TWAS hub - NUDC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0210	0.00013	0.027	0.028	0.023	0.032	0.027	2.6e-04	2.2e-04	7.8e-04	7.4e-05	2.6e-04
2	GTEx	Artery Tibial	0.1295	0.0507	0.00190	-0.003	NA	0.004	NA	0.000	8.4e-01	NA	1.5e-01	NA	3.3e-01
3	GTEx	Brain Cortex	0.1620	0.0710	0.00310	0.039	NA	-0.002	NA	0.030	3.1e-02	NA	3.6e-01	NA	5.2e-02
4	GTEx	Nerve Tibial	0.1153	0.0457	0.00630	-0.003	NA	0.005	NA	0.005	7.2e-01	NA	1.3e-01	NA	1.3e-01
5	GTEx	Testis	0.1030	0.0530	0.00880	0.007	NA	0.059	NA	0.047	1.4e-01	NA	1.3e-03	NA	3.8e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.1824	0.0364	0.00000	0.152	0.201	0.225	0.221	0.218	4.4e-19	3.2e-25	2.1e-28	6.9e-28	1.5e-27
7	TCGA	Prostate Adenocarcinoma	0.0827	0.0475	0.00750	0.013	0.029	0.022	NA	0.009	1.3e-02	4.4e-04	1.9e-03	NA	3.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
HDL Cholesterol	5.5	9.2	19.9	-4.5	-1.0	-4.0	1.8	-3.8	-3.1	0.0
High blood pressure (mother)	5.1	7.1	21.9	4.7	0.7	2.9	-0.5	2.4	2.9	2.0
High cholesterol (Self-reported)	4.7	8.3	22.3	4.7	1.9	2.7	-0.1	1.7	4.2	2.2
Qualifications: O levels/GCSEs or equivalent	4.5	7.2	14.2	2.2	-0.4	3.3	2.2	-2.2	3.8	3.2
Deep venous thrombosis (DVT) (self-reported)	4.1	5.3	11.1	-3.3	-0.5	-2.1	-1.4	-1.4	-3.3	-2.5
Blood clot in the leg (DVT)	4.0	5.1	12.0	-3.5	-0.4	-2.2	-1.2	-1.5	-3.2	-2.2
Medication: Bendroflumethiazide	3.8	5.8	15.8	3.2	1.2	4.0	-1.9	1.2	2.8	0.4
Height	3.7	71.5	112.4	8.7	4.3	8.4	9.7	5.7	10.6	9.8
Medication: Allopurinol	3.7	4.9	10.3	3.2	0.4	3.0	-2.7	1.9	1.6	0.9
Exposure to tobacco smoke at home	3.6	4.1	10.2	-2.1	-0.8	0.1	-3.2	-1.9	-2.0	-2.4
Medication: Atorvastatin	3.5	4.3	7.5	2.7	1.7	2.7	-1.9	0.6	2.7	1.0
Cholesterol lowering medication	3.5	5.2	12.5	3.5	1.8	2.6	-0.5	0.3	3.4	1.4
Heel T-Score	3.4	27.1	77.3	-0.4	-5.3	3.9	4.0	-8.8	5.0	5.3
Cardiovascular Disease	3.4	11.4	29.1	5.4	1.2	4.5	-2.9	2.7	3.6	0.8
Standing height	3.3	33.1	57.6	5.7	4.0	5.0	7.6	4.5	6.6	5.9
Medication: Blood pressure	3.3	6.3	17.7	3.1	2.1	4.2	-2.1	-0.5	2.8	0.7
Osteoarthritis (self-reported)	3.2	4.1	6.8	-2.6	-2.6	-2.0	-0.2	-1.3	-1.8	-2.6
LDL Cholesterol	3.0	4.7	15.4	3.9	0.6	2.3	0.0	0.3	3.4	0.0
Sitting height	2.9	20.3	41.0	3.5	4.4	4.3	6.4	4.2	4.5	3.6
Comparative height size at age 10	2.9	15.7	20.7	4.5	4.5	4.2	2.5	4.5	4.0	2.9
Irritability	2.9	4.9	9.1	-2.7	-2.1	-2.2	1.0	1.0	-3.0	-2.5
Medication: Co-codamol	2.8	3.3	7.5	-2.7	0.5	-2.3	0.2	-1.6	-2.2	-1.6
Medication: Simvastatin	2.8	4.1	11.3	3.4	0.5	2.3	-0.3	1.5	2.8	1.4
Illnesses of siblings	2.8	3.9	9.4	-2.5	-0.7	-3.1	0.8	-0.7	-2.7	-1.8
Medication: Cholesterol lowering	2.8	4.3	10.6	3.2	1.3	1.6	-1.4	2.6	2.4	1.0
Forced vital capacity (FVC)	2.7	10.3	31.5	0.4	2.9	1.8	5.6	0.2	3.3	4.2
High blood pressure (siblings)	2.7	4.0	10.8	2.5	0.3	3.3	-1.2	1.3	2.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	8.5	2.8	1.7	1.8	2.9	2.4	2.7	1.7
Unable to work because of sickness or disability	2.7	3.5	7.6	-1.6	-0.8	-1.1	-1.9	-2.2	-1.9	-2.8
Blood Platelet Count	2.6	30.4	61.9	7.9	-3.2	7.7	-1.4	-2.0	7.5	4.5
Long-standing illness, disability or infirmity	2.5	3.8	11.8	-1.5	0.0	-1.1	-3.4	-0.0	-1.9	-2.8
Gout (self-reported)	2.4	3.3	11.6	2.5	0.2	1.9	-3.4	0.8	0.9	0.4
Neck or shoulder pain in last month	2.4	3.4	9.9	-3.1	0.5	-1.8	1.4	-1.9	-1.4	-1.8
