Hub : Genes

CENPE

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0980 0.0290 6.9e-10 0.097 0.091 0.100 0.098 0.107 7.1e-12 3.3e-11 3.8e-12 6.5e-12 5.8e-13
2 ROSMAP Brain Pre-frontal Cortex 0.0578 0.0201 2.1e-07 0.073 0.055 0.064 0.055 0.065 1.2e-09 1.1e-07 1.1e-08 1.2e-07 9.4e-09
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0422 0.0430 4.5e-03 0.010 0.015 0.019 NA 0.012 2.1e-02 7.5e-03 2.6e-03 NA 1.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.3 0.2 0.2 -0.5
Bipolar Disorder or Schizophrenia 2.1 5.0 6.0 2.1 2.5 -2.2
Depressed Affect (Nagel 2018) 1.0 2.2 3.9 -1.1 -1.2 2.0
Depression (Nagel 2018) 0.1 0.1 0.2 -0.2 -0.2 0.4
Intelligence (Savage-Jansen 2018) 2.8 8.5 12.9 3.6 3.3 -1.3
Neuroticism (Nagel 2018) 0.8 1.9 4.1 -0.8 -1.0 2.0
Schizophrenia (2018) 3.4 7.0 8.8 2.6 3.0 -2.4
Schizophrenia vs Biploar Disorder 0.5 0.7 1.0 1.0 0.9 0.3
Worry (Nagel 2018) 0.1 0.3 0.8 0.0 0.1 0.9
Alzheimer’s Disease (in mother) 0.6 0.8 1.3 1.1 1.0 -0.0
Alzheimer’s Disease (in father) 1.1 1.2 1.9 -1.4 -1.3 0.1
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.3 0.1 0.2
Crohns Disease (2017) 1.0 2.1 2.8 -1.7 -1.5 1.1
Irritable Bowel Disease (IBD) 0.3 0.8 1.9 0.4 0.6 -1.4
Ulcerative Colitis (UC) 3.3 6.1 8.7 2.2 2.2 -3.0
Major Depression (MDD) 0.2 0.2 0.5 0.1 0.4 -0.7
Reaction Time 0.4 0.8 1.5 0.6 0.7 -1.2
Verbal and Numeric Reasoning (VNR) 0.8 1.9 3.3 1.8 1.5 -0.3
Breast Cancer 0.7 1.7 2.7 -1.6 -1.0 -1.2
Ovarian Cancer 0.0 0.1 0.1 -0.1 0.1 -0.4
Prostate Cancer 0.2 0.2 0.3 0.5 0.5 -0.4
Age at First Birth 0.1 0.2 0.2 0.5 0.4 -0.4
Bipolar Disorder (2011) 3.8 3.7 5.4 2.3 2.2 -0.9
Body Mass Index (BMI) (2010) 4.2 5.7 7.7 -2.5 -2.8 1.7
Coronary Artery Disease (CAD) 0.5 0.6 1.0 -0.9 -1.0 0.4
Crohns Disease (2012) 0.9 1.5 2.2 -0.9 -1.1 1.5
Mean Putamen Volume 0.1 0.1 0.3 -0.1 0.2 -0.5
Fasting Glucose 2.2 2.7 3.2 -1.6 -1.5 1.8
HbA1C 3.6 4.0 4.2 -2.0 -2.0 2.0
HDL Cholesterol 1.9 3.2 4.0 2.0 1.9 -1.4
LDL Cholesterol 0.1 0.2 0.3 -0.5 -0.5 0.4
Lupus 0.1 0.1 0.2 0.3 -0.3 0.4
Neuroticism (2016) 1.2 1.7 1.9 -1.2 -1.3 1.4
Primary Biliary Cirrhosis 6.0 8.6 9.2 2.9 3.0 -2.9
Rheumatoid Arthritis 0.6 0.8 1.4 1.2 1.0 -0.1
Schizophrenia (2014) 3.8 8.4 11.2 3.0 3.3 -2.2
Triglycerides 1.4 2.3 2.5 -1.6 -1.6 1.3
Type 2 Diabetes (T2D) (2012) 6.2 7.2 15.5 -1.5 -1.9 3.9
Ulcerative Colitis 1.9 2.8 3.3 1.8 1.8 -1.3
Blood Eosinophil Count 0.0 0.2 0.4 -0.2 -0.5 0.6
Blood Platelet Count 0.0 0.1 0.2 -0.1 0.2 0.4
Blood Red Count 0.3 3.1 3.3 -1.8 -1.8 1.7
Blood White Count 0.7 5.0 7.8 -2.8 -2.7 -0.1
Heel T-Score 0.1 1.1 3.0 -0.2 0.6 -1.7
BMI 3.0 17.3 21.0 -4.2 -4.6 3.6
Height 1.5 28.4 34.5 4.7 5.4 -5.9
Waist Hip Ratio (WHR) 0.4 1.8 2.2 -1.0 -1.4 1.5
Systolic Blood Pressure 0.4 2.0 4.5 1.1 0.4 2.1
