Hub : Genes

CLCNKA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1576	0.0337	0.0e+00	0.179	0.169	0.211	0.198	0.210	2.2e-22	3.7e-21	1.4e-26	7.6e-25	1.8e-26
2	TCGA	Breast Invasive Carcinoma	0.0747	0.0307	2.4e-08	0.026	0.051	0.051	NA	0.039	3.5e-06	1.1e-10	9.7e-11	NA	1.6e-08
3	TCGA	Colon Adenocarcinoma	0.0580	0.0310	5.9e-03	0.017	0.028	0.025	NA	0.017	3.3e-02	9.8e-03	1.3e-02	NA	3.3e-02
4	TCGA	Brain Lower Grade Glioma	0.0218	0.0116	5.9e-03	0.015	0.010	0.008	NA	0.009	6.6e-03	2.3e-02	3.6e-02	NA	2.9e-02
5	TCGA	Prostate Adenocarcinoma	0.2238	0.0534	0.0e+00	0.284	0.275	0.273	NA	0.284	6.8e-30	7.6e-29	1.3e-28	NA	7.8e-30
6	TCGA	Testicular Germ Cell Tumors	0.2130	0.0710	3.5e-06	0.144	0.182	0.178	NA	0.147	9.1e-06	5.1e-07	7.0e-07	NA	7.0e-06
7	TCGA	Thyroid Carcinoma	0.0860	0.0310	9.4e-09	0.108	0.088	0.092	NA	0.098	1.1e-10	6.5e-09	2.9e-09	NA	9.2e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	0.9	0.8	-0.9	-0.5	0.9	-0.6	0.6	0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.3	0.5	0.8	0.3	0.4	0.4	0.2	1.1
Depressed Affect (Nagel 2018)	1.4	2.9	5.5	-1.5	2.0	1.3	-1.8	2.4	-1.6	-1.1
Depression (Nagel 2018)	0.1	0.2	0.6	-0.0	0.5	0.7	-0.1	0.8	-0.0	0.4
Intelligence (Savage-Jansen 2018)	2.9	9.0	13.0	-3.3	1.8	3.6	-2.9	3.1	-3.2	-2.7
Neuroticism (Nagel 2018)	1.5	3.5	7.0	-1.4	1.7	2.1	-1.7	2.7	-2.1	-0.7
Schizophrenia (2018)	0.4	0.7	2.8	-0.1	1.7	0.8	-0.1	0.9	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.1	0.2	0.9	0.2	0.0	-0.1	0.2	-0.2	1.0	0.3
Worry (Nagel 2018)	0.6	1.2	2.6	-0.1	1.3	1.6	-0.3	1.4	-1.2	0.7
Alzheimer’s Disease (in mother)	0.1	0.2	0.7	-0.2	0.3	0.3	0.2	0.3	-0.8	0.2
Alzheimer’s Disease (in father)	2.1	2.3	3.9	1.2	-1.7	-2.0	1.4	-1.8	1.6	0.7
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.2	-0.6	-0.4	0.6	-0.4	-0.1	0.2
Crohns Disease (2017)	1.8	3.9	5.9	2.4	-1.1	-2.2	1.9	-1.4	2.1	2.2
Irritable Bowel Disease (IBD)	0.4	1.1	2.1	1.1	-1.1	-1.2	0.6	-0.5	1.4	0.9
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.3	-0.8	-0.5	-0.7	0.3	0.7	-0.6
Major Depression (MDD)	1.4	1.7	4.0	-1.2	1.3	0.7	-1.0	1.3	-2.0	-1.2
Reaction Time	0.6	1.2	3.3	0.2	-1.4	-1.8	0.2	-1.1	1.3	-0.4
Verbal and Numeric Reasoning (VNR)	2.4	5.8	7.1	-2.6	1.9	2.7	-2.3	2.6	-2.6	-2.1
Breast Cancer	0.7	1.6	4.3	0.7	-1.9	-0.6	0.7	-1.2	2.1	0.5
Ovarian Cancer	7.6	10.1	12.8	3.3	-3.1	-2.8	3.5	-3.6	3.1	2.7
Prostate Cancer	1.4	1.9	7.2	-0.6	0.9	2.7	-0.6	1.5	-1.6	0.1
Age at First Birth	1.4	2.0	4.4	1.6	0.5	-1.4	1.1	-0.7	1.8	2.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	5.6	0.5	-2.4	-0.3	0.9	-1.3	0.5	-0.0
Coronary Artery Disease (CAD)	0.6	0.7	1.7	-0.4	1.2	1.3	0.2	0.4	-1.2	0.6
Crohns Disease (2012)	0.3	0.5	1.3	1.0	0.6	-0.4	0.5	0.1	0.4	1.2
Mean Putamen Volume	0.5	0.6	1.3	1.0	-0.0	-0.5	0.7	-0.2	0.9	1.1
Fasting Glucose	0.7	0.9	2.3	-0.7	1.5	0.7	-0.9	0.9	-1.1	-0.1
HbA1C	2.3	2.5	7.0	-1.7	0.9	0.2	-1.8	1.7	-0.7	-2.7
HDL Cholesterol	1.3	2.1	4.0	-1.1	1.4	2.0	-1.2	1.7	-1.5	-0.8
LDL Cholesterol	0.0	0.0	0.1	0.0	0.3	0.1	-0.1	-0.1	-0.1	-0.0
Lupus	0.2	0.3	1.0	0.5	0.3	-0.1	0.8	-0.4	0.5	1.0
Neuroticism (2016)	0.9	1.3	5.3	-0.2	2.3	0.6	-0.1	1.0	-1.5	0.5
Primary Biliary Cirrhosis	0.7	1.0	2.1	1.4	0.1	-0.3	1.1	-0.8	0.9	1.4
Rheumatoid Arthritis	0.4	0.5	2.4	-0.3	1.5	0.3	-0.2	0.7	-0.5	0.1
