TWAS hub - ADK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0290	0.0130	1.8e-03	0.031	0.029	0.031	0.028	0.036	9.0e-05	1.7e-04	9.3e-05	2.2e-04	2.6e-05
2	GTEx	Colon Transverse	0.2490	0.0710	2.9e-07	0.137	NA	0.103	NA	0.125	4.5e-07	NA	1.3e-05	NA	1.6e-06
3	GTEx	Heart Atrial Appendage	0.1220	0.0520	3.0e-03	0.119	NA	0.100	NA	0.101	5.6e-06	NA	3.2e-05	NA	2.8e-05
4	GTEx	Heart Left Ventricle	0.2101	0.0702	5.8e-05	0.112	NA	0.118	NA	0.118	1.5e-06	NA	7.9e-07	NA	8.1e-07
5	GTEx	Lung	0.1506	0.0440	5.6e-10	0.166	NA	0.139	NA	0.170	1.1e-12	NA	8.5e-11	NA	4.8e-13
6	GTEx	Prostate	0.3780	0.1250	1.8e-03	-0.008	NA	-0.008	NA	0.009	5.7e-01	NA	5.9e-01	NA	1.8e-01
7	GTEx	Thyroid	0.1030	0.0470	1.8e-03	0.053	NA	0.017	NA	0.047	6.9e-05	NA	1.7e-02	NA	1.6e-04
8	GTEx	Whole Blood	0.2420	0.0510	3.3e-11	0.167	NA	0.228	NA	0.177	3.1e-15	NA	8.4e-21	NA	4.3e-16
9	METSIM	Adipose	0.0427	0.0184	7.3e-04	0.018	0.013	0.019	0.013	0.022	9.2e-04	3.6e-03	7.1e-04	4.0e-03	2.2e-04
10	NTR	Blood	0.0807	0.0204	6.7e-14	0.044	0.049	0.042	0.047	0.044	3.8e-14	2.0e-15	2.1e-13	5.8e-15	6.4e-14
11	YFS	Blood	0.4164	0.0443	0.0e+00	0.383	0.436	0.445	0.442	0.428	1.2e-134	2.1e-159	1.4e-163	3.7e-162	3.9e-155
12	TCGA	Lung Adenocarcinoma	0.0496	0.0228	7.0e-08	0.056	0.071	0.073	NA	0.067	4.1e-07	1.1e-08	7.3e-09	NA	2.6e-08
13	TCGA	Thyroid Carcinoma	0.1000	0.0390	1.7e-13	0.157	0.143	0.142	NA	0.147	4.8e-15	8.9e-14	1.0e-13	NA	3.7e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Hearing difficulty/problems: Yes	5.4	8.2	20.5	-4.5	-4.3	0.3	0.4	3.8	-0.2	4.0	0.4	-2.1	1.9	0.1	3.4	4.1
Worry (Nagel 2018)	4.8	10.1	23.6	2.8	1.1	4.4	4.5	-4.0	-1.6	-4.0	-0.8	-0.6	-1.4	-2.0	-4.9	-4.1
Tense / ‘highly strung’	4.5	7.5	18.9	2.5	1.3	3.5	3.5	-3.7	-1.6	-3.9	-0.2	0.1	-0.6	-0.9	-4.3	-3.8
Exposure to tobacco smoke outside home	4.5	6.0	10.5	-2.3	-1.2	-1.9	-1.8	3.2	0.8	3.0	2.7	1.4	2.8	3.0	3.2	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	4.5	5.8	15.4	3.1	2.0	2.1	2.1	-3.2	-1.2	-3.4	0.6	1.1	-0.0	0.6	-3.9	-3.5
Worrier / anxious feelings	4.0	7.6	15.8	3.0	1.4	3.3	3.3	-3.8	-1.8	-3.7	-1.0	-0.7	-1.3	-1.7	-4.0	-3.6
Hearing difficulty/problems with background noise	3.9	6.3	21.8	-3.2	-4.7	2.9	3.0	2.3	-2.9	2.4	0.5	-2.3	0.1	-0.6	0.7	2.4
Systolic Blood Pressure	3.7	18.5	47.6	6.2	6.9	-0.9	-1.1	-5.2	1.5	-5.5	1.1	5.0	-1.2	2.0	-5.3	-5.8
Systolic blood pressure, automated reading	3.7	10.7	31.4	4.6	5.6	-1.9	-2.1	-3.5	1.8	-3.7	0.9	4.3	-0.3	2.1	-3.0	-4.0
