[Hub]/) : Traits : Cardiovascular Disease :

chr1:26,327,671-28,406,173

Best TWAS P=1.85e-15 · Best GWAS P=4.12e-13 conditioned to 0.0441

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NUDC 0.05 0.03 bslmm 257 0.03 7.4e-05 6.7 5.4 7.0e-08 0.60 0.30 0.61 FALSE
2 CommonMind Brain Pre-frontal Cortex PIGV 0.04 0.03 bslmm 295 0.03 4.2e-05 6.7 -6.5 8.2e-11 -0.66 0.31 0.69 FALSE
3 GTEx Adipose Subcutaneous PIGV 0.04 0.04 lasso 6 0.03 2.6e-03 6.8 -7.2 4.1e-13 -0.74 0.09 0.87 FALSE
4 GTEx Artery Aorta PIGV 0.11 0.10 lasso 9 0.08 2.7e-05 6.6 -7.2 7.8e-13 -0.63 0.31 0.67 FALSE
5 GTEx Breast Mammary Tissue PIGV 0.10 0.14 lasso 10 0.10 7.6e-06 6.6 -6.8 7.5e-12 -0.71 0.15 0.84 FALSE
6 GTEx Breast Mammary Tissue (Female) PIGV 0.10 0.08 lasso 3 0.06 6.0e-03 6.6 -6.7 2.8e-11 -0.66 0.10 0.70 FALSE
7 GTEx Cells Transformed fibroblasts PIGV 0.05 0.00 enet 10 0.03 4.3e-03 7.2 -6.5 8.3e-11 -0.85 0.04 0.95 FALSE
8 GTEx Colon Transverse PIGV 0.17 0.15 lasso 2 0.14 3.4e-07 6.6 -6.7 2.9e-11 -0.66 0.28 0.72 FALSE
9 GTEx Esophagus Gastroesophageal Junction PIGV 0.13 0.02 lasso 10 0.01 1.2e-01 6.1 -6.3 2.1e-10 -0.69 0.12 0.41 FALSE
10 GTEx Esophagus Mucosa PIGV 0.16 0.15 lasso 6 0.14 7.0e-10 6.6 -6.7 2.3e-11 -0.68 0.26 0.74 FALSE
11 GTEx Esophagus Muscularis PIGV 0.09 0.07 enet 25 0.13 3.4e-08 6.7 -8.0 1.9e-15 -0.66 0.25 0.75 TRUE
12 GTEx Muscle Skeletal PIGV 0.07 0.01 enet 12 0.02 2.1e-03 6.6 -6.1 1.4e-09 -0.57 0.24 0.52 FALSE
13 GTEx Pituitary PIGV 0.25 0.12 lasso 10 0.02 8.8e-02 6.7 -6.9 5.3e-12 -0.67 0.13 0.34 FALSE
14 GTEx Prostate RP1-50O24.6 0.15 0.02 lasso 9 0.02 1.1e-01 6.7 6.7 1.8e-11 0.67 0.06 0.20 FALSE
15 GTEx Skin Sun Exposed Lower leg PIGV 0.05 0.07 lasso 2 0.06 5.0e-06 6.6 -6.6 3.9e-11 -0.69 0.20 0.80 FALSE
16 GTEx Spleen PIGV 0.16 0.13 lasso 13 0.16 6.6e-05 3.8 -6.0 1.8e-09 -0.49 0.15 0.53 FALSE
17 GTEx Stomach PIGV 0.09 0.14 lasso 1 0.12 1.5e-06 6.6 -6.6 3.2e-11 -0.66 0.25 0.73 FALSE
18 GTEx Testis ZDHHC18 0.23 0.11 lasso 2 0.13 2.4e-06 7.0 5.7 1.2e-08 0.90 0.02 0.98 FALSE
19 GTEx Thyroid PIGV 0.14 0.12 lasso 7 0.10 2.7e-08 6.1 -6.2 6.3e-10 -0.62 0.19 0.81 FALSE
20 GTEx Thyroid ZDHHC18 0.11 0.10 lasso 4 0.13 4.2e-10 7.2 7.6 3.1e-14 0.96 0.01 0.99 FALSE
21 GTEx Whole Blood ZDHHC18 0.04 0.02 lasso 1 0.01 5.7e-02 6.7 6.7 2.9e-11 0.68 0.11 0.75 FALSE
22 METSIM Adipose PIGV 0.03 0.02 enet 25 0.04 2.8e-06 -1.1 -5.6 2.0e-08 -0.44 0.28 0.55 FALSE
23 METSIM Adipose ZDHHC18 0.04 0.03 lasso 2 0.04 3.8e-06 6.1 6.2 4.7e-10 0.58 0.27 0.72 FALSE
24 NTR Blood ARID1A 0.03 0.03 enet 20 0.03 7.8e-11 6.8 -7.1 1.4e-12 -0.66 0.25 0.75 FALSE
25 NTR Blood ZDHHC18 0.01 0.00 bslmm 285 0.01 5.7e-03 7.2 6.3 2.3e-10 0.81 0.01 0.97 FALSE
26 ROSMAP Brain Pre-frontal Cortex CD164L2 0.16 0.13 bslmm 220 0.16 2.4e-20 -3.9 -5.8 7.7e-09 -0.09 1.00 0.00 TRUE
27 YFS Blood PIGV 0.02 0.01 blup 295 0.01 1.6e-04 6.6 -5.4 6.5e-08 -0.67 0.22 0.75 FALSE
28 YFS Blood ZDHHC18 0.08 0.11 bslmm 286 0.11 2.1e-33 7.2 7.5 7.1e-14 0.97 0.01 0.99 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma PIGV 0.02 0.02 lasso 10 0.03 1.3e-06 7.2 -7.6 3.1e-14 -0.92 0.01 0.99 FALSE
30 The Cancer Genome Atlas Colon Adenocarcinoma PIGV 0.05 0.03 blup 19 0.02 2.0e-02 7.0 -7.4 1.2e-13 -0.90 0.00 0.72 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GPN2 0.03 0.01 lasso 9 0.02 3.2e-03 6.7 6.8 1.1e-11 0.67 0.12 0.50 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PIGV 0.03 0.05 lasso 7 0.04 4.2e-05 6.8 -7.2 5.1e-13 -0.79 0.07 0.92 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma ZDHHC18 0.04 0.01 enet 5 0.02 4.7e-03 7.2 5.5 4.0e-08 0.77 0.00 0.68 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma FAM46B 0.04 0.00 blup 23 0.01 3.5e-02 -2.0 -5.7 9.7e-09 -0.27 0.00 0.26 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma PIGV 0.09 0.09 lasso 1 0.08 5.1e-09 7.0 -7.0 2.0e-12 -0.99 0.00 1.00 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma PIGV 0.04 0.04 lasso 4 0.04 2.1e-04 7.3 -7.2 4.1e-13 -1.00 0.00 0.98 FALSE
37 The Cancer Genome Atlas Thyroid Carcinoma ZDHHC18 0.34 0.42 enet 5 0.41 8.1e-43 7.3 7.1 1.1e-12 1.00 0.00 1.00 FALSE