Townsend deprivation index at recruitment	2.3	3.2	6.2	-1.3	0.8	-0.9	-2.5	1.6	-2.1	-2.5
Qualifications: A levels/AS levels or equivalent	2.3	5.1	8.5	2.5	-0.2	2.4	2.5	0.7	2.9	2.9
Angina (self-reported)	2.3	3.1	4.5	2.0	1.9	1.9	-1.5	1.4	2.1	1.1
Friendships satisfaction	2.3	2.8	5.8	-2.4	-0.0	-1.6	-1.3	-1.9	-2.2	-1.0
Age when periods started (menarche)	2.2	5.2	15.0	-1.4	-0.3	0.5	3.9	-3.7	1.4	1.8
Shortness of breath walking on level ground	2.2	2.6	7.7	1.8	2.8	1.6	-0.7	1.9	1.0	-0.3
Worry (Nagel 2018)	2.1	4.4	9.1	2.8	-0.6	2.1	-0.3	-0.2	3.0	3.0
Relative age of first facial hair	2.1	4.3	14.4	2.1	0.2	3.8	0.5	0.6	2.8	1.6
Hand grip strength (right)	2.1	5.8	15.5	1.5	1.4	2.8	1.7	0.6	3.2	3.9
Health satisfaction	2.1	2.7	6.8	-2.0	0.4	-1.4	0.4	-0.8	-2.3	-2.6
Knee pain experienced in last month	2.1	3.2	8.3	-1.7	-2.0	-1.3	-0.3	-0.8	-2.2	-2.9
Back pain experienced in last month	2.1	3.0	7.6	-2.4	0.2	-1.1	-0.4	-1.4	-2.1	-2.8
Medication: Lisinopril	2.1	2.7	5.9	2.4	-0.1	2.4	-1.6	0.9	1.9	0.5
Alzheimer’s Disease (including proxy)	2.0	2.9	4.8	-1.9	-0.8	-1.1	-1.5	-1.8	-2.0	-2.2
Ever had hysterectomy (womb removed)	2.0	2.2	6.2	1.2	-1.5	-0.3	2.5	1.4	1.5	1.2
Father’s age at death	2.0	2.8	5.8	-2.4	-2.4	-0.7	0.9	-2.1	-1.4	0.5
Medication: Ventolin 100micrograms inhaler	2.0	2.6	7.9	0.0	-1.2	-0.3	-2.3	1.5	-1.1	-2.8
Forced vital capacity (FVC), Best measure	2.0	7.2	26.0	0.2	2.2	1.1	5.1	0.6	2.5	3.4
Hypertension (Self-reported)	2.0	5.5	13.3	3.1	1.7	3.6	-2.5	1.0	2.4	0.5
Alzheimer’s Disease (in father)	1.9	2.1	5.0	-2.0	-0.5	-0.2	-0.0	-2.2	-1.4	-1.8
Number of treatments/medications taken	1.9	3.3	9.3	3.0	1.3	2.5	-1.4	0.7	1.9	0.2
Angina	1.9	2.5	3.8	1.8	1.7	1.8	-1.3	1.3	1.9	1.0
High blood pressure	1.9	5.4	13.8	2.8	1.6	3.7	-2.9	0.6	2.2	0.4
Nervous feelings	1.9	3.5	7.5	2.3	0.4	1.8	-0.3	-1.2	2.6	2.7
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	26.1	-0.6	1.8	1.3	5.1	0.2	2.0	3.2
Qualifications: nursing, teaching	1.9	3.0	6.6	2.6	-1.0	2.1	2.0	0.7	1.7	1.3
Medication for cholesterol	1.9	2.9	7.5	-2.5	-1.0	-2.7	1.4	0.1	-1.9	-0.3
Pain type(s) experienced in last month: Hip pain	1.9	2.4	8.9	-1.0	-0.6	0.8	-3.0	0.4	-1.2	-2.2
Vascular/heart problems diagnosed by doctor	1.9	5.1	11.6	-2.6	-2.1	-3.4	3.1	-1.1	-1.6	-0.1
Alzheimer’s Disease (in mother)	1.8	2.1	4.1	-1.6	-0.3	-0.9	-1.6	-0.9	-2.0	-2.0
Systolic Blood Pressure	1.8	9.2	21.8	4.7	2.5	2.6	-1.5	1.9	4.2	2.5
Hand grip strength (left)	1.8	4.8	14.8	1.4	1.1	2.4	1.4	0.9	2.6	3.9
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	13.2	-1.8	-3.1	0.2	0.1	-3.6	-0.0	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	25.5	-0.7	1.6	0.6	5.0	0.5	1.5	3.0
Glaucoma (self-reported)	1.8	2.1	7.6	-1.8	-1.2	-0.7	0.7	-2.8	-0.9	-0.6
Had major operations	1.8	2.1	6.2	1.1	0.0	1.3	0.6	-1.4	2.5	1.8
Age at last live birth	1.8	2.7	5.3	-2.3	-0.7	-1.9	1.0	-1.9	-2.1	-0.7
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.3	-0.2	-0.3	0.8	1.5	-1.9	1.9	2.1
HbA1C	1.7	1.9	5.9	-1.4	-0.2	-2.4	0.4	-1.1	-1.8	-1.0
Diabetes (self-reported)	1.7	2.6	5.6	2.3	0.8	0.1	-2.4	2.3	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.3	-2.3	-1.1	-2.2	1.7	-1.3	-1.8	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	6.1	1.3	0.4	2.5	-0.8	0.0	1.5	1.8