Stomach or abdominal pain in last month	3.7	4.6	9.5	2.9	2.9	0.7	0.6	-2.8	0.7	-3.1	0.8	2.0	0.3	0.7	-3.0	-3.1
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	12.0	2.3	1.1	2.8	2.7	-2.5	-1.1	-3.0	2.5	1.0	1.3	2.0	-3.5	-3.0
Schizophrenia vs Biploar Disorder	3.5	4.6	10.5	-3.0	-3.1	0.3	0.5	2.8	-2.0	2.9	0.1	-2.0	0.3	-0.3	2.5	3.2
Lung FEV1/FVC ratio	3.5	17.5	41.0	5.3	3.3	2.5	2.4	-6.4	-2.0	-6.4	-2.5	0.2	-0.6	-2.4	-6.3	-6.3
Illnesses of father: High blood pressure	3.4	4.2	11.5	2.7	2.5	0.4	0.3	-2.8	1.1	-3.1	1.1	1.4	0.6	1.0	-2.5	-3.4
Number of full sisters	3.3	4.0	10.4	-3.0	-3.2	0.8	0.8	2.3	-2.1	2.2	1.4	-0.5	1.8	1.6	1.9	2.3
Cardiovascular Disease	3.2	10.5	26.9	5.0	5.2	-1.3	-1.6	-4.4	2.6	-4.5	-0.9	1.3	-1.4	0.1	-3.1	-4.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	13.0	2.9	2.6	1.5	1.4	-2.9	-0.4	-3.1	0.5	0.7	0.7	0.5	-3.6	-3.3
High blood pressure (mother)	3.1	4.3	10.1	3.2	2.6	0.2	0.1	-2.8	0.2	-2.9	-0.1	1.9	-0.7	0.6	-3.2	-2.9
Nervous feelings	3.1	5.9	14.1	2.2	0.9	2.9	2.9	-3.0	-1.7	-3.1	-1.4	-0.5	-1.7	-2.0	-3.8	-3.0
Bipolar Disorder (2018)	2.9	4.7	12.8	2.5	2.0	1.6	1.7	-2.8	-0.0	-2.9	1.2	1.9	0.7	0.7	-3.6	-3.2
High blood pressure	2.8	7.8	18.5	4.0	3.8	-0.5	-0.6	-3.9	1.2	-4.0	0.2	2.3	0.0	1.2	-3.4	-4.3
Suffer from ‘nerves’	2.8	4.5	12.0	1.8	0.9	2.6	2.6	-2.2	-2.1	-2.6	1.8	0.8	1.0	0.9	-3.5	-2.6
Illnesses of father: None of the above (group 1)	2.8	3.4	11.4	-2.4	-3.4	1.8	1.8	1.7	-2.5	1.9	-0.7	-1.6	-0.2	-0.8	1.2	1.8
Medication: Blood pressure	2.8	5.3	14.7	3.5	3.8	-1.6	-1.7	-2.8	1.4	-2.9	-0.1	1.8	-0.4	0.5	-2.3	-3.0
Hypertension (Self-reported)	2.7	7.6	16.2	4.0	3.9	-0.7	-0.9	-3.7	1.5	-3.9	0.2	2.4	0.2	1.3	-3.2	-4.0
Neuroticism (Nagel 2018)	2.6	6.0	17.1	1.6	0.3	4.1	4.1	-2.5	-2.5	-2.7	1.2	0.6	0.3	0.2	-3.5	-2.6
Length of working week for main job	2.6	2.9	10.3	-0.6	-0.4	-0.5	-0.5	1.2	0.7	0.8	3.2	2.2	3.1	2.7	1.3	0.8
Medication: Blood pressure	2.6	4.5	12.2	2.9	2.2	0.9	0.8	-3.3	0.6	-3.3	0.2	0.6	-0.2	0.3	-3.0	-3.5
Vascular/heart problems diagnosed by doctor	2.6	7.2	17.5	-3.9	-4.2	1.1	1.3	3.5	-1.6	3.7	-0.1	-2.5	-0.0	-1.2	2.8	3.8
Worry too long after embarrassment	2.5	4.2	11.8	1.7	0.8	3.4	3.4	-2.1	-1.8	-2.3	0.8	0.2	0.0	-0.2	-3.1	-2.0
Health satisfaction	2.4	3.2	12.7	-0.7	0.1	-0.4	-0.4	1.1	0.7	0.7	3.3	2.7	2.5	3.6	0.8	0.8
Osteoarthritis (self-reported)	2.4	3.2	6.1	2.3	2.5	-1.1	-1.1	-2.3	1.8	-2.2	-2.1	-1.2	-0.7	-1.7	-0.8	-2.0
Bipolar Disorder (2011)	2.3	2.3	4.8	1.7	1.4	0.6	0.6	-1.8	0.2	-1.9	1.0	1.6	1.5	1.0	-2.2	-2.2
