[Hub]/) : Traits : Cardiovascular Disease : ← →

chr4:102,868,793-104,627,833

Best TWAS P=5.79e-13 · Best GWAS P=8.44e-15 conditioned to 2.07e-16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	GTEx	Nerve Tibial	CISD2	0.19	0.14	enet	43	0.14	7.5e-10	-6.9	7.2	5.8e-13	0.06	0.04	0.96	TRUE
20	GTEx	Esophagus Muscularis	CISD2	0.19	0.22	enet	25	0.21	6.2e-13	-6.8	7.1	1.1e-12	0.07	0.06	0.94	FALSE
16	GTEx	Colon Sigmoid	CISD2	0.20	0.24	enet	15	0.13	2.1e-05	-7.0	7.1	1.3e-12	0.07	0.05	0.95	FALSE
15	GTEx	Cells Transformed fibroblasts	CISD2	0.16	0.17	enet	12	0.13	9.7e-10	-6.7	7.1	1.4e-12	0.08	0.07	0.93	FALSE
3	GTEx	Adrenal Gland	CISD2	0.08	0.03	lasso	2	0.03	4.1e-02	-7.1	7.1	1.5e-12	0.07	0.04	0.88	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	CISD2	0.15	0.34	lasso	9	0.34	1.2e-44	-7.1	7.0	1.9e-12	0.09	0.05	0.95	FALSE
5	GTEx	Artery Aorta	CISD2	0.10	0.08	lasso	4	0.06	1.8e-04	-7.1	7.0	2.0e-12	0.11	0.05	0.95	FALSE
19	GTEx	Esophagus Mucosa	CISD2	0.12	0.06	enet	13	0.05	2.1e-04	-7.1	7.0	2.0e-12	0.10	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CISD2	0.05	0.01	blup	18	0.06	1.9e-03	-7.0	7.0	2.1e-12	0.07	0.01	0.69	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE2D3	0.03	0.04	enet	11	0.03	1.4e-04	-6.9	7.0	2.2e-12	0.09	0.02	0.98	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CISD2	0.12	0.20	lasso	14	0.20	1.1e-16	-7.2	7.0	2.9e-12	0.11	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	CISD2	0.05	0.08	enet	5	0.06	1.9e-06	-7.0	7.0	3.5e-12	0.09	0.01	0.99	FALSE
28	GTEx	Small Intestine Terminal Ileum	CISD2	0.29	0.19	enet	34	0.15	3.2e-04	-7.1	7.0	3.6e-12	0.10	0.06	0.83	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	RP11-10L12.4	0.08	0.10	lasso	7	0.09	5.1e-12	-7.2	6.9	3.8e-12	0.08	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	CISD2	0.06	0.09	enet	12	0.06	7.3e-06	-7.1	6.9	4.7e-12	0.10	0.04	0.96	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CISD2	0.10	0.05	enet	6	0.04	1.6e-02	6.7	6.9	4.8e-12	0.11	0.05	0.85	FALSE
7	GTEx	Artery Tibial	CISD2	0.11	0.12	lasso	4	0.10	3.1e-08	-6.8	6.9	5.6e-12	0.09	0.06	0.94	FALSE
9	GTEx	Brain Cerebellum	CISD2	0.13	0.18	lasso	3	0.17	1.1e-05	-6.8	6.9	5.8e-12	0.10	0.05	0.94	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CISD2	0.13	0.14	enet	18	0.10	6.0e-06	-7.0	6.9	6.0e-12	0.08	0.04	0.96	FALSE
4	GTEx	Artery Aorta	UBE2D3	0.07	0.06	lasso	5	0.04	3.5e-03	-6.8	6.8	9.0e-12	0.09	0.05	0.92	FALSE
11	GTEx	Breast Mammary Tissue (Male)	CISD2	0.15	0.02	lasso	3	-0.01	6.5e-01	-7.0	6.8	1.4e-11	0.18	0.04	0.37	FALSE
24	GTEx	Ovary	CISD2	0.12	0.12	lasso	4	0.07	6.9e-03	-6.7	6.7	1.9e-11	0.09	0.05	0.78	FALSE
6	GTEx	Artery Coronary	CISD2	0.14	0.15	lasso	8	0.12	7.4e-05	6.7	6.6	3.0e-11	0.18	0.04	0.93	FALSE
