[Hub]/) : Traits : Cardiovascular Disease :

chr4:102,868,793-104,627,833

Best TWAS P=5.79e-13 · Best GWAS P=8.44e-15 conditioned to 2.07e-16

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SLC9B1 0.13 0.23 enet 24 0.24 4.4e-29 -7.0 5.9 4.9e-09 0.14 0.04 0.96 FALSE
2 GTEx Adipose Subcutaneous CISD2 0.06 0.09 enet 12 0.06 7.3e-06 -7.1 6.9 4.7e-12 0.10 0.04 0.96 FALSE
3 GTEx Adrenal Gland CISD2 0.08 0.03 lasso 2 0.03 4.1e-02 -7.1 7.1 1.5e-12 0.07 0.04 0.88 FALSE
4 GTEx Artery Aorta UBE2D3 0.07 0.06 lasso 5 0.04 3.5e-03 -6.8 6.8 9.0e-12 0.09 0.05 0.92 FALSE
5 GTEx Artery Aorta CISD2 0.10 0.08 lasso 4 0.06 1.8e-04 -7.1 7.0 2.0e-12 0.11 0.05 0.95 FALSE
6 GTEx Artery Coronary CISD2 0.14 0.15 lasso 8 0.12 7.4e-05 6.7 6.6 3.0e-11 0.18 0.04 0.93 FALSE
7 GTEx Artery Tibial CISD2 0.11 0.12 lasso 4 0.10 3.1e-08 -6.8 6.9 5.6e-12 0.09 0.06 0.94 FALSE
8 GTEx Brain Cerebellum MANBA 0.18 0.03 enet 27 0.05 1.2e-02 -3.3 5.4 7.2e-08 0.04 0.10 0.10 FALSE
9 GTEx Brain Cerebellum CISD2 0.13 0.18 lasso 3 0.17 1.1e-05 -6.8 6.9 5.8e-12 0.10 0.05 0.94 FALSE
10 GTEx Breast Mammary Tissue CISD2 0.21 0.08 enet 13 0.08 6.0e-05 -7.0 6.0 2.5e-09 0.21 0.06 0.94 FALSE
11 GTEx Breast Mammary Tissue (Male) CISD2 0.15 0.02 lasso 3 -0.01 6.5e-01 -7.0 6.8 1.4e-11 0.18 0.04 0.37 FALSE
12 GTEx Breast Mammary Tissue (Female) CISD2 0.12 0.04 enet 12 0.07 5.0e-03 -6.8 5.7 1.1e-08 0.23 0.06 0.79 FALSE
13 GTEx Cells Transformed fibroblasts MANBA 0.26 0.22 lasso 9 0.27 1.9e-20 -3.2 -5.3 1.5e-07 -0.07 1.00 0.00 FALSE
14 GTEx Cells Transformed fibroblasts UBE2D3 0.11 0.09 enet 13 0.08 2.3e-06 -7.0 6.6 3.4e-11 0.12 0.05 0.95 FALSE
15 GTEx Cells Transformed fibroblasts CISD2 0.16 0.17 enet 12 0.13 9.7e-10 -6.7 7.1 1.4e-12 0.08 0.07 0.93 FALSE
16 GTEx Colon Sigmoid CISD2 0.20 0.24 enet 15 0.13 2.1e-05 -7.0 7.1 1.3e-12 0.07 0.05 0.95 FALSE
17 GTEx Colon Transverse CISD2 0.12 0.09 enet 19 0.06 1.0e-03 -6.7 6.4 1.6e-10 0.08 0.05 0.92 FALSE
18 GTEx Esophagus Gastroesophageal Junction CISD2 0.10 0.05 enet 6 0.04 1.6e-02 6.7 6.9 4.8e-12 0.11 0.05 0.85 FALSE
19 GTEx Esophagus Mucosa CISD2 0.12 0.06 enet 13 0.05 2.1e-04 -7.1 7.0 2.0e-12 0.10 0.04 0.96 FALSE
20 GTEx Esophagus Muscularis CISD2 0.19 0.22 enet 25 0.21 6.2e-13 -6.8 7.1 1.1e-12 0.07 0.06 0.94 FALSE
21 GTEx Lung CISD2 0.06 0.05 enet 10 0.04 5.4e-04 -6.7 5.3 1.5e-07 0.21 0.05 0.95 FALSE
22 GTEx Nerve Tibial UBE2D3 0.14 0.07 lasso 5 0.04 4.9e-04 -5.8 6.1 1.3e-09 0.06 0.13 0.49 FALSE
23 GTEx Nerve Tibial CISD2 0.19 0.14 enet 43 0.14 7.5e-10 -6.9 7.2 5.8e-13 0.06 0.04 0.96 TRUE
24 GTEx Ovary CISD2 0.12 0.12 lasso 4 0.07 6.9e-03 -6.7 6.7 1.9e-11 0.09 0.05 0.78 FALSE