Medication: Aspirin	1.7	2.3	4.5	2.0	2.1	1.5	0.0	1.1	1.7	1.1
Intelligence (Savage-Jansen 2018)	1.6	4.9	16.2	2.8	-1.2	4.0	-0.8	1.7	1.9	1.4
Systolic blood pressure, automated reading	1.6	4.6	9.9	3.0	0.5	3.1	-2.2	1.1	2.4	1.2
Number of full brothers	1.6	2.0	3.8	1.8	-0.7	1.9	-0.4	1.3	1.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	6.6	-1.0	-0.4	0.2	-2.6	-2.0	-1.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.0	-1.8	-0.3	-0.5	-2.1	-0.0	-2.0	-2.4
Illnesses of father: High blood pressure	1.6	2.0	5.2	-0.4	0.4	0.2	-1.3	2.3	-1.4	-2.1
Triglycerides	1.5	2.5	7.4	2.7	0.3	1.8	-1.3	1.5	1.8	0.0
Ulcerative Colitis	1.5	2.2	5.4	1.6	0.0	1.4	-0.7	-0.9	1.9	2.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	7.8	0.7	1.2	-0.0	-1.2	2.8	0.2	-0.4
Diabetes (mother)	1.5	1.9	10.8	0.1	-0.3	-0.7	-3.3	0.2	-1.4	-0.4
Worrier / anxious feelings	1.5	2.8	5.2	2.3	-1.1	2.3	-0.9	-0.6	1.9	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.5	-0.9	-0.5	-1.3	-1.5	-0.2	-2.1	-2.1
Wheeze or whistling in the chest in last year	1.5	2.6	12.2	0.4	-0.3	0.4	-3.5	1.0	-0.5	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.8	5.4	-1.2	-0.8	-1.4	-1.2	0.4	-1.1	-2.3
Smoking status: Previous	1.5	2.3	5.3	-2.3	0.5	-1.9	0.6	0.8	-2.2	-0.9
Diabetes diagnosed by doctor	1.5	2.5	5.9	2.4	0.2	0.0	-2.1	2.4	0.9	0.9
Medication: Aspirin	1.5	2.0	5.9	1.6	2.4	1.2	0.1	0.8	1.5	1.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	-1.8	-1.1	-1.7	0.0	-1.4	-1.6	-0.4
Schizophrenia (2018)	1.4	2.9	9.0	-2.3	-0.1	-3.0	-0.1	-1.3	-1.8	-0.9
Schizophrenia (2014)	1.4	3.1	9.8	-2.5	0.0	-3.1	0.4	-1.7	-1.5	-0.4
Blood Eosinophil Count	1.4	10.9	28.5	5.3	1.5	4.0	-1.4	3.1	3.8	2.0
Maternal smoking around birth	1.4	2.0	4.4	-2.1	-1.4	-1.5	-0.6	0.3	-1.7	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	10.4	-1.1	-2.3	0.9	0.7	-3.2	0.6	1.7
Body mass index (BMI)	1.4	5.8	18.7	-1.1	-0.6	0.2	-4.3	-1.9	-2.3	-3.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.9	-2.0	-0.3	-0.0	-1.4	-1.3	-1.3	-1.8
Osteoporosis (self-reported)	1.4	1.8	3.9	0.4	0.2	-2.0	-0.5	1.9	-1.2	-1.8
Age started oral contraceptive pill	1.4	1.8	3.5	1.2	0.3	0.8	1.9	1.1	1.7	1.6
Verbal and Numeric Reasoning (VNR)	1.3	3.0	11.9	1.8	-0.9	3.5	-1.4	0.5	1.3	1.1
Lupus	1.3	1.9	4.3	1.2	0.6	2.0	0.1	-0.1	2.1	1.8
BMI	1.3	7.7	20.2	-0.9	-2.1	0.2	-4.4	-0.7	-2.9	-4.5
Happiness	1.3	1.6	3.2	0.1	-1.8	-1.1	1.7	-1.6	0.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.8	-0.7	-2.4	0.2	-1.1	-1.7	-0.9	-1.6
Eye problems/disorders: Cataract	1.3	1.5	6.4	1.7	-0.6	-0.1	-1.1	2.5	0.1	0.2
Heart disease (siblings)	1.3	1.6	2.9	1.2	1.5	1.6	-0.0	1.0	1.7	1.2
Alcohol drinker status: Previous	1.3	1.5	3.6	1.9	0.9	1.6	-0.1	1.4	1.4	0.2
Financial difficulties in last 2 years	1.2	1.6	6.1	-0.5	-1.0	0.1	-2.5	0.0	-1.3	-1.3
Time employed in main current job	1.2	1.3	3.2	0.3	0.9	0.7	1.2	-1.0	1.8	1.5
Illnesses of mother	1.2	1.4	4.2	-2.0	0.3	-1.1	0.6	-0.8	-1.4	-1.2
Pulse wave reflection index	1.2	1.5	4.0	1.7	0.5	2.0	-1.0	0.4	1.5	0.7
Leg fat percentage (right)	1.2	4.3	11.6	-0.4	-1.8	-0.2	-3.2	-1.2	-1.9	-3.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.4	0.9	-1.3	0.6	-1.7	0.3	-0.5	-1.9
Arm fat percentage (left)	1.2	4.7	13.6	-0.1	-1.7	-0.4	-3.7	-1.7	-1.9	-3.0