Schizophrenia (2014)	0.4	0.9	2.6	1.1	0.2	-0.4	1.2	-0.5	0.7	1.6
Triglycerides	0.1	0.2	1.3	-0.2	0.3	-0.3	0.2	-0.0	-1.1	0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.4	-0.4	1.3	0.8	-0.4	0.7	-1.9	0.0
Ulcerative Colitis	0.9	1.3	2.2	-1.2	0.6	1.4	-1.4	1.5	-0.6	-0.9
Blood Eosinophil Count	0.3	2.0	4.3	-1.4	-0.6	1.9	-0.7	1.4	-2.1	-1.2
Blood Platelet Count	0.0	0.1	0.3	-0.1	-0.5	-0.0	0.0	-0.1	0.2	-0.1
Blood Red Count	4.0	38.2	56.4	-7.5	3.4	6.4	-6.4	5.5	-6.5	-6.7
Blood White Count	0.3	2.0	4.1	-1.5	-0.5	1.9	-0.8	0.9	-2.0	-1.5
Heel T-Score	2.6	20.9	40.8	4.3	-2.6	-6.4	5.0	-5.2	3.8	3.5
BMI	1.4	8.2	11.6	3.2	-2.1	-2.7	2.9	-2.5	3.4	3.0
Height	0.9	17.2	31.7	-4.0	4.4	3.2	-4.5	5.6	-3.9	-2.8
Waist Hip Ratio (WHR)	0.8	3.7	9.3	-1.1	3.0	2.3	-1.1	2.0	-2.2	0.0
Systolic Blood Pressure	6.3	31.5	39.3	-5.6	6.3	4.8	-5.5	6.0	-6.2	-4.6
Smoking Status	0.6	1.4	3.5	1.8	0.7	-0.3	1.3	-0.6	0.9	1.9
Allergy or Eczema	4.9	12.9	20.0	-3.0	4.2	4.5	-2.8	3.9	-4.2	-1.7
Cardiovascular Disease	6.7	22.2	26.8	-5.2	3.5	4.6	-4.8	5.1	-5.1	-4.5
Hypothyroidism (self reported)	1.2	2.8	4.4	1.6	-2.1	-0.8	2.1	-1.5	1.5	1.8
Respiratory disease	0.5	1.1	2.2	-1.2	1.0	0.5	-1.1	0.7	-1.1	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	-1.0	0.7	1.1	-0.6	0.8	-1.3	-0.5
Lung FEV1/FVC ratio	0.9	4.8	12.7	2.2	0.8	-3.6	0.9	-1.5	3.1	1.6
Lung FVC	1.0	5.1	9.7	-2.8	0.6	3.0	-1.6	1.5	-3.1	-2.1
Neuroticism	2.7	6.6	11.4	-1.9	3.2	2.7	-2.4	3.4	-2.6	-1.0
Chronotype (morning person)	0.3	0.8	1.7	-1.3	-0.0	1.1	-0.9	1.0	-0.2	-0.6
Hair Pigment	1.0	29.2	51.1	5.3	-3.7	-7.2	6.1	-6.8	3.7	3.7
Tanning	0.2	1.9	5.4	1.0	-1.9	-1.2	0.8	-1.0	2.3	0.7
Hand grip strength (left)	1.8	4.7	8.2	2.6	-1.1	-1.6	2.4	-1.9	2.2	2.9
Number of treatments/medications taken	3.0	5.3	7.5	-2.4	1.6	2.4	-2.3	2.3	-2.7	-2.3
Average weekly spirits intake	1.1	1.3	4.2	-0.6	2.0	0.1	-1.3	1.3	-0.8	-0.8
Sensitivity / hurt feelings	0.7	1.2	2.7	-0.7	1.2	0.1	-1.0	1.3	-1.6	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.2	-0.4	-0.1	0.3	-0.3	-0.5	-0.5
Hearing difficulty/problems: Yes	0.5	0.7	2.1	1.0	1.5	-0.3	0.7	-0.1	-0.5	1.0
Relative age of first facial hair	0.6	1.2	2.7	-1.1	1.7	0.4	-0.8	1.1	-1.4	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	-0.7	0.6	1.3	-0.0	0.5	-1.3	0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.4	0.8	1.6	-0.8	0.7	-0.3	-0.4	1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.4	-0.1	-0.2	-0.3	0.3	-0.3	-0.6
Systolic blood pressure, automated reading	3.7	10.6	17.4	-2.9	4.2	2.7	-3.2	3.7	-3.5	-2.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.7	0.9	0.1	-1.0	0.9	-0.3	1.0	1.3
Angina	0.0	0.1	0.2	-0.1	0.4	0.0	-0.2	0.3	0.1	0.1
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.2	-0.2	-0.0	0.5	-0.5	-0.2	0.2
Vitamin and mineral supplements	1.2	1.7	3.0	-1.4	0.9	1.7	-1.3	1.3	-1.1	-1.0
Supplements: Zinc	1.2	1.3	3.2	0.8	-1.8	-1.2	1.3	-1.4	0.6	0.5
Medication: Co-codamol	0.9	1.0	1.8	-1.3	-0.0	1.3	-0.8	0.8	-1.0	-1.0
Medication: Metformin	0.5	0.7	2.8	-0.1	1.7	0.5	0.3	0.3	-1.0	0.6
Diabetes (father)	1.9	2.4	5.0	-0.6	2.2	1.9	-0.6	1.6	-2.1	0.5
Diabetes (mother)	1.8	2.3	3.4	-1.8	1.5	1.1	-1.4	1.4	-1.7	-1.6
Severe depression (siblings)	0.1	0.1	0.4	0.3	-0.6	-0.0	0.2	-0.1	0.6	0.3
Pack years adult smoking proportion	0.1	0.1	0.2	0.1	0.5	-0.0	-0.4	0.4	-0.0	-0.3
