TWAS hub - CENPE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0290	6.9e-10	0.097	0.091	0.100	0.098	0.107	7.1e-12	3.3e-11	3.8e-12	6.5e-12	5.8e-13
2	ROSMAP	Brain Pre-frontal Cortex	0.0578	0.0201	2.1e-07	0.073	0.055	0.064	0.055	0.065	1.2e-09	1.1e-07	1.1e-08	1.2e-07	9.4e-09
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0422	0.0430	4.5e-03	0.010	0.015	0.019	NA	0.012	2.1e-02	7.5e-03	2.6e-03	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Ramipril	12.5	16.1	20.0	-4.4	-4.5	3.0
Number of treatments/medications taken	11.5	20.8	27.2	-4.0	-4.3	5.2
Impedance of arm (right)	9.2	42.7	54.9	5.7	6.3	-7.4
Impedance of arm (left)	9.1	42.1	58.6	5.6	6.1	-7.7
Medication: Blood pressure	8.8	15.5	25.7	-2.9	-3.5	5.1
Medication: Metformin	8.5	11.9	15.0	-3.0	-3.4	3.9
Relative age voice broke	7.4	11.4	13.3	3.6	3.5	-2.9
Medication for cholesterol	7.3	11.1	13.0	3.1	3.6	-3.3
Medication: Gliclazide	7.3	8.2	8.9	-2.8	-3.0	2.8
Taking other prescription medications	6.7	10.4	14.0	-2.8	-3.0	3.7
Medication: Blood pressure	6.7	12.8	17.6	-3.7	-4.2	2.7
Headache pain in last month	6.6	11.3	21.1	-2.4	-2.6	4.6
Medication for cholesterol, blood pressure or diabetes	6.4	10.6	20.5	2.0	2.7	-4.5
Type 2 Diabetes (T2D) (2012)	6.2	7.2	15.5	-1.5	-1.9	3.9
Cardiovascular Disease	6.1	20.3	34.6	-3.3	-3.9	5.9
Primary Biliary Cirrhosis	6.0	8.6	9.2	2.9	3.0	-2.9
Diabetes diagnosed by doctor	6.0	9.9	13.5	-2.6	-3.1	3.7
Hypertension (Self-reported)	5.9	16.4	22.3	-3.4	-3.9	4.7
Medication: Paracetamol	5.9	9.2	17.0	-2.2	-2.4	4.1
Impedance of whole body	5.8	29.7	40.5	4.6	5.2	-6.4
Relative age of first facial hair	5.6	11.5	13.3	3.5	3.6	-3.0
High blood pressure	5.4	15.1	19.5	-3.3	-3.9	4.4
Vascular/heart problems diagnosed by doctor	5.3	14.5	19.4	3.2	3.8	-4.4
Diastolic blood pressure, automated reading	5.2	16.1	18.2	-3.5	-4.2	4.3
Medication: Omeprazole (e.g. Zanprol)	5.0	6.1	6.9	-2.6	-2.6	2.2
Number of self-reported non-cancer illnesses	4.7	8.1	15.4	-1.9	-2.3	3.9
Medication for pain relief, constipation, heartburn	4.6	7.9	13.5	2.2	2.3	-3.7
Alcohol drinker status: Never	4.6	5.5	8.0	-2.8	-2.6	1.3
Medication: Omeprazole	4.5	5.3	6.2	-2.5	-2.4	2.0
Mouth/teeth dental problems: Mouth ulcers	4.4	7.0	8.4	-2.9	-2.5	2.5
Number of live births	4.3	6.1	8.3	-2.1	-2.3	2.9
Chronic bronchitis/emphysema (mother)	4.3	5.0	5.8	-1.9	-2.3	2.4
Body Mass Index (BMI) (2010)	4.2	5.7	7.7	-2.5	-2.8	1.7
Medication: Paracetamol	4.1	6.8	11.8	-2.0	-2.1	3.4
Medication: Lisinopril	4.1	5.3	6.8	-2.1	-2.2	2.6
Overall health rating	3.9	8.3	8.5	-2.9	-2.9	2.8
Bipolar Disorder (2011)	3.8	3.7	5.4	2.3	2.2	-0.9
Schizophrenia (2014)	3.8	8.4	11.2	3.0	3.3	-2.2
Supplements: Vitamin C	3.8	4.5	6.7	-2.6	-2.5	0.6
HbA1C	3.6	4.0	4.2	-2.0	-2.0	2.0
