TWAS hub - AP3M1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1360	0.0630	1.7e-03	0.030	NA	0.035	NA	0.036	1.4e-02	NA	8.5e-03	NA	7.7e-03
2	GTEx	Muscle Skeletal	0.1368	0.0503	3.4e-06	0.062	NA	0.058	NA	0.061	1.0e-06	NA	2.4e-06	NA	1.2e-06
3	GTEx	Nerve Tibial	0.0582	0.0379	6.7e-03	0.017	NA	-0.004	NA	0.016	2.0e-02	NA	8.9e-01	NA	2.6e-02
4	GTEx	Whole Blood	0.1150	0.0510	6.0e-03	0.062	NA	0.031	NA	0.041	2.0e-06	NA	6.8e-04	NA	1.2e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.0215	0.0136	7.4e-03	0.007	0.019	0.008	0.019	0.010	3.7e-02	1.3e-03	3.2e-02	1.4e-03	1.6e-02
6	YFS	Blood	0.2718	0.0562	0.0e+00	0.108	0.132	0.143	0.142	0.147	1.6e-33	5.6e-41	1.5e-44	3.2e-44	1.5e-45
7	TCGA	Pancreatic Adenocarcinoma	0.1070	0.0670	3.4e-04	0.088	0.092	0.087	NA	0.099	1.6e-04	1.1e-04	1.7e-04	NA	6.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Systolic blood pressure, automated reading	7.4	21.4	52.1	4.5	2.4	5.2	1.3	7.2	4.4	4.8
Hearing difficulty/problems with background noise	7.4	11.8	18.0	-4.0	-3.2	-4.0	-0.3	-4.1	-2.2	-4.2
Hearing difficulty/problems: Yes	6.5	9.9	28.6	-3.0	-0.6	-3.4	-0.3	-5.3	-2.2	-3.9
Systolic Blood Pressure	6.3	31.4	99.0	4.7	1.5	6.1	1.4	9.9	5.0	5.7
Illnesses of father: None of the above (group 1)	5.4	6.6	11.8	-2.8	-2.0	-2.9	-0.9	-3.4	-2.1	-3.0
Medication: Blood pressure	5.3	10.1	21.5	3.7	1.9	3.5	-0.0	4.6	2.4	3.7
Knee pain experienced in last month	4.9	7.6	11.3	-3.3	-2.8	-3.3	0.5	-3.3	-1.0	-3.4
Cardiovascular Disease	4.8	16.0	32.3	4.6	1.9	5.1	-0.5	5.7	1.9	5.0
Vascular/heart problems diagnosed by doctor	4.5	12.2	23.9	-3.9	-1.6	-4.5	0.1	-4.9	-2.6	-4.1
Number of full sisters	4.1	5.0	11.2	-2.5	-1.0	-3.0	0.8	-3.3	-0.0	-2.5
Hypertension (Self-reported)	4.1	11.3	23.5	3.6	1.2	4.1	0.2	4.8	2.7	4.1
Reaction Time	3.9	7.4	12.4	-3.1	-1.9	-3.5	-0.4	-3.4	-2.1	-3.2
High blood pressure	3.9	10.9	23.8	3.5	0.9	4.1	0.0	4.9	2.6	4.0
Medication: Amlodipine	3.7	5.1	11.7	1.8	0.9	2.2	1.5	3.4	3.1	1.9
Schizophrenia vs Biploar Disorder	3.6	4.8	9.7	-2.5	-0.6	-2.6	-0.1	-2.6	-1.9	-3.1
High blood pressure (mother)	3.5	4.9	14.4	1.7	0.2	2.5	0.6	3.8	1.9	2.6
Illnesses of father: High blood pressure	3.5	4.4	12.5	1.4	0.0	2.1	1.0	3.5	2.0	2.6
Stomach or abdominal pain in last month	3.4	4.3	8.8	1.8	-0.5	3.0	0.9	2.6	2.1	2.4
Mean time to correctly identify matches	3.4	6.4	11.4	-2.9	-1.6	-3.4	-0.4	-3.2	-1.8	-3.0
Relative age voice broke	3.3	5.0	9.4	-2.8	-2.1	-3.1	0.7	-1.7	-1.0	-3.0
Hair/balding pattern: Pattern 2	3.3	4.2	8.7	-2.9	-2.9	-2.3	1.3	-0.1	-0.5	-2.3
Osteoarthritis (self-reported)	3.3	4.3	7.9	2.8	1.3	2.8	-2.1	0.6	-0.9	2.7
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	6.5	2.4	1.3	2.5	0.5	1.7	1.7	2.5
Smoking status: Current	3.2	5.0	8.1	2.8	2.4	2.4	0.5	2.6	1.7	2.4
Eye problems/disorders: None of the above	3.0	3.5	9.0	-2.5	-3.0	-1.9	-0.4	-0.6	-1.8	-1.5
Depression (Nagel 2018)	2.7	4.1	13.1	-0.2	-1.0	-0.0	3.4	1.8	3.6	0.5
BMI	2.7	15.9	32.0	5.0	5.7	3.7	2.4	1.5	4.7	3.2
Current tobacco smoking	2.7	4.4	6.6	2.6	2.4	1.9	1.1	2.2	2.3	2.0
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	7.3	-1.9	-1.5	-2.7	2.6	-2.3	1.2	-2.2
Wheeze or whistling in the chest in last year	2.7	4.9	10.4	3.2	3.1	2.5	-0.6	1.2	-0.2	2.4
Medication: Co-codamol	2.6	3.0	7.1	1.8	1.7	1.3	-2.7	-0.5	-2.0	1.5