Impedance of leg (right)	1.5	7.0	15.3	-2.1	3.9	2.1	-1.8	2.2	-3.8	-1.6
Leg fat-free mass (left)	0.1	0.7	2.2	0.5	-1.4	-0.8	-0.0	0.0	1.5	0.0
Trunk fat percentage	0.5	2.0	3.1	1.7	-0.4	-1.7	1.6	-1.5	1.2	1.3
Hand grip strength (right)	1.7	4.5	8.4	2.4	-1.0	-1.5	2.3	-1.7	2.5	2.9
Townsend deprivation index at recruitment	0.7	1.0	3.8	0.6	-0.1	-2.0	0.5	-1.4	0.6	-0.3
Current tobacco smoking	0.2	0.4	0.7	0.8	0.6	-0.3	0.8	-0.5	0.3	0.8
Average weekly fortified wine intake	0.6	0.7	3.4	-0.4	1.9	-0.2	-0.8	0.9	-0.3	-0.2
Maternal smoking around birth	1.2	1.7	2.9	1.3	-0.6	-1.0	1.5	-1.3	1.7	1.5
Fed-up feelings	1.5	2.8	5.6	-1.8	1.3	0.2	-2.0	1.7	-1.5	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.6	-0.1	1.3	0.2	-0.2	0.6	-0.3	0.2
Relative age voice broke	1.3	2.0	3.7	1.4	-0.2	-1.0	1.9	-1.6	1.1	1.8
Taking other prescription medications	2.3	3.5	6.0	-1.7	2.3	2.1	-1.4	1.6	-2.4	-1.3
Age when periods started (menarche)	0.4	0.9	3.3	-1.0	-0.2	1.8	-0.6	0.9	-0.7	-0.4
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	6.3	1.2	-1.2	-2.5	1.5	-1.7	1.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	7.7	1.3	-1.4	-2.8	1.6	-2.1	1.1	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.2	-0.4	0.1	0.0	0.1	-0.6	-0.3
Qualifications: CSEs or equivalent	0.8	1.0	3.3	0.7	-0.7	-1.8	0.3	-0.8	1.4	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.7	0.5	-0.5	0.7	-0.3	0.7	1.1
High blood pressure	6.1	16.9	20.2	-4.5	3.6	3.4	-4.5	4.3	-4.3	-4.1
Hayfever, allergic rhinitis or eczema	2.2	4.7	8.8	-1.6	3.0	2.9	-1.4	2.3	-2.4	-0.6
Multivitamins +/- minerals	6.8	8.6	11.1	3.0	-2.6	-3.3	2.8	-3.3	3.1	2.2
Stomach or abdominal pain in last month	0.5	0.6	2.5	0.4	1.6	-0.0	0.5	0.4	-0.6	1.0
Supplements: Glucosamine	0.3	0.4	0.9	0.6	-0.5	-0.8	0.2	-0.6	1.0	0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.2	-0.9	2.1	-0.6	-1.3	0.7	-0.3	-1.1
Medication: Atenolol	0.8	1.0	3.0	-1.0	-1.1	0.2	-1.0	0.4	-0.6	-1.7
Medication: Levothyroxine sodium	0.5	0.9	1.8	0.7	-1.3	-0.3	1.3	-1.2	0.4	0.7
Sitting height	2.1	14.7	19.9	-4.5	2.3	2.9	-4.1	4.3	-4.2	-4.1
Chronic bronchitis/emphysema (father)	0.4	0.5	2.8	-0.2	-1.7	0.3	-0.0	-0.2	0.5	-0.5
High blood pressure (mother)	2.2	3.0	4.4	-2.1	0.5	1.7	-1.7	1.8	-2.1	-1.8
Body mass index (BMI)	1.3	5.5	8.6	2.4	-2.4	-2.0	2.2	-2.3	2.9	2.0
Impedance of leg (left)	0.8	3.8	11.8	-1.2	3.4	1.6	-0.9	1.5	-2.9	-0.4
Leg predicted mass (left)	0.2	0.9	2.7	0.6	-1.6	-1.0	0.1	-0.2	1.6	0.1
Trunk fat mass	0.3	1.5	2.6	1.4	-0.4	-1.6	1.2	-1.1	1.3	1.1
Waist circumference	0.1	0.4	0.8	0.8	-0.1	-0.4	0.6	-0.3	0.9	0.9
Number of incorrect matches in round	0.5	0.8	1.6	-0.9	-0.2	1.3	-0.9	0.7	-0.9	-0.9
Past tobacco smoking	0.7	1.2	2.9	-1.6	-1.0	0.6	-1.2	0.5	-0.6	-1.7
Alcohol usually taken with meals	0.3	0.5	2.8	-0.1	-1.7	-0.1	0.5	-0.6	-0.2	-0.2
Nervous feelings	2.1	3.9	6.6	-1.4	2.4	2.4	-1.4	2.2	-2.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.2	-0.4	2.1	-0.2	-0.4	0.7	-1.2	-0.3
Hearing difficulty/problems with background noise	2.0	3.2	15.9	0.0	4.0	0.5	-0.2	1.4	-2.1	0.7
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.1	1.0	0.3	-0.5	0.5	-0.0	-0.1
Had menopause	0.5	0.6	1.4	-0.8	0.9	-0.1	-0.7	0.5	-1.2	-0.8
Had other major operations	0.5	0.6	1.2	0.4	-0.7	-1.1	0.9	-1.1	0.2	0.2
