Hub : Genes

ADK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0290 0.0130 1.8e-03 0.031 0.029 0.031 0.028 0.036 9.0e-05 1.7e-04 9.3e-05 2.2e-04 2.6e-05
2 GTEx Colon Transverse 0.2490 0.0710 2.9e-07 0.137 NA 0.103 NA 0.125 4.5e-07 NA 1.3e-05 NA 1.6e-06
3 GTEx Heart Atrial Appendage 0.1220 0.0520 3.0e-03 0.119 NA 0.100 NA 0.101 5.6e-06 NA 3.2e-05 NA 2.8e-05
4 GTEx Heart Left Ventricle 0.2101 0.0702 5.8e-05 0.112 NA 0.118 NA 0.118 1.5e-06 NA 7.9e-07 NA 8.1e-07
5 GTEx Lung 0.1506 0.0440 5.6e-10 0.166 NA 0.139 NA 0.170 1.1e-12 NA 8.5e-11 NA 4.8e-13
6 GTEx Prostate 0.3780 0.1250 1.8e-03 -0.008 NA -0.008 NA 0.009 5.7e-01 NA 5.9e-01 NA 1.8e-01
7 GTEx Thyroid 0.1030 0.0470 1.8e-03 0.053 NA 0.017 NA 0.047 6.9e-05 NA 1.7e-02 NA 1.6e-04
8 GTEx Whole Blood 0.2420 0.0510 3.3e-11 0.167 NA 0.228 NA 0.177 3.1e-15 NA 8.4e-21 NA 4.3e-16
9 METSIM Adipose 0.0427 0.0184 7.3e-04 0.018 0.013 0.019 0.013 0.022 9.2e-04 3.6e-03 7.1e-04 4.0e-03 2.2e-04
10 NTR Blood 0.0807 0.0204 6.7e-14 0.044 0.049 0.042 0.047 0.044 3.8e-14 2.0e-15 2.1e-13 5.8e-15 6.4e-14
11 YFS Blood 0.4164 0.0443 0.0e+00 0.383 0.436 0.445 0.442 0.428 1.2e-134 2.1e-159 1.4e-163 3.7e-162 3.9e-155
12 TCGA Lung Adenocarcinoma 0.0496 0.0228 7.0e-08 0.056 0.071 0.073 NA 0.067 4.1e-07 1.1e-08 7.3e-09 NA 2.6e-08
13 TCGA Thyroid Carcinoma 0.1000 0.0390 1.7e-13 0.157 0.143 0.142 NA 0.147 4.8e-15 8.9e-14 1.0e-13 NA 3.7e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 2.9 4.7 12.8 2.5 2.0 1.6 1.7 -2.8 -0.0 -2.9 1.2 1.9 0.7 0.7 -3.6 -3.2
Bipolar Disorder or Schizophrenia 1.3 3.2 8.4 1.1 0.2 2.7 2.7 -1.8 -1.2 -2.0 1.5 1.2 1.0 0.7 -2.9 -2.1
Depressed Affect (Nagel 2018) 1.7 3.5 10.4 -0.7 -1.7 3.2 3.2 0.1 -1.9 -0.2 3.0 1.0 1.6 2.1 -0.9 -0.2
Depression (Nagel 2018) 2.1 3.2 12.5 0.8 0.5 1.1 1.1 -0.8 -0.7 -1.3 3.2 2.2 2.1 3.5 -1.4 -1.3
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.6 0.9 0.3 1.1 1.1 -1.2 -0.2 -0.7 -1.1 -0.9 -0.1 -1.2 -0.6 -0.9
Neuroticism (Nagel 2018) 2.6 6.0 17.1 1.6 0.3 4.1 4.1 -2.5 -2.5 -2.7 1.2 0.6 0.3 0.2 -3.5 -2.6
Schizophrenia (2018) 0.6 1.2 4.5 -0.7 -1.3 2.1 2.1 -0.1 -1.5 -0.3 0.9 0.0 0.7 0.4 -0.8 -0.1
Schizophrenia vs Biploar Disorder 3.5 4.6 10.5 -3.0 -3.1 0.3 0.5 2.8 -2.0 2.9 0.1 -2.0 0.3 -0.3 2.5 3.2
Worry (Nagel 2018) 4.8 10.1 23.6 2.8 1.1 4.4 4.5 -4.0 -1.6 -4.0 -0.8 -0.6 -1.4 -2.0 -4.9 -4.1
Alzheimer’s Disease (in mother) 1.3 1.6 4.3 -0.1 0.0 -1.5 -1.5 0.7 1.1 0.8 -1.4 -2.1 -1.2 -1.3 1.9 0.9
Alzheimer’s Disease (in father) 0.6 0.7 3.8 -0.4 -1.0 1.1 1.1 0.4 -2.0 0.4 0.9 0.1 0.4 -0.1 -0.4 0.4
Alzheimer’s Disease (including proxy) 1.4 2.0 6.0 -0.6 -0.6 -1.1 -1.1 0.9 0.2 1.1 -1.8 -2.4 -1.5 -2.3 1.6 1.0
Crohns Disease (2017) 1.1 2.4 4.4 -1.8 -1.4 -0.6 -0.6 1.7 1.0 2.0 -1.4 -2.1 -1.1 -2.0 1.6 1.9
Irritable Bowel Disease (IBD) 2.0 4.9 10.0 -2.3 -1.5 -1.1 -1.1 2.3 0.8 2.7 -2.2 -3.2 -1.8 -2.7 2.9 2.7
Ulcerative Colitis (UC) 1.5 2.9 7.0 -1.6 -0.7 -1.3 -1.2 1.6 0.4 1.9 -1.6 -2.6 -1.2 -1.7 2.6 2.0
Major Depression (MDD) 1.2 1.5 5.0 1.2 1.6 -1.4 -1.4 -0.8 2.2 -0.9 0.7 1.2 0.7 1.1 0.2 -1.1
Reaction Time 2.0 3.9 14.1 -2.8 -3.8 1.6 1.7 2.1 -1.7 2.2 -0.2 -1.5 -0.6 -0.2 1.5 2.5
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.8 1.3 1.0 -0.2 -0.2 -1.0 1.3 -0.8 -0.8 -0.3 0.0 -0.8 -0.5 -0.7
Breast Cancer 0.6 1.5 4.8 1.5 2.2 -1.4 -1.4 -0.9 1.3 -0.8 -1.2 1.3 -1.1 -0.3 -0.1 -0.7
Ovarian Cancer 0.8 1.1 2.7 -1.2 -1.6 0.1 0.2 1.2 -0.6 1.4 -0.2 -1.3 -1.4 -0.7 0.8 1.0
Prostate Cancer 0.6 0.8 2.6 1.4 1.6 -1.1 -1.1 -1.0 0.2 -0.9 -0.8 0.4 -0.6 -0.3 0.0 -0.7
Age at First Birth 1.4 2.1 8.9 0.1 -0.1 0.4 0.3 -0.6 -0.5 -0.3 -2.8 -2.0 -3.0 -2.3 0.4 -0.2
Bipolar Disorder (2011) 2.3 2.3 4.8 1.7 1.4 0.6 0.6 -1.8 0.2 -1.9 1.0 1.6 1.5 1.0 -2.2 -2.2
Body Mass Index (BMI) (2010) 1.7 2.3 5.9 0.5 2.1 -2.2 -2.2 0.1 1.9 -0.1 0.9 1.6 2.4 1.5 0.1 -0.1
Coronary Artery Disease (CAD) 1.5 1.8 4.3 -1.1 -0.1 -1.5 -1.4 1.8 1.5 1.8 0.8 0.7 0.7 0.4 2.1 1.7
Crohns Disease (2012) 0.7 1.1 2.5 -1.5 -1.4 -0.6 -0.6 1.5 0.4 1.6 -0.1 -0.7 0.5 -0.6 1.0 1.2
Mean Putamen Volume 1.6 1.8 3.6 1.0 0.4 1.9 1.9 -1.7 -0.7 -1.8 0.0 1.3 -0.6 0.2 -1.8 -1.7
Fasting Glucose 1.0 1.1 2.7 -0.5 -0.4 -1.1 -1.1 1.0 0.3 0.9 1.3 1.2 1.6 1.5 1.2 0.9
HbA1C 0.3 0.3 1.7 0.3 -0.1 -0.1 -0.4 -0.4 1.0 -0.3 -0.5 -1.3 -0.2 -0.5 -0.0 -0.3
HDL Cholesterol 0.4 0.6 2.5 0.3 0.3 -1.0 -0.9 0.3 1.6 0.2 0.8 0.8 1.1 0.7 0.8 0.5
LDL Cholesterol 0.4 0.6 4.4 -0.2 0.0 0.1 0.1 0.5 -0.2 0.3 1.5 0.5 2.1 0.8 -0.2 0.3
Lupus 0.8 1.2 2.7 -1.1 -0.4 -1.4 -1.4 1.0 1.5 1.1 -0.8 -0.6 0.3 -0.4 1.6 1.0