Body mass index (BMI)	2.6	11.1	25.5	4.2	5.0	3.0	1.6	1.0	3.8	2.8
Health satisfaction	2.6	3.4	13.7	-0.1	0.4	0.0	3.2	0.1	3.7	-0.4
Miserableness	2.6	4.5	6.9	-2.4	-2.6	-2.6	1.7	-1.3	0.8	-2.5
Relative age of first facial hair	2.5	5.1	9.7	-2.0	-0.9	-2.3	-1.8	-2.5	-3.1	-2.4
Impedance of leg (left)	2.5	12.0	29.4	-3.3	-3.9	-1.6	-3.9	-2.5	-5.4	-2.0
Length of working week for main job	2.5	2.7	9.2	-0.0	0.5	-0.9	3.0	-0.3	3.0	-0.4
Exposure to tobacco smoke outside home	2.5	3.4	6.5	-0.5	1.6	-1.6	2.5	-2.4	2.0	-1.4
Mineral and other dietary supplements	2.4	3.3	10.4	1.3	0.2	1.5	1.1	3.2	1.7	2.1
Myopia	2.4	3.4	6.7	-2.0	-2.6	-1.7	2.5	-0.6	1.7	-1.1
Impedance of whole body	2.4	12.3	20.0	-4.5	-4.2	-3.1	-1.9	-3.1	-3.7	-3.5
Depressed Affect (Nagel 2018)	2.3	4.8	10.9	-2.4	-3.3	-1.9	2.4	-0.8	1.7	-2.0
Irritable Bowel Disease (IBD)	2.3	5.5	17.2	-0.7	0.9	-1.4	-2.3	-4.1	-3.2	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	8.0	0.5	-1.9	1.2	0.6	2.8	2.0	1.8
Impedance of leg (right)	2.2	10.4	24.9	-3.2	-4.1	-1.5	-3.2	-2.3	-5.0	-1.8
Supplements: Glucosamine	2.2	2.8	9.5	-1.4	-0.0	-1.7	-0.2	-3.1	-1.5	-1.8
Impedance of arm (left)	2.2	10.3	19.6	-4.4	-3.6	-3.5	-0.3	-3.0	-1.9	-3.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	8.8	0.9	-1.2	2.0	1.0	3.0	1.9	1.9
Crohns Disease (2017)	2.1	4.5	17.8	-1.0	0.4	-1.4	-1.7	-4.2	-2.4	-1.4
Body Mass Index (BMI) (2010)	2.1	2.9	5.3	1.7	2.3	1.8	1.2	0.9	2.0	1.6
Frequency of depressed mood in last 2 weeks	2.1	3.0	9.9	0.3	-1.1	0.7	2.5	1.3	3.1	1.0
Average weekly fortified wine intake	2.1	2.5	6.1	1.7	1.4	1.8	-0.7	2.5	0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	8.0	0.2	-0.6	0.2	2.7	1.7	2.8	0.8
Impedance of arm (right)	2.1	9.7	17.1	-4.1	-3.6	-3.3	-0.3	-3.1	-1.7	-3.7
Breastfed as a baby	2.1	2.6	9.5	0.9	0.6	1.0	-3.1	0.4	-2.1	1.2
Loneliness, isolation	2.1	2.9	9.4	0.5	-1.4	1.5	1.4	3.1	1.6	1.4
Fed-up feelings	2.0	3.7	10.6	-1.9	-3.3	-0.8	2.4	0.8	1.8	-1.3
Serious illness, injury or assault to yourself	2.0	2.4	3.9	1.9	0.3	1.7	0.5	1.5	2.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.1	-0.4	-2.6	0.4	2.2	1.4	2.7	0.9
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.4	1.7	0.9	1.2	0.9	1.2	2.1	2.0
Arm fat mass (right)	2.0	8.1	16.9	3.2	4.1	2.3	2.2	0.4	3.9	2.0
Leg fat mass (right)	2.0	7.7	16.9	3.4	4.1	2.8	1.4	0.1	3.1	2.5
Leg fat-free mass (left)	1.9	10.0	28.2	2.7	3.3	1.7	4.0	1.6	5.3	1.7
Chronic bronchitis/emphysema (father)	1.9	2.3	4.2	2.1	1.9	1.7	-1.5	0.7	-0.5	1.5
Leg predicted mass (left)	1.9	9.9	27.4	2.7	3.3	1.7	3.9	1.6	5.2	1.7
Waist circumference	1.9	7.0	16.5	3.0	4.1	2.0	2.0	-0.1	3.7	1.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.2	-0.7	-1.1	-0.3	-2.1	-2.5	-2.0	-0.6
High blood pressure (siblings)	1.9	2.7	5.0	2.0	0.6	2.2	-0.2	2.1	0.8	2.2
Leg fat percentage (right)	1.9	7.0	17.7	3.6	4.2	3.0	-0.3	-0.5	1.4	2.6
Medication: Blood pressure	1.9	3.4	7.3	1.5	-0.6	2.7	-0.5	2.7	0.7	2.5
Arm fat mass (left)	1.9	8.0	16.8	3.1	4.1	2.2	2.3	0.2	4.0	1.8
Number of self-reported non-cancer illnesses	1.9	3.3	5.9	2.0	-0.2	2.4	0.5	2.2	1.8	2.3
Supplements: Fish oil (including cod liver oil)	1.9	2.5	6.2	-0.7	0.3	-1.2	-1.7	-2.5	-1.9	-1.7
Medication: Bendroflumethiazide	1.9	2.9	8.1	1.6	0.7	2.1	-0.3	2.8	0.8	2.0