Forced vital capacity (FVC)	1.8	7.0	11.4	-3.0	1.8	3.0	-2.1	2.6	-3.4	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	12.9	2.2	-1.5	-3.6	2.2	-2.6	2.2	1.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.5	0.3	0.1	0.4	0.1	-0.5	0.7
Qualifications: None of the above	0.3	0.6	3.1	-0.2	-1.8	0.1	0.2	-0.6	0.4	-0.4
Financial difficulties in last 2 years	0.4	0.6	1.2	-0.7	0.2	-0.8	-0.5	0.6	-1.0	-1.1
Mouth/teeth dental problems	0.6	1.0	3.1	0.7	-0.6	-1.4	0.4	-0.8	1.8	0.4
Heart attack	0.0	0.1	0.1	-0.2	0.2	0.2	-0.4	0.0	0.2	-0.3
Allergy	1.2	2.8	6.8	1.2	-2.6	-1.8	1.3	-1.6	1.9	0.8
Pain all over the body in last month	0.1	0.2	0.5	-0.2	-0.1	-0.4	0.3	-0.4	-0.7	-0.4
Diabetes (self-reported)	0.3	0.5	2.0	-0.4	1.4	0.1	0.1	0.4	-1.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	-1.0	0.2	1.0	-0.7	0.5	-1.1	-1.0
Medication: Ramipril	0.6	0.8	1.6	-1.0	1.0	0.1	-1.3	0.7	-0.7	-1.1
Medication: Simvastatin	3.7	5.4	8.9	-2.0	3.0	2.5	-1.8	2.2	-3.0	-1.3
Fluid intelligence score	3.1	6.4	8.4	-2.6	2.1	2.5	-2.5	2.7	-2.9	-2.3
Illnesses of siblings	2.3	3.3	4.3	1.8	-1.9	-1.4	1.9	-2.1	2.0	1.5
Neuroticism score	2.6	5.5	11.7	-1.5	3.4	2.0	-1.9	2.8	-2.9	-0.8
Weight	0.2	1.1	2.5	1.2	-1.0	-1.1	0.8	-0.6	1.6	1.0
Impedance of arm (right)	0.9	4.0	10.8	-1.9	2.1	1.7	-1.2	1.4	-3.3	-1.7
Arm fat percentage (right)	0.9	3.5	4.4	2.0	-1.6	-1.9	2.1	-2.1	1.8	1.6
Trunk fat-free mass	0.1	0.4	1.0	-0.1	-0.6	-0.2	-0.8	1.0	1.0	-0.2
Hip circumference	0.3	1.3	2.7	1.0	-1.6	-1.2	0.8	-1.0	1.5	0.3
Time employed in main current job	3.4	3.9	7.3	1.6	-2.7	-1.4	1.9	-1.9	2.4	1.6
Alcohol intake versus 10 years previously	0.3	0.4	1.2	-0.7	-0.5	-0.1	-0.3	-0.6	-0.5	-1.1
Father’s age at death	2.2	2.9	5.1	1.8	-0.9	-2.1	1.7	-2.2	1.7	1.2
Worrier / anxious feelings	1.3	2.4	6.5	-1.1	1.1	2.0	-1.0	1.7	-2.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.3	-0.9	1.5	0.2	-0.5	0.7	-0.9	-0.6
Falls in the last year	0.1	0.1	0.3	-0.4	0.1	0.1	-0.4	0.5	-0.5	-0.4
Hair/balding pattern: Pattern 3	1.8	2.7	4.2	1.9	0.6	-2.0	1.9	-1.6	1.1	1.9
Number of live births	0.0	0.0	0.1	0.3	0.0	0.2	-0.1	-0.0	0.3	0.2
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.1	-2.0	2.0	1.9	-1.6	1.9	-2.3	-1.4
Pulse rate	1.3	2.1	3.7	-1.6	1.0	0.7	-1.9	1.5	-1.0	-1.9
Happiness	2.8	3.4	7.9	-2.1	0.0	1.0	-1.7	1.3	-2.5	-2.8
Noisy workplace	0.1	0.2	0.8	0.0	-0.9	0.2	-0.3	0.1	0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	-0.1	0.5	0.8	-0.2	0.7	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-0.9	0.6	1.0	-0.8	0.7	-0.8	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.1	1.5	-1.2	0.7	1.0	-1.1	0.9	-1.1	-1.2
Asthma	0.3	0.5	1.3	-0.8	0.2	0.7	-0.7	0.2	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.1	1.0	-0.6	-0.6	0.8	-0.6	0.7	0.9
Medication: Cholesterol lowering	0.8	1.2	2.8	-1.0	1.7	1.1	-0.7	1.1	-1.1	-0.2
Depression (self-reported)	0.3	0.4	1.3	-0.3	1.1	0.5	-0.4	0.7	-0.7	-0.0
Medication: Lansoprazole	0.3	0.3	0.6	0.5	0.0	-0.8	0.8	-0.7	-0.5	0.3
Prospective memory result	1.8	2.2	3.3	1.4	-1.5	-1.8	1.5	-1.8	1.3	0.9
Lung cancer (father)	0.4	0.5	1.3	-0.4	1.1	-0.0	-0.4	0.6	-1.1	-0.6
Illnesses of mother	3.3	4.0	6.0	2.2	-2.1	-1.3	2.1	-2.5	2.1	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.9	-1.2	1.4	1.4	-0.8	1.3	-1.7	-0.8
