TWAS
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Usage
Models
Genes
Traits
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Traits
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Cardiovascular Disease
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chr7:1,854,263-3,264,728
Best TWAS P=1.61e-09 · Best GWAS P=2.02e-10 conditioned to 0.00395
1.8M
2M
2.2M
2.4M
2.6M
2.8M
3M
3.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Colon Transverse
LFNG
0.25
0.20
lasso
3
0.17
1.1e-08
5.9
6.0
1.6e-09
0.73
0
1.00
TRUE
2
The Cancer Genome Atlas
Soft Tissue Sarcoma
LFNG
0.13
0.02
blup
43
0.05
8.0e-04
6.4
-5.7
1.3e-08
-0.63
0
0.76
FALSE