Pain experienced in last month	3.6	6.0	10.2	2.1	1.9	-3.2
Diabetes (father)	3.5	4.3	11.4	-0.6	-1.1	3.4
Wheeze or whistling in the chest in last year	3.5	6.3	7.6	-2.8	-2.7	1.9
Schizophrenia (2018)	3.4	7.0	8.8	2.6	3.0	-2.4
Ulcerative Colitis (UC)	3.3	6.1	8.7	2.2	2.2	-3.0
Body mass index (BMI)	3.2	13.7	18.2	-4.2	-4.3	2.4
Diabetes (self-reported)	3.2	4.9	9.0	-1.4	-1.9	3.0
Average weekly beer plus cider intake	3.2	4.6	5.7	2.4	2.2	-1.8
Mouth/teeth dental problems: Loose teeth	3.1	3.6	5.9	1.4	1.7	-2.4
Migraine (self-reported)	3.1	3.9	6.1	-1.7	-1.7	2.5
BMI	3.0	17.3	21.0	-4.2	-4.6	3.6
Allergy	3.0	7.0	7.7	2.5	2.8	-2.7
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	5.1	-2.2	-2.2	2.3
Hearing aid user	3.0	3.4	8.7	-0.5	-1.1	2.9
Type 2 Diabetes (T2D) (2018)	2.9	5.3	7.1	-1.9	-2.3	2.7
Birth weight	2.9	6.3	7.8	2.8	2.5	-2.2
Intelligence (Savage-Jansen 2018)	2.8	8.5	12.9	3.6	3.3	-1.3
Average weekly fortified wine intake	2.8	3.3	4.9	2.2	2.0	-1.2
Medication: Ibuprofen	2.8	3.4	4.1	-1.8	-1.6	2.0
Friendships satisfaction	2.8	3.5	4.5	1.8	2.1	-1.6
Medication: Bendroflumethiazide	2.8	4.2	4.7	-1.8	-2.1	2.2
Ever used hormone-replacement therapy (HRT)	2.7	3.5	4.7	-1.8	-2.2	1.6
Maternal smoking around birth	2.7	3.9	4.3	-1.8	-2.0	2.1
Stomach or abdominal pain in last month	2.7	3.4	5.2	2.0	2.3	-0.9
Average weekly red wine intake	2.7	4.0	5.8	2.4	2.3	-1.0
Number of operations (self-reported)	2.7	4.0	5.0	-1.8	-1.9	2.2
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	3.8	-2.0	-1.8	1.2
Medication: Simvastatin	2.6	3.8	5.7	-1.5	-1.8	2.4
Medication: Amlodipine	2.6	3.7	5.4	-1.4	-1.9	2.3
Alcohol intake frequency.	2.6	6.1	8.8	-3.0	-2.6	1.7
Hayfever, allergic rhinitis or eczema	2.5	5.4	6.3	-2.5	-2.5	1.9
Osteoporosis (self-reported)	2.5	3.1	5.4	2.3	1.9	-0.3
Allergy or Eczema	2.4	6.4	7.3	-2.4	-2.5	2.7
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	9.9	1.6	2.0	-3.1
Hair/balding pattern: Pattern 4	2.3	5.5	7.8	2.8	2.8	-1.0
Leg fat percentage (left)	2.3	8.2	12.2	-3.5	-3.4	0.8
Leg fat mass (left)	2.3	8.9	13.0	-3.6	-3.6	1.1
Fasting Glucose	2.2	2.7	3.2	-1.6	-1.5	1.8
Medication for hormone replacement therapy	2.2	2.5	6.5	-0.5	-0.9	2.5
Leg fat percentage (right)	2.2	7.8	11.5	-3.4	-3.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	3.8	-2.0	-1.9	0.7
Bipolar Disorder or Schizophrenia	2.1	5.0	6.0	2.1	2.5	-2.2
Leg fat mass (right)	2.1	8.3	12.0	-3.5	-3.5	1.0
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.6	1.0	1.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.4	1.0	1.2	-2.1
HDL Cholesterol	1.9	3.2	4.0	2.0	1.9	-1.4
Ulcerative Colitis	1.9	2.8	3.3	1.8	1.8	-1.3
Sitting height	1.9	13.6	25.8	2.4	3.0	-5.1
Had menopause	1.9	2.4	4.0	-1.7	-2.0	0.7
Alcohol intake versus 10 years previously	1.9	2.8	4.0	-2.0	-1.7	1.2