Neuroticism score	2.3	4.9	14.5	1.3	-0.0	3.8	3.8	-2.1	-2.4	-2.4	1.3	0.4	0.1	0.3	-3.1	-2.3
Birth weight of first child	2.3	4.2	10.7	1.4	-0.1	3.1	3.0	-2.3	-2.7	-2.3	-0.3	-0.1	-0.3	-0.8	-3.3	-2.3
Leg pain on walking	2.3	2.8	5.1	-1.5	-0.5	-0.9	-1.0	1.7	2.1	1.6	2.3	2.1	1.4	2.2	1.8	1.6
Knee pain experienced in last month	2.3	3.6	10.3	-2.5	-3.2	2.6	2.6	1.8	-1.0	1.7	1.4	-1.7	0.4	0.2	1.3	1.8
BMI	2.2	12.6	31.5	0.9	3.9	-5.6	-5.6	0.9	4.6	0.6	2.5	3.1	5.0	4.2	2.2	0.4
Frequency of depressed mood in last 2 weeks	2.2	3.1	6.3	1.7	1.2	1.2	1.2	-1.6	-0.8	-2.1	2.5	1.3	1.8	2.4	-2.2	-1.8
Body mass index (BMI)	2.2	9.5	24.9	0.4	2.7	-5.0	-5.0	0.8	4.1	0.6	1.9	2.7	4.5	3.6	2.0	0.5
Waist circumference	2.2	8.0	20.4	-0.6	1.5	-4.1	-4.1	1.5	3.4	1.2	2.3	2.7	4.5	3.8	2.0	1.2
Noisy workplace	2.2	2.8	6.3	-1.9	-0.9	-1.8	-1.9	2.3	0.9	2.5	-0.2	0.4	0.4	0.5	2.5	2.3
Eye problems/disorders: None of the above	2.2	2.6	9.1	-0.5	-1.7	2.9	3.0	-0.5	-1.6	-0.5	-0.7	-1.7	-1.8	-1.4	-0.8	-0.2
Loneliness, isolation	2.2	3.1	8.5	2.1	1.8	1.6	1.5	-2.3	-0.6	-2.6	0.8	0.7	-0.4	0.7	-2.9	-2.3
Depression (Nagel 2018)	2.1	3.2	12.5	0.8	0.5	1.1	1.1	-0.8	-0.7	-1.3	3.2	2.2	2.1	3.5	-1.4	-1.3
Relative age of first facial hair	2.1	4.3	10.2	-2.3	-2.7	0.8	0.8	1.7	-0.4	2.1	-2.1	-3.2	-2.9	-2.2	1.6	1.9
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	5.2	1.5	1.3	1.3	1.2	-2.0	-1.5	-2.1	-0.2	1.2	0.5	0.7	-2.3	-2.0
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.3	2.1	2.1	-1.0	-1.1	-1.9	0.6	-2.1	0.4	1.8	1.3	0.9	-1.6	-2.3
Arm fat percentage (right)	2.1	8.3	23.6	-0.8	1.3	-3.8	-3.8	1.5	3.6	1.2	2.4	3.0	4.9	3.8	2.2	0.9
Wheeze or whistling in the chest in last year	2.1	3.7	17.6	1.3	2.3	-3.0	-3.0	-0.5	4.2	-0.4	-1.0	-1.6	-0.9	-0.4	0.5	-0.3
Arm fat percentage (left)	2.1	8.3	23.2	-0.9	1.4	-3.8	-3.8	1.5	3.5	1.2	2.4	3.2	4.8	3.8	2.1	1.0
Friendships satisfaction	2.1	2.6	6.7	-2.2	-0.8	-0.2	-0.2	2.6	-0.4	2.4	1.6	0.6	1.5	1.6	1.5	2.5
Arm fat mass (left)	2.1	8.7	23.6	-0.5	1.8	-4.1	-4.1	1.4	3.5	1.1	2.7	3.0	4.9	4.0	2.0	0.9
Irritable Bowel Disease (IBD)	2.0	4.9	10.0	-2.3	-1.5	-1.1	-1.1	2.3	0.8	2.7	-2.2	-3.2	-1.8	-2.7	2.9	2.7
Reaction Time	2.0	3.9	14.1	-2.8	-3.8	1.6	1.7	2.1	-1.7	2.2	-0.2	-1.5	-0.6	-0.2	1.5	2.5
Hand grip strength (left)	2.0	5.3	10.8	2.6	2.1	-0.1	-0.1	-2.9	-0.9	-2.5	-2.5	-2.0	-3.2	-3.3	-2.2	-2.5
Relative age voice broke	2.0	3.0	7.7	-2.2	-2.8	2.0	2.0	1.8	-1.4	1.8	0.5	-2.0	-1.4	-0.0	1.0	1.7