Leg fat mass (left)	1.9	7.2	16.8	3.3	4.1	2.6	1.2	-0.1	3.1	2.2
Major Depression (MDD)	1.8	2.2	3.9	2.0	1.5	1.6	0.8	0.6	1.7	1.7
Medication: Metformin	1.8	2.5	4.5	1.6	1.1	1.8	1.7	0.3	2.1	1.7
Townsend deprivation index at recruitment	1.8	2.5	7.5	-1.2	-0.9	-1.6	2.7	0.3	1.8	-1.4
Number of full brothers	1.8	2.2	3.7	-1.8	-1.0	-1.6	1.3	-1.9	-0.3	-1.9
Family relationship satisfaction	1.8	2.2	3.9	-1.8	-0.7	-1.4	1.8	-0.7	1.4	-2.0
Friendships satisfaction	1.8	2.3	4.7	-1.6	-0.0	-1.2	2.2	-1.2	1.3	-2.0
Medication: Gliclazide	1.8	2.0	6.5	0.6	0.2	0.2	2.5	1.0	2.5	0.3
Medication: Paracetamol	1.8	2.8	8.1	-1.8	-1.0	-1.8	0.2	-2.9	-0.2	-2.0
Leg fat percentage (left)	1.8	6.4	18.2	3.4	4.3	2.7	-0.7	-0.8	1.1	2.3
Bipolar Disorder (2018)	1.7	2.6	4.6	0.6	-1.4	1.8	1.1	2.0	2.1	1.7
Weight	1.7	8.2	16.2	3.2	4.0	2.3	2.3	0.5	4.0	2.0
Depression (self-reported)	1.7	2.0	5.5	1.7	0.5	1.7	-0.6	1.6	-0.3	2.4
Pulse rate, automated reading	1.7	5.6	19.4	2.8	4.4	1.7	-0.4	-2.7	0.1	1.4
Medication: Aspirin	1.7	2.2	4.9	1.4	0.4	2.2	0.2	1.7	1.4	1.9
Blood Platelet Count	1.6	18.8	40.4	4.4	0.3	5.6	-2.4	6.4	1.1	5.7
Arm fat percentage (right)	1.6	6.2	14.3	2.7	3.8	1.9	1.8	-0.1	3.6	1.5
Illnesses of mother	1.6	1.9	3.8	-2.0	-1.7	-1.6	-0.1	-0.9	-1.0	-1.5
Emphysema/chronic bronchitis	1.6	1.9	5.0	0.6	-0.1	0.6	1.2	2.2	2.2	0.9
Whole body fat mass	1.6	6.8	15.8	2.8	4.0	2.1	1.8	-0.2	3.6	1.7
Suffer from ‘nerves’	1.6	2.6	6.1	-0.6	-2.5	0.3	2.0	1.9	1.9	0.7
Leg fat-free mass (right)	1.6	8.6	25.5	2.4	3.0	1.3	3.7	1.5	5.0	1.4
Arm fat percentage (left)	1.6	6.3	14.4	2.6	3.8	1.9	1.9	-0.0	3.6	1.5
Eye problems/disorders: Cataract	1.6	1.8	8.1	1.6	2.9	1.0	-0.0	-0.1	0.7	0.7
Osteoporosis (self-reported)	1.6	2.0	3.9	-2.0	-1.5	-1.3	-1.0	-1.0	-1.4	-1.3
Leg predicted mass (right)	1.6	8.6	25.1	2.4	3.1	1.4	3.7	1.5	5.0	1.4
Arm fat-free mass (left)	1.6	8.0	13.0	3.5	3.6	2.6	2.0	1.5	3.4	2.6
Lung FEV1/FVC ratio	1.5	7.5	17.4	2.1	-2.0	4.0	-1.9	2.5	-0.5	4.2
Qualifications: None of the above	1.5	3.2	6.8	-1.9	-0.5	-2.2	-0.0	-2.3	-1.3	-2.6
Fluid intelligence score	1.5	3.1	5.4	2.3	0.5	2.3	-2.0	1.1	-0.3	2.3
Hip circumference	1.5	6.4	15.2	2.7	3.5	1.8	2.2	-0.0	3.9	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.0	1.9	1.5	1.1	-0.7	0.6	-0.7	2.0
Medication for cholesterol	1.5	2.3	5.8	-1.6	-0.7	-1.8	0.0	-2.4	-0.9	-1.8
Number of operations (self-reported)	1.5	2.2	5.1	2.3	2.1	1.2	-1.4	-0.6	-0.1	1.4
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	6.0	0.2	-0.6	1.1	-2.5	-0.8	-1.9	0.8
Arm predicted mass (left)	1.5	7.6	12.4	3.4	3.5	2.6	1.8	1.4	3.3	2.5
Neuroticism (Nagel 2018)	1.4	3.3	16.3	-1.6	-4.0	-0.2	1.1	0.9	1.3	-0.3
Worry (Nagel 2018)	1.4	3.0	17.6	-1.0	-4.2	0.7	-0.6	1.0	-0.1	0.8
Age at First Birth	1.4	2.0	7.0	-0.1	-0.4	0.1	-2.6	-0.2	-2.6	-0.0
Neuroticism	1.4	3.3	14.9	-2.0	-3.9	-1.1	0.9	-0.1	0.9	-1.1
Hand grip strength (left)	1.4	3.6	6.8	1.8	0.3	2.1	-2.6	1.1	-1.8	2.5
Mouth/teeth dental problems: Dentures	1.4	2.3	5.8	1.5	1.9	1.3	0.9	0.7	2.4	1.3
Lung cancer (father)	1.4	1.7	4.2	-1.0	-0.4	-1.2	2.0	-0.9	1.4	-1.5
Arm predicted mass (right)	1.4	6.9	11.1	3.0	3.0	2.4	2.1	1.8	3.3	2.3
Whole body water mass	1.4	7.8	16.0	3.0	3.2	2.1	2.7	1.8	4.0	2.1
Basal metabolic rate	1.4	7.8	16.2	3.0	3.4	2.1	2.7	1.3	4.0	2.0
