-6.0	1.7	-4.4	-5.7	-6.6	-4.9	-5.2
Medication: Lisinopril	5.2	6.8	9.4	-2.6	-0.6	-2.7	-2.8	-3.1	-3.1	-2.5
Handedness (chirality/laterality): Left-handed	4.9	5.9	10.4	-2.8	0.5	-2.2	-2.5	-2.6	-3.2	-2.1
Vascular/heart problems diagnosed by doctor	4.9	13.3	18.1	3.9	-0.8	3.4	4.0	4.2	4.3	3.8
High cholesterol (Self-reported)	4.7	8.3	16.7	-3.0	-0.8	-3.8	-2.6	-3.0	-4.1	-1.3
Cholesterol lowering medication	4.2	6.2	12.5	-2.8	0.8	-2.9	-2.3	-2.6	-3.5	-1.3
Illnesses of mother	4.1	5.1	7.6	2.8	-2.0	2.0	2.4	2.6	2.0	1.8
Long-standing illness, disability or infirmity	3.9	5.9	10.0	-2.8	0.4	-2.5	-2.6	-2.6	-3.2	-2.1
Medication: Blood pressure	3.9	7.4	11.9	-2.7	1.6	-3.0	-2.9	-2.9	-3.4	-2.1
Pulse wave Arterial Stiffness index	3.8	4.4	7.1	-2.7	0.5	-1.0	-2.4	-2.4	-2.3	-2.5
Medication: Blood pressure	3.6	6.4	8.4	-2.7	-1.1	-2.3	-2.7	-2.9	-2.6	-2.9
Medication: Bendroflumethiazide	3.5	5.3	7.3	-2.2	-0.7	-2.2	-2.5	-2.6	-2.4	-2.7
Intelligence (Savage-Jansen 2018)	3.2	9.8	12.8	-3.4	-1.2	-3.6	-3.3	-3.6	-3.4	-2.8
High blood pressure (siblings)	3.2	4.6	6.3	-2.5	1.0	-2.4	-2.3	-2.4	-2.3	-1.9
Medication for cholesterol	3.2	4.9	10.1	2.1	-1.0	2.9	2.2	1.9	3.2	1.1
Allergy or Eczema	3.1	8.2	13.3	-3.6	0.2	-1.4	-3.2	-3.6	-2.4	-3.6
Number of treatments/medications taken	3.1	5.6	9.1	-2.5	-0.8	-2.6	-2.4	-2.7	-3.0	-1.9
Fluid intelligence score	3.0	6.3	10.3	-2.7	-0.2	-2.8	-2.7	-3.2	-2.7	-2.1
Pulse wave peak to peak time	3.0	3.5	5.8	2.4	-0.5	0.8	2.1	2.0	2.2	2.1
Crohns Disease (2017)	2.9	6.3	13.1	2.5	0.5	3.3	2.3	2.4	3.6	1.6
Verbal and Numeric Reasoning (VNR)	2.9	6.9	10.4	-2.8	-0.6	-3.2	-2.7	-3.1	-2.8	-2.1
High blood pressure (mother)	2.8	3.9	5.6	-2.3	0.3	-2.2	-2.0	-2.2	-2.4	-1.5
Medication: Simvastatin	2.8	4.2	9.3	-2.2	-0.4	-1.9	-1.9	-2.3	-3.0	-1.5
Exposure to tobacco smoke at home	2.8	3.2	4.6	2.1	-1.6	1.1	2.0	2.1	1.1	2.1
Happiness	2.7	3.3	4.5	-2.0	1.3	-1.8	-2.1	-1.9	-1.8	-1.6
Number of self-reported non-cancer illnesses	2.7	4.6	10.2	-2.1	0.6	-2.2	-2.1	-2.3	-3.2	-1.6
Systolic blood pressure, automated reading	2.6	7.4	12.8	-3.3	1.1	-1.6	-3.1	-3.6	-2.1	-3.2
Diabetes (mother)	2.6	3.3	4.8	-2.1	0.9	-2.2	-2.0	-1.9	-1.9	-1.3
Average weekly red wine intake	2.6	3.8	7.0	2.0	-0.6	1.2	2.3	2.4	1.6	2.7
Hair/balding pattern: Pattern 3	2.5	3.8	5.9	1.8	2.4	2.0	1.9	1.6	1.8	2.0
Length of working week for main job	2.5	2.7	4.2	1.8	-1.2	1.4	1.9	1.5	2.0	1.5
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	5.6	2.3	0.1	1.9	2.2	2.4	2.2	2.1
Pulse rate, automated reading	2.5	8.1	11.0	-3.2	1.6	-3.0	-3.3	-2.8	-2.6	-3.1
Miserableness	2.5	4.4	8.4	-2.4	-0.2	-1.5	-2.4	-2.9	-1.8	-2.3
Chest pain or discomfort	2.4	3.5	5.8	-2.0	0.5	-2.4	-1.9	-2.1	-2.4	-1.0
Risk taking	2.4	3.5	7.8	1.7	1.6	2.2	1.5	1.7	2.8	1.2
Number of children fathered	2.3	2.6	4.0	2.0	-1.1	1.5	1.8	1.7	1.7	1.3
Heel T-Score	2.2	17.6	32.9	3.8	4.3	3.0	4.1	4.6	3.1	5.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.0	1.8	0.1	1.2	2.0	1.9	1.4	1.8
Commuting to job workplace: Car/motor vehicle	2.2	2.5	4.9	1.6	1.3	2.2	1.4	1.2	2.1	0.7
Diastolic blood pressure, automated reading	2.2	6.7	10.0	-2.9	1.2	-1.6	-3.0	-3.2	-2.3	-3.1