Smoking Status 0.0 0.0 0.1 -0.1 0.3 0.1
Allergy or Eczema 2.4 6.4 7.3 -2.4 -2.5 2.7
Cardiovascular Disease 6.1 20.3 34.6 -3.3 -3.9 5.9
Hypothyroidism (self reported) 0.0 0.0 0.1 0.1 -0.1 0.3
Respiratory disease 1.1 2.4 4.3 -1.0 -1.4 2.1
Type 2 Diabetes (T2D) (2018) 2.9 5.3 7.1 -1.9 -2.3 2.7
Lung FEV1/FVC ratio 0.4 2.0 2.4 -1.6 -1.5 1.2
Lung FVC 0.2 1.1 2.8 0.5 0.5 -1.7
Neuroticism 0.6 1.5 4.3 -0.3 -0.4 2.1
Chronotype (morning person) 1.6 3.8 4.9 -2.0 -2.2 1.6
Hair Pigment 0.4 10.3 12.2 -3.3 -3.5 2.8
Tanning 0.0 0.3 0.4 0.7 0.6 0.2
Hand grip strength (left) 0.2 0.7 0.9 0.9 0.9 -0.5
Number of treatments/medications taken 11.5 20.8 27.2 -4.0 -4.3 5.2
Average weekly spirits intake 0.4 0.5 0.6 -0.8 -0.7 0.5
Sensitivity / hurt feelings 1.3 2.2 6.0 -0.5 -0.5 2.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 0.7 0.4 1.2
Hearing difficulty/problems: Yes 0.5 0.7 0.8 -0.8 -0.8 0.9
Relative age of first facial hair 5.6 11.5 13.3 3.5 3.6 -3.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.5 0.6 0.7 -0.5
Ever used hormone-replacement therapy (HRT) 2.7 3.5 4.7 -1.8 -2.2 1.6
Ever had hysterectomy (womb removed) 1.7 1.9 4.7 0.8 0.4 2.2
Systolic blood pressure, automated reading 0.1 0.3 0.9 0.2 -0.3 0.9
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 3.8 -2.0 -1.8 1.2
Angina 0.0 0.1 0.1 0.1 -0.2 0.3
Medication for hormone replacement therapy 2.2 2.5 6.5 -0.5 -0.9 2.5
Vitamin and mineral supplements 1.4 1.9 2.7 1.6 1.7 -0.6
Supplements: Zinc 0.2 0.2 0.4 -0.4 -0.4 0.7
Medication: Co-codamol 0.6 0.6 1.0 -1.0 -0.9 0.3
Medication: Metformin 8.5 11.9 15.0 -3.0 -3.4 3.9
Diabetes (father) 3.5 4.3 11.4 -0.6 -1.1 3.4
Diabetes (mother) 0.1 0.2 0.3 -0.5 -0.5 0.3
Severe depression (siblings) 0.8 0.9 1.4 0.7 0.9 -1.2
Pack years adult smoking proportion 0.3 0.5 1.1 -0.5 -0.5 1.0
Impedance of leg (right) 1.5 7.1 11.2 2.0 2.4 -3.4
Leg fat-free mass (left) 0.3 1.8 2.7 -1.6 -1.6 0.4
Trunk fat percentage 0.5 1.9 4.1 -1.0 -0.8 -2.0
Hand grip strength (right) 0.2 0.6 0.8 0.9 0.6 -0.8
Townsend deprivation index at recruitment 0.6 0.8 1.9 -0.3 -0.6 1.4
Current tobacco smoking 0.3 0.5 0.7 0.8 0.7 -0.6
Average weekly fortified wine intake 2.8 3.3 4.9 2.2 2.0 -1.2
Maternal smoking around birth 2.7 3.9 4.3 -1.8 -2.0 2.1
Fed-up feelings 0.4 0.6 1.1 -0.6 -0.7 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.2 -0.2 -0.4
Relative age voice broke 7.4 11.4 13.3 3.6 3.5 -2.9
Taking other prescription medications 6.7 10.4 14.0 -2.8 -3.0 3.7
Age when periods started (menarche) 0.6 1.4 1.9 1.0 1.2 -1.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.5 -0.4 0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.4 9.9 1.6 2.0 -3.1
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 3.6 1.0 1.3 -1.9