Neuroticism (2016) 0.6 0.8 2.0 1.0 0.6 0.7 0.6 -1.2 -0.1 -1.4 0.6 0.7 0.4 0.3 -1.3 -1.4
Primary Biliary Cirrhosis 0.4 0.6 1.3 -0.8 -0.9 -0.1 0.0 1.0 -0.4 1.1 0.7 -0.5 1.1 0.2 1.0 1.1
Rheumatoid Arthritis 0.5 0.7 2.1 1.1 1.5 -1.0 -1.0 -0.5 1.1 -0.3 -0.6 1.1 0.3 -0.0 0.5 -0.2
Schizophrenia (2014) 0.3 0.8 3.1 -0.6 -1.2 1.7 1.7 0.1 -1.2 -0.0 0.4 -0.4 0.5 -0.2 -0.5 0.2
Triglycerides 0.3 0.5 1.4 -0.6 0.0 -0.6 -0.6 1.0 -0.0 1.1 0.3 -0.0 1.2 0.6 0.7 0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.9 0.2 1.1 -1.4 -1.3 -0.0 0.9 -0.4 0.6 0.5 0.9 0.6 0.2 -0.5
Ulcerative Colitis 1.8 2.6 7.5 -1.4 -0.3 -2.3 -2.2 1.7 1.0 1.9 -1.3 -0.5 -0.2 -0.6 2.7 1.9
Blood Eosinophil Count 0.6 4.5 10.9 3.3 3.0 0.3 0.3 -2.6 -0.9 -3.0 1.2 1.0 0.4 0.9 -2.9 -3.1
Blood Platelet Count 1.6 18.9 43.6 6.6 6.5 0.2 0.2 -6.5 1.0 -6.3 -1.9 1.0 -0.7 -1.3 -5.4 -6.4
Blood Red Count 0.4 3.5 7.1 -0.6 0.7 -2.7 -2.7 1.5 2.0 1.4 1.0 2.3 2.3 2.0 2.0 1.5
Blood White Count 1.0 7.3 14.1 2.5 2.0 0.7 0.7 -2.4 -1.0 -2.8 3.6 3.7 3.6 3.8 -2.8 -2.7
Heel T-Score 0.2 1.6 5.3 -1.7 -1.1 -0.5 -0.5 1.6 1.1 1.8 -0.2 0.6 -0.3 -0.0 2.3 1.8
BMI 2.2 12.6 31.5 0.9 3.9 -5.6 -5.6 0.9 4.6 0.6 2.5 3.1 5.0 4.2 2.2 0.4
Height 0.1 2.8 8.2 -0.8 -1.3 2.8 2.9 0.6 -1.8 0.3 2.4 1.7 1.1 1.6 -1.4 0.4
Waist Hip Ratio (WHR) 0.0 0.2 0.8 -0.3 -0.3 -0.4 -0.4 0.2 0.1 0.2 -0.6 -0.9 -0.2 -0.7 0.2 0.5
Systolic Blood Pressure 3.7 18.5 47.6 6.2 6.9 -0.9 -1.1 -5.2 1.5 -5.5 1.1 5.0 -1.2 2.0 -5.3 -5.8
Smoking Status 0.4 0.9 2.2 0.7 1.5 -1.4 -1.3 -0.2 1.5 -0.2 0.7 0.8 0.2 1.2 -0.5 0.1
Allergy or Eczema 0.8 2.2 6.5 0.3 -0.5 2.5 2.6 -0.9 -1.7 -0.6 -0.7 -2.2 -1.5 -1.3 -1.3 -0.8
Cardiovascular Disease 3.2 10.5 26.9 5.0 5.2 -1.3 -1.6 -4.4 2.6 -4.5 -0.9 1.3 -1.4 0.1 -3.1 -4.5
Hypothyroidism (self reported) 0.6 1.3 5.1 1.9 2.2 -1.2 -1.2 -1.2 0.7 -1.1 -0.2 0.5 0.0 0.2 -0.7 -1.2
Respiratory disease 0.4 0.9 2.0 -1.1 -0.4 0.1 0.2 1.4 0.9 1.4 1.4 0.3 0.6 1.2 0.6 1.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.8 1.6 1.6 0.1 0.1 -1.3 -0.6 -1.5 0.8 0.8 0.8 0.9 -1.4 -1.7
Lung FEV1/FVC ratio 3.5 17.5 41.0 5.3 3.3 2.5 2.4 -6.4 -2.0 -6.4 -2.5 0.2 -0.6 -2.4 -6.3 -6.3
Lung FVC 0.4 2.0 3.7 1.7 1.7 -1.4 -1.4 -1.0 1.7 -1.2 0.8 1.9 1.7 1.3 -0.8 -1.4
Neuroticism 1.8 4.3 15.4 0.7 -0.8 3.9 3.9 -1.5 -2.6 -1.7 1.7 0.2 0.3 0.7 -2.5 -1.8
Chronotype (morning person) 0.5 1.1 3.6 -0.5 -0.4 -0.5 -0.6 0.9 0.4 1.1 -1.1 -1.9 -1.2 -1.8 0.7 1.0
Hair Pigment 0.0 0.2 0.7 0.2 0.2 -0.7 -0.6 0.1 0.8 0.0 0.7 0.2 -0.5 0.2 -0.1 0.2
Tanning 0.1 0.8 2.7 -0.5 -1.0 1.6 1.6 0.2 -1.4 0.1 0.9 0.4 0.5 0.5 -0.5 0.0
Hand grip strength (left) 2.0 5.3 10.8 2.6 2.1 -0.1 -0.1 -2.9 -0.9 -2.5 -2.5 -2.0 -3.2 -3.3 -2.2 -2.5
Number of treatments/medications taken 0.6 1.0 2.9 1.0 0.7 1.1 1.1 -1.5 0.3 -1.4 0.2 -0.2 0.3 0.1 -1.5 -1.7
Average weekly spirits intake 0.7 0.8 2.3 -1.4 -0.6 -0.5 -0.5 1.4 0.3 1.5 -0.2 -0.3 -0.0 -0.1 1.2 1.5
Sensitivity / hurt feelings 0.5 0.8 1.4 0.4 -0.4 1.2 1.2 -0.6 -0.4 -1.0 0.9 1.0 1.1 0.9 -1.0 -0.8
Frequency of depressed mood in last 2 weeks 2.2 3.1 6.3 1.7 1.2 1.2 1.2 -1.6 -0.8 -2.1 2.5 1.3 1.8 2.4 -2.2 -1.8
Hearing difficulty/problems: Yes 5.4 8.2 20.5 -4.5 -4.3 0.3 0.4 3.8 -0.2 4.0 0.4 -2.1 1.9 0.1 3.4 4.1
Relative age of first facial hair 2.1 4.3 10.2 -2.3 -2.7 0.8 0.8 1.7 -0.4 2.1 -2.1 -3.2 -2.9 -2.2 1.6 1.9
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.1 0.2 0.5 -0.8 -0.7 0.1 1.4 -0.1 0.7 0.9 0.6 1.1 0.3 0.2
Ever used hormone-replacement therapy (HRT) 1.3 1.7 5.2 1.1 0.8 0.5 0.5 -1.0 -0.4 -1.1 1.5 2.0 1.7 2.3 -1.0 -1.1
Ever had hysterectomy (womb removed) 0.3 0.4 1.7 -0.7 -0.5 0.3 0.3 0.0 -0.1 0.2 -1.3 -0.9 -0.7 -0.7 0.5 0.1
Systolic blood pressure, automated reading 3.7 10.7 31.4 4.6 5.6 -1.9 -2.1 -3.5 1.8 -3.7 0.9 4.3 -0.3 2.1 -3.0 -4.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.4 -0.6 -0.7 0.8 0.9 0.6 -0.1 0.5 1.6 0.2 1.2 1.0 -0.4 0.3
Angina 0.2 0.3 1.3 -0.3 0.4 -0.7 -0.6 0.6 0.5 0.5 0.0 0.0 0.1 0.1 1.1 0.7
Medication for hormone replacement therapy 0.7 0.8 3.8 -1.0 -1.4 0.7 0.7 0.7 -1.9 0.9 -0.3 -0.7 -0.0 -0.2 0.3 0.7
Vitamin and mineral supplements 0.1 0.1 0.2 -0.2 -0.4 -0.3 -0.4 0.0 0.5 -0.1 0.0 0.2 -0.3 0.3 0.5 -0.2
Supplements: Zinc 1.1 1.1 2.5 1.3 1.1 1.1 1.1 -1.3 -0.5 -1.3 -0.0 0.6 -0.8 0.1 -1.6 -1.6
Medication: Co-codamol 1.6 1.9 5.9 0.8 0.7 -1.6 -1.6 -0.8 1.1 -0.5 -2.4 -2.1 -1.5 -1.7 0.4 -0.5
Medication: Metformin 1.1 1.5 2.9 1.1 1.7 -1.0 -1.0 -0.8 0.4 -1.2 1.3 1.1 1.7 1.4 -1.2 -1.3
