Best TWAS P=1.85e-15 · Best GWAS P=4.12e-13 conditioned to 0.0441
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NUDC | 0.05 | 0.03 | bslmm | 257 | 0.03 | 7.4e-05 | 6.7 | 5.4 | 7.0e-08 | 0.60 | 0.30 | 0.61 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PIGV | 0.04 | 0.03 | bslmm | 295 | 0.03 | 4.2e-05 | 6.7 | -6.5 | 8.2e-11 | -0.66 | 0.31 | 0.69 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | PIGV | 0.04 | 0.04 | lasso | 6 | 0.03 | 2.6e-03 | 6.8 | -7.2 | 4.1e-13 | -0.74 | 0.09 | 0.87 | FALSE |
| 4 | GTEx | Artery Aorta | PIGV | 0.11 | 0.10 | lasso | 9 | 0.08 | 2.7e-05 | 6.6 | -7.2 | 7.8e-13 | -0.63 | 0.31 | 0.67 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | PIGV | 0.10 | 0.14 | lasso | 10 | 0.10 | 7.6e-06 | 6.6 | -6.8 | 7.5e-12 | -0.71 | 0.15 | 0.84 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | PIGV | 0.10 | 0.08 | lasso | 3 | 0.06 | 6.0e-03 | 6.6 | -6.7 | 2.8e-11 | -0.66 | 0.10 | 0.70 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | PIGV | 0.05 | 0.00 | enet | 10 | 0.03 | 4.3e-03 | 7.2 | -6.5 | 8.3e-11 | -0.85 | 0.04 | 0.95 | FALSE |
| 8 | GTEx | Colon Transverse | PIGV | 0.17 | 0.15 | lasso | 2 | 0.14 | 3.4e-07 | 6.6 | -6.7 | 2.9e-11 | -0.66 | 0.28 | 0.72 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | PIGV | 0.13 | 0.02 | lasso | 10 | 0.01 | 1.2e-01 | 6.1 | -6.3 | 2.1e-10 | -0.69 | 0.12 | 0.41 | FALSE |
| 10 | GTEx | Esophagus Mucosa | PIGV | 0.16 | 0.15 | lasso | 6 | 0.14 | 7.0e-10 | 6.6 | -6.7 | 2.3e-11 | -0.68 | 0.26 | 0.74 | FALSE |
| 11 | GTEx | Esophagus Muscularis | PIGV | 0.09 | 0.07 | enet | 25 | 0.13 | 3.4e-08 | 6.7 | -8.0 | 1.9e-15 | -0.66 | 0.25 | 0.75 | TRUE |
| 12 | GTEx | Muscle Skeletal | PIGV | 0.07 | 0.01 | enet | 12 | 0.02 | 2.1e-03 | 6.6 | -6.1 | 1.4e-09 | -0.57 | 0.24 | 0.52 | FALSE |
| 13 | GTEx | Pituitary | PIGV | 0.25 | 0.12 | lasso | 10 | 0.02 | 8.8e-02 | 6.7 | -6.9 | 5.3e-12 | -0.67 | 0.13 | 0.34 | FALSE |
| 14 | GTEx | Prostate | RP1-50O24.6 | 0.15 | 0.02 | lasso | 9 | 0.02 | 1.1e-01 | 6.7 | 6.7 | 1.8e-11 | 0.67 | 0.06 | 0.20 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | PIGV | 0.05 | 0.07 | lasso | 2 | 0.06 | 5.0e-06 | 6.6 | -6.6 | 3.9e-11 | -0.69 | 0.20 | 0.80 | FALSE |
| 16 | GTEx | Spleen | PIGV | 0.16 | 0.13 | lasso | 13 | 0.16 | 6.6e-05 | 3.8 | -6.0 | 1.8e-09 | -0.49 | 0.15 | 0.53 | FALSE |
| 17 | GTEx | Stomach | PIGV | 0.09 | 0.14 | lasso | 1 | 0.12 | 1.5e-06 | 6.6 | -6.6 | 3.2e-11 | -0.66 | 0.25 | 0.73 | FALSE |
| 18 | GTEx | Testis | ZDHHC18 | 0.23 | 0.11 | lasso | 2 | 0.13 | 2.4e-06 | 7.0 | 5.7 | 1.2e-08 | 0.90 | 0.02 | 0.98 | FALSE |