Sitting height	2.1	14.7	21.5	-4.5	1.6	-3.7	-4.5	-4.6	-3.0	-3.9
Forced vital capacity (FVC)	2.1	7.9	12.7	-3.2	-0.4	-3.4	-2.9	-3.6	-3.0	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	7.0	1.9	2.3	2.0	1.9	2.6	2.1	2.4
Illnesses of siblings	2.1	2.9	4.4	2.1	-0.9	1.3	1.9	1.8	1.7	1.9
Fractured/broken bones in last 5 years	2.1	2.7	4.2	-1.8	0.8	-1.8	-1.7	-1.7	-2.1	-1.4
Hand grip strength (left)	2.0	5.2	6.8	2.5	-1.0	2.2	2.6	2.3	2.5	2.5
Time employed in main current job	2.0	2.3	4.2	1.6	-1.1	0.7	1.6	2.0	1.3	1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.2	-1.5	0.4	-1.8	-1.6	-1.6	-2.1	-1.3
Commuting to job workplace: Cycle	2.0	2.4	14.1	0.7	-3.8	-0.2	0.9	0.9	0.1	0.8
Medication: Co-codamol	1.9	2.3	5.7	-1.5	-0.6	-2.4	-1.4	-1.2	-1.9	-0.7
Father’s age at death	1.9	2.6	5.1	1.8	0.7	1.0	1.8	2.2	1.2	1.9
Medication: Allopurinol	1.9	2.5	3.9	1.7	-0.4	1.8	1.7	1.8	2.0	1.1
Eye problems/disorders: Glaucoma	1.9	2.3	4.2	-1.5	-0.3	-1.4	-1.7	-1.5	-1.5	-2.0
Gout (self-reported)	1.8	2.4	3.6	1.7	-0.5	1.9	1.8	1.6	1.6	1.3
Age at last live birth	1.8	2.6	3.6	1.7	0.4	1.5	1.9	1.6	1.8	1.9
Lung FVC	1.7	8.8	19.1	-2.9	-1.3	-4.0	-2.4	-3.0	-4.4	-1.0
Hand grip strength (right)	1.7	4.7	6.1	2.3	-1.2	2.2	2.4	2.2	2.5	2.1
Taking other prescription medications	1.7	2.6	5.3	-1.5	-0.8	-1.9	-1.5	-1.8	-2.3	-1.1
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.3	1.3	1.4	0.3	1.3	1.5	1.3	2.1
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.2	-1.9	1.6	-0.6	-1.9	-2.0	-1.1	-2.0
Medication: Seretide 50 evohaler	1.7	2.0	5.2	-1.2	-1.6	-2.3	-1.0	-1.0	-1.7	-0.4
Alzheimer’s Disease (in father)	1.6	1.7	2.6	1.2	1.2	1.3	1.3	1.6	1.0	1.4
Age at First Birth	1.6	2.4	5.3	1.2	1.0	2.3	1.4	1.4	2.0	0.7
Lung FEV1/FVC ratio	1.6	8.0	15.0	2.7	2.9	3.8	2.2	2.2	3.9	1.0
Financial difficulties in last 2 years	1.6	2.1	11.6	-1.3	3.4	-0.2	-1.0	-0.7	-0.3	-0.3
Prospective memory result	1.6	1.9	3.3	1.7	0.2	1.1	1.6	1.6	0.9	1.8
HbA1C	1.5	1.7	2.5	-0.8	1.3	-1.6	-1.2	-1.6	-1.2	-1.3
Neuroticism	1.5	3.5	7.4	-2.1	-0.7	-0.9	-2.1	-2.7	-1.1	-2.4
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.8	1.9	-1.4	1.1	1.8	2.2	1.7	1.8
Commuting to job workplace: Walk	1.5	1.6	3.9	-1.5	2.0	-0.7	-1.3	-1.3	-0.9	-0.8
Eye problems/disorders: Cataract	1.5	1.7	3.5	1.1	0.6	1.1	1.3	1.4	1.9	1.5
Guilty feelings	1.5	2.3	9.5	-1.0	-3.1	-1.2	-0.7	-0.8	-1.8	-0.3
Past tobacco smoking	1.4	2.5	5.0	-1.6	0.3	-2.2	-1.5	-1.6	-2.1	-0.9
Migraine (self-reported)	1.4	1.8	3.7	-1.0	1.5	-1.9	-1.0	-1.3	-1.7	0.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.7	-0.8	-1.9	-1.6	-1.1	-1.0	-1.1	-1.3
Breast cancer (self-reported)	1.4	1.7	7.3	0.6	2.7	1.1	0.7	1.0	1.0	0.7
Osteoporosis (self-reported)	1.4	1.8	3.0	-1.4	-0.4	-1.2	-1.2	-1.7	-1.7	-1.1
BMI	1.3	7.7	12.4	3.1	-0.2	2.7	3.0	3.5	2.8	2.7
Fed-up feelings	1.3	2.4	3.5	-1.7	1.1	-1.3	-1.9	-1.6	-1.5	-1.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.8	1.2	-0.7	1.9	1.5	1.2	0.7	1.3
Major Depression (MDD)	1.2	1.5	2.9	-1.3	1.7	-0.7	-1.3	-1.4	-1.0	-0.9
Hypothyroidism (self reported)	1.2	2.8	3.8	1.9	-1.4	1.4	1.7	1.9	1.8	1.4
