[Hub]/) : Traits : Cardiovascular Disease : ← →

chr1:26,327,671-28,406,173

Best TWAS P=1.85e-15 · Best GWAS P=4.12e-13 conditioned to 0.0441

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Esophagus Muscularis	PIGV	0.09	0.07	enet	25	0.13	3.4e-08	6.7	-8.0	1.9e-15	-0.66	0.25	0.75	TRUE
26	ROSMAP	Brain Pre-frontal Cortex	CD164L2	0.16	0.13	bslmm	220	0.16	2.4e-20	-3.9	-5.8	7.7e-09	-0.09	1.00	0.00	TRUE
20	GTEx	Thyroid	ZDHHC18	0.11	0.10	lasso	4	0.13	4.2e-10	7.2	7.6	3.1e-14	0.96	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	PIGV	0.02	0.02	lasso	10	0.03	1.3e-06	7.2	-7.6	3.1e-14	-0.92	0.01	0.99	FALSE
28	YFS	Blood	ZDHHC18	0.08	0.11	bslmm	286	0.11	2.1e-33	7.2	7.5	7.1e-14	0.97	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	PIGV	0.05	0.03	blup	19	0.02	2.0e-02	7.0	-7.4	1.2e-13	-0.90	0.00	0.72	FALSE
3	GTEx	Adipose Subcutaneous	PIGV	0.04	0.04	lasso	6	0.03	2.6e-03	6.8	-7.2	4.1e-13	-0.74	0.09	0.87	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	PIGV	0.04	0.04	lasso	4	0.04	2.1e-04	7.3	-7.2	4.1e-13	-1.00	0.00	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIGV	0.03	0.05	lasso	7	0.04	4.2e-05	6.8	-7.2	5.1e-13	-0.79	0.07	0.92	FALSE
4	GTEx	Artery Aorta	PIGV	0.11	0.10	lasso	9	0.08	2.7e-05	6.6	-7.2	7.8e-13	-0.63	0.31	0.67	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	ZDHHC18	0.34	0.42	enet	5	0.41	8.1e-43	7.3	7.1	1.1e-12	1.00	0.00	1.00	FALSE
24	NTR	Blood	ARID1A	0.03	0.03	enet	20	0.03	7.8e-11	6.8	-7.1	1.4e-12	-0.66	0.25	0.75	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIGV	0.09	0.09	lasso	1	0.08	5.1e-09	7.0	-7.0	2.0e-12	-0.99	0.00	1.00	FALSE
13	GTEx	Pituitary	PIGV	0.25	0.12	lasso	10	0.02	8.8e-02	6.7	-6.9	5.3e-12	-0.67	0.13	0.34	FALSE
5	GTEx	Breast Mammary Tissue	PIGV	0.10	0.14	lasso	10	0.10	7.6e-06	6.6	-6.8	7.5e-12	-0.71	0.15	0.84	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPN2	0.03	0.01	lasso	9	0.02	3.2e-03	6.7	6.8	1.1e-11	0.67	0.12	0.50	FALSE
14	GTEx	Prostate	RP1-50O24.6	0.15	0.02	lasso	9	0.02	1.1e-01	6.7	6.7	1.8e-11	0.67	0.06	0.20	FALSE
10	GTEx	Esophagus Mucosa	PIGV	0.16	0.15	lasso	6	0.14	7.0e-10	6.6	-6.7	2.3e-11	-0.68	0.26	0.74	FALSE
6	GTEx	Breast Mammary Tissue (Female)	PIGV	0.10	0.08	lasso	3	0.06	6.0e-03	6.6	-6.7	2.8e-11	-0.66	0.10	0.70	FALSE
8	GTEx	Colon Transverse	PIGV	0.17	0.15	lasso	2	0.14	3.4e-07	6.6	-6.7	2.9e-11	-0.66	0.28	0.72	FALSE
21	GTEx	Whole Blood	ZDHHC18	0.04	0.02	lasso	1	0.01	5.7e-02	6.7	6.7	2.9e-11	0.68	0.11	0.75	FALSE
17	GTEx	Stomach	PIGV	0.09	0.14	lasso	1	0.12	1.5e-06	6.6	-6.6	3.2e-11	-0.66	0.25	0.73	FALSE
15	GTEx	Skin Sun Exposed Lower leg	PIGV	0.05	0.07	lasso	2	0.06	5.0e-06	6.6	-6.6	3.9e-11	-0.69	0.20	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PIGV	0.04	0.03	bslmm	295	0.03	4.2e-05	6.7	-6.5	8.2e-11	-0.66	0.31	0.69	FALSE
7	GTEx	Cells Transformed fibroblasts	PIGV	0.05	0.00	enet	10	0.03	4.3e-03	7.2	-6.5	8.3e-11	-0.85	0.04	0.95	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	PIGV	0.13	0.02	lasso	10	0.01	1.2e-01	6.1	-6.3	2.1e-10	-0.69	0.12	0.41	FALSE
25	NTR	Blood	ZDHHC18	0.01	0.00	bslmm	285	0.01	5.7e-03	7.2	6.3	2.3e-10	0.81	0.01	0.97	FALSE
23	METSIM	Adipose	ZDHHC18	0.04	0.03	lasso	2	0.04	3.8e-06	6.1	6.2	4.7e-10	0.58	0.27	0.72	FALSE
19	GTEx	Thyroid	PIGV	0.14	0.12	lasso	7	0.10	2.7e-08	6.1	-6.2	6.3e-10	-0.62	0.19	0.81	FALSE
12	GTEx	Muscle Skeletal	PIGV	0.07	0.01	enet	12	0.02	2.1e-03	6.6	-6.1	1.4e-09	-0.57	0.24	0.52	FALSE
16	GTEx	Spleen	PIGV	0.16	0.13	lasso	13	0.16	6.6e-05	3.8	-6.0	1.8e-09	-0.49	0.15	0.53	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM46B	0.04	0.00	blup	23	0.01	3.5e-02	-2.0	-5.7	9.7e-09	-0.27	0.00	0.26	FALSE
18	GTEx	Testis	ZDHHC18	0.23	0.11	lasso	2	0.13	2.4e-06	7.0	5.7	1.2e-08	0.90	0.02	0.98	FALSE
22	METSIM	Adipose	PIGV	0.03	0.02	enet	25	0.04	2.8e-06	-1.1	-5.6	2.0e-08	-0.44	0.28	0.55	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	ZDHHC18	0.04	0.01	enet	5	0.02	4.7e-03	7.2	5.5	4.0e-08	0.77	0.00	0.68	FALSE
27	YFS	Blood	PIGV	0.02	0.01	blup	295	0.01	1.6e-04	6.6	-5.4	6.5e-08	-0.67	0.22	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NUDC	0.05	0.03	bslmm	257	0.03	7.4e-05	6.7	5.4	7.0e-08	0.60	0.30	0.61	FALSE