Qualifications: CSEs or equivalent 1.2 1.5 4.5 -0.4 0.1 -2.1
Serious illness, injury or assault to yourself 1.0 1.3 1.9 -0.9 -1.0 1.4
High blood pressure 5.4 15.1 19.5 -3.3 -3.9 4.4
Hayfever, allergic rhinitis or eczema 2.5 5.4 6.3 -2.5 -2.5 1.9
Multivitamins +/- minerals 0.2 0.2 0.4 -0.6 -0.5 -0.2
Stomach or abdominal pain in last month 2.7 3.4 5.2 2.0 2.3 -0.9
Supplements: Glucosamine 0.1 0.1 0.2 -0.5 -0.3 0.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 0.8 -0.9 -0.9 0.9
Medication: Atenolol 0.3 0.4 1.3 0.1 -0.1 1.1
Medication: Levothyroxine sodium 0.2 0.3 0.4 -0.4 -0.5 0.6
Sitting height 1.9 13.6 25.8 2.4 3.0 -5.1
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 -0.1 0.1 -1.3
High blood pressure (mother) 0.1 0.2 0.2 -0.4 -0.5 0.5
Body mass index (BMI) 3.2 13.7 18.2 -4.2 -4.3 2.4
Impedance of leg (left) 1.5 7.4 12.1 2.0 2.5 -3.5
Leg predicted mass (left) 0.3 1.7 2.5 -1.5 -1.6 0.4
Trunk fat mass 0.5 2.1 2.2 -1.5 -1.3 -1.5
Waist circumference 1.7 6.4 9.5 -3.0 -3.1 0.9
Number of incorrect matches in round 0.2 0.3 0.6 -0.3 -0.3 0.8
Past tobacco smoking 0.3 0.5 0.7 0.8 0.5 -0.8
Alcohol usually taken with meals 0.4 0.6 1.4 -0.5 -0.5 1.2
Nervous feelings 0.4 0.7 0.8 0.8 0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.4 0.4 0.5 -0.6
Hearing difficulty/problems with background noise 0.2 0.3 0.4 0.6 0.6 0.4
Hair/balding pattern: Pattern 2 0.5 0.7 1.0 -1.0 -0.9 -0.5
Had menopause 1.9 2.4 4.0 -1.7 -2.0 0.7
Had other major operations 1.0 1.3 1.8 -1.3 -1.3 0.7
Forced vital capacity (FVC) 1.5 5.8 10.9 1.6 2.0 -3.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 5.3 0.1 0.5 -2.3
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 1.9 -1.3 -1.4 1.0
Qualifications: None of the above 1.2 2.5 5.0 -1.0 -1.2 2.2
Financial difficulties in last 2 years 0.5 0.7 2.0 0.0 0.3 -1.4
Mouth/teeth dental problems 1.7 2.6 3.8 1.6 1.1 -1.9
Heart attack 0.0 0.0 0.1 -0.3 -0.1 0.0
Allergy 3.0 7.0 7.7 2.5 2.8 -2.7
Pain all over the body in last month 0.9 1.0 1.7 -0.8 -0.9 1.3
Diabetes (self-reported) 3.2 4.9 9.0 -1.4 -1.9 3.0
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 3.3 -1.8 -1.8 0.9
Medication: Ramipril 12.5 16.1 20.0 -4.4 -4.5 3.0
Medication: Simvastatin 2.6 3.8 5.7 -1.5 -1.8 2.4
Fluid intelligence score 1.6 3.3 3.6 1.9 1.9 -1.6
Illnesses of siblings 0.7 0.9 2.1 -0.7 -0.4 -1.4
Neuroticism score 0.3 0.7 2.0 -0.0 0.0 1.4
Weight 0.8 3.8 5.8 -2.4 -2.4 0.1
Impedance of arm (right) 9.2 42.7 54.9 5.7 6.3 -7.4
Arm fat percentage (right) 0.8 3.3 5.0 -2.2 -2.1 -0.7
Trunk fat-free mass 0.5 2.6 3.3 -1.8 -1.8 1.2
Hip circumference 0.8 3.4 5.3 -2.3 -2.2 -0.2
Time employed in main current job 0.2 0.2 0.4 -0.6 -0.5 -0.1
Alcohol intake versus 10 years previously 1.9 2.8 4.0 -2.0 -1.7 1.2
Father’s age at death 0.4 0.6 1.4 0.4 0.3 1.2