Pulse wave Arterial Stiffness index	3.7	4.3	6.7	-2.3	1.6	2.3	-2.2	2.6	-2.0	-1.3
Impedance of arm (left)	0.6	2.7	7.7	-1.1	2.6	0.8	-0.6	0.9	-2.8	-1.0
Arm fat mass (right)	0.5	2.2	3.9	1.4	-1.6	-1.5	1.2	-1.4	2.0	1.1
Trunk predicted mass	0.1	0.5	1.1	-0.2	-0.5	-0.3	-0.9	1.0	1.0	-0.3
Standing height	0.7	7.4	14.1	-2.4	3.0	1.9	-2.9	3.8	-2.6	-1.9
Length of working week for main job	2.9	3.2	5.1	2.0	-1.4	-0.8	1.9	-1.6	2.3	2.2
Exposure to tobacco smoke at home	2.6	2.9	4.7	1.9	-1.3	-0.9	2.2	-2.0	1.5	1.8
Breastfed as a baby	0.2	0.2	0.5	-0.4	0.7	0.3	-0.5	0.2	-0.2	-0.5
Tense / ‘highly strung’	1.3	2.1	4.1	-1.0	2.0	1.4	-1.1	1.6	-1.8	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	5.5	0.2	2.4	1.3	0.0	0.7	-1.7	0.6
Hair/balding pattern: Pattern 4	0.8	2.0	8.0	0.6	-2.8	-1.2	0.4	-1.1	1.8	-0.1
Birth weight of first child	0.6	1.2	2.6	0.7	-1.4	0.5	0.8	-0.7	1.6	1.3
Peak expiratory flow (PEF)	0.2	0.6	1.0	0.8	0.4	-0.9	1.0	-0.6	0.2	1.0
Pulse wave reflection index	0.8	1.0	2.5	-0.8	1.6	0.7	-0.7	1.1	-1.4	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.8	0.0	0.9	-0.0	0.0	0.3	-0.3	0.2
Loud music exposure frequency	0.7	0.7	1.8	0.9	0.7	-0.6	1.2	-0.5	-0.0	1.4
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	5.4	-1.8	2.3	1.1	-2.0	2.3	-1.9	-1.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.8	1.4	-0.1	0.2	1.6	-0.9	-0.2	2.0
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.3	0.6	-0.5	-0.6	0.0	-0.2	-0.6
Medication: Paracetamol	0.3	0.5	1.3	-0.6	0.6	0.3	-0.6	0.6	-1.1	-0.9
Headache pain in last month	0.3	0.6	1.5	0.5	-1.2	-0.7	0.9	-0.9	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	2.5	4.2	5.4	2.1	-2.3	-2.2	2.0	-2.3	2.0	1.4
Glaucoma (self-reported)	0.5	0.6	2.0	-0.7	0.4	-0.0	-1.1	0.5	-0.4	-1.4
Gout (self-reported)	1.6	2.2	3.5	1.8	-0.4	-1.1	1.5	-1.4	1.7	1.9
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	6.4	1.8	-2.5	-0.8	2.4	-2.0	1.6	1.8
Medication: Amlodipine	0.8	1.2	2.4	-1.0	0.7	0.9	-1.1	1.0	-1.5	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.5	0.0	-1.2	-0.0	-0.0	-0.6	0.3	-0.5
Birth weight	0.3	0.7	1.0	0.7	-1.0	-0.9	0.7	-0.4	0.8	1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.1	-0.2	-0.8	-0.0	-0.5	0.5	-0.2
High blood pressure (siblings)	2.9	4.1	5.0	-2.2	2.0	1.4	-2.2	2.1	-2.2	-2.0
Forced vital capacity (FVC), Best measure	1.0	3.8	7.0	-2.1	1.4	2.4	-1.4	2.0	-2.6	-1.4
Body fat percentage	0.7	2.9	3.9	2.0	-0.7	-2.0	1.9	-1.9	1.5	1.6
Leg fat percentage (right)	0.6	2.1	3.2	1.5	-0.8	-1.7	1.7	-1.8	1.3	1.1
Arm fat-free mass (right)	0.2	1.1	4.2	0.9	-1.0	-1.1	0.1	0.0	2.0	0.7
Exposure to tobacco smoke outside home	0.3	0.5	1.4	-0.7	-1.2	-0.4	-0.3	-0.1	0.3	-1.1
Comparative body size at age 10	0.4	1.1	2.4	0.9	-1.3	-1.1	0.6	-1.0	1.6	0.4
Number of full brothers	1.4	1.7	4.2	1.0	-2.1	-1.5	0.9	-1.9	0.7	-0.2
Worry too long after embarrassment	0.8	1.4	3.7	0.0	1.9	1.4	-0.4	1.3	-1.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	0.4	1.2	1.2	0.4	0.1	-1.0	0.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	1.3	0.8	-1.0	1.4	-1.1	0.2	1.1
Number of children fathered	2.1	2.4	4.6	1.7	-1.3	-1.5	1.2	-1.5	2.1	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	4.1	-1.8	0.3	0.9	-1.4	1.0	-1.8	-2.0
Age at first live birth	1.1	1.9	4.2	1.3	-1.5	-1.5	0.8	-0.9	2.1	1.0