Qualifications: A levels/AS levels or equivalent	1.9	4.1	6.5	2.6	2.3	-0.8
Pulse wave peak to peak time	1.9	2.2	5.5	0.4	1.0	-2.3
Health satisfaction	1.9	2.4	3.3	-1.4	-1.4	1.8
Eye problems/disorders: None of the above	1.9	2.2	2.8	1.6	1.7	-1.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.3	-1.8	-1.8	0.9
Long-standing illness, disability or infirmity	1.8	2.7	3.4	-1.5	-1.5	1.9
Ever had hysterectomy (womb removed)	1.7	1.9	4.7	0.8	0.4	2.2
Waist circumference	1.7	6.4	9.5	-3.0	-3.1	0.9
Mouth/teeth dental problems	1.7	2.6	3.8	1.6	1.1	-1.9
Arm fat-free mass (right)	1.7	8.6	10.7	-3.2	-3.3	2.3
Heart disease (mother)	1.7	2.1	3.2	1.8	1.7	0.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	2.3	1.5	1.5	-1.2
Chronotype (morning person)	1.6	3.8	4.9	-2.0	-2.2	1.6
Fluid intelligence score	1.6	3.3	3.6	1.9	1.9	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	2.8	-1.4	-1.3	1.7
Standing height	1.6	15.7	21.9	3.4	3.7	-4.7
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	7.9	0.8	1.3	-2.8
Height	1.5	28.4	34.5	4.7	5.4	-5.9
Impedance of leg (right)	1.5	7.1	11.2	2.0	2.4	-3.4
Impedance of leg (left)	1.5	7.4	12.1	2.0	2.5	-3.5
Forced vital capacity (FVC)	1.5	5.8	10.9	1.6	2.0	-3.3
Arm fat-free mass (left)	1.5	7.4	8.9	-3.0	-3.0	2.1
Commuting to job workplace: Cycle	1.5	1.9	2.6	-1.4	-1.6	1.0
Triglycerides	1.4	2.3	2.5	-1.6	-1.6	1.3
Vitamin and mineral supplements	1.4	1.9	2.7	1.6	1.7	-0.6
Pulse wave Arterial Stiffness index	1.4	1.7	4.1	-0.3	-0.9	2.0
Heart disease (siblings)	1.4	1.7	2.1	1.4	1.4	-0.9
Sensitivity / hurt feelings	1.3	2.2	6.0	-0.5	-0.5	2.5
Qualifications: College or University degree	1.3	4.1	7.0	2.6	2.2	-0.8
Arm predicted mass (right)	1.3	6.7	8.2	-2.8	-2.9	2.0
Asthma (self-reported)	1.3	2.6	3.8	-1.3	-1.5	2.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.2	1.5	1.4	0.3
Neuroticism (2016)	1.2	1.7	1.9	-1.2	-1.3	1.4
Qualifications: CSEs or equivalent	1.2	1.5	4.5	-0.4	0.1	-2.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.9	-1.3	-1.4	1.0
Qualifications: None of the above	1.2	2.5	5.0	-1.0	-1.2	2.2
Medication: Cholesterol lowering	1.2	1.8	5.3	-0.0	-0.4	2.3
Depression (self-reported)	1.2	1.5	2.6	-0.8	-1.1	1.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.4	1.4	1.2	-1.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.6	-1.6	-1.1	1.0
Leg pain on walking	1.2	1.5	1.8	-1.1	-1.2	1.4
Medication: Aspirin	1.2	1.6	4.6	0.0	-0.4	2.2
Fractured/broken bones in last 5 years	1.2	1.5	1.8	-1.1	-1.4	1.2
Arm predicted mass (left)	1.2	6.1	7.2	-2.6	-2.7	2.0
Alzheimer’s Disease (in father)	1.1	1.2	1.9	-1.4	-1.3	0.1
Respiratory disease	1.1	2.4	4.3	-1.0	-1.4	2.1
Asthma	1.1	2.1	2.9	-1.2	-1.4	1.7