Worrier / anxious feelings 0.4 0.7 2.0 -0.1 -0.0 1.4
Frequency of tiredness / lethargy in last 2 weeks 3.0 4.9 5.1 -2.2 -2.2 2.3
Falls in the last year 0.3 0.4 0.6 0.6 0.3 0.8
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 -0.2 -0.1 0.9
Number of live births 4.3 6.1 8.3 -2.1 -2.3 2.9
Forced expiratory volume in 1-second (FEV1) 0.9 3.2 6.9 1.0 1.3 -2.6
Pulse rate 0.9 1.6 3.5 -0.5 -1.0 1.9
Happiness 0.1 0.2 0.3 -0.4 -0.1 0.5
Noisy workplace 0.0 0.0 0.0 -0.1 0.1 0.2
Qualifications: A levels/AS levels or equivalent 1.9 4.1 6.5 2.6 2.3 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.2 0.3 0.5 0.5
Mouth/teeth dental problems: Dentures 0.0 0.0 0.1 -0.1 0.2 0.1
Asthma 1.1 2.1 2.9 -1.2 -1.4 1.7
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 2.8 -1.4 -1.3 1.7
Medication: Cholesterol lowering 1.2 1.8 5.3 -0.0 -0.4 2.3
Depression (self-reported) 1.2 1.5 2.6 -0.8 -1.1 1.6
Medication: Lansoprazole 1.0 1.2 2.2 -0.7 -0.9 1.5
Prospective memory result 0.3 0.4 0.5 -0.7 -0.7 0.5
Lung cancer (father) 0.5 0.5 0.9 -0.7 -0.3 -1.0
Illnesses of mother 0.3 0.4 0.5 -0.7 -0.5 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 5.3 0.2 0.5 -2.3
Pulse wave Arterial Stiffness index 1.4 1.7 4.1 -0.3 -0.9 2.0
Impedance of arm (left) 9.1 42.1 58.6 5.6 6.1 -7.7
Arm fat mass (right) 1.1 4.5 6.8 -2.6 -2.6 0.1
Trunk predicted mass 0.4 2.4 3.0 -1.7 -1.7 1.1
Standing height 1.6 15.7 21.9 3.4 3.7 -4.7
Length of working week for main job 0.1 0.1 0.2 0.5 0.3 0.3
Exposure to tobacco smoke at home 0.3 0.3 0.4 -0.5 -0.6 0.7
Breastfed as a baby 0.3 0.4 0.6 -0.6 -0.8 0.5
Tense / ‘highly strung’ 0.7 1.1 1.8 1.3 1.3 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.1 -0.1 -0.4 1.8
Hair/balding pattern: Pattern 4 2.3 5.5 7.8 2.8 2.8 -1.0
Birth weight of first child 0.8 1.4 2.0 1.4 1.4 -0.5
Peak expiratory flow (PEF) 0.2 0.5 0.9 -0.5 -0.5 1.0
Pulse wave reflection index 0.8 1.0 2.8 0.5 0.2 1.7
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.0 -0.1 0.0 0.0
Loud music exposure frequency 0.3 0.3 0.8 0.3 0.2 -0.9
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 2.4 1.4 1.2 -1.5
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.6 -1.6 -1.1 1.0
Blood clot in the leg (DVT) 0.4 0.6 1.4 0.3 0.4 -1.2
Medication: Paracetamol 4.1 6.8 11.8 -2.0 -2.1 3.4
Headache pain in last month 6.6 11.3 21.1 -2.4 -2.6 4.6
Medication for cholesterol, blood pressure or diabetes 6.4 10.6 20.5 2.0 2.7 -4.5
Glaucoma (self-reported) 0.4 0.4 1.3 0.1 0.0 1.1
Gout (self-reported) 0.7 1.0 1.6 -1.3 -1.0 -0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.5 -0.4 -0.4 0.7
Medication: Amlodipine 2.6 3.7 5.4 -1.4 -1.9 2.3
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.2 -0.6 -0.9 1.8
Birth weight 2.9 6.3 7.8 2.8 2.5 -2.2