Average weekly beer plus cider intake	1.2	1.8	3.8	-1.9	-0.6	-0.7	-0.9	-0.1	-1.8	-1.9
Risk taking	1.2	1.8	5.2	-0.7	0.4	1.5	-2.3	-0.2	-0.9	-1.9
Diastolic blood pressure, automated reading	1.2	3.9	9.3	2.1	0.6	3.0	0.3	0.5	3.0	1.9
Pain experienced in last month	1.2	2.0	7.2	1.7	0.3	-0.1	-0.2	1.2	1.5	2.7
Bipolar Disorder or Schizophrenia	1.1	2.7	9.8	-2.2	0.0	-3.1	0.4	-1.3	-1.4	-0.3
Age at First Birth	1.1	1.6	4.7	-1.6	1.0	-2.2	1.1	-0.5	-1.1	-0.4
Blood White Count	1.1	8.0	39.2	-2.1	-1.4	-2.9	1.2	-6.3	0.1	1.0
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.1	2.2	-0.2	0.2	-1.8	2.3	1.0	0.8
Supplements: Zinc	1.1	1.2	3.5	1.1	0.2	1.4	0.1	0.5	1.2	1.9
Medication: Metformin	1.1	1.5	5.5	0.8	-0.1	-0.4	-2.0	2.3	-0.4	-0.6
Diabetes (father)	1.1	1.4	3.1	0.3	-1.6	0.0	0.2	-1.8	1.0	1.8
Medication: Atenolol	1.1	1.4	2.6	1.6	1.3	1.5	-0.9	0.9	1.2	0.6
Hair/balding pattern: Pattern 2	1.1	1.3	4.8	-0.5	1.7	-2.2	-0.1	1.0	-0.6	0.3
Fluid intelligence score	1.1	2.2	6.7	2.0	-1.0	2.6	0.2	0.4	1.2	1.6
Arm fat percentage (right)	1.1	4.4	14.7	-0.0	-1.5	-0.3	-3.8	-1.1	-2.0	-3.0
Lung cancer (father)	1.1	1.2	3.9	1.1	1.6	0.6	-2.0	0.2	0.5	0.7
Peak expiratory flow (PEF)	1.1	2.5	10.7	-1.6	-0.3	0.4	3.3	0.0	0.5	2.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.5	-0.4	-1.9	-1.6	-0.5	0.6	-1.4	-0.7
Asthma (self-reported)	1.1	2.1	9.6	0.6	-0.0	-0.1	-3.1	0.2	-1.0	-1.9
Hearing aid user	1.1	1.2	3.1	1.2	-0.5	1.3	0.5	-0.1	1.8	1.3
Mother’s age at death	1.1	1.3	6.1	-0.1	-0.3	0.8	0.9	-0.9	1.0	2.5
Leg fat percentage (left)	1.1	4.1	12.4	-0.5	-1.4	-0.2	-3.5	-1.6	-1.7	-2.9
Reaction Time	1.0	1.9	4.3	-1.7	0.9	-2.0	2.1	-0.6	-1.0	-0.4
Body Mass Index (BMI) (2010)	1.0	1.3	2.3	-1.5	-0.9	-1.4	-1.0	-1.1	-1.5	0.0
Respiratory disease	1.0	2.2	9.0	1.0	-0.2	0.1	-3.0	1.1	-0.9	-1.8
Pack years adult smoking proportion	1.0	1.5	4.3	0.8	1.1	2.1	-1.0	1.4	0.3	-1.2
Qualifications: None of the above	1.0	2.2	5.0	-1.6	0.7	-2.2	-1.5	0.8	-1.2	-1.8
Asthma	1.0	2.0	9.7	0.5	-0.1	0.0	-3.1	-0.3	-0.9	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.8	-1.6	-0.1	-0.4	-0.6	-1.7	-1.3	-1.1
Medication: Lansoprazole	1.0	1.2	2.8	-0.8	0.4	-1.0	-1.7	-0.1	-1.4	-1.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.7	1.5	-1.1	-0.4	0.2	1.7	1.1	0.8
Number of children fathered	1.0	1.2	5.8	-1.0	0.0	0.1	0.9	-2.4	0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.8	-1.4	-1.3	-1.0	0.6	-1.4	-1.0	-0.7
Overall health rating	1.0	2.1	7.8	-1.5	0.2	-0.6	-0.8	-0.9	-1.5	-2.8
Mineral and other dietary supplements	1.0	1.3	4.2	0.7	0.7	0.1	-1.3	2.0	-1.0	-1.1
Smoking status: Current	1.0	1.5	4.6	-0.1	0.3	2.2	-1.8	-0.6	-0.2	-1.5
Ever taken oral contraceptive pill	1.0	1.2	4.3	-2.1	-0.6	-1.0	0.9	0.7	-1.0	-0.5
Pack years of smoking	1.0	1.5	4.1	0.7	1.1	2.0	-0.8	1.6	0.3	-1.2
Ulcerative Colitis (UC)	0.9	1.7	4.3	0.2	-0.9	1.2	-2.1	-1.8	0.9	1.3
Breast Cancer	0.9	2.3	5.0	-1.0	1.7	-1.9	-0.3	1.4	-2.2	-1.1
Rheumatoid Arthritis	0.9	1.2	3.4	-0.2	1.5	-0.6	1.9	-0.9	0.3	1.3
Sensitivity / hurt feelings	0.9	1.6	3.9	1.2	-1.2	2.0	-1.9	-0.7	0.6	0.1
Taking other prescription medications	0.9	1.4	4.2	-0.1	-0.4	0.4	-2.1	-1.2	-0.6	-1.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.2	-1.8	-0.3	-0.9	0.4	-1.6	-0.3	-0.2
Serious illness, injury or assault to yourself	0.9	1.1	3.1	-1.2	0.3	-1.7	1.2	-0.8	-0.9	-0.4