Vitamin and mineral supplements	1.2	1.7	2.5	-1.3	-0.5	-1.3	-1.4	-1.4	-1.3	-1.6
Mood swings	1.2	2.2	4.0	-1.5	2.0	-0.5	-1.6	-1.9	-0.6	-1.5
Hearing aid user	1.2	1.3	2.2	-1.5	-0.3	-1.3	-1.3	-1.0	-1.1	-1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.5	1.6	-0.9	1.0	1.4	1.4	1.0	1.3
Smoking Status	1.1	2.7	4.8	1.8	-0.9	2.2	1.6	1.6	2.0	1.0
Impedance of leg (right)	1.1	5.3	9.5	-2.7	1.5	-2.2	-2.2	-3.1	-2.6	-1.3
Relative age voice broke	1.1	1.7	3.3	1.3	-0.5	1.0	1.5	1.6	0.7	1.8
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.5	-2.1	-0.0	-0.4	-1.7	-2.0	-1.2	-2.1
Body mass index (BMI)	1.1	4.8	8.6	2.6	-1.0	1.8	2.4	2.9	1.9	2.1
Nervous feelings	1.1	2.0	4.3	-1.7	-0.2	-1.0	-1.5	-2.1	-1.4	-1.4
Neuroticism score	1.1	2.3	5.3	-1.8	0.6	-0.5	-1.8	-2.3	-1.0	-1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	7.1	-2.2	0.5	-2.1	-2.0	-2.7	-1.5	-1.5
Forced vital capacity (FVC), Best measure	1.1	4.1	8.4	-2.4	-0.0	-2.3	-2.1	-2.9	-1.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.0	0.9	1.2	1.4	1.0	1.0	0.8	1.1
Back pain experienced in last month	1.1	1.5	2.4	-1.6	1.2	-1.3	-1.4	-1.0	-1.2	-1.0
Average weekly champagne plus white wine intake	1.1	1.6	3.1	1.4	-0.5	0.8	1.6	1.3	1.0	1.8
Neuroticism (Nagel 2018)	1.0	2.3	4.7	-1.8	-1.0	-0.8	-1.7	-2.2	-1.0	-1.6
Mean Putamen Volume	1.0	1.1	2.7	1.0	-0.2	1.6	0.9	1.0	1.4	0.4
Primary Biliary Cirrhosis	1.0	1.4	2.3	1.5	-0.9	0.8	1.4	1.0	1.0	1.3
Pulse rate	1.0	1.7	2.5	-1.3	0.4	-1.5	-1.6	-1.2	-1.3	-1.6
Age at first live birth	1.0	1.7	4.2	1.2	0.5	1.5	1.2	1.3	2.1	0.8
Heart disease (mother)	1.0	1.2	2.7	-1.3	-0.2	-1.6	-1.0	-1.2	-1.2	-0.2
Medication: Aspirin	1.0	1.3	1.8	-1.3	1.3	-0.8	-1.2	-1.3	-0.7	-1.2
Illnesses of father: None of the above (group 1)	1.0	1.2	3.6	-0.8	-1.2	-1.9	-0.9	-0.7	-1.2	-0.6
Financial situation satisfaction	1.0	1.2	1.9	-1.3	1.4	-0.4	-1.3	-1.3	-0.4	-1.1
Ever smoked	1.0	1.8	4.3	1.2	0.4	2.1	1.1	0.9	2.0	0.5
Leg fat percentage (left)	1.0	3.5	5.7	2.2	0.0	1.4	2.2	2.4	1.2	2.3
Depressed Affect (Nagel 2018)	0.9	2.0	3.9	-1.7	-0.0	-0.8	-1.7	-2.0	-0.8	-1.8
Prostate Cancer	0.9	1.3	4.4	-0.9	-2.1	-0.2	-0.9	-1.1	-0.2	-1.3
Ulcerative Colitis	0.9	1.3	2.3	-0.7	-1.5	-1.0	-1.1	-1.1	-0.9	-1.5
Respiratory disease	0.9	1.9	3.3	-1.4	1.1	-1.7	-1.2	-1.4	-1.8	-0.7
Hair Pigment	0.9	25.5	44.4	4.9	4.3	4.5	5.4	5.4	3.7	6.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.4	1.3	1.6	0.9	1.2	1.7	0.7	2.1
Number of full brothers	0.9	1.1	1.7	1.2	0.5	1.0	1.2	1.3	0.6	1.2
Neck or shoulder pain in last month	0.9	1.3	5.0	-1.3	2.2	0.7	-0.7	-0.6	-0.5	-0.7
Arm fat percentage (left)	0.9	3.7	6.7	2.2	0.1	1.5	2.1	2.6	1.4	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.1	-0.5	-1.8	-1.5	-0.6	-0.5	-1.1	-0.3
Medication: Aspirin	0.9	1.2	1.6	-1.2	1.3	-1.0	-1.1	-1.3	-0.5	-0.9
Irritability	0.9	1.5	3.4	-1.4	1.0	-0.3	-1.3	-1.8	-0.5	-1.4
Fasting Glucose	0.8	1.0	1.7	-1.1	1.3	-0.7	-0.7	-1.2	-1.2	-0.5
HDL Cholesterol	0.8	1.4	2.5	-1.1	-1.2	-0.7	-1.2	-1.6	-1.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.8	-1.5	0.6	-1.4	-1.2	-1.4	-1.7	-0.6
Supplements: Zinc	0.8	0.8	2.2	0.6	0.7	0.7	0.8	1.5	0.9	0.9