Trunk fat mass	1.3	5.6	13.9	2.2	3.4	1.6	2.1	-0.4	3.7	1.1
Heart attack	1.3	1.7	3.9	1.4	0.8	1.7	-0.7	2.0	0.3	1.5
Tense / ‘highly strung’	1.3	2.1	10.1	-0.2	-3.2	1.1	-0.2	1.3	0.6	1.2
Headache pain in last month	1.3	2.3	5.5	-1.8	-1.5	-1.5	0.3	-2.4	-0.4	-1.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.1	-1.5	-0.1	-2.3	0.8	-1.7	-0.4	-2.0
Arm fat-free mass (right)	1.3	6.4	11.0	2.8	2.9	2.2	2.1	1.7	3.3	2.2
Comparative body size at age 10	1.3	3.5	10.4	2.4	3.2	1.4	0.7	1.3	1.6	1.4
Supplements: Vitamin C	1.3	1.5	2.9	-1.4	-0.7	-1.2	1.4	-1.3	0.3	-1.7
Whole body fat-free mass	1.3	7.5	15.3	3.0	3.1	2.1	2.6	1.7	3.9	2.1
Fractured/broken bones in last 5 years	1.3	1.7	2.8	1.5	1.3	1.1	0.7	1.7	0.9	1.6
Age started oral contraceptive pill	1.3	1.6	3.0	1.5	1.7	1.7	-1.0	0.4	-0.1	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.9	1.4	0.8	1.7	-0.7	2.0	0.3	1.5
Crohns Disease (2012)	1.2	2.0	9.7	-0.8	0.4	-1.1	-0.1	-3.1	-1.1	-1.0
Medication: Atenolol	1.2	1.5	2.4	1.3	0.8	1.5	0.9	1.3	1.1	1.5
Neuroticism score	1.2	2.6	13.6	-1.5	-3.7	-0.4	0.8	0.5	0.9	-0.4
Medication: Cholesterol lowering	1.2	1.8	3.8	1.6	0.7	1.9	-1.1	0.9	0.6	1.9
Body fat percentage	1.2	4.8	12.7	2.3	3.6	1.8	1.3	-0.8	2.9	1.3
Worry too long after embarrassment	1.2	2.0	11.2	-1.4	-3.3	0.1	0.4	0.8	0.5	-0.2
Number of children fathered	1.2	1.4	2.7	1.6	1.2	1.3	-0.6	1.0	0.8	1.3
Mood swings	1.2	2.2	4.8	-1.3	-2.2	-0.9	1.6	-1.3	1.5	-1.1
Medication: Aspirin	1.2	1.6	4.3	1.2	0.2	2.1	-0.2	1.4	0.9	1.8
Pain experienced in last month	1.2	2.0	4.3	1.1	0.6	1.3	-1.8	2.1	-1.1	1.3
Ulcerative Colitis (UC)	1.1	2.1	5.1	0.0	1.2	-0.5	-1.6	-2.1	-2.3	-0.8
Prostate Cancer	1.1	1.5	2.7	1.6	1.2	1.4	-0.4	1.4	0.0	1.5
Ulcerative Colitis	1.1	1.5	4.7	0.8	2.2	0.5	-1.2	-1.4	-1.4	-0.2
Taking other prescription medications	1.1	1.6	4.3	1.6	0.2	2.1	-1.1	0.6	0.0	1.7
Commuting to job workplace: Public transport	1.1	1.3	5.5	-1.1	-2.4	-0.7	0.5	1.2	-0.1	-0.5
Breast Cancer	1.0	2.4	3.6	1.6	1.5	1.9	-1.1	1.9	0.1	1.7
Bipolar Disorder (2011)	1.0	1.0	2.1	0.7	-0.5	1.3	0.7	1.4	0.0	1.4
Mean Putamen Volume	1.0	1.1	3.8	-0.5	-1.8	0.4	0.1	1.9	0.6	0.4
Hypothyroidism (self reported)	1.0	2.3	5.0	2.2	1.3	1.8	-0.5	1.0	1.2	1.8
Ever used hormone-replacement therapy (HRT)	1.0	1.3	5.1	0.5	-0.4	0.7	0.6	1.6	2.3	0.7
Diabetes (father)	1.0	1.3	2.3	1.1	-0.1	1.5	0.5	1.5	1.2	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.5	0.3	-1.1	1.6	-0.3	1.6	0.5	1.1
Had other major operations	1.0	1.3	2.6	1.5	1.6	1.0	-0.7	-0.1	1.1	1.1
Trunk fat-free mass	1.0	5.8	8.8	3.0	2.8	2.2	1.8	1.7	2.9	2.2
Worrier / anxious feelings	1.0	2.0	9.2	-0.0	-3.0	1.1	-0.9	0.8	-0.6	1.2
Hair/balding pattern: Pattern 3	1.0	1.5	4.6	1.6	2.1	0.8	-1.1	-0.4	-0.9	0.9
Pulse rate	1.0	1.6	6.9	0.3	2.1	0.2	0.2	-2.6	-0.1	-0.4
Medication: Lansoprazole	1.0	1.1	2.1	1.2	-0.1	1.5	-0.6	1.4	0.5	1.3
Trunk predicted mass	1.0	5.6	8.7	3.0	2.8	2.1	1.8	1.6	2.8	2.2
Overall health rating	1.0	2.2	7.1	0.4	-0.6	1.1	2.3	1.0	2.7	0.6
Leg pain on walking	1.0	1.3	4.2	-0.2	0.9	-0.4	1.6	-0.8	2.0	-0.8
Diabetes diagnosed by doctor	1.0	1.7	6.4	0.7	-0.3	0.7	1.9	0.2	2.5	0.8
Qualifications: nursing, teaching	1.0	1.6	3.6	1.6	0.6	1.8	-0.5	1.1	-0.4	1.9
Alzheimer’s Disease (including proxy)	0.9	1.4	4.8	0.5	1.0	-0.2	-1.3	-1.3	-2.2	-0.2