Chronic bronchitis/emphysema (mother) 4.3 5.0 5.8 -1.9 -2.3 2.4
High blood pressure (siblings) 0.2 0.4 0.5 0.7 0.4 0.7
Forced vital capacity (FVC), Best measure 0.8 3.0 7.6 0.7 0.9 -2.8
Body fat percentage 0.8 3.3 4.7 -2.2 -2.0 -1.2
Leg fat percentage (right) 2.2 7.8 11.5 -3.4 -3.3 0.9
Arm fat-free mass (right) 1.7 8.6 10.7 -3.2 -3.3 2.3
Exposure to tobacco smoke outside home 0.4 0.5 0.7 0.5 0.8 -0.8
Comparative body size at age 10 0.4 1.0 1.6 -1.3 -1.2 0.2
Number of full brothers 0.2 0.2 0.6 0.1 -0.0 0.8
Worry too long after embarrassment 0.3 0.5 1.3 -0.2 -0.3 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.6 0.7 0.5 0.7
Wheeze or whistling in the chest in last year 3.5 6.3 7.6 -2.8 -2.7 1.9
Number of children fathered 0.2 0.3 0.8 -0.1 0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 4.4 1.0 1.2 -2.1
Age at first live birth 0.4 0.7 0.8 0.8 0.7 -0.9
Pulse wave peak to peak time 1.9 2.2 5.5 0.4 1.0 -2.3
Health satisfaction 1.9 2.4 3.3 -1.4 -1.4 1.8
Shortness of breath walking on level ground 0.7 0.8 1.3 1.1 1.2 -0.0
Qualifications: College or University degree 1.3 4.1 7.0 2.6 2.2 -0.8
Eye problems/disorders: None of the above 1.9 2.2 2.8 1.6 1.7 -1.1
Mouth/teeth dental problems: Loose teeth 3.1 3.6 5.9 1.4 1.7 -2.4
Emphysema/chronic bronchitis 0.5 0.6 0.9 -0.4 -0.9 0.8
Medication for pain relief, constipation, heartburn 4.6 7.9 13.5 2.2 2.3 -3.7
Neck or shoulder pain in last month 0.5 0.7 1.3 -1.2 -0.6 0.6
Medication: Blood pressure 8.8 15.5 25.7 -2.9 -3.5 5.1
Angina (self-reported) 0.1 0.1 0.2 0.5 0.2 0.0
Migraine (self-reported) 3.1 3.9 6.1 -1.7 -1.7 2.5
Medication: Ibuprofen 2.8 3.4 4.1 -1.8 -1.6 2.0
Medication: Allopurinol 1.0 1.3 2.1 -1.4 -1.3 0.6
Medication: Omeprazole 4.5 5.3 6.2 -2.5 -2.4 2.0
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.1 -0.1 -0.6
Mean time to correctly identify matches 0.4 0.8 1.7 0.6 0.7 -1.3
Heart disease (mother) 1.7 2.1 3.2 1.8 1.7 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.5 0.9 1.2 0.4
Whole body fat mass 0.8 3.5 5.3 -2.3 -2.2 -0.6
Leg fat mass (right) 2.1 8.3 12.0 -3.5 -3.5 1.0
Arm predicted mass (right) 1.3 6.7 8.2 -2.8 -2.9 2.0
Pulse rate, automated reading 0.4 1.2 1.5 -0.8 -1.2 1.2
Alcohol intake frequency. 2.6 6.1 8.8 -3.0 -2.6 1.7
Comparative height size at age 10 0.7 4.1 4.9 2.2 2.1 -1.8
Number of full sisters 0.3 0.3 0.5 0.6 0.7 -0.2
Suffer from ‘nerves’ 0.2 0.4 0.6 0.7 0.8 0.0
Overall health rating 3.9 8.3 8.5 -2.9 -2.9 2.8
Chest pain or discomfort 0.5 0.7 1.4 -0.4 -0.7 1.2
Had major operations 0.6 0.7 1.5 -0.3 -0.6 1.2
Age at last live birth 0.4 0.6 0.9 0.9 0.8 -0.4
Family relationship satisfaction 0.2 0.2 0.5 0.5 0.7 -0.1
Leg pain on walking 1.2 1.5 1.8 -1.1 -1.2 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.6 -0.7 -0.4 -0.8