Pulse wave peak to peak time	2.7	3.2	5.0	2.0	-1.3	-2.0	1.9	-2.2	1.8	1.1
Health satisfaction	0.2	0.2	0.7	-0.2	0.7	-0.3	-0.2	0.1	-0.9	-0.3
Shortness of breath walking on level ground	0.2	0.3	1.2	-0.1	0.1	-1.1	-0.0	-0.5	0.1	-0.5
Qualifications: College or University degree	0.3	0.8	3.1	-0.2	1.8	1.1	-0.1	0.8	-0.9	0.5
Eye problems/disorders: None of the above	0.7	0.8	3.5	-0.1	-1.9	-0.4	0.1	-1.1	0.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.1	0.2	-0.8	-0.4	-0.0	0.1	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.7	0.1	-0.2	-0.3	0.1	-0.5	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.4	-0.5	-0.0	0.8	-0.6	0.5	0.7
Neck or shoulder pain in last month	0.7	1.0	3.4	-0.4	1.8	0.5	-0.6	1.2	-1.3	0.2
Medication: Blood pressure	3.7	6.4	9.3	-2.7	1.9	3.1	-2.8	2.9	-2.2	-2.0
Angina (self-reported)	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3	0.3	-0.1	-0.1
Migraine (self-reported)	1.4	1.7	4.2	-1.2	1.9	0.1	-0.7	0.5	-2.1	-1.5
Medication: Ibuprofen	0.2	0.2	0.8	0.7	-0.2	0.2	0.5	-0.1	0.1	0.9
Medication: Allopurinol	1.9	2.5	5.4	1.8	-0.9	-1.5	1.2	-1.5	2.3	1.4
Medication: Omeprazole	0.0	0.1	0.1	-0.4	-0.1	0.0	-0.4	0.0	-0.1	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	1.9	-1.1	-1.4	1.3	-0.5	0.4	-0.6	-1.0
Mean time to correctly identify matches	0.1	0.1	0.7	-0.2	-0.2	-0.8	-0.3	-0.2	0.0	-0.4
Heart disease (mother)	0.5	0.6	1.4	-0.8	-0.2	1.2	-0.3	0.7	-0.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.4	4.9	1.9	-0.8	-1.4	2.1	-2.2	2.0	2.0
Whole body fat mass	0.5	2.1	3.4	1.6	-0.8	-1.8	1.4	-1.4	1.8	1.2
Leg fat mass (right)	0.6	2.2	3.3	1.6	-1.0	-1.6	1.4	-1.5	1.8	1.2
Arm predicted mass (right)	0.2	1.1	4.3	1.0	-1.0	-1.1	0.2	-0.1	2.1	0.8
Pulse rate, automated reading	2.3	7.6	12.8	-3.4	1.7	1.4	-3.4	2.7	-2.3	-3.6
Alcohol intake frequency.	0.6	1.4	3.9	0.4	-1.2	-2.0	1.0	-1.8	0.5	-0.2
Comparative height size at age 10	0.1	0.7	2.3	-0.6	1.0	-0.4	-1.0	1.5	-0.5	-0.3
Number of full sisters	0.2	0.3	1.0	0.4	-1.0	-0.1	0.3	-0.5	0.7	0.1
Suffer from ‘nerves’	0.6	0.9	3.3	0.2	1.8	0.6	0.0	0.7	-1.2	0.8
Overall health rating	0.5	1.1	2.5	-1.2	0.9	1.1	-0.7	0.9	-1.6	-0.8
Chest pain or discomfort	1.7	2.4	3.8	-1.9	1.2	1.2	-1.3	1.4	-1.9	-1.7
Had major operations	0.8	0.9	3.5	0.9	1.0	0.6	0.6	0.5	0.4	1.9
Age at last live birth	2.0	2.9	4.1	2.0	-0.9	-1.8	1.6	-1.6	2.0	1.7
Family relationship satisfaction	0.3	0.4	1.3	-0.4	0.6	-0.4	-0.3	0.3	-1.1	-0.8
Leg pain on walking	0.3	0.4	1.1	-0.6	-1.0	0.6	-0.4	0.1	-0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.1	0.7	-0.6	-0.4	-0.3	-0.8	-0.8
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.0	1.3	1.2	-1.4	0.9	-0.5	0.7	1.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.4	-1.2	-0.5	1.1	-1.5	0.9	-0.2	-1.6
Medication: Aspirin	1.0	1.3	3.0	-1.0	1.7	0.7	-1.1	1.3	-1.0	-0.8
Supplements: Vitamin C	0.7	0.9	1.9	-0.6	1.4	0.5	-0.8	1.2	-1.1	-0.4
Knee pain experienced in last month	0.3	0.4	0.8	-0.5	0.9	0.4	-0.6	0.9	-0.7	-0.3
Hypertension (Self-reported)	5.6	15.6	19.7	-4.4	3.1	3.2	-4.4	4.1	-4.0	-4.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.1	-0.3	-0.8	0.1	-0.6	-0.2	-0.7
Illnesses of father: Heart disease	1.2	1.6	5.2	1.0	2.3	0.4	0.8	0.1	-0.1	2.0
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.1	-0.5	-0.3	0.3	-0.2	0.1	0.1