25 GTEx Pancreas UBE2D3 0.13 0.09 enet 12 0.12 6.7e-06 -4.4 6.2 6.3e-10 0.03 0.06 0.94 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic CISD2 0.13 0.14 enet 18 0.10 6.0e-06 -7.0 6.9 6.0e-12 0.08 0.04 0.96 FALSE
27 GTEx Skin Sun Exposed Lower leg CISD2 0.12 0.20 lasso 14 0.20 1.1e-16 -7.2 7.0 2.9e-12 0.11 0.03 0.97 FALSE
28 GTEx Small Intestine Terminal Ileum CISD2 0.29 0.19 enet 34 0.15 3.2e-04 -7.1 7.0 3.6e-12 0.10 0.06 0.83 FALSE
29 GTEx Testis CISD2 0.10 0.04 lasso 5 0.03 1.3e-02 -7.1 6.6 5.3e-11 0.07 0.04 0.91 FALSE
30 GTEx Thyroid CISD2 0.12 0.07 lasso 3 0.05 8.8e-05 -6.7 6.6 4.7e-11 0.11 0.05 0.95 FALSE
31 GTEx Uterus CISD2 0.34 0.22 enet 25 0.19 8.9e-05 -6.7 5.9 2.9e-09 0.08 0.05 0.90 FALSE
32 METSIM Adipose UBE2D3 0.04 0.02 bslmm 332 0.03 2.0e-05 -6.9 5.3 1.2e-07 0.10 0.06 0.91 FALSE
33 ROSMAP Brain Pre-frontal Cortex UBE2D3 0.05 0.06 blup 337 0.07 5.0e-09 -6.7 6.4 1.7e-10 0.11 0.05 0.95 FALSE
34 ROSMAP Brain Pre-frontal Cortex CISD2 0.15 0.34 lasso 9 0.34 1.2e-44 -7.1 7.0 1.9e-12 0.09 0.05 0.95 FALSE
35 ROSMAP Brain Pre-frontal Cortex RP11-10L12.4 0.08 0.10 lasso 7 0.09 5.1e-12 -7.2 6.9 3.8e-12 0.08 0.04 0.96 FALSE
36 The Cancer Genome Atlas Bladder Urothelial Carcinoma MANBA 0.10 0.13 lasso 4 0.11 1.8e-09 -5.8 -5.8 8.1e-09 -0.07 0.66 0.34 FALSE
37 The Cancer Genome Atlas Breast Invasive Carcinoma MANBA 0.11 0.16 lasso 4 0.16 3.4e-32 -5.8 -5.2 2.1e-07 -0.07 0.91 0.09 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma NHEDC1 0.01 0.01 blup 58 0.01 1.1e-03 6.8 -6.1 9.3e-10 -0.09 0.03 0.75 FALSE
39 The Cancer Genome Atlas Colon Adenocarcinoma MANBA 0.33 0.11 enet 13 0.21 2.0e-12 -2.8 -5.6 2.2e-08 -0.07 0.01 0.99 FALSE
40 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CENPE 0.04 0.01 enet 10 0.02 2.6e-03 -4.5 5.9 4.0e-09 0.12 0.01 0.87 FALSE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MANBA 0.03 0.03 blup 71 0.04 2.0e-05 -3.6 -5.7 1.4e-08 -0.08 0.03 0.96 FALSE
42 The Cancer Genome Atlas Brain Lower Grade Glioma UBE2D3 0.02 0.02 enet 6 0.02 3.7e-03 -6.8 6.5 6.0e-11 0.09 0.02 0.79 FALSE
43 The Cancer Genome Atlas Lung Adenocarcinoma CISD2 0.02 0.02 enet 7 0.02 1.3e-03 6.1 -6.6 3.5e-11 0.01 0.01 0.86 FALSE
44 The Cancer Genome Atlas Pancreatic Adenocarcinoma CISD2 0.05 0.01 blup 18 0.06 1.9e-03 -7.0 7.0 2.1e-12 0.07 0.01 0.69 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma MANBA 0.11 0.04 lasso 7 0.04 3.5e-05 -5.8 -5.2 2.3e-07 -0.06 0.20 0.77 FALSE
46 The Cancer Genome Atlas Prostate Adenocarcinoma UBE2D3 0.03 0.04 enet 11 0.03 1.4e-04 -6.9 7.0 2.2e-12 0.09 0.02 0.98 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma CISD2 0.05 0.08 enet 5 0.06 1.9e-06 -7.0 7.0 3.5e-12 0.09 0.01 0.99 FALSE