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.0 0.7 1.0 -0.7
Illness, injury, bereavement, stress in last 2 years 1.7 2.0 2.3 1.5 1.5 -1.2
Medication: Aspirin 1.0 1.3 3.7 0.1 -0.2 1.9
Supplements: Vitamin C 3.8 4.5 6.7 -2.6 -2.5 0.6
Knee pain experienced in last month 0.6 0.9 1.1 -1.0 -0.9 0.8
Hypertension (Self-reported) 5.9 16.4 22.3 -3.4 -3.9 4.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 3.8 -2.0 -1.9 0.7
Illnesses of father: Heart disease 0.4 0.5 0.8 0.8 0.9 0.3
Illnesses of siblings: Diabetes 0.4 0.5 0.6 -0.8 -0.5 0.8
Smoking status: Previous 0.7 1.1 1.4 -1.2 -0.8 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 7.9 0.8 1.3 -2.8
Whole body fat-free mass 0.5 2.9 3.8 -1.9 -1.9 1.1
Leg fat-free mass (right) 0.2 1.1 1.7 -1.2 -1.3 0.3
Arm fat percentage (left) 0.9 3.6 5.4 -2.3 -2.2 -0.7
Average weekly red wine intake 2.7 4.0 5.8 2.4 2.3 -1.0
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.4 -0.5 -0.4 1.9
Mood swings 1.1 1.9 4.6 -0.6 -0.9 2.1
Loneliness, isolation 0.8 1.1 3.1 -0.2 -0.4 1.8
Long-standing illness, disability or infirmity 1.8 2.7 3.4 -1.5 -1.5 1.9
Ever had bowel cancer screening 1.0 1.2 1.3 -1.1 -1.1 1.1
Diabetes diagnosed by doctor 6.0 9.9 13.5 -2.6 -3.1 3.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.3 -0.3 0.6
Friendships satisfaction 2.8 3.5 4.5 1.8 2.1 -1.6
Qualifications: nursing, teaching 0.2 0.4 0.5 -0.7 -0.7 0.2
Commuting to job workplace: Walk 0.8 0.9 1.3 0.8 0.8 -1.2
Eye problems/disorders: Cataract 0.8 0.9 1.6 -1.3 -1.0 -0.0
Mouth/teeth dental problems: Mouth ulcers 4.4 7.0 8.4 -2.9 -2.5 2.5
Medication for cholesterol 7.3 11.1 13.0 3.1 3.6 -3.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.1 1.3 1.4 -0.3
Back pain experienced in last month 0.3 0.5 1.0 -1.0 -0.3 0.6
Mineral and other dietary supplements 0.6 0.9 1.2 1.0 1.1 -0.6
Breast cancer (self-reported) 0.1 0.1 0.4 0.0 0.2 -0.6
Asthma (self-reported) 1.3 2.6 3.8 -1.3 -1.5 2.0
Osteoporosis (self-reported) 2.5 3.1 5.4 2.3 1.9 -0.3
Osteoarthritis (self-reported) 0.1 0.1 0.3 0.1 0.5 0.3
Medication: Aspirin 1.2 1.6 4.6 0.0 -0.4 2.2
Medication: Gliclazide 7.3 8.2 8.9 -2.8 -3.0 2.8
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 -0.3 -0.1 -0.6
Smoking status: Current 0.7 1.1 1.3 1.2 1.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 3.1 -1.8 -1.7 0.2
Whole body water mass 0.5 2.9 3.8 -1.9 -1.9 1.1
Leg predicted mass (right) 0.2 0.9 1.4 -1.1 -1.2 0.2
Arm fat mass (left) 1.1 4.6 7.1 -2.7 -2.6 0.1
Number of self-reported non-cancer illnesses 4.7 8.1 15.4 -1.9 -2.3 3.9
Average weekly champagne plus white wine intake 0.4 0.6 1.1 0.6 0.5 1.1
Miserableness 0.5 0.8 1.4 1.0 1.2 -0.3
Guilty feelings 0.2 0.3 0.8 -0.2 -0.3 0.9