Arm fat mass (right)	1.1	4.5	6.8	-2.6	-2.6	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.2	-0.6	-0.9	1.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.4	-0.5	-0.4	1.9
Mood swings	1.1	1.9	4.6	-0.6	-0.9	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.1	1.3	1.4	-0.3
Arm fat mass (left)	1.1	4.6	7.1	-2.7	-2.6	0.1
Medication: Atorvastatin	1.1	1.4	1.9	1.4	1.3	0.7
Cholesterol lowering medication	1.1	1.6	2.5	-1.3	-1.6	0.8
Depressed Affect (Nagel 2018)	1.0	2.2	3.9	-1.1	-1.2	2.0
Crohns Disease (2017)	1.0	2.1	2.8	-1.7	-1.5	1.1
Serious illness, injury or assault to yourself	1.0	1.3	1.9	-0.9	-1.0	1.4
Had other major operations	1.0	1.3	1.8	-1.3	-1.3	0.7
Medication: Lansoprazole	1.0	1.2	2.2	-0.7	-0.9	1.5
Medication: Allopurinol	1.0	1.3	2.1	-1.4	-1.3	0.6
Medication: Aspirin	1.0	1.3	3.7	0.1	-0.2	1.9
Ever had bowel cancer screening	1.0	1.2	1.3	-1.1	-1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.1	-1.8	-1.7	0.2
Illnesses of father: High blood pressure	1.0	1.2	1.8	-1.3	-1.3	0.5
Crohns Disease (2012)	0.9	1.5	2.2	-0.9	-1.1	1.5
Pain all over the body in last month	0.9	1.0	1.7	-0.8	-0.9	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	6.9	1.0	1.3	-2.6
Pulse rate	0.9	1.6	3.5	-0.5	-1.0	1.9
Arm fat percentage (left)	0.9	3.6	5.4	-2.3	-2.2	-0.7
Financial situation satisfaction	0.9	1.1	1.5	1.1	1.2	-0.8
Risk taking	0.9	1.4	2.0	1.4	1.4	-0.3
Neuroticism (Nagel 2018)	0.8	1.9	4.1	-0.8	-1.0	2.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.3	1.8	1.5	-0.3
Severe depression (siblings)	0.8	0.9	1.4	0.7	0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.3	0.1	0.5	-2.3
Weight	0.8	3.8	5.8	-2.4	-2.4	0.1
Arm fat percentage (right)	0.8	3.3	5.0	-2.2	-2.1	-0.7
Hip circumference	0.8	3.4	5.3	-2.3	-2.2	-0.2
Birth weight of first child	0.8	1.4	2.0	1.4	1.4	-0.5
Pulse wave reflection index	0.8	1.0	2.8	0.5	0.2	1.7
Forced vital capacity (FVC), Best measure	0.8	3.0	7.6	0.7	0.9	-2.8
Body fat percentage	0.8	3.3	4.7	-2.2	-2.0	-1.2
Whole body fat mass	0.8	3.5	5.3	-2.3	-2.2	-0.6
Loneliness, isolation	0.8	1.1	3.1	-0.2	-0.4	1.8
Commuting to job workplace: Walk	0.8	0.9	1.3	0.8	0.8	-1.2
Eye problems/disorders: Cataract	0.8	0.9	1.6	-1.3	-1.0	-0.0
Mother’s age at death	0.8	1.0	3.0	-0.2	-0.3	1.7
Basal cell carcinoma (self-reported)	0.8	0.9	1.7	1.3	0.9	0.5
Breast Cancer	0.7	1.7	2.7	-1.6	-1.0	-1.2
Blood White Count	0.7	5.0	7.8	-2.8	-2.7	-0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	0.8	-0.9	-0.9	0.9
Illnesses of siblings	0.7	0.9	2.1	-0.7	-0.4	-1.4
Tense / ‘highly strung’	0.7	1.1	1.8	1.3	1.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.1	-0.1	-0.4	1.8
Gout (self-reported)	0.7	1.0	1.6	-1.3	-1.0	-0.5
Shortness of breath walking on level ground	0.7	0.8	1.3	1.1	1.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	0.9	1.2	0.4
Comparative height size at age 10	0.7	4.1	4.9	2.2	2.1	-1.8