Smoking status: Previous	0.3	0.4	1.1	0.7	0.9	0.2	0.5	0.2	0.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.2	-1.1	1.1	0.4	-1.1	1.4	-1.5	-1.0
Whole body fat-free mass	0.1	0.6	2.2	0.3	-1.0	-0.6	-0.3	0.5	1.5	0.1
Leg fat-free mass (right)	0.3	1.4	4.2	0.9	-1.8	-1.0	0.3	-0.3	2.0	0.5
Arm fat percentage (left)	1.1	4.3	5.3	2.2	-1.5	-2.3	2.2	-2.3	2.1	1.7
Average weekly red wine intake	3.6	5.3	8.5	2.1	-2.9	-1.8	2.6	-2.6	1.9	2.0
Handedness (chirality/laterality): Left-handed	4.4	5.3	7.8	-2.8	0.9	2.0	-2.5	2.2	-2.6	-2.5
Mood swings	2.0	3.7	9.5	-1.4	3.1	0.5	-1.8	2.2	-2.2	-1.3
Loneliness, isolation	0.5	0.6	2.7	0.3	-0.7	-1.6	0.6	-0.7	0.6	-0.1
Long-standing illness, disability or infirmity	3.7	5.7	8.0	-2.8	1.9	2.1	-2.2	2.4	-2.8	-2.4
Ever had bowel cancer screening	0.2	0.3	0.8	0.6	0.3	-0.2	0.4	-0.4	0.6	0.9
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.1	0.7	-0.2	0.4	-0.1	-0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.5	0.9	-0.8	-1.2	1.1	-1.2	-0.0	0.4
Friendships satisfaction	0.6	0.7	2.7	-0.5	-0.1	-0.8	-1.0	0.1	-0.5	-1.7
Qualifications: nursing, teaching	0.0	0.1	0.3	0.2	0.4	-0.5	0.1	-0.1	0.0	0.0
Commuting to job workplace: Walk	1.0	1.1	2.1	-1.0	1.4	0.1	-1.0	0.8	-1.2	-1.1
Eye problems/disorders: Cataract	1.8	2.1	4.6	1.6	-0.1	-1.2	1.8	-0.9	1.4	2.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.2	-0.9	0.1	0.8	-0.7	-0.4	0.2
Medication for cholesterol	2.3	3.5	8.4	2.4	-0.0	-0.7	1.9	-1.2	2.3	2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.8	-0.5	1.0	-0.4	0.3	-0.7	-0.8
Back pain experienced in last month	1.1	1.6	3.0	-1.3	1.2	0.7	-1.2	1.2	-1.7	-1.4
Mineral and other dietary supplements	0.6	0.7	1.3	-0.8	0.6	1.1	-0.6	0.8	-1.1	-0.7
Breast cancer (self-reported)	1.0	1.2	3.9	0.8	1.3	-2.0	0.6	-0.9	0.7	0.6
Asthma (self-reported)	0.2	0.5	1.2	-0.8	0.1	0.7	-0.6	0.1	-0.9	-1.1
Osteoporosis (self-reported)	2.1	2.6	5.2	-1.3	2.3	1.6	-1.6	1.5	-1.7	-0.9
Osteoarthritis (self-reported)	1.9	2.5	4.7	1.1	-2.0	-0.9	2.2	-1.8	1.1	1.4
Medication: Aspirin	0.7	0.9	2.1	-0.8	1.4	0.7	-0.8	1.1	-0.9	-0.6
Medication: Gliclazide	0.1	0.1	0.3	-0.4	-0.6	0.0	-0.2	0.1	-0.4	-0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	-1.0	-1.5	0.3	-0.6	0.0	-0.1	-1.5
Smoking status: Current	0.4	0.6	1.0	1.0	0.3	-0.6	1.0	-0.7	0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.4	-0.7	1.0	0.8	-0.1	0.1	-1.6	-0.6
Whole body water mass	0.1	0.7	2.7	0.5	-1.2	-0.8	-0.2	0.3	1.6	0.2
Leg predicted mass (right)	0.3	1.5	4.4	0.9	-1.8	-1.1	0.4	-0.4	2.1	0.6
Arm fat mass (left)	0.6	2.6	4.3	1.7	-1.4	-1.8	1.5	-1.4	2.1	1.3
Number of self-reported non-cancer illnesses	3.2	5.5	10.6	-2.4	2.7	1.7	-1.9	1.9	-3.2	-2.1
Average weekly champagne plus white wine intake	1.7	2.4	3.7	1.6	-1.1	-0.9	1.8	-1.6	1.6	1.9
Miserableness	4.1	7.1	10.2	-2.3	3.2	2.5	-2.5	3.2	-3.0	-1.7
Guilty feelings	0.9	1.3	5.3	-0.8	-1.1	2.3	-0.4	0.8	-1.1	-0.2
Wears glasses or contact lenses	0.1	0.1	0.4	0.1	-0.6	-0.3	0.4	-0.4	-0.2	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.5	-0.2	0.4	-0.5	-0.2	0.1
Hearing aid user	0.8	0.9	2.2	-1.1	0.3	1.5	-0.6	1.0	-1.1	-0.7
Mother’s age at death	0.6	0.7	2.1	0.7	1.4	0.4	0.3	0.2	0.5	1.4
