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Cardiovascular Disease
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chr6:159,843,841-161,571,560
Best TWAS P=1.8e-10 · Best GWAS P=1.03e-19 conditioned to 5.74e-10
159.8M
160M
160.2M
160.4M
160.6M
160.8M
161M
161.2M
161.4M
161.6M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
SLC22A1
0.04
0.00
bslmm
534
0.01
0.01280
2.6
-6.4
1.8e-10
-0.14
0.06
0.06
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
SLC22A1
0.04
0.01
enet
17
0.01
0.00052
5.4
-5.5
2.9e-08
-0.59
0.01
0.94
TRUE
1
GTEx
Skin Not Sun Exposed Suprapubic
SLC22A3
0.15
0.05
lasso
9
0.05
0.00099
3.1
5.2
1.5e-07
0.06
0.74
0.02
FALSE