Diabetes (father) 1.0 1.3 3.3 1.5 1.8 0.3 0.3 -1.4 1.3 -1.5 0.6 0.9 -0.0 0.6 -0.9 -1.6
Diabetes (mother) 0.5 0.6 1.8 0.8 0.6 1.0 1.0 -1.0 0.2 -1.0 0.5 0.1 0.3 0.1 -1.4 -0.8
Severe depression (siblings) 0.4 0.4 2.6 0.2 0.3 -0.5 -0.5 0.1 -0.6 0.0 0.5 0.7 1.6 1.2 0.2 -0.0
Pack years adult smoking proportion 0.5 0.8 2.3 0.1 1.1 -1.5 -1.5 0.3 0.9 0.2 0.2 1.1 0.8 1.1 0.7 0.2
Impedance of leg (right) 1.9 9.2 23.2 -0.5 -2.2 4.1 4.1 -1.4 -3.6 -1.0 -3.7 -3.3 -3.6 -4.8 -1.9 -0.7
Leg fat-free mass (left) 1.6 8.2 23.0 0.4 2.3 -3.2 -3.2 1.1 3.3 0.6 3.8 3.5 4.2 4.8 1.1 0.3
Trunk fat percentage 1.7 7.0 22.2 -1.8 0.2 -2.9 -2.9 1.9 2.6 1.6 2.5 2.9 4.7 3.7 2.2 1.5
Hand grip strength (right) 0.7 2.0 5.7 1.1 0.9 0.4 0.4 -1.6 -0.7 -1.5 -1.1 -1.5 -2.4 -2.0 -1.7 -1.4
Townsend deprivation index at recruitment 1.4 2.0 6.8 -1.1 -0.9 0.7 0.8 1.3 -1.4 1.0 2.6 0.7 2.1 2.2 0.0 1.3
Current tobacco smoking 1.5 2.4 5.7 1.3 2.0 -2.4 -2.4 -0.3 2.0 -0.4 1.2 2.1 0.7 1.9 -0.1 -0.3
Average weekly fortified wine intake 1.4 1.6 5.3 1.7 2.3 -1.3 -1.3 -0.9 1.1 -0.9 -0.6 0.5 -1.8 -0.7 -0.9 -0.8
Maternal smoking around birth 0.3 0.4 1.1 0.2 1.1 -0.7 -0.6 0.3 0.2 0.2 1.0 1.0 0.4 0.9 0.6 0.1
Fed-up feelings 1.8 3.2 10.4 0.1 -0.8 3.2 3.2 -0.6 -1.7 -1.0 2.4 0.9 0.9 1.8 -2.1 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 6.9 0.7 0.4 0.6 0.6 -0.8 -0.5 -1.3 2.3 1.2 1.0 2.6 -1.5 -1.3
Relative age voice broke 2.0 3.0 7.7 -2.2 -2.8 2.0 2.0 1.8 -1.4 1.8 0.5 -2.0 -1.4 -0.0 1.0 1.7
Taking other prescription medications 1.3 2.0 5.1 1.9 1.8 0.0 -0.1 -2.0 0.7 -2.0 -1.1 0.0 -1.1 -0.8 -1.6 -2.2
Age when periods started (menarche) 0.0 0.1 0.5 -0.2 -0.2 0.5 0.5 0.0 0.0 -0.0 0.1 0.0 -0.7 -0.4 -0.0 -0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.1 0.6 0.8 -1.0 -1.1 -0.2 1.0 -0.2 0.2 -0.8 0.8 0.2 0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.1 0.3 0.7 0.1 0.1 -0.5 0.0 -0.4 -1.4 -0.6 -0.9 -1.5 -0.2 -0.2
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 5.2 1.5 1.3 1.3 1.2 -2.0 -1.5 -2.1 -0.2 1.2 0.5 0.7 -2.3 -2.0
Qualifications: CSEs or equivalent 0.5 0.6 2.7 0.5 0.7 0.2 0.1 -0.2 1.7 -0.3 0.9 0.9 1.0 1.0 -0.5 -0.4
Serious illness, injury or assault to yourself 1.8 2.1 4.9 1.9 1.7 -0.1 -0.1 -1.9 1.1 -2.1 0.6 1.6 0.6 0.9 -1.7 -2.2
High blood pressure 2.8 7.8 18.5 4.0 3.8 -0.5 -0.6 -3.9 1.2 -4.0 0.2 2.3 0.0 1.2 -3.4 -4.3
Hayfever, allergic rhinitis or eczema 0.7 1.4 4.0 -0.4 -0.7 1.7 1.8 -0.1 -1.5 0.2 -0.8 -2.0 -1.5 -1.4 -0.5 0.0
Multivitamins +/- minerals 0.7 0.9 2.5 1.4 1.6 -0.5 -0.5 -1.1 0.0 -0.9 -1.1 -0.2 -0.5 -1.2 -1.0 -0.6
Stomach or abdominal pain in last month 3.7 4.6 9.5 2.9 2.9 0.7 0.6 -2.8 0.7 -3.1 0.8 2.0 0.3 0.7 -3.0 -3.1
Supplements: Glucosamine 1.6 2.1 4.7 -2.1 -1.9 -0.1 -0.1 1.9 -0.6 2.0 -0.2 -1.6 -0.2 -0.8 2.2 1.9
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 5.3 2.1 2.1 -1.0 -1.1 -1.9 0.6 -2.1 0.4 1.8 1.3 0.9 -1.6 -2.3
Medication: Atenolol 0.8 1.0 3.5 1.4 1.9 -0.7 -0.7 -1.0 -0.3 -1.2 0.5 1.1 1.1 0.7 -0.6 -1.1
Medication: Levothyroxine sodium 0.3 0.5 1.3 0.9 0.4 0.0 0.0 -0.9 0.5 -0.9 0.0 1.0 0.5 0.6 -0.8 -1.1
Sitting height 0.1 0.5 1.8 0.7 1.2 -0.1 -0.1 -0.1 0.7 -0.3 1.4 0.7 0.9 0.9 -0.5 -0.3
Chronic bronchitis/emphysema (father) 1.3 1.6 4.0 0.9 1.9 -1.8 -1.9 -0.4 2.0 -0.3 -1.4 0.2 -1.2 -0.6 0.9 -0.1
High blood pressure (mother) 3.1 4.3 10.1 3.2 2.6 0.2 0.1 -2.8 0.2 -2.9 -0.1 1.9 -0.7 0.6 -3.2 -2.9
Body mass index (BMI) 2.2 9.5 24.9 0.4 2.7 -5.0 -5.0 0.8 4.1 0.6 1.9 2.7 4.5 3.6 2.0 0.5
Impedance of leg (left) 2.0 9.6 26.9 -0.8 -2.4 3.9 3.9 -1.1 -3.4 -0.7 -4.0 -3.6 -4.0 -5.2 -1.5 -0.3
Leg predicted mass (left) 1.5 8.1 22.2 0.4 2.3 -3.3 -3.3 1.1 3.3 0.6 3.8 3.5 4.0 4.7 1.1 0.4
Trunk fat mass 1.8 7.9 23.0 -1.2 1.1 -3.5 -3.5 1.7 3.2 1.4 2.6 3.1 4.8 3.9 2.1 1.2
Waist circumference 2.2 8.0 20.4 -0.6 1.5 -4.1 -4.1 1.5 3.4 1.2 2.3 2.7 4.5 3.8 2.0 1.2
Number of incorrect matches in round 0.4 0.6 1.4 -1.2 -1.2 0.2 0.3 0.8 -0.9 0.7 0.1 -0.7 0.5 -0.1 1.0 1.1
Past tobacco smoking 0.2 0.3 0.8 0.9 0.5 0.4 0.3 -0.6 -0.9 -0.7 0.5 0.1 -0.4 -0.1 -0.7 -0.7
Alcohol usually taken with meals 0.6 1.0 4.9 0.5 -0.3 -0.1 -0.1 -0.6 -0.2 -0.4 -1.5 -2.2 -1.2 -1.6 -0.6 -0.2
Nervous feelings 3.1 5.9 14.1 2.2 0.9 2.9 2.9 -3.0 -1.7 -3.1 -1.4 -0.5 -1.7 -2.0 -3.8 -3.0
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 12.0 2.3 1.1 2.8 2.7 -2.5 -1.1 -3.0 2.5 1.0 1.3 2.0 -3.5 -3.0
Hearing difficulty/problems with background noise 3.9 6.3 21.8 -3.2 -4.7 2.9 3.0 2.3 -2.9 2.4 0.5 -2.3 0.1 -0.6 0.7 2.4