Impedance of leg (left)	2.0	9.6	26.9	-0.8	-2.4	3.9	3.9	-1.1	-3.4	-0.7	-4.0	-3.6	-4.0	-5.2	-1.5	-0.3
Father’s age at death	2.0	2.7	4.6	1.8	1.2	0.8	0.7	-1.9	-2.0	-1.8	-1.8	-0.7	-2.2	-2.0	-1.6	-1.7
Mouth/teeth dental problems: Dentures	2.0	3.3	15.7	-0.2	0.8	-1.9	-1.9	0.3	0.4	0.1	1.7	2.5	4.0	3.2	0.4	-0.0
Depression (self-reported)	2.0	2.4	5.4	2.1	1.9	-0.3	-0.4	-2.2	0.6	-2.3	-1.5	-1.2	-1.0	-0.8	-1.4	-2.3
Arm fat mass (right)	2.0	8.3	22.7	-0.3	1.9	-4.1	-4.1	1.2	3.5	0.8	2.5	3.0	4.8	3.9	1.9	0.7
Medication: Amlodipine	2.0	2.9	8.7	1.9	2.2	-0.7	-0.8	-1.4	1.1	-1.6	1.6	2.9	1.1	2.3	-1.2	-1.7
Whole body fat mass	2.0	8.2	22.2	-0.7	1.6	-4.0	-4.0	1.4	3.5	1.1	2.3	3.1	4.7	3.7	2.2	1.0
Impedance of leg (right)	1.9	9.2	23.2	-0.5	-2.2	4.1	4.1	-1.4	-3.6	-1.0	-3.7	-3.3	-3.6	-4.8	-1.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	5.2	1.8	1.5	-0.7	-0.7	-1.4	1.6	-1.6	0.8	1.5	2.3	1.5	-1.2	-1.6
Breastfed as a baby	1.9	2.3	8.7	1.3	1.0	-0.6	-0.6	-1.3	0.6	-0.9	-2.9	-1.3	-2.6	-2.5	-0.4	-0.9
Mean time to correctly identify matches	1.9	3.5	13.7	-2.6	-3.7	1.4	1.4	2.0	-1.6	2.2	0.1	-1.2	0.0	0.1	1.7	2.4
Number of self-reported non-cancer illnesses	1.9	3.3	8.2	2.5	2.3	0.5	0.4	-2.6	0.4	-2.9	0.3	1.1	-0.4	0.3	-2.4	-2.9
Ulcerative Colitis	1.8	2.6	7.5	-1.4	-0.3	-2.3	-2.2	1.7	1.0	1.9	-1.3	-0.5	-0.2	-0.6	2.7	1.9
Neuroticism	1.8	4.3	15.4	0.7	-0.8	3.9	3.9	-1.5	-2.6	-1.7	1.7	0.2	0.3	0.7	-2.5	-1.8
Fed-up feelings	1.8	3.2	10.4	0.1	-0.8	3.2	3.2	-0.6	-1.7	-1.0	2.4	0.9	0.9	1.8	-2.1	-0.9
Serious illness, injury or assault to yourself	1.8	2.1	4.9	1.9	1.7	-0.1	-0.1	-1.9	1.1	-2.1	0.6	1.6	0.6	0.9	-1.7	-2.2
Trunk fat mass	1.8	7.9	23.0	-1.2	1.1	-3.5	-3.5	1.7	3.2	1.4	2.6	3.1	4.8	3.9	2.1	1.2
Qualifications: None of the above	1.8	3.8	10.8	-3.3	-2.8	0.3	0.3	2.6	-1.1	2.6	0.3	0.2	0.0	0.4	2.9	2.7
Qualifications: A levels/AS levels or equivalent	1.8	3.9	7.5	2.7	2.0	1.2	1.2	-2.6	0.0	-2.3	-2.4	-1.0	-2.0	-2.4	-2.3	-1.8
Body fat percentage	1.8	7.1	21.6	-1.2	1.0	-3.6	-3.6	1.5	3.2	1.3	1.9	2.7	4.7	3.2	2.2	1.2
Leg fat mass (right)	1.8	6.8	20.0	0.1	2.3	-4.0	-4.0	0.6	3.3	0.3	1.5	2.4	4.5	2.9	1.6	0.4
Family relationship satisfaction	1.8	2.3	5.3	-1.9	-1.3	0.4	0.5	2.0	-0.7	1.9	2.3	0.9	1.6	2.0	0.8	1.6
Eye problems/disorders: Cataract	1.8	2.1	8.7	-0.4	0.7	-2.9	-3.0	1.3	1.2	1.4	0.4	0.5	1.2	0.6	1.2	1.0
Supplements: Fish oil (including cod liver oil)	1.8	2.3	5.4	-1.9	-1.6	-0.5	-0.4	1.8	0.9	2.2	-1.3	-1.4	-0.6	-1.0	2.3	2.2
Leg fat mass (left)	1.8	6.9	19.7	-0.1	2.1	-4.0	-4.0	0.8	3.4	0.6	1.5	2.5	4.4	2.9	1.8	0.6