Wears glasses or contact lenses 0.1 0.1 0.3 -0.5 -0.3 -0.2
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.5 0.7 0.1
Hearing aid user 3.0 3.4 8.7 -0.5 -1.1 2.9
Mother’s age at death 0.8 1.0 3.0 -0.2 -0.3 1.7
Financial situation satisfaction 0.9 1.1 1.5 1.1 1.2 -0.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.1 -0.2 0.5
Commuting to job workplace: Public transport 0.5 0.6 0.8 -0.7 -0.9 0.8
Eye problems/disorders: Glaucoma 0.7 0.9 2.1 -0.5 -0.5 1.5
Medication: Blood pressure 6.7 12.8 17.6 -3.7 -4.2 2.7
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.5 -0.6 -0.4 0.7
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 0.1 0.1 -0.5
High cholesterol (Self-reported) 0.2 0.4 0.5 -0.6 -0.7 0.6
Medication: Bendroflumethiazide 2.8 4.2 4.7 -1.8 -2.1 2.2
Medication: Paracetamol 5.9 9.2 17.0 -2.2 -2.4 4.1
Medication: Lisinopril 4.1 5.3 6.8 -2.1 -2.2 2.6
Medication: Atorvastatin 1.1 1.4 1.9 1.4 1.3 0.7
Illnesses of father: High blood pressure 1.0 1.2 1.8 -1.3 -1.3 0.5
Alcohol drinker status: Never 4.6 5.5 8.0 -2.8 -2.6 1.3
Ever smoked 0.1 0.1 0.2 0.2 0.4 -0.3
Basal metabolic rate 0.5 3.0 4.2 -2.1 -2.0 0.8
Leg fat percentage (left) 2.3 8.2 12.2 -3.5 -3.4 0.8
Arm fat-free mass (left) 1.5 7.4 8.9 -3.0 -3.0 2.1
Number of operations (self-reported) 2.7 4.0 5.0 -1.8 -1.9 2.2
Average weekly beer plus cider intake 3.2 4.6 5.7 2.4 2.2 -1.8
Irritability 0.1 0.2 0.5 0.1 0.1 0.7
Risk taking 0.9 1.4 2.0 1.4 1.4 -0.3
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.2 1.5 1.4 0.3
Fractured/broken bones in last 5 years 1.2 1.5 1.8 -1.1 -1.4 1.2
Age started oral contraceptive pill 0.4 0.5 1.4 -0.1 0.1 -1.2
Diastolic blood pressure, automated reading 5.2 16.1 18.2 -3.5 -4.2 4.3
Ever depressed for a whole week 0.6 0.7 0.9 -0.9 -0.7 -0.8
Unable to work because of sickness or disability 0.2 0.3 0.5 0.4 0.4 0.7
Commuting to job workplace: Cycle 1.5 1.9 2.6 -1.4 -1.6 1.0
Myopia 0.2 0.2 0.4 0.5 0.4 -0.6
Vascular/heart problems diagnosed by doctor 5.3 14.5 19.4 3.2 3.8 -4.4
Cholesterol lowering medication 1.1 1.6 2.5 -1.3 -1.6 0.8
Medication: Omeprazole (e.g. Zanprol) 5.0 6.1 6.9 -2.6 -2.6 2.2
Pain experienced in last month 3.6 6.0 10.2 2.1 1.9 -3.2
Supplements: Calcium 0.2 0.3 0.5 -0.7 -0.5 0.2
Basal cell carcinoma (self-reported) 0.8 0.9 1.7 1.3 0.9 0.5
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.0 0.1 0.0
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.9 0.3 0.5 -1.4
Heart disease (siblings) 1.4 1.7 2.1 1.4 1.4 -0.9
Alcohol drinker status: Previous 0.7 0.7 1.0 -1.0 -1.0 0.6
Pack years of smoking 0.3 0.4 0.8 -0.5 -0.5 0.9
Impedance of whole body 5.8 29.7 40.5 4.6 5.2 -6.4
Leg fat mass (left) 2.3 8.9 13.0 -3.6 -3.6 1.1
Arm predicted mass (left) 1.2 6.1 7.2 -2.6 -2.7 2.0