Mouth/teeth dental problems	0.9	1.4	3.7	1.6	0.4	0.4	1.3	-0.0	1.1	1.9
Allergy	0.9	2.0	5.2	-0.0	1.6	0.6	2.3	-0.8	1.7	1.5
Tense / ‘highly strung’	0.9	1.6	4.1	1.5	-0.4	1.0	0.5	0.8	2.0	1.6
Hair/balding pattern: Pattern 4	0.9	2.1	5.1	-1.8	-1.1	-0.0	-1.7	-2.2	-1.1	-0.9
Loud music exposure frequency	0.9	1.0	4.0	-0.1	-0.9	0.4	-0.3	-2.0	-0.1	-1.4
Number of full sisters	0.9	1.1	2.4	-0.5	1.3	-0.0	-1.4	1.6	-0.7	-0.7
Average weekly red wine intake	0.9	1.3	3.4	-1.3	-1.0	-0.4	-0.1	0.1	-1.9	-1.7
Eye problems/disorders: Glaucoma	0.9	1.0	3.6	-1.2	-0.9	-0.7	0.1	-1.9	-0.5	-0.7
Irritable Bowel Disease (IBD)	0.8	1.8	5.6	1.4	-0.6	0.1	-2.4	-1.2	1.4	1.1
Primary Biliary Cirrhosis	0.8	1.1	6.0	-0.6	-0.2	-1.0	-0.3	-2.4	-0.3	0.5
Medication for hormone replacement therapy	0.8	0.9	1.6	-0.7	-1.0	-0.7	0.4	-1.1	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	0.9	-1.4	0.7	0.8	0.8	1.1	0.9
Stomach or abdominal pain in last month	0.8	1.0	2.3	-0.6	1.4	1.5	0.9	-1.0	0.2	-0.6
Pain all over the body in last month	0.8	0.8	1.7	1.3	-0.1	-0.9	-1.3	0.9	-0.1	-1.0
Trunk fat-free mass	0.8	4.7	11.8	1.5	2.9	3.4	1.4	1.4	2.1	1.5
Trunk predicted mass	0.8	4.5	11.6	1.4	2.9	3.4	1.3	1.5	1.9	1.4
Birth weight	0.8	1.8	8.4	0.1	2.9	1.2	1.4	0.6	0.6	0.5
Body fat percentage	0.8	3.1	8.3	0.4	-1.7	0.1	-2.9	-1.4	-1.2	-2.6
Emphysema/chronic bronchitis	0.8	0.9	4.5	0.0	-2.1	-1.1	-0.5	0.7	-0.3	0.2
Migraine (self-reported)	0.8	0.9	4.3	0.2	-0.3	1.3	-0.5	-2.1	0.2	0.2
Mean time to correctly identify matches	0.8	1.5	4.0	-1.7	0.7	-1.2	2.0	-1.1	-0.7	-0.3
Illnesses of siblings: Diabetes	0.8	1.0	1.8	1.1	-0.2	1.1	-1.2	-0.1	1.4	1.1
Mood swings	0.8	1.4	3.3	-1.1	-1.3	-1.0	-1.4	-0.1	-1.8	-0.8
Ever had bowel cancer screening	0.8	0.9	3.0	-1.4	0.7	0.6	-0.7	-1.7	-0.2	-0.5
Wears glasses or contact lenses	0.8	0.9	1.8	0.6	0.2	1.0	1.3	0.1	1.2	1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.8	-0.2	-1.2	0.5	0.9	-1.1	1.3	1.2
Ever depressed for a whole week	0.8	0.9	2.9	0.5	-1.2	0.9	-1.7	-0.3	-0.7	-0.7
Commuting to job workplace: Cycle	0.8	1.0	2.7	1.4	-0.1	0.9	0.5	0.5	1.0	1.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.2	-1.5	1.3	-1.1	-0.2	-1.0	-0.7	-0.4
Major Depression (MDD)	0.7	0.9	4.4	-0.8	0.0	-0.7	0.5	-2.1	0.4	-0.1
Ovarian Cancer	0.7	0.9	3.1	0.4	1.7	-1.0	0.9	1.0	-0.2	0.1
Hair Pigment	0.7	21.1	45.3	6.2	1.1	3.6	3.1	2.5	6.7	5.8
Current tobacco smoking	0.7	1.2	3.1	-0.2	0.4	1.8	-1.5	-0.9	-0.2	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.7	-0.8	-1.6	-0.5	-1.2	-0.5	-1.1	-0.4
Multivitamins +/- minerals	0.7	0.9	1.8	1.1	0.8	1.3	-0.5	-0.7	1.4	0.3
Impedance of leg (left)	0.7	3.3	6.1	2.0	-0.2	-0.2	2.5	1.6	2.3	2.2
Number of incorrect matches in round	0.7	1.1	2.9	-0.5	0.5	-1.3	1.3	-1.7	0.4	0.9
Past tobacco smoking	0.7	1.3	3.0	1.7	-0.8	0.5	0.7	-0.6	1.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.8	-0.7	-1.4	1.1	-1.0	-1.7	-0.5	-0.7
Pulse rate	0.7	1.1	3.3	-0.0	-0.7	-0.8	1.7	1.8	-0.2	-0.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.7	1.2	-0.0	1.2	-0.6	1.3	0.1	-0.7
Arm fat mass (right)	0.7	2.7	10.2	0.5	-0.3	0.9	-3.2	-0.6	-1.2	-2.4
Medication: Paracetamol	0.7	1.1	3.6	-0.4	1.9	0.1	-1.8	-0.3	-0.5	-0.6
Medication: Blood pressure	0.7	1.3	3.7	1.2	0.2	1.6	-1.9	0.8	0.8	-0.5