Depressed Affect (Nagel 2018)	1.7	3.5	10.4	-0.7	-1.7	3.2	3.2	0.1	-1.9	-0.2	3.0	1.0	1.6	2.1	-0.9	-0.2
Body Mass Index (BMI) (2010)	1.7	2.3	5.9	0.5	2.1	-2.2	-2.2	0.1	1.9	-0.1	0.9	1.6	2.4	1.5	0.1	-0.1
Trunk fat percentage	1.7	7.0	22.2	-1.8	0.2	-2.9	-2.9	1.9	2.6	1.6	2.5	2.9	4.7	3.7	2.2	1.5
Hair/balding pattern: Pattern 2	1.7	2.2	8.2	-1.1	-2.0	2.9	2.8	0.6	-1.5	0.4	1.3	-1.0	-1.1	-0.1	-0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	7.2	-2.0	-2.5	1.3	1.4	1.7	0.6	1.3	2.7	-0.1	1.3	2.0	1.0	1.7
Pulse rate, automated reading	1.7	5.6	19.8	-1.1	1.0	-4.4	-4.4	1.7	2.9	1.8	-0.3	-0.6	1.6	0.3	3.3	1.5
Mineral and other dietary supplements	1.7	2.3	5.1	2.2	2.0	-0.0	-0.0	-2.0	-0.2	-2.2	0.5	1.5	-0.1	0.6	-2.1	-2.2
Mean Putamen Volume	1.6	1.8	3.6	1.0	0.4	1.9	1.9	-1.7	-0.7	-1.8	0.0	1.3	-0.6	0.2	-1.8	-1.7
Blood Platelet Count	1.6	18.9	43.6	6.6	6.5	0.2	0.2	-6.5	1.0	-6.3	-1.9	1.0	-0.7	-1.3	-5.4	-6.4
Medication: Co-codamol	1.6	1.9	5.9	0.8	0.7	-1.6	-1.6	-0.8	1.1	-0.5	-2.4	-2.1	-1.5	-1.7	0.4	-0.5
Leg fat-free mass (left)	1.6	8.2	23.0	0.4	2.3	-3.2	-3.2	1.1	3.3	0.6	3.8	3.5	4.2	4.8	1.1	0.3
Supplements: Glucosamine	1.6	2.1	4.7	-2.1	-1.9	-0.1	-0.1	1.9	-0.6	2.0	-0.2	-1.6	-0.2	-0.8	2.2	1.9
Hip circumference	1.6	6.8	18.8	-0.2	1.7	-3.5	-3.5	1.2	2.4	1.0	2.6	3.2	4.3	3.7	1.8	0.9
Pulse rate	1.6	2.7	5.3	-1.9	-0.4	-2.2	-2.2	2.0	1.1	2.0	0.2	0.4	2.0	0.7	2.3	1.7
High blood pressure (siblings)	1.6	2.4	6.9	2.6	2.6	-0.4	-0.4	-2.1	0.9	-2.1	0.0	-0.5	-0.4	-0.2	-1.4	-2.1
Age at first live birth	1.6	2.9	7.2	1.2	0.7	0.7	0.7	-1.8	0.2	-1.6	-2.3	-2.3	-2.7	-2.6	-1.4	-1.4
Commuting to job workplace: Public transport	1.6	1.9	6.2	1.0	-0.5	2.5	2.5	-1.3	-0.8	-1.4	-0.0	-1.0	-1.1	-0.0	-1.9	-0.9
Myopia	1.6	2.4	6.6	-0.2	-1.1	2.6	2.5	-0.3	-1.7	-0.8	2.4	-0.2	1.8	1.2	-1.5	-0.6
Ulcerative Colitis (UC)	1.5	2.9	7.0	-1.6	-0.7	-1.3	-1.2	1.6	0.4	1.9	-1.6	-2.6	-1.2	-1.7	2.6	2.0
Coronary Artery Disease (CAD)	1.5	1.8	4.3	-1.1	-0.1	-1.5	-1.4	1.8	1.5	1.8	0.8	0.7	0.7	0.4	2.1	1.7
Current tobacco smoking	1.5	2.4	5.7	1.3	2.0	-2.4	-2.4	-0.3	2.0	-0.4	1.2	2.1	0.7	1.9	-0.1	-0.3
Leg predicted mass (left)	1.5	8.1	22.2	0.4	2.3	-3.3	-3.3	1.1	3.3	0.6	3.8	3.5	4.0	4.7	1.1	0.4
Fluid intelligence score	1.5	3.1	8.7	2.9	2.6	-0.4	-0.3	-2.5	1.8	-2.2	-1.6	-0.3	-0.6	-1.4	-1.4	-1.8
Weight	1.5	7.4	17.4	0.0	2.2	-4.0	-4.0	1.1	3.3	0.8	2.4	2.8	4.2	3.7	1.7	0.7
Smoking status: Current	1.5	2.4	6.2	1.8	2.5	-2.3	-2.3	-0.8	2.2	-0.9	0.5	1.4	-0.0	1.1	-0.4	-0.9