Ovarian Cancer	0.9	1.2	2.5	-1.0	-0.2	-1.5	-0.2	-1.6	-0.9	-1.3
Blood Eosinophil Count	0.9	6.9	24.0	1.9	-0.1	2.4	1.8	4.9	2.4	2.5
Blood White Count	0.9	6.4	18.0	1.3	-0.5	2.2	2.7	2.9	4.2	2.1
Medication for hormone replacement therapy	0.9	1.0	1.6	-1.2	-0.8	-1.2	-0.5	-1.0	-1.0	-1.2
Trunk fat percentage	0.9	3.6	10.0	1.4	2.8	1.0	1.8	-1.0	3.2	0.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.1	-1.6	-1.8	-1.1	-1.6	-0.7	-1.6	-1.3
Multivitamins +/- minerals	0.9	1.1	2.1	1.2	0.6	1.4	-1.2	0.8	-0.6	1.2
Nervous feelings	0.9	1.7	7.3	-0.5	-2.7	0.9	-0.8	0.9	-1.0	0.8
Medication: Ramipril	0.9	1.1	2.8	1.4	1.7	0.9	-0.8	0.5	-0.2	1.1
Happiness	0.9	1.1	3.0	-1.1	-1.0	-0.7	1.7	-0.3	1.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.2	-1.2	-0.4	-1.2	1.5	-0.7	0.9	-1.3
Age at first live birth	0.9	1.7	4.9	0.4	-0.6	0.5	-2.2	0.3	-2.2	1.0
Average weekly red wine intake	0.9	1.4	4.2	-0.2	-0.3	-0.1	-1.9	-1.2	-2.0	-0.3
Long-standing illness, disability or infirmity	0.9	1.3	3.7	1.1	1.2	1.0	0.9	0.8	1.9	0.8
Wears glasses or contact lenses	0.9	1.1	2.8	1.1	0.3	1.3	-0.4	0.7	1.7	1.1
Financial situation satisfaction	0.9	1.1	4.4	0.9	2.1	0.4	1.2	0.2	0.9	0.2
Medication: Lisinopril	0.9	1.2	2.6	1.0	-0.8	1.4	-0.5	1.6	0.2	1.3
Irritability	0.9	1.5	3.7	-1.1	-1.9	-1.0	-0.2	-1.7	0.5	-1.1
Heart disease (siblings)	0.9	1.0	2.2	-0.5	-0.1	-1.0	1.2	-1.2	1.5	-0.9
Bipolar Disorder or Schizophrenia	0.8	1.9	6.7	-1.0	-2.6	0.1	1.4	1.1	1.6	0.2
Schizophrenia (2018)	0.8	1.7	4.8	-1.7	-2.2	-1.3	0.9	-0.3	0.3	-1.2
Allergy or Eczema	0.8	2.1	6.1	-1.7	-2.5	-1.1	-1.3	0.0	-1.4	-1.0
Lung FVC	0.8	4.0	9.6	1.8	1.5	1.3	1.4	3.1	2.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.4	-0.9	-0.9	-1.0	1.2	-0.8	0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.1	1.5	1.1	0.8	0.3	1.0	0.5	1.0
Mouth/teeth dental problems	0.8	1.3	2.9	-1.3	-0.5	-1.7	1.2	0.6	0.0	-1.5
Diabetes (self-reported)	0.8	1.3	4.2	0.7	-0.3	0.8	1.6	0.4	2.1	0.9
Noisy workplace	0.8	1.0	3.0	-0.1	1.7	-0.7	-0.7	-1.3	-0.7	-1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.0	0.8	-1.0	1.2	-2.0	1.3	-1.4	1.3
Birth weight of first child	0.8	1.4	8.5	-1.1	-2.9	-0.0	-0.3	0.0	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.3	-0.2	-0.6	-0.4	1.8	0.0	1.8	-0.1
Loud music exposure frequency	0.8	0.9	1.5	-0.7	-0.0	-1.2	-0.8	-1.1	-1.0	-1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	1.1	-0.0	1.4	0.1	1.6	0.9	1.6
Gout (self-reported)	0.8	1.1	3.2	1.0	0.3	1.1	0.9	1.8	0.7	1.1
Qualifications: College or University degree	0.8	2.6	4.8	1.9	0.1	2.1	-1.2	2.0	0.0	2.2
Medication: Ibuprofen	0.8	1.0	2.2	-1.1	-0.2	-1.2	1.0	-1.0	0.4	-1.5
Medication: Allopurinol	0.8	1.1	2.3	1.3	0.3	1.2	0.3	1.5	0.8	1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.2	-0.8	-0.7	-0.5	-1.4	-0.3	-1.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.7	1.0	-0.5	1.4	-0.8	1.6	-0.2	1.4
High cholesterol (Self-reported)	0.8	1.5	2.6	1.5	1.0	1.6	-0.6	1.3	0.6	1.6
Alzheimer’s Disease (in mother)	0.7	0.8	2.1	0.9	1.4	-0.2	-0.9	-0.4	-1.4	0.2
Alzheimer’s Disease (in father)	0.7	0.8	1.5	-1.1	-1.2	-0.7	0.5	-0.8	-0.0	-1.1
Coronary Artery Disease (CAD)	0.7	0.8	2.3	0.2	1.4	-0.0	1.5	-1.0	-0.0	-0.4
Primary Biliary Cirrhosis	0.7	1.0	5.3	-0.5	-0.1	-0.6	0.1	-2.3	-0.1	-1.0