Maternal smoking around birth	0.8	1.2	2.0	1.1	-0.2	0.4	1.2	1.4	1.4	1.2
Chronic bronchitis/emphysema (father)	0.8	0.9	5.5	0.5	-2.3	-0.6	0.1	0.3	-0.5	0.1
Impedance of arm (right)	0.8	3.9	5.6	-2.4	1.0	-2.3	-2.0	-2.3	-2.3	-0.9
Arm fat percentage (right)	0.8	3.0	5.5	2.0	-0.2	1.3	2.0	2.4	1.2	2.1
Worrier / anxious feelings	0.8	1.5	3.2	-1.7	0.0	-0.9	-1.4	-1.8	-1.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.8	-0.8	-0.6	-1.4	-0.9	-0.9	-1.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.9	0.7	0.5	1.7	0.8	0.6	1.5	0.5
Medication: Cholesterol lowering	0.8	1.2	2.2	-1.5	0.2	-1.0	-1.1	-1.2	-1.4	-0.9
Pulse wave reflection index	0.8	1.0	2.5	-1.2	1.6	0.1	-0.9	-1.2	-0.6	-0.8
Loud music exposure frequency	0.8	0.8	1.6	0.3	1.2	1.1	0.6	0.6	1.1	1.0
Medication: Amlodipine	0.8	1.1	1.7	-0.9	0.0	-1.3	-1.1	-1.2	-1.3	-0.7
Overall health rating	0.8	1.8	4.0	-1.5	0.6	-1.6	-1.2	-1.2	-2.0	-0.6
Medication: Paracetamol	0.8	1.2	1.9	-1.2	0.0	-0.9	-1.3	-1.2	-1.0	-1.4
Medication: Atorvastatin	0.8	1.0	2.8	-1.0	-0.1	-1.7	-0.9	-0.8	-1.3	-0.3
Illnesses of father: High blood pressure	0.8	1.0	2.0	1.2	-0.9	0.1	1.2	0.9	0.5	1.4
Irritable Bowel Disease (IBD)	0.7	1.8	4.5	1.6	-0.6	1.4	1.1	1.2	2.1	0.6
Crohns Disease (2012)	0.7	1.2	3.0	1.1	-0.2	1.6	0.8	0.6	1.7	0.5
Height	0.7	12.6	23.6	-4.3	1.2	-1.5	-4.3	-4.7	-1.4	-4.9
Chronotype (morning person)	0.7	1.6	2.9	-1.3	-0.7	-1.7	-1.1	-1.2	-1.6	-0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.9	0.6	1.1	1.1	0.7	0.6	1.4	0.6
Diabetes (father)	0.7	0.9	2.5	-1.2	0.3	-0.0	-0.9	-1.6	-0.9	-0.7
Townsend deprivation index at recruitment	0.7	1.0	5.0	0.6	2.2	0.0	0.6	0.7	0.2	1.0
Hearing difficulty/problems with background noise	0.7	1.2	5.2	-0.6	2.3	1.5	-0.3	-0.5	0.1	-0.4
Had menopause	0.7	0.9	2.9	-0.9	1.7	-0.4	-0.8	-0.6	-1.0	-0.5
Medication: Ramipril	0.7	0.9	2.1	-0.9	0.9	-0.6	-0.9	-0.8	-1.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.1	-1.2	1.4	-1.0	-1.0	-1.0	-1.2	-0.4
Mouth/teeth dental problems: Dentures	0.7	1.2	2.2	-1.0	-0.3	-1.4	-1.1	-0.9	-1.5	-1.0
Body fat percentage	0.7	2.9	4.8	2.0	0.3	1.4	1.9	2.2	1.3	2.1
Emphysema/chronic bronchitis	0.7	0.8	2.1	-0.9	1.4	-1.1	-0.7	-0.5	-0.9	-0.2
Osteoarthritis (self-reported)	0.7	1.0	3.4	0.7	-0.1	-0.2	1.0	1.3	0.2	1.9
Commuting to job workplace: Public transport	0.7	0.9	2.5	-1.1	1.6	0.1	-0.9	-0.9	-0.6	-0.5
Ever depressed for a whole week	0.7	0.8	2.2	0.8	-1.2	-0.5	0.9	0.7	0.0	1.5
Impedance of whole body	0.7	3.7	5.9	-2.3	1.9	-1.8	-1.8	-2.4	-2.0	-0.8
Average weekly spirits intake	0.6	0.8	1.8	-0.4	1.3	0.9	-0.6	-0.8	0.3	-1.4
Hearing difficulty/problems: Yes	0.6	0.9	2.3	1.0	0.6	1.5	0.8	0.8	1.0	0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.9	-1.1	-0.1	-1.0	-0.7	-0.5	-1.7	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	0.7	1.4	1.1	0.8	0.4	0.6	0.8
Allergy	0.6	1.5	2.6	1.5	-0.5	0.6	1.3	1.6	1.1	1.5
Diabetes (self-reported)	0.6	1.0	4.3	-1.0	2.1	-0.5	-0.6	-0.5	-0.9	0.1
Medication: Lansoprazole	0.6	0.7	3.1	0.3	1.8	0.2	0.5	0.2	0.6	1.1
Tense / ‘highly strung’	0.6	1.1	2.1	-1.3	0.3	-0.7	-1.2	-1.4	-0.7	-1.1
Wheeze or whistling in the chest in last year	0.6	1.1	2.5	1.2	0.6	0.8	1.3	1.0	0.6	1.6