Smoking status: Previous	0.7	1.1	1.4	-1.2	-0.8	1.1
Smoking status: Current	0.7	1.1	1.3	1.2	1.1	-0.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.1	-0.5	-0.5	1.5
Alcohol drinker status: Previous	0.7	0.7	1.0	-1.0	-1.0	0.6
Alzheimer’s Disease (in mother)	0.6	0.8	1.3	1.1	1.0	-0.0
Rheumatoid Arthritis	0.6	0.8	1.4	1.2	1.0	-0.1
Neuroticism	0.6	1.5	4.3	-0.3	-0.4	2.1
Medication: Co-codamol	0.6	0.6	1.0	-1.0	-0.9	0.3
Townsend deprivation index at recruitment	0.6	0.8	1.9	-0.3	-0.6	1.4
Age when periods started (menarche)	0.6	1.4	1.9	1.0	1.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.3	0.2	0.5	-2.3
Had major operations	0.6	0.7	1.5	-0.3	-0.6	1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	0.7	1.0	-0.7
Knee pain experienced in last month	0.6	0.9	1.1	-1.0	-0.9	0.8
Mineral and other dietary supplements	0.6	0.9	1.2	1.0	1.1	-0.6
Ever depressed for a whole week	0.6	0.7	0.9	-0.9	-0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	0.3	0.5	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	1.0	0.9	0.3
Coronary Artery Disease (CAD)	0.5	0.6	1.0	-0.9	-1.0	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.7	0.4	1.2
Hearing difficulty/problems: Yes	0.5	0.7	0.8	-0.8	-0.8	0.9
Trunk fat percentage	0.5	1.9	4.1	-1.0	-0.8	-2.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	-0.1	0.1	-1.3
Trunk fat mass	0.5	2.1	2.2	-1.5	-1.3	-1.5
Hair/balding pattern: Pattern 2	0.5	0.7	1.0	-1.0	-0.9	-0.5
Financial difficulties in last 2 years	0.5	0.7	2.0	0.0	0.3	-1.4
Trunk fat-free mass	0.5	2.6	3.3	-1.8	-1.8	1.2
Lung cancer (father)	0.5	0.5	0.9	-0.7	-0.3	-1.0
Emphysema/chronic bronchitis	0.5	0.6	0.9	-0.4	-0.9	0.8
Neck or shoulder pain in last month	0.5	0.7	1.3	-1.2	-0.6	0.6
Chest pain or discomfort	0.5	0.7	1.4	-0.4	-0.7	1.2
Whole body fat-free mass	0.5	2.9	3.8	-1.9	-1.9	1.1
Whole body water mass	0.5	2.9	3.8	-1.9	-1.9	1.1
Miserableness	0.5	0.8	1.4	1.0	1.2	-0.3
Commuting to job workplace: Public transport	0.5	0.6	0.8	-0.7	-0.9	0.8
Basal metabolic rate	0.5	3.0	4.2	-2.1	-2.0	0.8
Reaction Time	0.4	0.8	1.5	0.6	0.7	-1.2
Waist Hip Ratio (WHR)	0.4	1.8	2.2	-1.0	-1.4	1.5
Systolic Blood Pressure	0.4	2.0	4.5	1.1	0.4	2.1
Lung FEV1/FVC ratio	0.4	2.0	2.4	-1.6	-1.5	1.2
Hair Pigment	0.4	10.3	12.2	-3.3	-3.5	2.8
Average weekly spirits intake	0.4	0.5	0.6	-0.8	-0.7	0.5
Fed-up feelings	0.4	0.6	1.1	-0.6	-0.7	1.1
Alcohol usually taken with meals	0.4	0.6	1.4	-0.5	-0.5	1.2
Nervous feelings	0.4	0.7	0.8	0.8	0.8	0.9
Father’s age at death	0.4	0.6	1.4	0.4	0.3	1.2
Worrier / anxious feelings	0.4	0.7	2.0	-0.1	-0.0	1.4
Trunk predicted mass	0.4	2.4	3.0	-1.7	-1.7	1.1
Blood clot in the leg (DVT)	0.4	0.6	1.4	0.3	0.4	-1.2
Glaucoma (self-reported)	0.4	0.4	1.3	0.1	0.0	1.1