Smoking Status	0.7	1.6	2.4	1.5	1.4	1.3	0.7	1.3	1.3	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.8	1.0	-0.0	1.2	1.1	0.1	1.9	1.2
Pack years adult smoking proportion	0.7	1.0	2.1	1.3	1.5	1.2	0.4	0.3	1.0	0.9
Allergy	0.7	1.7	2.9	1.7	1.7	1.4	0.8	0.7	0.7	1.5
Father’s age at death	0.7	1.0	1.8	0.4	-0.6	1.0	-1.3	1.1	-1.1	1.2
Falls in the last year	0.7	1.0	1.7	-0.9	-0.3	-1.0	1.3	-1.2	0.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	-1.1	-0.8	-1.3	0.1	-0.7	-0.6	-1.3
Medication: Omeprazole	0.7	0.8	1.9	0.1	-0.5	0.9	-1.4	-0.9	-1.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.0	-1.3	-1.0	-1.4	0.3	-0.5	0.2	-1.2
Illnesses of father: Heart disease	0.7	1.0	1.6	1.3	1.0	1.0	0.6	0.8	1.1	1.1
Guilty feelings	0.7	1.1	2.0	0.7	-0.7	0.6	0.9	1.4	1.4	1.2
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.9	-0.5	-1.5	0.6	-1.1	0.3	-0.9
Fasting Glucose	0.6	0.8	2.2	0.4	1.1	-0.2	1.5	-0.4	1.2	-0.1
Lupus	0.6	0.9	3.5	0.4	1.3	0.2	-0.5	-1.9	-0.9	0.0
Neuroticism (2016)	0.6	0.8	1.5	0.1	-0.5	1.2	1.0	1.2	0.8	1.0
Schizophrenia (2014)	0.6	1.4	3.4	-1.6	-1.8	-1.3	0.6	-0.5	-0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	1.0	1.2	0.9	0.2	-0.5	0.8	0.7
Average weekly spirits intake	0.6	0.8	2.2	-0.6	0.5	-0.7	-1.0	-1.5	-0.5	-1.0
Financial difficulties in last 2 years	0.6	0.8	1.9	0.7	0.5	0.2	1.4	0.8	1.4	0.4
Medication: Simvastatin	0.6	0.8	1.4	1.2	1.0	1.2	-0.9	0.5	0.1	1.0
Illnesses of siblings	0.6	0.8	1.6	-0.6	0.5	-0.8	-1.0	-0.6	-1.2	-1.2
Exposure to tobacco smoke at home	0.6	0.7	2.4	-0.5	0.2	-0.5	-0.6	-1.5	-1.1	-0.5
Peak expiratory flow (PEF)	0.6	1.3	2.2	-0.5	0.6	-1.0	1.5	-1.4	1.4	-1.1
Medication: Paracetamol	0.6	1.0	3.5	-1.1	-0.5	-0.9	-0.4	-1.9	-0.4	-1.1
Birth weight	0.6	1.2	3.1	-0.8	-1.3	-0.7	1.5	0.4	1.8	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.9	0.5	1.2	0.6	-1.4	-0.5	-1.0	0.2
Illnesses of siblings: Diabetes	0.6	0.7	1.8	-0.6	-0.8	-0.3	1.4	-1.0	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.2	1.2	0.5	1.2	-1.1	1.4	-0.7	1.5
Mother’s age at death	0.6	0.8	1.8	0.5	0.4	1.3	0.8	1.4	0.5	0.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	-0.4	1.1	-0.7	0.0	-1.3	-0.7	-0.8
Alcohol drinker status: Never	0.6	0.8	2.3	-0.6	-0.2	-1.1	-0.3	-1.5	-0.2	-1.1
Average weekly beer plus cider intake	0.6	0.9	2.7	0.7	-0.0	0.5	1.5	0.2	1.6	0.6
Cholesterol lowering medication	0.6	0.9	2.1	1.1	1.4	1.0	0.1	1.0	0.5	0.9
Rheumatoid Arthritis	0.5	0.7	1.1	1.0	1.0	0.9	-1.1	0.5	0.2	0.9
Sensitivity / hurt feelings	0.5	0.9	2.7	-0.3	-1.1	-0.2	1.6	0.8	1.2	0.0
Qualifications: CSEs or equivalent	0.5	0.6	1.7	0.2	-0.1	0.3	1.1	1.0	1.3	0.2
Had menopause	0.5	0.6	1.9	-0.4	-0.7	-0.6	1.0	0.3	1.4	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.7	0.7	0.4	0.8	1.1	0.4	1.3	0.6
Heart disease (mother)	0.5	0.7	1.4	1.1	1.2	0.4	-0.7	-1.0	0.3	0.5
Age at last live birth	0.5	0.7	2.4	0.1	-0.4	0.6	-1.2	0.5	-1.5	0.8
Smoking status: Previous	0.5	0.8	2.0	-0.9	-0.3	-0.9	-0.5	-1.4	-0.5	-1.1
Back pain experienced in last month	0.5	0.7	2.3	0.3	1.5	-0.4	1.1	-0.9	0.7	-0.3
Diastolic blood pressure, automated reading	0.5	1.5	5.6	0.9	-0.1	1.5	-0.7	2.4	0.3	1.3
Pack years of smoking	0.5	0.7	1.3	0.9	1.1	0.9	0.5	0.1	1.0	0.7