Family relationship satisfaction	0.6	0.7	4.2	-0.3	2.0	0.6	-0.3	-0.3	0.2	-0.4
Arm fat mass (left)	0.6	2.3	4.3	1.8	-0.2	1.4	1.6	2.1	1.6	1.4
Leg fat mass (left)	0.6	2.4	4.1	1.9	-0.3	1.4	1.7	2.0	1.4	1.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.0	0.7	-1.4	-0.5	0.6	0.8	-0.2	1.1
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-1.2	0.5	-0.4	-0.5	-0.7	-1.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	-0.8	0.5	-0.5	-0.7	-0.8	-1.2	-0.1
Relative age of first facial hair	0.5	1.0	2.1	-1.1	0.9	-0.8	-1.0	-1.2	-1.5	-0.4
Trunk fat percentage	0.5	2.1	3.3	1.7	0.2	1.0	1.6	1.8	1.2	1.8
Average weekly fortified wine intake	0.5	0.6	2.0	-0.5	1.4	0.7	-0.5	-0.3	0.2	-1.0
Age when periods started (menarche)	0.5	1.1	2.0	-1.1	-1.4	-0.7	-1.1	-0.8	-1.0	-1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.6	1.3	0.2	0.3	0.9	0.6	1.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.7	2.2	-0.4	1.5	-0.3	-0.7	-0.4	-0.7	-1.0
Impedance of leg (left)	0.5	2.3	4.9	-1.9	1.1	-1.2	-1.3	-2.2	-1.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.8	-0.6	1.9	0.2	-0.5	-0.7	0.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.6	-1.0	-0.2	-0.5	-0.8	-0.7	-1.3	-0.9
Alcohol intake versus 10 years previously	0.5	0.8	2.7	-0.4	0.3	-1.5	-0.4	-0.1	-1.6	0.2
Asthma	0.5	1.0	2.9	-0.7	-0.4	-1.6	-0.7	-0.7	-1.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.6	-1.5	0.5	-1.3	-1.3	-2.1	-0.7	-0.8
Impedance of arm (left)	0.5	2.2	3.4	-1.7	1.8	-1.5	-1.4	-1.7	-1.5	-0.3
Standing height	0.5	4.9	10.2	-2.5	1.1	-0.6	-2.7	-3.0	-0.2	-3.2
Leg fat percentage (right)	0.5	1.9	3.5	1.7	0.2	0.8	1.6	1.8	0.6	1.9
Whole body fat mass	0.5	2.2	3.7	1.8	0.2	1.3	1.6	1.9	1.5	1.4
Leg fat mass (right)	0.5	2.0	3.6	1.7	-0.1	1.2	1.6	1.9	1.2	1.4
Alcohol intake frequency.	0.5	1.2	3.0	0.4	1.6	-1.0	0.5	1.0	-0.7	1.7
Had major operations	0.5	0.6	1.3	0.6	-1.1	1.1	0.7	0.5	0.9	0.3
Illnesses of father: Heart disease	0.5	0.7	2.2	0.3	1.0	1.5	0.7	0.5	0.8	0.5
Smoking status: Previous	0.5	0.7	1.5	0.8	-0.8	1.2	0.7	0.8	1.0	0.3
Diabetes diagnosed by doctor	0.5	0.7	3.6	-0.7	1.9	-0.5	-0.3	-0.2	-0.8	0.4
Mineral and other dietary supplements	0.5	0.7	1.1	-1.1	0.4	-0.6	-0.9	-1.0	-0.6	-0.9
Asthma (self-reported)	0.5	0.9	2.5	-0.7	-0.2	-1.6	-0.6	-0.7	-1.6	-0.2
Smoking status: Current	0.5	0.8	1.5	1.0	0.5	1.1	0.9	0.6	1.2	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.7	0.7	0.4	0.8	0.8	0.9	0.7	0.8
Age started oral contraceptive pill	0.5	0.6	1.1	-0.8	1.1	-0.7	-0.8	-0.1	-0.8	-0.8
Reaction Time	0.4	0.7	2.0	0.7	1.4	0.8	0.5	1.1	0.7	0.1
Schizophrenia (2014)	0.4	0.9	2.3	0.8	0.5	1.0	0.9	0.9	1.5	0.9
Blood White Count	0.4	2.8	6.0	-1.3	-1.8	-2.1	-1.3	-1.4	-2.5	-0.5
Waist Hip Ratio (WHR)	0.4	1.7	4.0	-1.4	-1.0	-0.8	-1.1	-1.6	-2.0	-0.9
Medication: Atenolol	0.4	0.5	0.9	-0.6	-0.0	-0.8	-0.8	-0.5	-1.0	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.4	0.9	-0.6	0.4	0.9	1.2	0.7	0.9
Trunk fat mass	0.4	1.7	2.6	1.5	0.2	1.1	1.3	1.6	1.4	1.3
Number of incorrect matches in round	0.4	0.7	1.1	-1.0	-0.2	-0.5	-0.9	-0.8	-0.9	-1.0
Arm fat mass (right)	0.4	1.8	3.6	1.6	-0.5	1.1	1.4	1.9	1.3	1.2