Medication: Lisinopril	1.5	1.9	5.1	1.9	0.9	1.0	0.9	-2.2	-0.5	-2.2	-0.3	0.4	0.3	0.2	-2.3	-2.0
Leg fat percentage (left)	1.5	5.3	17.9	-0.2	1.8	-4.2	-4.2	0.6	3.2	0.6	-0.2	1.1	3.3	1.2	2.2	0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	6.0	-0.6	-0.6	-1.1	-1.1	0.9	0.2	1.1	-1.8	-2.4	-1.5	-2.3	1.6	1.0
Age at First Birth	1.4	2.1	8.9	0.1	-0.1	0.4	0.3	-0.6	-0.5	-0.3	-2.8	-2.0	-3.0	-2.3	0.4	-0.2
Townsend deprivation index at recruitment	1.4	2.0	6.8	-1.1	-0.9	0.7	0.8	1.3	-1.4	1.0	2.6	0.7	2.1	2.2	0.0	1.3
Average weekly fortified wine intake	1.4	1.6	5.3	1.7	2.3	-1.3	-1.3	-0.9	1.1	-0.9	-0.6	0.5	-1.8	-0.7	-0.9	-0.8
Leg fat percentage (right)	1.4	5.1	17.0	0.2	2.2	-4.1	-4.1	0.2	3.1	0.2	-0.2	1.3	3.4	1.3	1.8	0.3
Medication: Aspirin	1.4	1.8	4.9	1.8	2.2	-0.2	-0.3	-1.8	-0.1	-1.9	0.1	1.3	0.1	0.5	-1.5	-2.0
Leg fat-free mass (right)	1.4	7.4	21.3	0.2	2.0	-3.0	-3.0	1.3	3.1	0.8	3.8	3.4	3.7	4.6	1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.0	2.2	2.0	0.7	0.6	-2.1	0.3	-2.1	-0.8	-0.9	-1.3	-1.1	-1.6	-1.9
Leg predicted mass (right)	1.4	7.5	20.9	0.2	2.0	-3.1	-3.1	1.2	3.2	0.8	3.7	3.3	3.7	4.6	1.2	0.6
Miserableness	1.4	2.4	6.3	-1.3	-2.1	2.5	2.5	1.1	-1.9	0.9	2.2	-0.2	0.2	1.1	0.0	0.9
Financial situation satisfaction	1.4	1.8	4.8	-0.8	0.5	-2.2	-2.1	1.5	1.8	1.3	0.6	0.5	0.5	0.9	1.5	1.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.0	0.7	0.3	0.7	0.7	-1.6	0.1	-1.4	-2.2	-1.0	-1.1	-2.1	-1.7	-1.4
Bipolar Disorder or Schizophrenia	1.3	3.2	8.4	1.1	0.2	2.7	2.7	-1.8	-1.2	-2.0	1.5	1.2	1.0	0.7	-2.9	-2.1
Alzheimer’s Disease (in mother)	1.3	1.6	4.3	-0.1	0.0	-1.5	-1.5	0.7	1.1	0.8	-1.4	-2.1	-1.2	-1.3	1.9	0.9
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.2	1.1	0.8	0.5	0.5	-1.0	-0.4	-1.1	1.5	2.0	1.7	2.3	-1.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	6.9	0.7	0.4	0.6	0.6	-0.8	-0.5	-1.3	2.3	1.2	1.0	2.6	-1.5	-1.3
Taking other prescription medications	1.3	2.0	5.1	1.9	1.8	0.0	-0.1	-2.0	0.7	-2.0	-1.1	0.0	-1.1	-0.8	-1.6	-2.2
Chronic bronchitis/emphysema (father)	1.3	1.6	4.0	0.9	1.9	-1.8	-1.9	-0.4	2.0	-0.3	-1.4	0.2	-1.2	-0.6	0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.7	-2.2	-1.9	-0.1	-0.0	2.3	-0.7	2.2	0.5	-0.4	0.5	-0.2	1.9	2.4
Emphysema/chronic bronchitis	1.3	1.5	4.7	1.1	1.0	0.3	0.2	-1.0	-0.7	-1.2	1.8	1.0	1.1	2.2	-1.6	-1.5
Medication: Aspirin	1.3	1.7	4.5	1.8	2.1	0.0	-0.0	-1.9	-0.3	-1.9	-0.3	0.9	-0.4	0.0	-1.6	-1.9