Hair/balding pattern: Pattern 2 1.7 2.2 8.2 -1.1 -2.0 2.9 2.8 0.6 -1.5 0.4 1.3 -1.0 -1.1 -0.1 -0.6 0.7
Had menopause 0.4 0.5 2.1 -0.3 -0.6 0.7 0.7 0.2 -0.6 0.1 1.4 0.9 0.2 1.4 0.2 -0.1
Had other major operations 0.6 0.7 2.5 0.5 1.0 -1.6 -1.5 -0.1 -0.4 -0.0 0.3 1.5 0.2 0.7 0.5 -0.0
Forced vital capacity (FVC) 0.2 0.7 3.2 -0.1 -0.0 0.5 0.6 0.7 0.1 0.4 1.5 1.1 1.8 1.2 -0.5 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.7 -0.1 -0.0 0.7 0.8 -0.5 0.6 -0.4 -1.1 -0.6 -0.8 -1.3 -0.2 -0.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.5 0.2 0.6 -0.4 -0.4 -0.2 -0.8 -0.5 0.6 0.7 1.2 1.2 0.1 -0.1
Qualifications: None of the above 1.8 3.8 10.8 -3.3 -2.8 0.3 0.3 2.6 -1.1 2.6 0.3 0.2 0.0 0.4 2.9 2.7
Financial difficulties in last 2 years 0.4 0.5 2.3 0.4 0.9 -0.5 -0.5 0.1 1.5 -0.2 0.9 0.5 0.8 1.1 -0.2 -0.2
Mouth/teeth dental problems 0.6 0.8 2.8 -0.9 -1.1 0.4 0.4 1.4 -0.2 1.3 0.3 -0.4 -1.7 -0.5 0.7 1.1
Heart attack 0.6 0.8 2.1 1.2 1.4 -0.7 -0.7 -1.2 -0.0 -1.1 -0.3 0.0 -0.2 0.3 -0.8 -1.5
Allergy 0.4 0.9 2.9 0.7 0.9 -1.7 -1.7 -0.4 1.2 -0.5 -0.3 1.3 0.9 0.5 0.5 -0.4
Pain all over the body in last month 0.2 0.2 1.1 0.3 -0.4 0.5 0.5 -0.5 -1.0 -0.4 0.0 -0.4 0.1 -0.1 -0.5 -0.5
Diabetes (self-reported) 0.7 1.1 2.4 1.4 1.4 0.4 0.4 -1.1 -0.2 -1.3 1.2 0.7 0.7 0.8 -1.6 -1.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 0.5 0.4 0.1 0.1 -0.8 0.6 -0.7 -0.7 -0.6 -0.2 -0.7 -0.6 -0.7
Medication: Ramipril 0.7 0.9 3.6 0.2 0.6 -1.6 -1.6 -0.1 1.9 -0.0 -0.7 -1.0 -0.9 -0.6 0.4 -0.4
Medication: Simvastatin 0.3 0.4 1.3 0.8 1.1 -0.9 -1.0 -0.5 1.1 -0.4 -0.5 0.3 0.2 -0.1 -0.2 -0.3
Fluid intelligence score 1.5 3.1 8.7 2.9 2.6 -0.4 -0.3 -2.5 1.8 -2.2 -1.6 -0.3 -0.6 -1.4 -1.4 -1.8
Illnesses of siblings 0.9 1.2 2.9 -1.6 -1.1 -0.6 -0.6 1.5 0.1 1.7 -0.8 -0.7 -0.5 -0.8 1.4 1.5
Neuroticism score 2.3 4.9 14.5 1.3 -0.0 3.8 3.8 -2.1 -2.4 -2.4 1.3 0.4 0.1 0.3 -3.1 -2.3
Weight 1.5 7.4 17.4 0.0 2.2 -4.0 -4.0 1.1 3.3 0.8 2.4 2.8 4.2 3.7 1.7 0.7
Impedance of arm (right) 1.0 4.4 14.4 -2.7 -3.8 3.4 3.5 1.4 -2.1 1.5 0.0 -0.4 -0.9 -0.7 0.3 1.6
Arm fat percentage (right) 2.1 8.3 23.6 -0.8 1.3 -3.8 -3.8 1.5 3.6 1.2 2.4 3.0 4.9 3.8 2.2 0.9
Trunk fat-free mass 0.5 3.0 7.0 1.4 2.6 -2.6 -2.6 -0.2 2.4 -0.4 1.3 1.3 1.4 2.0 0.3 -0.5
Hip circumference 1.6 6.8 18.8 -0.2 1.7 -3.5 -3.5 1.2 2.4 1.0 2.6 3.2 4.3 3.7 1.8 0.9
Time employed in main current job 0.6 0.6 2.1 0.5 0.6 -0.3 -0.3 -0.5 -0.3 -0.6 0.7 1.5 1.4 1.3 -0.6 -0.6
Alcohol intake versus 10 years previously 0.5 0.7 2.0 -1.4 -0.8 -0.5 -0.4 1.1 -0.3 1.2 0.2 0.1 -0.5 0.3 1.4 1.0
Father’s age at death 2.0 2.7 4.6 1.8 1.2 0.8 0.7 -1.9 -2.0 -1.8 -1.8 -0.7 -2.2 -2.0 -1.6 -1.7
Worrier / anxious feelings 4.0 7.6 15.8 3.0 1.4 3.3 3.3 -3.8 -1.8 -3.7 -1.0 -0.7 -1.3 -1.7 -4.0 -3.6
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 7.2 -2.0 -2.5 1.3 1.4 1.7 0.6 1.3 2.7 -0.1 1.3 2.0 1.0 1.7
Falls in the last year 1.0 1.3 3.9 -1.2 -1.2 0.3 0.3 1.1 0.1 0.9 2.0 -0.5 1.8 1.7 1.0 1.0
Hair/balding pattern: Pattern 3 0.8 1.2 4.6 0.2 0.3 -2.1 -2.2 0.4 0.6 0.6 -1.4 -0.8 -0.3 -1.0 1.1 0.5
Number of live births 0.4 0.5 1.5 0.1 -0.4 0.2 0.2 -0.8 -1.2 -0.7 -1.2 -0.3 -0.2 -0.9 -0.9 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 3.9 0.8 0.6 1.0 1.0 -0.5 -0.3 -0.8 1.3 1.6 2.0 1.0 -1.6 -0.8
Pulse rate 1.6 2.7 5.3 -1.9 -0.4 -2.2 -2.2 2.0 1.1 2.0 0.2 0.4 2.0 0.7 2.3 1.7
Happiness 0.5 0.6 3.1 -0.7 -0.5 0.9 0.9 0.5 -0.4 0.2 1.7 0.3 0.7 1.2 -0.1 0.1
Noisy workplace 2.2 2.8 6.3 -1.9 -0.9 -1.8 -1.9 2.3 0.9 2.5 -0.2 0.4 0.4 0.5 2.5 2.3
Qualifications: A levels/AS levels or equivalent 1.8 3.9 7.5 2.7 2.0 1.2 1.2 -2.6 0.0 -2.3 -2.4 -1.0 -2.0 -2.4 -2.3 -1.8
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.1 5.2 1.8 1.5 -0.7 -0.7 -1.4 1.6 -1.6 0.8 1.5 2.3 1.5 -1.2 -1.6
Mouth/teeth dental problems: Dentures 2.0 3.3 15.7 -0.2 0.8 -1.9 -1.9 0.3 0.4 0.1 1.7 2.5 4.0 3.2 0.4 -0.0
Asthma 0.5 0.9 2.3 -1.4 -1.1 0.1 0.2 1.4 1.0 1.5 0.3 -0.7 0.1 -0.0 1.0 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.6 -1.6 -1.1 0.3 0.3 1.4 -0.8 1.2 1.2 1.3 0.7 0.8 1.0 1.3
Medication: Cholesterol lowering 1.0 1.6 3.1 1.7 1.7 -0.5 -0.5 -1.7 1.3 -1.6 -1.0 0.7 -0.6 0.1 -1.4 -1.7
Depression (self-reported) 2.0 2.4 5.4 2.1 1.9 -0.3 -0.4 -2.2 0.6 -2.3 -1.5 -1.2 -1.0 -0.8 -1.4 -2.3
Medication: Lansoprazole 0.9 1.1 2.7 1.2 0.6 0.3 0.3 -1.6 0.4 -1.6 0.3 1.4 0.4 0.1 -1.6 -1.4
Prospective memory result 0.5 0.6 1.4 0.7 0.8 0.4 0.4 -1.1 0.2 -1.1 -0.9 -0.4 -0.7 -0.9 -0.9 -1.2