14	GTEx	Cells Transformed fibroblasts	UBE2D3	0.11	0.09	enet	13	0.08	2.3e-06	-7.0	6.6	3.4e-11	0.12	0.05	0.95	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	CISD2	0.02	0.02	enet	7	0.02	1.3e-03	6.1	-6.6	3.5e-11	0.01	0.01	0.86	FALSE
30	GTEx	Thyroid	CISD2	0.12	0.07	lasso	3	0.05	8.8e-05	-6.7	6.6	4.7e-11	0.11	0.05	0.95	FALSE
29	GTEx	Testis	CISD2	0.10	0.04	lasso	5	0.03	1.3e-02	-7.1	6.6	5.3e-11	0.07	0.04	0.91	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBE2D3	0.02	0.02	enet	6	0.02	3.7e-03	-6.8	6.5	6.0e-11	0.09	0.02	0.79	FALSE
17	GTEx	Colon Transverse	CISD2	0.12	0.09	enet	19	0.06	1.0e-03	-6.7	6.4	1.6e-10	0.08	0.05	0.92	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	UBE2D3	0.05	0.06	blup	337	0.07	5.0e-09	-6.7	6.4	1.7e-10	0.11	0.05	0.95	FALSE
25	GTEx	Pancreas	UBE2D3	0.13	0.09	enet	12	0.12	6.7e-06	-4.4	6.2	6.3e-10	0.03	0.06	0.94	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	NHEDC1	0.01	0.01	blup	58	0.01	1.1e-03	6.8	-6.1	9.3e-10	-0.09	0.03	0.75	FALSE
22	GTEx	Nerve Tibial	UBE2D3	0.14	0.07	lasso	5	0.04	4.9e-04	-5.8	6.1	1.3e-09	0.06	0.13	0.49	FALSE
10	GTEx	Breast Mammary Tissue	CISD2	0.21	0.08	enet	13	0.08	6.0e-05	-7.0	6.0	2.5e-09	0.21	0.06	0.94	FALSE
31	GTEx	Uterus	CISD2	0.34	0.22	enet	25	0.19	8.9e-05	-6.7	5.9	2.9e-09	0.08	0.05	0.90	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CENPE	0.04	0.01	enet	10	0.02	2.6e-03	-4.5	5.9	4.0e-09	0.12	0.01	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SLC9B1	0.13	0.23	enet	24	0.24	4.4e-29	-7.0	5.9	4.9e-09	0.14	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MANBA	0.10	0.13	lasso	4	0.11	1.8e-09	-5.8	-5.8	8.1e-09	-0.07	0.66	0.34	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CISD2	0.12	0.04	enet	12	0.07	5.0e-03	-6.8	5.7	1.1e-08	0.23	0.06	0.79	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MANBA	0.03	0.03	blup	71	0.04	2.0e-05	-3.6	-5.7	1.4e-08	-0.08	0.03	0.96	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	MANBA	0.33	0.11	enet	13	0.21	2.0e-12	-2.8	-5.6	2.2e-08	-0.07	0.01	0.99	FALSE
8	GTEx	Brain Cerebellum	MANBA	0.18	0.03	enet	27	0.05	1.2e-02	-3.3	5.4	7.2e-08	0.04	0.10	0.10	FALSE
32	METSIM	Adipose	UBE2D3	0.04	0.02	bslmm	332	0.03	2.0e-05	-6.9	5.3	1.2e-07	0.10	0.06	0.91	FALSE
13	GTEx	Cells Transformed fibroblasts	MANBA	0.26	0.22	lasso	9	0.27	1.9e-20	-3.2	-5.3	1.5e-07	-0.07	1.00	0.00	FALSE
21	GTEx	Lung	CISD2	0.06	0.05	enet	10	0.04	5.4e-04	-6.7	5.3	1.5e-07	0.21	0.05	0.95	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	MANBA	0.11	0.16	lasso	4	0.16	3.4e-32	-5.8	-5.2	2.1e-07	-0.07	0.91	0.09	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	MANBA	0.11	0.04	lasso	7	0.04	3.5e-05	-5.8	-5.2	2.3e-07	-0.06	0.20	0.77	FALSE