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Cardiovascular Disease
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chr10:74,740,461-77,160,682
Best TWAS P=1.37e-08 · Best GWAS P=1.14e-07 conditioned to 0.122
75M
75.5M
76M
76.5M
77M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
AP3M1
0.02
0.01
blup
231
0.02
1.3e-03
-4.5
5.7
1.4e-08
0.76
0.05
0.51
TRUE
2
GTEx
Pancreas
AGAP5
0.13
0.05
lasso
5
0.06
1.8e-03
4.3
5.2
1.8e-07
0.65
0.06
0.49
FALSE
1
GTEx
Colon Transverse
ADK
0.25
0.14
lasso
9
0.12
1.6e-06
5.0
5.2
2.1e-07
0.90
0.02
0.97
FALSE