Lung cancer (father) 1.2 1.4 4.4 -1.2 -0.8 0.2 0.2 1.7 -0.9 1.5 2.1 0.8 0.9 0.9 1.3 1.4
Illnesses of mother 0.9 1.1 3.7 -1.1 -1.3 1.5 1.6 0.5 -1.9 0.5 0.2 -0.8 -0.6 -1.0 -0.0 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.5 0.9 1.0 0.2 0.3 -0.7 0.1 -0.8 0.5 0.7 1.2 0.3 -1.2 -0.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.5 -0.7 -0.5 -1.1 -1.1 1.0 1.0 1.1 -0.2 -0.5 0.4 -0.1 1.2 1.2
Impedance of arm (left) 1.1 5.0 15.3 -3.0 -3.9 3.4 3.4 1.6 -2.5 1.7 0.0 -0.2 -1.1 -0.9 0.3 1.8
Arm fat mass (right) 2.0 8.3 22.7 -0.3 1.9 -4.1 -4.1 1.2 3.5 0.8 2.5 3.0 4.8 3.9 1.9 0.7
Trunk predicted mass 0.5 2.9 7.2 1.4 2.6 -2.7 -2.7 -0.1 2.3 -0.3 1.3 1.3 1.4 2.0 0.4 -0.5
Standing height 0.1 1.1 3.1 -0.7 -0.8 1.7 1.8 0.5 -1.3 0.4 1.6 1.0 0.0 0.9 -0.7 0.3
Length of working week for main job 2.6 2.9 10.3 -0.6 -0.4 -0.5 -0.5 1.2 0.7 0.8 3.2 2.2 3.1 2.7 1.3 0.8
Exposure to tobacco smoke at home 0.6 0.7 1.7 -1.0 -1.0 -0.3 -0.2 0.7 0.1 0.8 -1.0 -1.1 -1.3 -0.4 1.0 1.0
Breastfed as a baby 1.9 2.3 8.7 1.3 1.0 -0.6 -0.6 -1.3 0.6 -0.9 -2.9 -1.3 -2.6 -2.5 -0.4 -0.9
Tense / ‘highly strung’ 4.5 7.5 18.9 2.5 1.3 3.5 3.5 -3.7 -1.6 -3.9 -0.2 0.1 -0.6 -0.9 -4.3 -3.8
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.9 13.0 2.9 2.6 1.5 1.4 -2.9 -0.4 -3.1 0.5 0.7 0.7 0.5 -3.6 -3.3
Hair/balding pattern: Pattern 4 0.2 0.5 2.0 -0.3 -0.3 1.1 1.1 -0.2 -1.4 -0.2 0.2 -0.2 0.9 -0.0 -0.6 -0.7
Birth weight of first child 2.3 4.2 10.7 1.4 -0.1 3.1 3.0 -2.3 -2.7 -2.3 -0.3 -0.1 -0.3 -0.8 -3.3 -2.3
Peak expiratory flow (PEF) 0.9 2.0 4.4 -1.2 -0.4 -0.8 -0.8 1.9 0.3 1.7 1.3 1.7 2.1 1.4 1.8 1.8
Pulse wave reflection index 0.3 0.4 1.7 -0.7 -1.3 0.4 0.4 0.4 -0.2 0.5 -0.2 -0.9 -0.4 -0.5 0.1 0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.4 0.3 0.0 0.5 0.5 -0.0 -1.0 -0.3 1.8 0.9 1.0 1.4 -0.5 -0.3
Loud music exposure frequency 0.7 0.7 1.9 -1.0 -1.0 -0.1 -0.2 1.2 0.8 1.4 -0.5 -0.8 -0.5 -0.4 0.9 1.1
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 5.5 2.3 1.9 0.2 0.2 -1.9 1.6 -1.9 -0.0 0.1 -0.0 0.3 -1.8 -1.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.7 -0.2 -0.6 1.2 1.2 -0.5 0.3 -0.3 -1.3 -1.6 -0.7 -1.4 -0.4 -0.1
Blood clot in the leg (DVT) 0.2 0.3 0.7 -0.2 -0.9 -0.9 -0.8 0.3 0.3 0.1 0.5 -0.1 0.1 0.6 0.0 0.5
Medication: Paracetamol 0.3 0.6 2.0 -1.4 -1.1 0.4 0.4 0.9 -0.8 0.9 0.4 -0.2 0.5 0.1 0.7 0.7
Headache pain in last month 0.8 1.4 5.3 -1.7 -1.8 1.3 1.4 0.8 -2.3 0.8 0.6 -0.2 1.1 0.3 0.3 0.6
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 5.7 -2.2 -1.9 -0.1 -0.0 2.3 -0.7 2.2 0.5 -0.4 0.5 -0.2 1.9 2.4
Glaucoma (self-reported) 0.3 0.3 0.7 0.9 0.5 -0.4 -0.5 -0.7 -0.2 -0.8 0.1 0.0 0.5 0.4 -0.4 -0.8
Gout (self-reported) 0.4 0.6 1.2 1.1 0.8 -0.2 -0.2 -0.9 0.2 -1.1 0.6 0.7 1.0 0.7 -0.5 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.6 0.8 0.4 0.3 0.3 -0.5 0.0 -0.6 1.2 1.5 1.1 1.6 -0.9 -0.8
Medication: Amlodipine 2.0 2.9 8.7 1.9 2.2 -0.7 -0.8 -1.4 1.1 -1.6 1.6 2.9 1.1 2.3 -1.2 -1.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.4 -0.8 -1.2 0.7 0.7 0.8 -0.4 0.8 -0.3 -0.8 -0.8 -0.4 0.2 0.9
Birth weight 0.4 1.0 3.0 -0.0 -0.3 1.2 1.2 -0.0 0.3 -0.2 1.7 0.7 1.4 1.5 -1.2 -0.3
Chronic bronchitis/emphysema (mother) 0.6 0.8 1.6 -0.7 0.1 -1.3 -1.3 0.6 0.9 0.8 -0.9 -1.3 -0.6 -0.8 0.7 0.8
High blood pressure (siblings) 1.6 2.4 6.9 2.6 2.6 -0.4 -0.4 -2.1 0.9 -2.1 0.0 -0.5 -0.4 -0.2 -1.4 -2.1
Forced vital capacity (FVC), Best measure 0.1 0.3 1.3 0.0 0.2 0.2 0.2 0.4 0.1 0.2 1.1 0.6 1.1 0.8 -0.4 0.2
Body fat percentage 1.8 7.1 21.6 -1.2 1.0 -3.6 -3.6 1.5 3.2 1.3 1.9 2.7 4.7 3.2 2.2 1.2
Leg fat percentage (right) 1.4 5.1 17.0 0.2 2.2 -4.1 -4.1 0.2 3.1 0.2 -0.2 1.3 3.4 1.3 1.8 0.3
Arm fat-free mass (right) 0.7 3.7 8.0 1.0 2.6 -2.8 -2.8 0.0 2.2 -0.2 1.9 1.9 2.3 2.6 0.4 -0.3
Exposure to tobacco smoke outside home 4.5 6.0 10.5 -2.3 -1.2 -1.9 -1.8 3.2 0.8 3.0 2.7 1.4 2.8 3.0 3.2 2.8
Comparative body size at age 10 1.2 3.4 10.8 0.2 1.1 -3.2 -3.2 0.9 3.3 0.9 1.0 0.9 1.6 1.8 1.5 0.8
Number of full brothers 1.2 1.6 3.6 -1.9 -1.5 0.8 0.8 1.6 -1.6 1.5 0.9 0.0 0.7 0.5 1.2 1.6
Worry too long after embarrassment 2.5 4.2 11.8 1.7 0.8 3.4 3.4 -2.1 -1.8 -2.3 0.8 0.2 0.0 -0.2 -3.1 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 4.5 5.8 15.4 3.1 2.0 2.1 2.1 -3.2 -1.2 -3.4 0.6 1.1 -0.0 0.6 -3.9 -3.5
Wheeze or whistling in the chest in last year 2.1 3.7 17.6 1.3 2.3 -3.0 -3.0 -0.5 4.2 -0.4 -1.0 -1.6 -0.9 -0.4 0.5 -0.3