| 19 | GTEx | Thyroid | PIGV | 0.14 | 0.12 | lasso | 7 | 0.10 | 2.7e-08 | 6.1 | -6.2 | 6.3e-10 | -0.62 | 0.19 | 0.81 | FALSE |
| 20 | GTEx | Thyroid | ZDHHC18 | 0.11 | 0.10 | lasso | 4 | 0.13 | 4.2e-10 | 7.2 | 7.6 | 3.1e-14 | 0.96 | 0.01 | 0.99 | FALSE |
| 21 | GTEx | Whole Blood | ZDHHC18 | 0.04 | 0.02 | lasso | 1 | 0.01 | 5.7e-02 | 6.7 | 6.7 | 2.9e-11 | 0.68 | 0.11 | 0.75 | FALSE |
| 22 | METSIM | Adipose | PIGV | 0.03 | 0.02 | enet | 25 | 0.04 | 2.8e-06 | -1.1 | -5.6 | 2.0e-08 | -0.44 | 0.28 | 0.55 | FALSE |
| 23 | METSIM | Adipose | ZDHHC18 | 0.04 | 0.03 | lasso | 2 | 0.04 | 3.8e-06 | 6.1 | 6.2 | 4.7e-10 | 0.58 | 0.27 | 0.72 | FALSE |
| 24 | NTR | Blood | ARID1A | 0.03 | 0.03 | enet | 20 | 0.03 | 7.8e-11 | 6.8 | -7.1 | 1.4e-12 | -0.66 | 0.25 | 0.75 | FALSE |
| 25 | NTR | Blood | ZDHHC18 | 0.01 | 0.00 | bslmm | 285 | 0.01 | 5.7e-03 | 7.2 | 6.3 | 2.3e-10 | 0.81 | 0.01 | 0.97 | FALSE |
| 26 | ROSMAP | Brain Pre-frontal Cortex | CD164L2 | 0.16 | 0.13 | bslmm | 220 | 0.16 | 2.4e-20 | -3.9 | -5.8 | 7.7e-09 | -0.09 | 1.00 | 0.00 | TRUE |
| 27 | YFS | Blood | PIGV | 0.02 | 0.01 | blup | 295 | 0.01 | 1.6e-04 | 6.6 | -5.4 | 6.5e-08 | -0.67 | 0.22 | 0.75 | FALSE |
| 28 | YFS | Blood | ZDHHC18 | 0.08 | 0.11 | bslmm | 286 | 0.11 | 2.1e-33 | 7.2 | 7.5 | 7.1e-14 | 0.97 | 0.01 | 0.99 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PIGV | 0.02 | 0.02 | lasso | 10 | 0.03 | 1.3e-06 | 7.2 | -7.6 | 3.1e-14 | -0.92 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIGV | 0.05 | 0.03 | blup | 19 | 0.02 | 2.0e-02 | 7.0 | -7.4 | 1.2e-13 | -0.90 | 0.00 | 0.72 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPN2 | 0.03 | 0.01 | lasso | 9 | 0.02 | 3.2e-03 | 6.7 | 6.8 | 1.1e-11 | 0.67 | 0.12 | 0.50 | FALSE |
| 32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PIGV | 0.03 | 0.05 | lasso | 7 | 0.04 | 4.2e-05 | 6.8 | -7.2 | 5.1e-13 | -0.79 | 0.07 | 0.92 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZDHHC18 | 0.04 | 0.01 | enet | 5 | 0.02 | 4.7e-03 | 7.2 | 5.5 | 4.0e-08 | 0.77 | 0.00 | 0.68 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM46B | 0.04 | 0.00 | blup | 23 | 0.01 | 3.5e-02 | -2.0 | -5.7 | 9.7e-09 | -0.27 | 0.00 | 0.26 | FALSE |
| 35 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIGV | 0.09 | 0.09 | lasso | 1 | 0.08 | 5.1e-09 | 7.0 | -7.0 | 2.0e-12 | -0.99 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | PIGV | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.1e-04 | 7.3 | -7.2 | 4.1e-13 | -1.00 | 0.00 | 0.98 | FALSE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | ZDHHC18 | 0.34 | 0.42 | enet | 5 | 0.41 | 8.1e-43 | 7.3 | 7.1 | 1.1e-12 | 1.00 | 0.00 | 1.00 | FALSE |