Leg fat mass (right)	0.7	2.8	8.0	0.2	-1.0	0.8	-2.8	-0.7	-1.3	-2.8
Alcohol intake frequency.	0.7	1.6	8.2	0.3	2.9	0.5	-1.3	0.1	0.6	-0.4
Chest pain or discomfort	0.7	1.1	2.5	1.2	-0.1	1.6	-0.3	1.3	0.4	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	0.4	1.2	-0.2	0.8	1.2	0.7	1.2
Arm fat mass (left)	0.7	2.7	9.4	0.4	-0.3	0.9	-3.1	-0.7	-1.3	-2.5
Fractured/broken bones in last 5 years	0.7	0.8	2.3	0.1	0.9	-1.5	0.7	1.4	-0.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.3	-0.3	1.1	0.6	-1.2	1.5	0.1	-0.6
Impedance of whole body	0.7	3.5	7.7	2.3	-0.8	-0.7	2.8	1.7	1.9	1.9
Arm predicted mass (left)	0.7	3.5	12.8	1.1	2.6	3.6	-0.0	1.4	1.3	0.3
Crohns Disease (2017)	0.6	1.3	3.4	1.7	0.4	-1.2	-1.9	0.7	0.9	-0.2
Prostate Cancer	0.6	0.8	2.8	-1.7	0.3	-0.8	0.8	-0.8	-1.0	-0.3
Crohns Disease (2012)	0.6	0.9	2.8	1.5	0.2	-0.9	-1.7	0.0	0.8	-0.0
Chronotype (morning person)	0.6	1.4	2.5	-1.6	0.7	-1.2	-1.5	-1.1	-1.1	-0.8
Impedance of leg (right)	0.6	3.0	7.2	1.8	-0.7	-0.4	2.7	2.1	1.8	1.4
Relative age voice broke	0.6	0.9	2.3	0.3	0.0	1.5	0.3	-0.9	1.2	1.2
Chronic bronchitis/emphysema (father)	0.6	0.8	1.7	1.3	-0.5	0.8	-0.6	-1.1	1.1	0.1
Alcohol usually taken with meals	0.6	0.9	2.2	-0.9	-1.1	-0.3	0.1	-0.7	-1.5	-1.4
Heart attack	0.6	0.8	2.1	0.1	1.0	0.8	-1.2	1.4	0.4	-0.4
Medication: Ramipril	0.6	0.8	1.8	1.4	-0.3	0.2	-1.1	1.3	0.5	-0.8
Impedance of arm (right)	0.6	2.9	5.3	2.2	-1.1	-1.3	2.1	2.3	0.9	1.4
Falls in the last year	0.6	0.8	2.1	-1.1	0.1	-1.4	1.4	-0.1	-0.6	-0.4
Impedance of arm (left)	0.6	3.0	6.8	2.2	-1.3	-1.3	2.6	1.3	1.2	1.6
Length of working week for main job	0.6	0.7	1.3	0.6	0.9	1.0	-1.0	1.1	0.0	-0.6
Breastfed as a baby	0.6	0.7	2.0	-1.3	0.2	-1.4	-0.2	0.0	-1.1	0.0
Arm fat-free mass (right)	0.6	3.1	11.9	0.9	2.5	3.5	0.3	0.3	1.5	0.4
Medication: Omeprazole	0.6	0.7	2.4	-1.1	1.6	-0.8	-0.3	-0.8	-0.2	0.1
Arm predicted mass (right)	0.6	3.2	11.8	1.2	2.5	3.4	0.5	0.6	1.6	0.7
Suffer from ‘nerves’	0.6	0.9	2.3	1.5	-0.7	0.4	0.8	0.3	1.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	-1.2	-0.2	-0.9	1.2	-0.6	-0.0	-0.6
Medication: Gliclazide	0.6	0.6	2.0	1.0	0.9	-0.7	-0.5	1.4	0.2	0.1
Arm fat-free mass (left)	0.6	3.2	12.5	1.1	2.5	3.5	-0.2	1.2	1.1	0.2
Supplements: Calcium	0.6	0.7	2.5	-0.1	-0.9	-1.6	0.6	-0.2	0.6	1.0
Leg fat mass (left)	0.6	2.5	8.0	0.1	-0.7	0.6	-2.8	-0.9	-1.2	-2.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.9	0.0	-1.2	-0.0	-1.1	-0.9	0.0
Hypothyroidism (self reported)	0.5	1.1	2.8	1.7	0.3	1.2	-0.8	-0.3	1.4	0.6
Average weekly spirits intake	0.5	0.6	1.5	-0.5	0.8	-0.3	-0.2	1.0	-1.2	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	0.9	-1.4	1.1	-0.7	-0.4	0.5	0.5
Hearing difficulty/problems: Yes	0.5	0.8	2.0	0.9	-0.6	1.0	0.5	0.4	1.4	1.1
Trunk fat percentage	0.5	2.0	5.1	1.1	-1.4	0.5	-2.3	-1.0	-0.6	-1.9
Supplements: Glucosamine	0.5	0.7	1.7	-0.7	-1.0	-0.1	1.3	-1.2	0.2	0.5
Hearing difficulty/problems with background noise	0.5	0.7	1.5	-1.1	1.1	-1.2	-0.0	-0.5	-0.6	-0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	0.5	0.6	-0.4	-1.2	1.0	-0.7	-1.0
Number of live births	0.5	0.7	2.9	-0.9	-0.1	-0.9	1.7	-0.3	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	0.4	0.1	0.7	-1.4	0.2	-0.7	-0.9
Prospective memory result	0.5	0.6	2.4	0.1	0.2	-0.3	0.8	-0.8	0.7	1.6