Number of children fathered 0.9 1.0 3.7 1.2 1.9 -1.0 -1.1 -0.7 1.6 -0.7 -0.2 1.0 -0.2 -0.3 -0.3 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.1 1.3 0.9 -1.3 -1.4 -1.2 0.2 -1.2 -1.4 -1.6 -0.8 -1.8 -0.4 -0.7
Age at first live birth 1.6 2.9 7.2 1.2 0.7 0.7 0.7 -1.8 0.2 -1.6 -2.3 -2.3 -2.7 -2.6 -1.4 -1.4
Pulse wave peak to peak time 0.7 0.9 1.7 0.9 0.8 1.1 1.0 -1.1 -0.9 -1.2 0.1 0.7 -0.5 0.2 -1.2 -1.3
Health satisfaction 2.4 3.2 12.7 -0.7 0.1 -0.4 -0.4 1.1 0.7 0.7 3.3 2.7 2.5 3.6 0.8 0.8
Shortness of breath walking on level ground 0.6 0.7 2.6 -0.6 0.9 -0.8 -0.8 0.8 1.6 0.8 0.5 0.8 -0.1 0.7 1.1 0.8
Qualifications: College or University degree 1.1 3.5 8.7 2.8 3.0 0.1 0.1 -2.5 1.6 -2.4 -1.4 -0.4 -1.0 -1.1 -2.1 -2.3
Eye problems/disorders: None of the above 2.2 2.6 9.1 -0.5 -1.7 2.9 3.0 -0.5 -1.6 -0.5 -0.7 -1.7 -1.8 -1.4 -0.8 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.4 0.4 0.6 -0.3 -0.2 -0.8 0.1 -1.0 0.3 -0.2 0.8 0.7 -0.6 -1.2
Emphysema/chronic bronchitis 1.3 1.5 4.7 1.1 1.0 0.3 0.2 -1.0 -0.7 -1.2 1.8 1.0 1.1 2.2 -1.6 -1.5
Medication for pain relief, constipation, heartburn 0.1 0.2 1.1 0.3 -0.0 -0.4 -0.3 0.1 0.8 0.2 -0.6 -1.0 -0.7 -0.3 0.2 0.2
Neck or shoulder pain in last month 0.2 0.3 1.0 -0.8 -0.3 0.4 0.4 0.7 0.8 0.5 1.0 0.5 -0.1 0.3 -0.1 0.6
Medication: Blood pressure 2.6 4.5 12.2 2.9 2.2 0.9 0.8 -3.3 0.6 -3.3 0.2 0.6 -0.2 0.3 -3.0 -3.5
Angina (self-reported) 0.2 0.2 1.0 -0.2 0.5 -0.6 -0.6 0.3 0.5 0.4 -0.1 -0.1 -0.1 -0.0 1.0 0.5
Migraine (self-reported) 0.3 0.4 1.1 0.0 -0.2 0.7 0.6 -0.4 -0.9 -0.4 -0.5 -0.6 -1.1 -1.0 -0.4 -0.2
Medication: Ibuprofen 1.0 1.2 3.4 -1.9 -1.1 0.1 0.1 1.7 -0.1 1.6 1.0 0.7 0.2 0.4 1.2 1.7
Medication: Allopurinol 0.6 0.8 2.0 1.4 1.3 -0.2 -0.2 -1.1 1.0 -1.2 0.2 0.5 0.6 0.4 -0.7 -1.4
Medication: Omeprazole 0.7 0.9 2.0 0.5 -0.0 0.6 0.6 -1.3 0.1 -1.2 -1.3 -0.7 -0.1 -1.3 -1.4 -1.1
Medication: Seretide 50 evohaler 0.1 0.1 0.4 0.2 -0.1 -0.1 -0.0 -0.2 0.2 -0.2 -0.1 0.5 0.7 0.7 0.3 -0.3
Mean time to correctly identify matches 1.9 3.5 13.7 -2.6 -3.7 1.4 1.4 2.0 -1.6 2.2 0.1 -1.2 0.0 0.1 1.7 2.4
Heart disease (mother) 0.5 0.7 1.8 -0.2 -0.1 -1.1 -1.1 0.2 1.4 0.3 0.0 0.2 1.2 0.9 1.2 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.7 -0.7 -0.5 -0.5 -0.5 0.9 0.9 0.9 1.3 1.0 1.0 1.1 1.1 0.6
Whole body fat mass 2.0 8.2 22.2 -0.7 1.6 -4.0 -4.0 1.4 3.5 1.1 2.3 3.1 4.7 3.7 2.2 1.0
Leg fat mass (right) 1.8 6.8 20.0 0.1 2.3 -4.0 -4.0 0.6 3.3 0.3 1.5 2.4 4.5 2.9 1.6 0.4
Arm predicted mass (right) 0.8 3.9 8.6 1.2 2.8 -2.9 -2.9 -0.1 2.3 -0.3 1.8 1.9 2.2 2.5 0.5 -0.4
Pulse rate, automated reading 1.7 5.6 19.8 -1.1 1.0 -4.4 -4.4 1.7 2.9 1.8 -0.3 -0.6 1.6 0.3 3.3 1.5
Alcohol intake frequency. 0.4 0.9 2.6 -1.6 -1.1 -0.1 -0.1 1.4 0.5 1.4 0.5 -0.5 0.9 0.6 0.9 1.1
Comparative height size at age 10 0.0 0.3 0.6 0.4 0.3 0.8 0.8 -0.6 -0.6 -0.4 -0.5 0.3 -0.1 -0.5 -0.4 -0.4
Number of full sisters 3.3 4.0 10.4 -3.0 -3.2 0.8 0.8 2.3 -2.1 2.2 1.4 -0.5 1.8 1.6 1.9 2.3
Suffer from ‘nerves’ 2.8 4.5 12.0 1.8 0.9 2.6 2.6 -2.2 -2.1 -2.6 1.8 0.8 1.0 0.9 -3.5 -2.6
Overall health rating 1.0 2.0 6.8 0.7 0.9 0.7 0.7 -0.8 0.2 -1.2 2.1 1.9 1.8 2.6 -1.3 -1.4
Chest pain or discomfort 0.6 0.8 4.9 0.5 0.7 -0.0 -0.0 -0.2 2.2 -0.4 0.8 -1.8 0.5 0.3 -0.2 -0.3
Had major operations 0.1 0.1 0.4 -0.0 -0.5 0.3 0.4 -0.2 -0.1 -0.2 -0.2 -0.3 -0.6 0.5 0.1 0.1
Age at last live birth 1.0 1.4 3.1 0.7 0.5 0.6 0.5 -1.3 0.4 -1.2 -1.6 -1.2 -1.8 -1.7 -1.4 -1.3
Family relationship satisfaction 1.8 2.3 5.3 -1.9 -1.3 0.4 0.5 2.0 -0.7 1.9 2.3 0.9 1.6 2.0 0.8 1.6
Leg pain on walking 2.3 2.8 5.1 -1.5 -0.5 -0.9 -1.0 1.7 2.1 1.6 2.3 2.1 1.4 2.2 1.8 1.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.8 -0.6 -1.3 1.0 0.9 0.6 -0.6 0.6 0.3 0.2 -1.3 -0.4 -0.1 0.0
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 -0.7 -0.6 -0.2 -0.2 0.6 0.3 0.6 0.6 0.7 0.9 0.0 0.5 0.2
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 3.5 -0.6 -1.2 0.7 0.7 0.0 -1.9 0.3 -1.3 -0.9 -1.6 -0.9 0.3 0.4
Medication: Aspirin 1.4 1.8 4.9 1.8 2.2 -0.2 -0.3 -1.8 -0.1 -1.9 0.1 1.3 0.1 0.5 -1.5 -2.0
Supplements: Vitamin C 1.2 1.5 3.3 -1.8 -1.4 0.4 0.5 1.7 -1.0 1.5 1.1 0.2 0.9 0.5 1.2 1.8
Knee pain experienced in last month 2.3 3.6 10.3 -2.5 -3.2 2.6 2.6 1.8 -1.0 1.7 1.4 -1.7 0.4 0.2 1.3 1.8
Hypertension (Self-reported) 2.7 7.6 16.2 4.0 3.9 -0.7 -0.9 -3.7 1.5 -3.9 0.2 2.4 0.2 1.3 -3.2 -4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.1 -0.4 -0.7 1.0 1.0 -0.4 -0.9 -0.4 -0.5 -0.2 -0.9 -1.0 -0.4 -0.3
Illnesses of father: Heart disease 0.5 0.6 2.0 0.7 1.0 -0.9 -1.0 -0.4 1.4 -0.5 0.5 0.8 0.8 0.8 -0.5 -0.5