Birth weight of first child	0.4	0.7	1.9	0.7	-1.4	0.7	0.7	0.8	0.8	0.1
Peak expiratory flow (PEF)	0.4	1.0	2.9	0.5	1.7	0.8	0.7	0.3	1.3	1.0
Birth weight	0.4	0.8	2.0	0.5	0.9	1.1	0.6	0.6	1.4	0.5
Exposure to tobacco smoke outside home	0.4	0.5	2.2	-0.4	-0.0	-1.5	-0.6	-0.2	-0.9	-0.0
Shortness of breath walking on level ground	0.4	0.5	2.7	-0.0	1.6	-0.6	-0.0	0.2	-0.5	0.4
Medication: Ibuprofen	0.4	0.5	2.0	0.4	0.0	1.4	0.6	0.2	1.0	0.3
Mean time to correctly identify matches	0.4	0.7	3.8	-0.2	1.9	0.7	-0.2	0.3	0.1	-0.5
Leg pain on walking	0.4	0.5	0.9	-0.8	-0.4	-0.8	-0.7	-0.4	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.4	-1.0	0.8	-0.4	-1.1	-1.2	-0.2	-1.0
Loneliness, isolation	0.4	0.6	2.5	0.4	1.6	0.5	0.4	0.4	0.7	0.7
Ever had bowel cancer screening	0.4	0.5	1.3	0.7	-1.1	0.3	0.7	0.8	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.0	-0.6	0.4	-1.3	-0.5	-1.4	-1.2	0.2
Myopia	0.4	0.6	1.9	-0.1	-0.5	-1.4	-0.0	0.0	-1.1	1.0
Heart disease (siblings)	0.4	0.5	1.3	-0.6	-0.2	0.1	-0.8	-1.0	0.2	-1.1
Bipolar Disorder (2018)	0.3	0.5	0.9	0.7	-0.2	0.9	0.7	0.7	0.9	0.7
Breast Cancer	0.3	0.6	1.8	0.7	-1.3	-0.2	0.7	0.7	0.7	0.6
Triglycerides	0.3	0.4	2.1	-0.4	1.4	-0.3	-0.2	-0.2	-0.7	0.4
Current tobacco smoking	0.3	0.4	0.8	0.7	0.4	0.8	0.7	0.4	0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.1	-0.6	1.1	0.5	-0.4	-0.4	0.4	-0.6
Supplements: Glucosamine	0.3	0.4	0.8	0.9	-0.7	0.5	0.7	0.6	0.6	0.3
Had other major operations	0.3	0.4	1.2	0.6	0.8	-0.1	0.7	0.5	-0.0	1.1
Mouth/teeth dental problems	0.3	0.5	1.8	0.6	0.7	0.4	0.6	0.6	1.3	0.5
Weight	0.3	1.5	2.7	1.3	-0.3	1.4	1.1	1.5	1.7	0.6
Falls in the last year	0.3	0.4	1.2	-0.6	1.1	-0.1	-0.5	-0.8	-0.2	-0.5
Lung cancer (father)	0.3	0.3	1.4	-0.4	1.2	-0.1	-0.5	-0.6	-0.1	-0.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	1.1	-1.0	0.2	0.7	1.0	1.1	0.4
Arm fat-free mass (right)	0.3	1.6	4.6	1.2	-0.4	1.7	0.8	1.1	2.1	-0.2
Comparative body size at age 10	0.3	0.8	1.7	1.3	-0.6	0.6	1.0	1.1	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-1.0	-0.5	0.4	-0.3	-0.6	0.9
Health satisfaction	0.3	0.4	2.0	-0.3	1.4	-0.0	-0.2	-0.4	-0.5	0.1
Arm predicted mass (right)	0.3	1.7	4.6	1.3	-0.5	1.8	0.9	1.2	2.1	-0.1
Comparative height size at age 10	0.3	1.9	6.5	-1.0	2.5	1.1	-0.8	-0.7	1.3	-1.3
Number of full sisters	0.3	0.3	1.5	0.4	-1.2	-0.3	0.3	0.5	0.1	0.3
Supplements: Vitamin C	0.3	0.3	0.6	-0.7	0.2	-0.2	-0.8	-0.7	-0.5	-0.7
Leg fat-free mass (right)	0.3	1.6	4.1	1.3	-0.9	1.4	0.8	1.3	2.0	0.1
Friendships satisfaction	0.3	0.3	1.5	-0.2	1.2	0.1	-0.5	-0.1	-0.3	-0.6
Leg predicted mass (right)	0.3	1.7	4.4	1.4	-0.9	1.4	0.9	1.3	2.1	0.1
Mother’s age at death	0.3	0.4	1.0	0.7	-1.0	0.6	0.7	0.3	0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.6	0.6	-1.1	-0.7	-0.1	-0.5	-0.5
Alcohol drinker status: Never	0.3	0.4	1.1	0.3	1.0	-0.1	0.4	0.6	0.6	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.6	-0.2	1.3	0.4	-0.1	0.4	0.0	-0.3
Supplements: Calcium	0.3	0.3	0.5	-0.7	0.6	-0.4	-0.7	-0.3	-0.5	-0.5
Worry (Nagel 2018)	0.2	0.3	0.9	-0.6	-0.7	0.3	-0.4	-0.9	0.2	-0.5
Blood Eosinophil Count	0.2	1.6	2.1	-1.2	-1.5	-1.2	-1.3	-1.4	-1.3	-0.8