Chronotype (morning person)	0.4	0.9	3.6	-0.4	0.5	-0.6	-1.1	-0.4	-1.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.7	0.3	-0.1	0.4	-1.9	-0.6	-1.1	0.2
Number of incorrect matches in round	0.4	0.7	1.6	-1.0	-0.3	-0.7	0.7	-1.3	-0.6	-0.9
Alcohol usually taken with meals	0.4	0.6	2.7	0.3	0.1	0.1	-1.2	0.2	-1.6	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.3	-0.3	-0.7	0.0	-1.8	-0.7	-1.3	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	0.8	-0.0	0.9	-0.9	0.7	-0.7	0.6
Time employed in main current job	0.4	0.4	1.3	0.6	0.4	0.4	0.1	0.7	1.1	0.7
Asthma	0.4	0.8	2.0	-0.8	-0.3	-1.0	-0.1	-1.1	-0.5	-1.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.0	0.4	1.0	-0.2	-0.6	-1.0	-0.5	-0.3
Pulse wave reflection index	0.4	0.5	0.8	-0.7	-0.5	-0.9	-0.6	-0.8	-0.6	-0.8
Glaucoma (self-reported)	0.4	0.5	1.1	0.9	0.5	0.8	0.1	0.6	0.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	4.9	0.3	-0.3	0.2	0.8	0.2	2.2	0.2
Pulse wave peak to peak time	0.4	0.5	1.2	-0.3	-0.9	0.3	0.6	1.1	0.6	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	1.0	0.3	0.9	0.0	0.1	0.8	1.1
Neck or shoulder pain in last month	0.4	0.6	1.3	-0.7	-0.4	-0.9	0.9	-1.1	0.6	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	3.0	-0.4	0.2	-0.4	-0.0	-1.7	0.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.8	-1.0	-0.0	-0.9	-0.1	-0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	0.4	-0.2	0.7	0.3	0.4	1.2	0.7
Asthma (self-reported)	0.4	0.8	2.2	-0.9	-0.2	-1.1	0.0	-1.1	-0.5	-1.5
Ever taken oral contraceptive pill	0.4	0.4	0.7	0.7	0.5	0.8	-0.6	-0.6	-0.7	0.6
Hearing aid user	0.4	0.5	2.0	0.5	1.4	-0.1	-0.6	-0.5	-0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.6	0.6	0.2	0.8	0.3	1.3	0.4	0.7
Supplements: Calcium	0.4	0.5	1.2	0.2	0.6	-0.1	-0.9	-1.1	-1.0	-0.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.7	-0.1	-1.1	-0.1	-1.9	-0.5	-1.3	0.1
HbA1C	0.3	0.4	1.3	0.5	0.0	0.4	-1.1	0.1	-0.9	0.3
HDL Cholesterol	0.3	0.4	0.8	0.7	0.9	-0.2	0.8	0.5	0.9	0.3
LDL Cholesterol	0.3	0.5	2.6	-0.3	-0.1	-0.2	1.6	-0.4	0.8	-0.4
Height	0.3	5.3	8.5	-2.5	-2.9	-2.1	2.6	-1.4	2.0	-2.2
Respiratory disease	0.3	0.7	1.8	-0.7	-0.3	-0.9	0.9	0.3	0.8	-1.3
Number of treatments/medications taken	0.3	0.5	1.1	0.3	-1.0	1.1	-0.8	0.4	0.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.7	0.8	0.6	0.3	0.4	0.9	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.4	-0.3	-0.2	-1.1	-0.3	-0.9	-0.3
Supplements: Zinc	0.3	0.3	1.1	-0.1	-1.0	0.6	-0.3	0.8	0.3	0.4
Hand grip strength (right)	0.3	0.7	1.3	0.5	-0.3	1.0	-1.1	0.7	-0.9	1.1
Maternal smoking around birth	0.3	0.4	1.0	0.7	0.6	0.7	0.1	0.7	1.0	0.2
Forced vital capacity (FVC)	0.3	1.3	4.3	-0.7	-0.6	-0.9	2.1	0.2	1.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.6	-0.3	-0.9	-0.1	1.9	0.5	1.8	0.0
Prospective memory result	0.3	0.3	0.7	0.3	-0.4	0.6	-0.5	0.9	-0.3	0.7
Shortness of breath walking on level ground	0.3	0.4	1.3	0.4	0.7	0.4	0.1	0.6	1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	0.0	0.4	-0.3	0.6	-1.1	0.8	-0.5
Alcohol intake frequency.	0.3	0.7	1.5	-0.7	-0.1	-1.0	0.6	-1.2	0.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.6	0.9	-0.0	-0.9	-0.1	-0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	0.9	0.7	0.4	-0.5	0.6	0.1	0.6
Ever depressed for a whole week	0.3	0.4	1.7	0.1	0.1	-0.0	1.3	-0.4	0.7	0.1