Financial situation satisfaction	1.0	1.2	2.2	-1.1	0.7	0.6	-1.2	1.5	-1.4	-1.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.2	0.6	0.7	-0.4	0.2	-0.5	-0.3
Commuting to job workplace: Public transport	0.7	0.9	3.2	-0.7	1.0	0.7	-0.3	0.7	-1.8	-0.5
Eye problems/disorders: Glaucoma	2.1	2.5	4.2	-1.7	1.0	1.3	-2.0	1.6	-1.2	-2.0
Medication: Blood pressure	4.0	7.7	14.2	-3.1	1.7	1.1	-3.0	2.3	-3.4	-3.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.7	0.6	0.0	-0.3	0.3	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.8	1.3	-0.5	-0.8	1.2	-1.1	0.9	1.4
High cholesterol (Self-reported)	3.5	6.2	13.7	-2.7	1.6	2.9	-1.7	2.0	-3.7	-2.1
Medication: Bendroflumethiazide	3.3	5.0	8.2	-2.6	1.1	1.9	-2.9	2.6	-1.4	-2.4
Medication: Paracetamol	1.1	1.6	2.2	-1.2	1.1	1.0	-1.4	1.4	-1.5	-1.3
Medication: Lisinopril	5.4	7.0	8.4	-2.9	2.2	2.7	-2.7	2.6	-2.8	-2.5
Medication: Atorvastatin	0.3	0.3	0.6	-0.8	0.3	0.6	-0.5	0.6	-0.5	-0.6
Illnesses of father: High blood pressure	0.7	0.8	1.4	0.9	-1.2	-0.3	1.1	-1.1	0.4	0.9
Alcohol drinker status: Never	0.5	0.5	1.6	0.5	-0.6	-1.3	0.6	-0.8	0.7	0.0
Ever smoked	0.6	1.0	2.9	1.2	1.7	-0.4	0.9	-0.0	0.2	1.4
Basal metabolic rate	0.1	0.6	2.3	0.5	-1.0	-0.8	-0.1	0.2	1.5	0.3
Leg fat percentage (left)	1.1	3.8	4.8	2.1	-1.2	-2.0	2.2	-2.2	2.0	1.8
Arm fat-free mass (left)	0.2	0.9	3.2	0.6	-1.4	-0.7	-0.0	0.1	1.8	0.4
Number of operations (self-reported)	0.1	0.2	0.8	-0.1	0.0	0.5	0.2	0.3	-0.9	0.0
Average weekly beer plus cider intake	0.1	0.1	0.4	0.2	0.5	0.6	0.2	-0.1	0.3	0.4
Irritability	2.0	3.5	10.6	-1.2	3.2	0.9	-1.4	2.4	-1.9	-0.5
Risk taking	1.7	2.5	4.9	1.8	-0.5	-2.2	1.5	-1.5	1.8	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	0.8	-0.5	-0.7	1.0	-0.9	0.8	1.0
Fractured/broken bones in last 5 years	1.8	2.3	5.1	-1.9	0.2	0.9	-1.5	0.9	-1.8	-2.3
Age started oral contraceptive pill	0.6	0.8	1.7	-0.9	-1.3	-0.6	-0.8	-0.0	0.4	-1.3
Diastolic blood pressure, automated reading	3.3	10.3	15.0	-3.0	3.6	2.3	-3.2	3.3	-3.9	-3.0
Ever depressed for a whole week	0.6	0.7	1.8	0.8	-1.4	-0.1	1.0	-1.1	0.0	0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	0.2	0.2	-0.6	0.3	-0.2	0.1	0.1
Commuting to job workplace: Cycle	2.0	2.4	8.4	0.9	-2.9	0.8	1.1	-1.1	1.8	1.2
Myopia	0.6	0.8	4.0	-0.2	-2.0	0.0	0.5	-0.9	-0.5	-0.7
Vascular/heart problems diagnosed by doctor	5.5	15.0	18.2	4.2	-3.8	-2.8	4.3	-4.0	4.0	4.0
Cholesterol lowering medication	3.2	4.7	9.4	-2.3	1.8	2.0	-1.7	2.0	-3.1	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.3	-0.0	-0.1	-0.5	-0.2	0.0	0.2	0.0
Pain experienced in last month	0.2	0.3	0.8	-0.5	0.2	0.3	-0.9	0.5	0.1	-0.8
Supplements: Calcium	0.3	0.3	0.7	-0.7	0.0	-0.1	-0.6	0.4	-0.6	-0.8
Basal cell carcinoma (self-reported)	0.1	0.2	0.7	0.4	0.8	0.0	0.1	0.2	-0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.2	0.1	-0.3	0.0	-0.1	-0.3	0.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	-0.3	0.5	-0.6	-0.5	-0.1	-0.2	-0.7
Heart disease (siblings)	0.9	1.1	2.5	-0.6	1.6	0.9	-1.0	1.5	-0.9	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.3	0.0	0.3	-0.6	0.3	-0.6	-0.3	-0.2
Pack years of smoking	0.0	0.1	0.1	0.3	0.1	-0.3	-0.3	0.2	0.2	-0.3
Impedance of whole body	0.9	4.8	12.2	-1.6	3.5	1.5	-1.1	1.6	-3.4	-1.1
Leg fat mass (left)	0.6	2.5	4.2	1.7	-1.0	-1.7	1.5	-1.5	2.0	1.4
Arm predicted mass (left)	0.2	0.9	3.2	0.6	-1.4	-0.7	-0.0	0.1	1.8	0.4