Illnesses of siblings: Diabetes 0.7 0.9 3.0 -0.1 -0.5 0.8 0.8 -0.2 -1.4 -0.4 1.1 1.7 1.1 1.4 -0.5 0.0
Smoking status: Previous 0.4 0.6 2.0 -1.4 -1.1 0.3 0.3 0.9 -0.1 0.9 -0.2 0.0 0.8 0.4 0.8 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.2 -0.5 0.2 -0.7 -0.7 1.1 0.5 1.0 1.0 -0.1 0.9 0.6 0.4 0.7
Whole body fat-free mass 0.8 4.7 10.0 1.0 2.6 -3.0 -3.0 0.3 2.8 0.0 2.3 2.3 2.5 3.2 0.7 -0.2
Leg fat-free mass (right) 1.4 7.4 21.3 0.2 2.0 -3.0 -3.0 1.3 3.1 0.8 3.8 3.4 3.7 4.6 1.2 0.6
Arm fat percentage (left) 2.1 8.3 23.2 -0.9 1.4 -3.8 -3.8 1.5 3.5 1.2 2.4 3.2 4.8 3.8 2.1 1.0
Average weekly red wine intake 0.7 1.0 5.5 -0.1 -0.2 0.2 0.3 -0.1 -0.7 0.1 -1.4 -2.3 -1.4 -1.9 -0.0 0.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.4 1.2 0.5 0.4 0.4 -0.9 -1.2 -0.8 0.2 -0.7 -0.1 -0.0 -0.6 -0.8
Mood swings 1.2 2.2 4.7 -0.2 -1.1 2.2 2.2 -0.2 -1.8 -0.5 2.1 1.0 1.8 1.7 -1.5 -0.4
Loneliness, isolation 2.2 3.1 8.5 2.1 1.8 1.6 1.5 -2.3 -0.6 -2.6 0.8 0.7 -0.4 0.7 -2.9 -2.3
Long-standing illness, disability or infirmity 0.6 1.0 3.2 0.2 1.0 -1.2 -1.1 0.2 1.2 -0.0 1.1 1.6 0.7 1.8 -0.0 -0.3
Ever had bowel cancer screening 0.2 0.2 0.6 0.5 0.3 0.4 0.4 -0.7 -0.4 -0.8 0.2 0.0 0.4 0.1 -0.3 -0.6
Diabetes diagnosed by doctor 0.9 1.5 3.3 1.2 1.3 0.4 0.4 -0.9 -0.5 -1.3 1.8 1.0 1.4 1.6 -1.5 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.0 -0.2 0.3 -1.0 -1.0 0.4 0.6 0.6 -0.5 0.4 -0.7 0.0 0.5 0.7
Friendships satisfaction 2.1 2.6 6.7 -2.2 -0.8 -0.2 -0.2 2.6 -0.4 2.4 1.6 0.6 1.5 1.6 1.5 2.5
Qualifications: nursing, teaching 1.0 1.5 3.5 1.9 1.6 -0.5 -0.4 -1.7 0.6 -1.7 -0.9 -0.8 -0.8 -1.4 -1.2 -1.2
Commuting to job workplace: Walk 0.3 0.3 0.9 -0.9 -0.6 -0.2 -0.3 0.7 -0.7 0.7 -0.2 0.5 -0.3 0.4 0.4 0.7
Eye problems/disorders: Cataract 1.8 2.1 8.7 -0.4 0.7 -2.9 -3.0 1.3 1.2 1.4 0.4 0.5 1.2 0.6 1.2 1.0
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.0 2.2 2.0 0.7 0.6 -2.1 0.3 -2.1 -0.8 -0.9 -1.3 -1.1 -1.6 -1.9
Medication for cholesterol 0.8 1.3 2.8 -1.6 -1.6 0.5 0.6 1.5 0.3 1.6 0.3 -0.7 0.4 -0.2 1.3 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 0.7 0.7 0.3 0.3 -0.9 0.8 -1.0 0.5 1.5 1.3 1.0 -0.9 -1.0
Back pain experienced in last month 1.2 1.7 4.3 -0.9 0.0 -1.6 -1.6 1.6 1.7 1.5 0.8 0.8 0.7 0.9 2.1 1.4
Mineral and other dietary supplements 1.7 2.3 5.1 2.2 2.0 -0.0 -0.0 -2.0 -0.2 -2.2 0.5 1.5 -0.1 0.6 -2.1 -2.2
Breast cancer (self-reported) 0.2 0.2 0.6 0.3 -0.0 0.8 0.8 -0.5 0.1 -0.5 0.0 -0.1 -0.3 -0.0 -0.5 -0.5
Asthma (self-reported) 0.5 1.1 2.6 -1.6 -1.2 0.1 0.1 1.5 1.1 1.6 0.4 -0.7 0.1 0.1 1.1 1.5
Osteoporosis (self-reported) 0.8 0.9 4.2 -1.1 -1.0 1.5 1.4 0.4 -2.1 0.4 -0.7 -0.3 -0.1 -0.5 -0.1 0.6
Osteoarthritis (self-reported) 2.4 3.2 6.1 2.3 2.5 -1.1 -1.1 -2.3 1.8 -2.2 -2.1 -1.2 -0.7 -1.7 -0.8 -2.0
Medication: Aspirin 1.3 1.7 4.5 1.8 2.1 0.0 -0.0 -1.9 -0.3 -1.9 -0.3 0.9 -0.4 0.0 -1.6 -1.9
Medication: Gliclazide 1.1 1.2 4.4 0.7 0.6 -0.2 -0.2 0.0 0.6 -0.3 2.1 1.8 1.1 2.1 -0.8 -0.3
Illnesses of father: None of the above (group 1) 2.8 3.4 11.4 -2.4 -3.4 1.8 1.8 1.7 -2.5 1.9 -0.7 -1.6 -0.2 -0.8 1.2 1.8
Smoking status: Current 1.5 2.4 6.2 1.8 2.5 -2.3 -2.3 -0.8 2.2 -0.9 0.5 1.4 -0.0 1.1 -0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.0 1.3 1.2 -0.4 -0.4 -1.4 0.1 -1.4 -1.2 -0.9 -0.9 -1.1 -1.1 -1.3
Whole body water mass 0.9 4.9 10.6 1.0 2.7 -3.1 -3.1 0.3 2.8 0.0 2.4 2.3 2.6 3.2 0.7 -0.2
Leg predicted mass (right) 1.4 7.5 20.9 0.2 2.0 -3.1 -3.1 1.2 3.2 0.8 3.7 3.3 3.7 4.6 1.2 0.6
Arm fat mass (left) 2.1 8.7 23.6 -0.5 1.8 -4.1 -4.1 1.4 3.5 1.1 2.7 3.0 4.9 4.0 2.0 0.9
Number of self-reported non-cancer illnesses 1.9 3.3 8.2 2.5 2.3 0.5 0.4 -2.6 0.4 -2.9 0.3 1.1 -0.4 0.3 -2.4 -2.9
Average weekly champagne plus white wine intake 0.4 0.5 1.2 -0.7 -0.2 -0.9 -0.8 0.9 -0.1 0.8 0.4 0.6 1.1 0.5 0.2 0.9
Miserableness 1.4 2.4 6.3 -1.3 -2.1 2.5 2.5 1.1 -1.9 0.9 2.2 -0.2 0.2 1.1 0.0 0.9
Guilty feelings 1.2 1.8 5.4 1.7 0.8 0.9 0.8 -1.7 0.5 -2.0 1.0 0.2 0.7 0.8 -2.3 -1.9
Wears glasses or contact lenses 1.2 1.4 6.6 1.3 1.2 -0.2 -0.2 -1.1 -1.1 -1.0 0.6 2.6 0.6 1.3 -1.0 -1.0
Ever taken oral contraceptive pill 0.4 0.4 1.3 0.3 0.7 -0.4 -0.5 -0.4 1.1 -0.3 -0.7 -1.1 0.1 -0.9 -0.0 -0.6
Hearing aid user 1.0 1.2 2.1 -1.0 -0.9 -1.4 -1.5 1.1 -0.2 1.3 -0.3 1.0 1.2 0.5 1.4 1.1
Mother’s age at death 0.3 0.4 1.9 0.8 1.4 -0.4 -0.3 -0.5 0.5 -0.6 0.2 0.8 0.4 0.0 -0.3 -0.5
Financial situation satisfaction 1.4 1.8 4.8 -0.8 0.5 -2.2 -2.1 1.5 1.8 1.3 0.6 0.5 0.5 0.9 1.5 1.4