Exposure to tobacco smoke outside home	0.4	0.5	0.7	0.5	0.8	-0.8
Comparative body size at age 10	0.4	1.0	1.6	-1.3	-1.2	0.2
Age at first live birth	0.4	0.7	0.8	0.8	0.7	-0.9
Mean time to correctly identify matches	0.4	0.8	1.7	0.6	0.7	-1.3
Pulse rate, automated reading	0.4	1.2	1.5	-0.8	-1.2	1.2
Age at last live birth	0.4	0.6	0.9	0.9	0.8	-0.4
Illnesses of father: Heart disease	0.4	0.5	0.8	0.8	0.9	0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.6	-0.8	-0.5	0.8
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.6	0.5	1.1
Age started oral contraceptive pill	0.4	0.5	1.4	-0.1	0.1	-1.2
Irritable Bowel Disease (IBD)	0.3	0.8	1.9	0.4	0.6	-1.4
Blood Red Count	0.3	3.1	3.3	-1.8	-1.8	1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.5	0.6	0.7	-0.5
Pack years adult smoking proportion	0.3	0.5	1.1	-0.5	-0.5	1.0
Leg fat-free mass (left)	0.3	1.8	2.7	-1.6	-1.6	0.4
Current tobacco smoking	0.3	0.5	0.7	0.8	0.7	-0.6
Medication: Atenolol	0.3	0.4	1.3	0.1	-0.1	1.1
Leg predicted mass (left)	0.3	1.7	2.5	-1.5	-1.6	0.4
Past tobacco smoking	0.3	0.5	0.7	0.8	0.5	-0.8
Neuroticism score	0.3	0.7	2.0	-0.0	0.0	1.4
Falls in the last year	0.3	0.4	0.6	0.6	0.3	0.8
Prospective memory result	0.3	0.4	0.5	-0.7	-0.7	0.5
Illnesses of mother	0.3	0.4	0.5	-0.7	-0.5	-0.7
Exposure to tobacco smoke at home	0.3	0.3	0.4	-0.5	-0.6	0.7
Breastfed as a baby	0.3	0.4	0.6	-0.6	-0.8	0.5
Loud music exposure frequency	0.3	0.3	0.8	0.3	0.2	-0.9
Worry too long after embarrassment	0.3	0.5	1.3	-0.2	-0.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.7	0.5	0.7
Number of full sisters	0.3	0.3	0.5	0.6	0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.6	-0.7	-0.4	-0.8
Back pain experienced in last month	0.3	0.5	1.0	-1.0	-0.3	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.5	-0.6	-0.4	0.7
Pack years of smoking	0.3	0.4	0.8	-0.5	-0.5	0.9
Major Depression (MDD)	0.2	0.2	0.5	0.1	0.4	-0.7
Prostate Cancer	0.2	0.2	0.3	0.5	0.5	-0.4
Lung FVC	0.2	1.1	2.8	0.5	0.5	-1.7
Hand grip strength (left)	0.2	0.7	0.9	0.9	0.9	-0.5
Supplements: Zinc	0.2	0.2	0.4	-0.4	-0.4	0.7
Hand grip strength (right)	0.2	0.6	0.8	0.9	0.6	-0.8
Multivitamins +/- minerals	0.2	0.2	0.4	-0.6	-0.5	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.4	-0.5	0.6
Number of incorrect matches in round	0.2	0.3	0.6	-0.3	-0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	0.4	0.5	-0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.6	0.6	0.4
Time employed in main current job	0.2	0.2	0.4	-0.6	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.2	-0.1	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	0.3	0.5	0.5
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.5	-0.5	1.0
High blood pressure (siblings)	0.2	0.4	0.5	0.7	0.4	0.7
Number of full brothers	0.2	0.2	0.6	0.1	-0.0	0.8