Comparative body size at age 10	0.5	1.4	2.8	-1.6	1.7	0.4	-0.7	-0.7	-1.5	-0.9
Pulse wave peak to peak time	0.5	0.6	1.0	-0.9	0.2	-0.7	0.9	-1.0	0.2	0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	3.7	-0.1	-1.9	-0.7	1.3	0.5	0.3	0.0
Heart disease (mother)	0.5	0.7	1.7	0.6	0.3	-0.2	1.3	0.7	1.1	0.7
Supplements: Vitamin C	0.5	0.6	1.3	-1.2	-0.2	-0.6	-0.7	-1.1	-0.9	-0.0
Illnesses of father: Heart disease	0.5	0.7	1.5	1.1	-1.2	-0.9	0.5	0.2	-0.4	-1.1
Whole body fat-free mass	0.5	3.1	9.7	1.3	2.4	3.1	0.7	1.1	1.4	0.7
Loneliness, isolation	0.5	0.6	1.2	0.9	0.6	-0.1	0.8	-0.9	0.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.1	0.6	1.0	0.6	-1.4	0.2	0.1	-0.7
Whole body water mass	0.5	3.1	9.9	1.3	2.4	3.1	0.7	1.1	1.4	0.7
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	1.4	0.4	1.2	-1.2	0.4	0.5	-0.5
Depression (Nagel 2018)	0.4	0.6	1.7	-0.2	-1.1	-0.6	-1.3	-0.2	-0.8	-0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.2	0.8	0.0	0.3	-0.4	0.9	1.1	0.6
Smoking Status	0.4	0.9	2.1	-0.6	0.1	1.1	-0.5	0.9	-1.5	-1.3
Lung FVC	0.4	2.0	5.5	-2.3	0.3	0.4	2.3	-1.1	-0.1	1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	-0.9	-0.6	-0.5	-0.2	-0.1	-1.2	-0.7
Vitamin and mineral supplements	0.4	0.5	1.2	-0.2	-0.8	-0.5	0.5	1.1	-0.8	-0.6
Fed-up feelings	0.4	0.8	2.6	1.0	-0.6	0.7	-1.6	1.0	0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-0.6	0.7	-1.0	0.8	-0.6	-0.3	0.7
Neuroticism score	0.4	0.9	1.9	1.4	-0.9	1.0	-0.9	0.1	0.9	1.1
Alcohol intake versus 10 years previously	0.4	0.7	2.5	-0.1	0.9	1.6	0.2	0.0	1.1	0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.1	-0.5	1.1	0.0	-1.2	0.7	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	-0.7	-0.7	-0.1	0.1	-1.4	-0.3	-0.6
Age at first live birth	0.4	0.6	2.4	-0.6	-0.2	-0.3	1.5	-1.0	-0.3	0.6
Qualifications: College or University degree	0.4	1.3	3.9	2.0	-0.9	-0.3	1.7	1.1	0.2	0.4
Eye problems/disorders: None of the above	0.4	0.5	1.1	-0.3	1.0	1.0	0.2	-0.3	0.5	0.8
Whole body fat mass	0.4	1.6	4.2	0.6	-0.6	0.8	-2.0	-0.9	-0.6	-2.0
Family relationship satisfaction	0.4	0.5	1.5	-0.8	-1.2	-0.1	0.1	-1.0	-0.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	-0.9	0.6	-0.7	0.5	0.5	-0.6	-0.5
Commuting to job workplace: Walk	0.4	0.5	1.6	-0.1	0.7	-0.3	1.3	-0.3	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.5	-1.2	0.7	0.0	1.9	-0.6	-0.2	0.8
Miserableness	0.4	0.7	2.2	-1.0	0.6	-0.1	-1.5	0.7	-1.0	-0.1
Guilty feelings	0.4	0.6	1.9	0.0	0.6	1.4	-0.9	-0.8	0.4	-0.1
Financial situation satisfaction	0.4	0.5	2.8	0.1	0.4	-0.8	-0.1	-1.7	-0.2	0.3
Medication: Paracetamol	0.4	0.6	2.7	0.2	1.6	0.4	-1.0	0.7	-0.2	0.1
Alcohol drinker status: Never	0.4	0.5	2.5	-0.0	1.6	-0.4	-0.9	0.1	0.2	-0.1
Ever smoked	0.4	0.7	1.3	-0.8	0.3	0.9	-1.2	-0.3	-0.9	-1.0
Basal metabolic rate	0.4	2.4	8.4	1.3	2.1	2.9	0.1	1.0	1.1	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	0.4	1.0	0.7	0.0	1.0	0.2	0.7
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.6	0.1	-1.3	0.8	-0.6	-0.0	0.6
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-0.5	0.0	-1.0	-1.3	0.4	-1.2	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.3	1.2	0.8	0.0	0.4	0.1	-0.4	1.1	0.4
Mean Putamen Volume	0.3	0.3	1.0	-0.1	0.2	0.8	0.4	-1.0	0.0	0.5
Waist Hip Ratio (WHR)	0.3	1.4	2.8	1.4	-0.8	-0.3	1.7	1.4	1.5	0.3