Impedance of whole body	1.3	6.6	16.8	-2.4	-3.7	4.1	4.1	0.5	-3.3	0.8	-1.8	-1.8	-2.3	-2.9	-0.6	1.0
Major Depression (MDD)	1.2	1.5	5.0	1.2	1.6	-1.4	-1.4	-0.8	2.2	-0.9	0.7	1.2	0.7	1.1	0.2	-1.1
Lung cancer (father)	1.2	1.4	4.4	-1.2	-0.8	0.2	0.2	1.7	-0.9	1.5	2.1	0.8	0.9	0.9	1.3	1.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.5	2.3	1.9	0.2	0.2	-1.9	1.6	-1.9	-0.0	0.1	-0.0	0.3	-1.8	-1.7
Comparative body size at age 10	1.2	3.4	10.8	0.2	1.1	-3.2	-3.2	0.9	3.3	0.9	1.0	0.9	1.6	1.8	1.5	0.8
Number of full brothers	1.2	1.6	3.6	-1.9	-1.5	0.8	0.8	1.6	-1.6	1.5	0.9	0.0	0.7	0.5	1.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.1	1.3	0.9	-1.3	-1.4	-1.2	0.2	-1.2	-1.4	-1.6	-0.8	-1.8	-0.4	-0.7
Supplements: Vitamin C	1.2	1.5	3.3	-1.8	-1.4	0.4	0.5	1.7	-1.0	1.5	1.1	0.2	0.9	0.5	1.2	1.8
Mood swings	1.2	2.2	4.7	-0.2	-1.1	2.2	2.2	-0.2	-1.8	-0.5	2.1	1.0	1.8	1.7	-1.5	-0.4
Back pain experienced in last month	1.2	1.7	4.3	-0.9	0.0	-1.6	-1.6	1.6	1.7	1.5	0.8	0.8	0.7	0.9	2.1	1.4
Guilty feelings	1.2	1.8	5.4	1.7	0.8	0.9	0.8	-1.7	0.5	-2.0	1.0	0.2	0.7	0.8	-2.3	-1.9
Wears glasses or contact lenses	1.2	1.4	6.6	1.3	1.2	-0.2	-0.2	-1.1	-1.1	-1.0	0.6	2.6	0.6	1.3	-1.0	-1.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.3	-1.2	-0.4	-1.2	-1.3	1.7	0.6	1.8	-0.0	-0.8	-0.1	-0.5	1.8	1.8
Medication: Bendroflumethiazide	1.2	1.8	4.4	2.0	1.8	-0.4	-0.5	-1.9	0.7	-1.9	-0.0	1.1	-0.2	0.2	-1.5	-2.1
Medication: Paracetamol	1.2	1.8	5.3	-2.3	-2.0	0.8	0.9	1.7	-0.2	1.6	1.2	-0.4	1.1	0.5	1.3	1.6
Crohns Disease (2017)	1.1	2.4	4.4	-1.8	-1.4	-0.6	-0.6	1.7	1.0	2.0	-1.4	-2.1	-1.1	-2.0	1.6	1.9
Supplements: Zinc	1.1	1.1	2.5	1.3	1.1	1.1	1.1	-1.3	-0.5	-1.3	-0.0	0.6	-0.8	0.1	-1.6	-1.6
Medication: Metformin	1.1	1.5	2.9	1.1	1.7	-1.0	-1.0	-0.8	0.4	-1.2	1.3	1.1	1.7	1.4	-1.2	-1.3
Impedance of arm (left)	1.1	5.0	15.3	-3.0	-3.9	3.4	3.4	1.6	-2.5	1.7	0.0	-0.2	-1.1	-0.9	0.3	1.8
Qualifications: College or University degree	1.1	3.5	8.7	2.8	3.0	0.1	0.1	-2.5	1.6	-2.4	-1.4	-0.4	-1.0	-1.1	-2.1	-2.3
Medication: Gliclazide	1.1	1.2	4.4	0.7	0.6	-0.2	-0.2	0.0	0.6	-0.3	2.1	1.8	1.1	2.1	-0.8	-0.3
Heart disease (siblings)	1.1	1.3	3.6	-1.0	-0.7	-0.2	-0.1	1.2	-0.1	1.1	1.4	1.8	1.6	1.9	0.7	1.1
Fasting Glucose	1.0	1.1	2.7	-0.5	-0.4	-1.1	-1.1	1.0	0.3	0.9	1.3	1.2	1.6	1.5	1.2	0.9
Blood White Count	1.0	7.3	14.1	2.5	2.0	0.7	0.7	-2.4	-1.0	-2.8	3.6	3.7	3.6	3.8	-2.8	-2.7
Diabetes (father)	1.0	1.3	3.3	1.5	1.8	0.3	0.3	-1.4	1.3	-1.5	0.6	0.9	-0.0	0.6	-0.9	-1.6