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.1	0.6	-0.6	0.7	1.1	0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.0	1.0	0.2	0.6	-1.4	0.0	-0.2	0.9
Blood Red Count	0.2	2.0	6.7	1.4	2.6	1.0	1.2	0.2	1.8	0.4
Diabetes (mother)	0.2	0.3	0.9	-0.2	-1.0	0.2	0.0	-0.8	0.6	0.3
Severe depression (siblings)	0.2	0.2	0.5	0.0	0.5	0.2	0.7	0.5	0.7	0.3
Medication: Levothyroxine sodium	0.2	0.4	1.2	0.7	0.0	0.6	-0.4	0.1	1.1	0.7
Sitting height	0.2	1.1	3.9	0.6	0.2	0.5	2.0	-0.0	1.8	0.4
Past tobacco smoking	0.2	0.3	0.8	0.1	-0.3	0.2	0.9	0.9	0.6	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.5	0.4	-0.6	-0.2	-0.8	0.1	-0.7
Number of live births	0.2	0.3	0.8	-0.1	-0.2	0.2	-0.7	-0.4	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.2	0.4	-0.2	0.5	1.1	0.9	0.9	0.6
Standing height	0.2	2.2	4.0	-1.6	-1.8	-1.3	2.0	-0.6	1.3	-1.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.9	-1.1	-0.2	-0.1	-0.7	-0.0	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.7	0.4	0.8	-0.3	0.6	0.1	0.4	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	3.1	-0.3	-0.2	-0.5	1.8	0.6	1.1	-0.3
Chest pain or discomfort	0.2	0.4	1.2	0.7	0.1	0.6	1.1	0.1	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.7	0.1	0.7	-0.4	1.3	-0.0	0.7	-0.4
Ever had bowel cancer screening	0.2	0.2	0.5	0.1	-0.4	0.4	0.5	0.7	0.3	0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.8	0.4	0.5	-0.5	0.1	-0.3	0.8
Ever smoked	0.2	0.4	1.3	0.7	0.5	0.6	-1.1	0.0	-0.5	0.5
Risk taking	0.2	0.2	0.5	-0.3	0.2	-0.6	-0.7	-0.5	-0.5	-0.3
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.4	-0.7	-0.9	-0.2	0.0	-0.3	-0.2
Triglycerides	0.1	0.2	0.4	0.0	0.6	0.0	0.6	-0.5	0.1	-0.6
Heel T-Score	0.1	0.8	1.8	-0.9	0.3	-0.6	-1.2	-1.0	-0.5	-1.3
Waist Hip Ratio (WHR)	0.1	0.3	1.3	0.1	0.3	0.2	-0.3	-1.1	-0.9	0.0
Tanning	0.1	1.3	2.8	-1.7	-1.6	-1.1	1.0	-0.4	0.3	-1.2
Angina	0.1	0.1	0.3	0.4	0.6	0.5	-0.1	-0.3	0.2	-0.1
Vitamin and mineral supplements	0.1	0.1	0.1	0.2	0.3	-0.3	0.1	0.3	0.3	0.3
Age when periods started (menarche)	0.1	0.1	0.3	-0.5	-0.6	-0.4	0.2	-0.3	0.1	-0.3
Pain all over the body in last month	0.1	0.1	0.4	-0.2	-0.4	-0.1	0.0	-0.6	-0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	0.4	0.3	-0.3	0.1	0.8	-0.5	0.0
Angina (self-reported)	0.1	0.2	0.4	0.5	0.5	0.6	-0.3	-0.3	0.1	0.1
Migraine (self-reported)	0.1	0.1	0.4	-0.1	-0.6	0.1	-0.4	0.0	-0.7	-0.1
Comparative height size at age 10	0.1	0.4	0.8	-0.3	-0.8	0.6	-0.9	-0.6	-0.8	-0.1
Had major operations	0.1	0.1	0.3	0.1	-0.3	-0.4	-0.6	0.2	0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.3	-0.3	0.6	-0.5	0.2	-0.0	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	0.2	-0.2	-0.4	-0.2	0.0	-0.5
Breast cancer (self-reported)	0.1	0.1	0.5	-0.3	-0.7	0.2	-0.3	-0.1	-0.0	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.7	-0.0	0.8	-0.1	0.5	0.1	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	0.6	-0.7	0.6	-0.1	0.2	0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	-0.1	0.5	-0.1	0.1	-0.5	0.3
Hair Pigment	0.0	0.4	0.8	0.5	0.6	0.2	0.9	0.5	0.9	0.5
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.3	0.0	0.0	0.2	-0.1	0.4	0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.0	0.3	-0.1	-0.0	-0.3	0.1	-0.1

Hub : Genes

AP3M1

Models

Trait associations