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.3 -1.2 -0.4 -1.2 -1.3 1.7 0.6 1.8 -0.0 -0.8 -0.1 -0.5 1.8 1.8
Commuting to job workplace: Public transport 1.6 1.9 6.2 1.0 -0.5 2.5 2.5 -1.3 -0.8 -1.4 -0.0 -1.0 -1.1 -0.0 -1.9 -0.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.6 0.1 -0.4 -0.4 -0.6 -0.7 -0.5 -0.1 0.0 0.3 0.2 -0.1 -0.6
Medication: Blood pressure 2.8 5.3 14.7 3.5 3.8 -1.6 -1.7 -2.8 1.4 -2.9 -0.1 1.8 -0.4 0.5 -2.3 -3.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 3.6 0.2 0.5 -0.8 -0.7 -0.1 1.9 -0.1 -0.6 -0.6 -1.0 0.1 0.5 -0.2
Supplements: Fish oil (including cod liver oil) 1.8 2.3 5.4 -1.9 -1.6 -0.5 -0.4 1.8 0.9 2.2 -1.3 -1.4 -0.6 -1.0 2.3 2.2
High cholesterol (Self-reported) 0.5 0.9 2.9 1.3 1.7 -0.8 -0.9 -1.1 1.3 -1.1 -0.3 0.5 -0.2 -0.1 -0.4 -1.2
Medication: Bendroflumethiazide 1.2 1.8 4.4 2.0 1.8 -0.4 -0.5 -1.9 0.7 -1.9 -0.0 1.1 -0.2 0.2 -1.5 -2.1
Medication: Paracetamol 1.2 1.8 5.3 -2.3 -2.0 0.8 0.9 1.7 -0.2 1.6 1.2 -0.4 1.1 0.5 1.3 1.6
Medication: Lisinopril 1.5 1.9 5.1 1.9 0.9 1.0 0.9 -2.2 -0.5 -2.2 -0.3 0.4 0.3 0.2 -2.3 -2.0
Medication: Atorvastatin 0.1 0.1 0.2 -0.3 0.1 -0.3 -0.3 0.3 0.4 0.2 -0.1 -0.4 -0.1 0.2 0.4 0.2
Illnesses of father: High blood pressure 3.4 4.2 11.5 2.7 2.5 0.4 0.3 -2.8 1.1 -3.1 1.1 1.4 0.6 1.0 -2.5 -3.4
Alcohol drinker status: Never 0.5 0.5 1.5 -1.2 -0.7 0.1 0.1 1.1 0.3 1.1 -0.1 -0.7 -0.1 -0.2 1.0 1.0
Ever smoked 0.1 0.2 1.0 0.2 0.5 -0.5 -0.5 -0.3 1.0 -0.2 -0.8 0.1 0.0 -0.3 -0.3 -0.1
Basal metabolic rate 1.0 5.5 11.6 0.7 2.5 -3.3 -3.3 0.6 3.0 0.3 2.5 2.4 3.1 3.4 1.0 0.1
Leg fat percentage (left) 1.5 5.3 17.9 -0.2 1.8 -4.2 -4.2 0.6 3.2 0.6 -0.2 1.1 3.3 1.2 2.2 0.7
Arm fat-free mass (left) 0.9 4.5 12.0 1.2 2.8 -3.5 -3.5 0.0 2.5 -0.2 1.7 1.6 2.5 2.6 0.7 -0.4
Number of operations (self-reported) 0.7 1.0 4.2 0.5 0.6 -2.1 -2.0 -0.3 0.6 -0.1 -1.0 -0.5 -1.0 -0.4 1.1 0.0
Average weekly beer plus cider intake 0.5 0.7 1.9 0.4 0.4 0.1 0.1 -0.5 1.1 -0.8 1.4 1.3 1.0 1.2 -0.2 -0.7
Irritability 0.5 0.8 3.8 -0.4 -0.7 1.9 1.9 -0.2 -0.8 -0.2 0.7 0.9 -0.0 0.6 -0.5 0.2
Risk taking 0.2 0.3 0.9 -0.6 -0.3 -0.3 -0.3 0.5 0.9 0.6 -0.8 -0.8 -0.4 -0.7 0.0 0.6
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.1 1.1 1.0 -0.1 -0.1 -0.7 0.8 -0.8 -0.1 0.1 -0.1 -0.2 -0.4 -0.8
Fractured/broken bones in last 5 years 0.6 0.7 1.7 1.1 1.3 -1.1 -1.2 -0.8 0.7 -0.9 0.2 -0.3 -0.2 0.6 0.0 -1.2
Age started oral contraceptive pill 0.6 0.8 2.6 0.9 1.4 -1.5 -1.6 -0.6 1.1 -0.5 -0.7 0.4 0.2 -0.1 0.4 -0.4
Diastolic blood pressure, automated reading 0.5 1.6 4.1 1.5 1.4 0.2 0.2 -1.6 0.5 -1.5 -0.9 0.7 -2.0 -0.7 -1.6 -1.8
Ever depressed for a whole week 0.2 0.3 1.8 0.1 0.4 -0.1 -0.1 0.1 -1.3 -0.1 0.6 -0.5 0.9 0.0 -0.0 -0.0
Unable to work because of sickness or disability 0.2 0.2 0.9 -0.3 -1.0 0.6 0.7 -0.1 0.3 -0.2 0.2 -0.7 -0.8 0.1 -0.4 -0.1
Commuting to job workplace: Cycle 0.3 0.4 0.7 -0.7 -0.2 -0.7 -0.7 0.8 0.3 0.6 0.4 -0.7 -0.3 0.5 0.9 0.7
Myopia 1.6 2.4 6.6 -0.2 -1.1 2.6 2.5 -0.3 -1.7 -0.8 2.4 -0.2 1.8 1.2 -1.5 -0.6
Vascular/heart problems diagnosed by doctor 2.6 7.2 17.5 -3.9 -4.2 1.1 1.3 3.5 -1.6 3.7 -0.1 -2.5 -0.0 -1.2 2.8 3.8
Cholesterol lowering medication 0.4 0.5 2.2 -0.3 0.6 -1.4 -1.5 0.2 0.7 0.1 0.3 0.6 0.7 0.6 0.7 -0.0
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 5.0 0.7 0.3 0.7 0.7 -1.6 0.1 -1.4 -2.2 -1.0 -1.1 -2.1 -1.7 -1.4
Pain experienced in last month 0.9 1.5 3.9 1.5 1.2 -0.5 -0.6 -1.3 0.1 -1.0 -2.0 -0.8 -2.0 -1.3 -1.4 -0.9
Supplements: Calcium 0.3 0.4 1.1 -0.5 -0.2 -0.6 -0.6 0.4 0.5 0.4 -0.4 -1.0 -1.1 -0.6 0.6 0.6
Basal cell carcinoma (self-reported) 0.6 0.7 2.2 -0.8 -1.5 0.5 0.4 0.7 -0.8 0.7 0.8 -0.5 1.3 0.9 0.4 0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.1 1.1 1.4 -0.8 -0.7 -1.1 -0.1 -1.1 -0.3 0.1 -0.4 0.3 -0.8 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.4 -0.5 -1.2 -0.7 -0.6 0.5 0.3 0.3 0.6 -0.3 0.1 0.7 0.2 0.7
Heart disease (siblings) 1.1 1.3 3.6 -1.0 -0.7 -0.2 -0.1 1.2 -0.1 1.1 1.4 1.8 1.6 1.9 0.7 1.1
Alcohol drinker status: Previous 0.1 0.1 0.5 0.2 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.3 -0.7 0.3 0.0 -0.5 -0.4
Pack years of smoking 0.5 0.8 2.2 -0.1 0.8 -1.2 -1.2 0.3 0.7 0.2 0.4 1.5 1.0 1.4 0.8 0.3
Impedance of whole body 1.3 6.6 16.8 -2.4 -3.7 4.1 4.1 0.5 -3.3 0.8 -1.8 -1.8 -2.3 -2.9 -0.6 1.0
Leg fat mass (left) 1.8 6.9 19.7 -0.1 2.1 -4.0 -4.0 0.8 3.4 0.6 1.5 2.5 4.4 2.9 1.8 0.6
Arm predicted mass (left) 0.9 4.6 11.6 1.1 2.8 -3.4 -3.4 0.1 2.6 -0.1 1.7 1.7 2.6 2.7 0.8 -0.2