Allergy or Eczema	0.3	0.9	3.4	1.0	-0.5	-0.0	-1.0	1.9	-0.6	-0.1
Tanning	0.3	3.6	8.5	-2.9	-0.2	-1.4	-1.1	0.1	-2.5	-2.7
Average weekly fortified wine intake	0.3	0.3	1.1	-0.4	0.4	0.6	-0.6	-1.1	-0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	0.6	-0.4	-0.1	-1.1	1.3	-0.8	-0.3
Trunk fat mass	0.3	1.3	2.4	1.3	-0.7	1.2	-1.6	-0.6	-0.1	-1.6
Waist circumference	0.3	1.2	4.0	0.9	-0.8	0.7	-1.5	0.2	-0.2	-2.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	0.2	-0.5	0.3	-0.0	-1.1	0.3	1.1
Weight	0.3	1.5	5.2	1.5	1.2	2.3	-0.8	0.3	0.7	-0.7
Noisy workplace	0.3	0.4	1.1	0.5	-1.0	0.0	-0.3	0.8	0.1	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	-0.5	1.4	-0.3	-0.4	1.0	0.0	-0.8
Birth weight of first child	0.3	0.6	2.9	0.9	-0.2	0.1	0.4	1.7	0.0	0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.2	0.7	-0.4	-0.4	0.5	-0.6	-0.8
Pulse rate, automated reading	0.3	1.0	5.8	0.3	-0.2	-0.7	2.4	0.6	0.5	-0.3
Leg fat-free mass (right)	0.3	1.5	5.7	1.1	1.8	2.4	-0.4	0.6	0.6	0.1
Breast cancer (self-reported)	0.3	0.3	0.6	0.6	0.1	-0.1	0.8	0.8	0.6	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	-0.7	1.2	0.3	-0.2	-0.2	0.2	0.6
Leg predicted mass (right)	0.3	1.5	5.6	1.1	1.7	2.4	-0.3	0.6	0.6	0.1
Number of operations (self-reported)	0.3	0.5	1.7	0.3	0.1	-0.3	1.3	-0.3	1.0	0.5
Myopia	0.3	0.5	2.0	-0.3	1.4	-0.6	0.6	-0.0	0.2	0.6
Neuroticism (2016)	0.2	0.3	0.9	0.6	-1.0	0.1	-0.2	0.6	0.3	0.1
Lung FEV1/FVC ratio	0.2	1.2	2.6	-0.6	-1.6	1.6	1.2	0.5	0.5	0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.1	0.7	-0.8	0.8	-0.4	0.5	-0.3
Leg fat-free mass (left)	0.2	1.3	5.3	1.0	1.2	2.3	-0.3	0.8	0.4	-0.4
Leg predicted mass (left)	0.2	1.2	5.0	0.9	1.2	2.2	-0.3	0.6	0.4	-0.4
Had menopause	0.2	0.3	1.2	-0.6	-0.1	0.4	1.1	0.4	0.0	-0.3
Had other major operations	0.2	0.3	0.9	0.4	-0.4	-1.0	-0.2	0.8	-0.4	-0.3
Hip circumference	0.2	1.0	3.0	1.1	-0.4	1.2	-1.7	0.3	-0.1	-1.1
Headache pain in last month	0.2	0.4	2.2	0.4	-0.6	1.5	0.1	-0.1	0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	0.7	0.2	0.8	-0.8	-0.6	0.6	-0.5
Medication: Amlodipine	0.2	0.3	1.1	-0.6	-0.2	0.3	-0.4	-1.0	0.2	0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.4	-0.2	0.2	-0.9	-0.3	-0.1	-1.1
Leg pain on walking	0.2	0.2	0.5	-0.2	0.7	0.5	-0.0	-0.5	0.2	-0.7
Commuting to job workplace: Public transport	0.2	0.2	1.0	-0.1	1.0	-0.3	0.3	-0.3	-0.6	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.3	0.5	0.2	0.5	-0.4	-0.1	0.3	0.6
Fasting Glucose	0.1	0.2	0.6	0.1	0.5	-0.8	0.4	0.4	-0.2	0.0
Blood Red Count	0.1	0.8	3.7	1.9	0.3	-0.6	-0.0	1.0	0.4	0.3
Neuroticism	0.1	0.3	1.1	0.7	-0.3	-0.0	-0.6	0.2	0.5	1.1
Severe depression (siblings)	0.1	0.1	0.3	-0.0	0.5	-0.1	0.1	-0.2	0.2	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.1	-0.5	-0.2	0.7	-0.5	-0.2	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.3	0.4	0.2	-0.2	-0.7	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.1	-0.3	-0.4	1.1	-0.4	0.1	-0.1	-0.2
Depression (self-reported)	0.1	0.2	1.0	0.4	-0.2	0.1	-0.1	-0.1	-0.1	-1.0
Worry too long after embarrassment	0.1	0.1	0.2	0.5	0.3	0.1	-0.5	-0.0	0.5	0.1
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	0.5	-0.0	0.5	-0.4	-0.5	-0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

NUDC

Models

Trait associations