Number of children fathered	0.2	0.3	0.8	-0.1	0.1	0.9
Suffer from ‘nerves’	0.2	0.4	0.6	0.7	0.8	0.0
Family relationship satisfaction	0.2	0.2	0.5	0.5	0.7	-0.1
Leg fat-free mass (right)	0.2	1.1	1.7	-1.2	-1.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.3	-0.3	0.6
Qualifications: nursing, teaching	0.2	0.4	0.5	-0.7	-0.7	0.2
Leg predicted mass (right)	0.2	0.9	1.4	-1.1	-1.2	0.2
Guilty feelings	0.2	0.3	0.8	-0.2	-0.3	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.5	0.7	0.1
High cholesterol (Self-reported)	0.2	0.4	0.5	-0.6	-0.7	0.6
Unable to work because of sickness or disability	0.2	0.3	0.5	0.4	0.4	0.7
Myopia	0.2	0.2	0.4	0.5	0.4	-0.6
Supplements: Calcium	0.2	0.3	0.5	-0.7	-0.5	0.2
Bipolar Disorder (2018)	0.1	0.1	0.3	0.2	0.2	-0.5
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.2	0.4
Worry (Nagel 2018)	0.1	0.3	0.8	0.0	0.1	0.9
Age at First Birth	0.1	0.2	0.2	0.5	0.4	-0.4
Mean Putamen Volume	0.1	0.1	0.3	-0.1	0.2	-0.5
LDL Cholesterol	0.1	0.2	0.3	-0.5	-0.5	0.4
Lupus	0.1	0.1	0.2	0.3	-0.3	0.4
Heel T-Score	0.1	1.1	3.0	-0.2	0.6	-1.7
Systolic blood pressure, automated reading	0.1	0.3	0.9	0.2	-0.3	0.9
Diabetes (mother)	0.1	0.2	0.3	-0.5	-0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	-0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	-0.4	0.1
Supplements: Glucosamine	0.1	0.1	0.2	-0.5	-0.3	0.3
High blood pressure (mother)	0.1	0.2	0.2	-0.4	-0.5	0.5
Happiness	0.1	0.2	0.3	-0.4	-0.1	0.5
Length of working week for main job	0.1	0.1	0.2	0.5	0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	-0.4	-0.4	0.7
Angina (self-reported)	0.1	0.1	0.2	0.5	0.2	0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	-0.1	-0.6
Breast cancer (self-reported)	0.1	0.1	0.4	0.0	0.2	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.1	0.5	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.3	-0.1	-0.6
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.1	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.1	0.1	-0.5
Ever smoked	0.1	0.1	0.2	0.2	0.4	-0.3
Irritability	0.1	0.2	0.5	0.1	0.1	0.7
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.3	0.1	0.2
Ovarian Cancer	0.0	0.1	0.1	-0.1	0.1	-0.4
Blood Eosinophil Count	0.0	0.2	0.4	-0.2	-0.5	0.6
Blood Platelet Count	0.0	0.1	0.2	-0.1	0.2	0.4
Smoking Status	0.0	0.0	0.1	-0.1	0.3	0.1
Hypothyroidism (self reported)	0.0	0.0	0.1	0.1	-0.1	0.3
Tanning	0.0	0.3	0.4	0.7	0.6	0.2
Angina	0.0	0.1	0.1	0.1	-0.2	0.3
Heart attack	0.0	0.0	0.1	-0.3	-0.1	0.0
Noisy workplace	0.0	0.0	0.0	-0.1	0.1	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.1	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	0.0	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.0	0.1	0.0

Hub : Genes

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Trait associations