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.5	0.8	0.2	-0.7	-1.0	-0.2	-0.6
Medication for hormone replacement therapy	0.2	0.2	0.9	-0.1	0.1	-0.7	-0.0	0.0	-0.9	0.5
Medication: Metformin	0.2	0.2	0.5	-0.5	0.6	-0.3	-0.2	-0.6	-0.7	0.2
Leg fat-free mass (left)	0.2	0.8	2.6	0.9	-0.6	1.0	0.4	0.9	1.6	-0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.2	0.4	0.5	0.5	0.4	0.5	0.7
Leg predicted mass (left)	0.2	1.1	3.1	1.1	-0.6	1.1	0.6	1.1	1.8	-0.1
Waist circumference	0.2	0.6	1.0	0.9	-1.0	0.5	0.8	1.0	0.3	0.6
Pain all over the body in last month	0.2	0.2	1.0	-0.0	1.0	-0.4	0.0	-0.0	-0.6	0.4
Hip circumference	0.2	1.0	2.1	1.3	-0.8	0.5	1.0	1.4	1.0	0.8
Noisy workplace	0.2	0.2	1.5	0.1	-1.2	-0.2	-0.1	0.3	-0.1	-0.2
Breastfed as a baby	0.2	0.2	0.6	-0.4	0.5	-0.3	-0.5	0.0	-0.6	-0.7
Medication: Paracetamol	0.2	0.3	0.4	-0.6	0.1	-0.4	-0.7	-0.5	-0.7	-0.5
Headache pain in last month	0.2	0.4	1.7	0.3	-0.3	-0.6	0.4	0.5	-0.1	1.3
Glaucoma (self-reported)	0.2	0.3	1.1	-0.1	0.1	-0.1	-0.5	-0.4	-0.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.2	-0.8	-0.7	0.1	0.2	-0.5	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.0	0.1	1.0	-0.1	0.1	0.5	0.0	0.1
Worry too long after embarrassment	0.2	0.3	1.0	-0.4	-0.9	0.2	-0.2	-1.0	-0.1	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.5	-0.9	-0.2	0.6	0.5	0.2	0.8
Suffer from ‘nerves’	0.2	0.4	1.5	-0.2	1.2	0.9	0.0	-0.5	0.1	-0.1
Knee pain experienced in last month	0.2	0.3	0.4	-0.5	-0.7	-0.5	-0.6	-0.2	-0.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	0.3	-0.1	-0.9	0.1	0.1	-0.5	0.7
Whole body fat-free mass	0.2	0.9	2.9	0.7	-0.5	1.3	0.2	0.7	1.7	-0.7
Medication: Gliclazide	0.2	0.2	0.4	-0.4	0.6	-0.5	-0.4	-0.3	-0.5	-0.2
Whole body water mass	0.2	1.1	3.5	0.9	-0.5	1.4	0.4	0.8	1.9	-0.5
Wears glasses or contact lenses	0.2	0.3	1.4	-0.5	1.2	0.2	-0.1	0.3	-0.3	0.2
Basal metabolic rate	0.2	1.0	3.1	0.9	-0.4	1.4	0.5	0.9	1.8	-0.4
Arm fat-free mass (left)	0.2	1.2	3.3	1.0	-0.7	1.4	0.6	0.9	1.8	-0.4
Pain experienced in last month	0.2	0.3	0.8	-0.3	-0.1	-0.2	-0.6	-0.6	-0.0	-0.9
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.3	0.4	0.8	0.4	0.1	0.5	0.2
Alcohol drinker status: Previous	0.2	0.2	0.4	0.1	0.6	-0.5	0.2	0.2	-0.5	0.6
Arm predicted mass (left)	0.2	1.2	3.2	1.0	-0.8	1.4	0.6	1.0	1.8	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	1.0	0.0	0.1	0.8	0.2	0.1	1.0	0.1
Depression (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.3	0.2	-0.3	-0.6	0.4	-0.7
Schizophrenia (2018)	0.1	0.1	0.3	-0.5	0.3	0.3	-0.3	-0.4	0.2	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.3	-0.5	0.2	0.2	0.5	0.5	-0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.1	-0.3	-0.4	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.2	0.6	0.1	0.3	0.3	0.1	0.6
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.3	-0.7	-0.4	-0.2	-0.0	0.4	-0.5
Lupus	0.1	0.2	0.3	0.2	0.5	0.1	0.4	0.6	0.4	0.5
Neuroticism (2016)	0.1	0.2	0.7	-0.4	0.9	0.2	-0.2	-0.6	-0.2	0.1
Rheumatoid Arthritis	0.1	0.2	0.4	-0.4	0.6	0.1	-0.3	-0.5	0.0	-0.5
Tanning	0.1	1.4	3.0	1.4	-1.2	0.5	1.0	1.4	1.7	0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.3	0.6	-0.6	-0.1	-0.2	-0.3	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.2	0.3	-0.5	-0.3	-0.2	0.1	-0.2
Angina	0.1	0.2	0.7	-0.4	0.8	0.3	-0.3	-0.5	-0.1	-0.4
Pack years adult smoking proportion	0.1	0.2	0.5	0.2	0.5	0.4	-0.0	-0.1	0.7	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.0	-0.4	-0.6	-0.1	-0.5	-0.5	0.2
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.2	0.4	0.5	0.3	-0.1	0.4	0.3
Alcohol usually taken with meals	0.1	0.1	0.6	-0.2	0.0	-0.8	-0.0	-0.0	-0.3	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	0.4	-0.3	0.5	0.5	-0.0	0.2	0.7
Qualifications: None of the above	0.1	0.3	0.8	-0.4	-0.6	-0.8	-0.2	0.2	-0.9	0.0
Heart attack	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.2	-0.2	-0.3	-0.3
Trunk fat-free mass	0.1	0.7	2.0	0.2	-0.2	1.2	-0.2	0.2	1.4	-1.2
Number of live births	0.1	0.1	0.5	0.3	-0.7	0.3	0.2	0.1	0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	-0.4	-0.1	0.8	-0.2	-0.5	0.4	-0.5
Depression (self-reported)	0.1	0.1	0.6	-0.4	0.0	-0.2	-0.3	-0.8	-0.2	-0.2
Trunk predicted mass	0.1	0.7	1.9	0.2	-0.1	1.2	-0.2	0.1	1.4	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.6	-0.0	0.1	0.8	0.1	-0.3	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.0	0.0	-0.4	0.0	-0.6	0.0	0.3
Blood clot in the leg (DVT)	0.1	0.2	0.9	-0.1	0.9	0.2	-0.2	-0.1	-0.1	-0.4
Qualifications: College or University degree	0.1	0.2	0.8	-0.4	-0.3	0.1	-0.3	-0.9	0.3	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.3	-0.3	-0.2	0.2	0.5	-0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.7	0.2	0.8	0.2	-0.0	0.1	0.1	-0.3
Angina (self-reported)	0.1	0.2	0.3	-0.5	0.5	0.2	-0.3	-0.6	-0.5	-0.4
Medication: Omeprazole	0.1	0.2	0.7	-0.4	-0.0	-0.4	-0.3	-0.1	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.3	0.7	-0.1	0.1	0.0	-0.3	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.4	0.6	-0.1	-0.2	0.4	-0.4	0.1
Qualifications: nursing, teaching	0.1	0.2	0.3	0.4	0.5	0.6	0.3	0.4	0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.2	-0.5	0.2	0.4	0.3	-0.0	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.6	-0.2	-0.1	0.4	0.1	0.1	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	-0.5	-0.1	0.2	-0.4	0.1	-0.6	-0.6
Number of operations (self-reported)	0.1	0.2	0.4	-0.1	-0.6	-0.6	-0.0	-0.4	-0.5	0.5
Unable to work because of sickness or disability	0.1	0.2	1.1	-0.2	1.1	-0.0	0.0	0.1	-0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	1.1	-0.0	1.0	0.2	-0.2	0.0	-0.1	-0.3
Pack years of smoking	0.1	0.2	0.6	0.4	0.6	0.6	0.1	0.1	0.8	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.1	-0.1	0.0	0.0
LDL Cholesterol	0.0	0.0	0.1	0.2	-0.3	0.1	0.1	-0.0	-0.2	0.2
Blood Platelet Count	0.0	0.1	0.2	-0.4	0.4	-0.2	-0.2	0.0	-0.1	-0.0
Severe depression (siblings)	0.0	0.0	0.1	-0.2	0.0	0.1	0.0	-0.1	0.3	0.1
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	-0.2	-0.2	-0.4	-0.2	-0.1	-0.1	-0.4
Average weekly beer plus cider intake	0.0	0.1	0.2	0.1	-0.5	0.3	0.1	0.0	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.3	0.1	-0.6	-0.2	0.1	0.1	0.0	-0.1

Hub : Genes

HSPB7

Models

Trait associations