Impedance of arm (right)	1.0	4.4	14.4	-2.7	-3.8	3.4	3.5	1.4	-2.1	1.5	0.0	-0.4	-0.9	-0.7	0.3	1.6
Falls in the last year	1.0	1.3	3.9	-1.2	-1.2	0.3	0.3	1.1	0.1	0.9	2.0	-0.5	1.8	1.7	1.0	1.0
Medication: Cholesterol lowering	1.0	1.6	3.1	1.7	1.7	-0.5	-0.5	-1.7	1.3	-1.6	-1.0	0.7	-0.6	0.1	-1.4	-1.7
Medication: Ibuprofen	1.0	1.2	3.4	-1.9	-1.1	0.1	0.1	1.7	-0.1	1.6	1.0	0.7	0.2	0.4	1.2	1.7
Overall health rating	1.0	2.0	6.8	0.7	0.9	0.7	0.7	-0.8	0.2	-1.2	2.1	1.9	1.8	2.6	-1.3	-1.4
Age at last live birth	1.0	1.4	3.1	0.7	0.5	0.6	0.5	-1.3	0.4	-1.2	-1.6	-1.2	-1.8	-1.7	-1.4	-1.3
Qualifications: nursing, teaching	1.0	1.5	3.5	1.9	1.6	-0.5	-0.4	-1.7	0.6	-1.7	-0.9	-0.8	-0.8	-1.4	-1.2	-1.2
Hearing aid user	1.0	1.2	2.1	-1.0	-0.9	-1.4	-1.5	1.1	-0.2	1.3	-0.3	1.0	1.2	0.5	1.4	1.1
Basal metabolic rate	1.0	5.5	11.6	0.7	2.5	-3.3	-3.3	0.6	3.0	0.3	2.5	2.4	3.1	3.4	1.0	0.1
Illnesses of siblings	0.9	1.2	2.9	-1.6	-1.1	-0.6	-0.6	1.5	0.1	1.7	-0.8	-0.7	-0.5	-0.8	1.4	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.6	-1.6	-1.1	0.3	0.3	1.4	-0.8	1.2	1.2	1.3	0.7	0.8	1.0	1.3
Medication: Lansoprazole	0.9	1.1	2.7	1.2	0.6	0.3	0.3	-1.6	0.4	-1.6	0.3	1.4	0.4	0.1	-1.6	-1.4
Illnesses of mother	0.9	1.1	3.7	-1.1	-1.3	1.5	1.6	0.5	-1.9	0.5	0.2	-0.8	-0.6	-1.0	-0.0	0.5
Peak expiratory flow (PEF)	0.9	2.0	4.4	-1.2	-0.4	-0.8	-0.8	1.9	0.3	1.7	1.3	1.7	2.1	1.4	1.8	1.8
Number of children fathered	0.9	1.0	3.7	1.2	1.9	-1.0	-1.1	-0.7	1.6	-0.7	-0.2	1.0	-0.2	-0.3	-0.3	-0.7
Diabetes diagnosed by doctor	0.9	1.5	3.3	1.2	1.3	0.4	0.4	-0.9	-0.5	-1.3	1.8	1.0	1.4	1.6	-1.5	-1.4
Whole body water mass	0.9	4.9	10.6	1.0	2.7	-3.1	-3.1	0.3	2.8	0.0	2.4	2.3	2.6	3.2	0.7	-0.2
Arm fat-free mass (left)	0.9	4.5	12.0	1.2	2.8	-3.5	-3.5	0.0	2.5	-0.2	1.7	1.6	2.5	2.6	0.7	-0.4
Pain experienced in last month	0.9	1.5	3.9	1.5	1.2	-0.5	-0.6	-1.3	0.1	-1.0	-2.0	-0.8	-2.0	-1.3	-1.4	-0.9
Arm predicted mass (left)	0.9	4.6	11.6	1.1	2.8	-3.4	-3.4	0.1	2.6	-0.1	1.7	1.7	2.6	2.7	0.8	-0.2
Ovarian Cancer	0.8	1.1	2.7	-1.2	-1.6	0.1	0.2	1.2	-0.6	1.4	-0.2	-1.3	-1.4	-0.7	0.8	1.0
Lupus	0.8	1.2	2.7	-1.1	-0.4	-1.4	-1.4	1.0	1.5	1.1	-0.8	-0.6	0.3	-0.4	1.6	1.0
Allergy or Eczema	0.8	2.2	6.5	0.3	-0.5	2.5	2.6	-0.9	-1.7	-0.6	-0.7	-2.2	-1.5	-1.3	-1.3	-0.8
Medication: Atenolol	0.8	1.0	3.5	1.4	1.9	-0.7	-0.7	-1.0	-0.3	-1.2	0.5	1.1	1.1	0.7	-0.6	-1.1
Hair/balding pattern: Pattern 3	0.8	1.2	4.6	0.2	0.3	-2.1	-2.2	0.4	0.6	0.6	-1.4	-0.8	-0.3	-1.0	1.1	0.5
Headache pain in last month	0.8	1.4	5.3	-1.7	-1.8	1.3	1.4	0.8	-2.3	0.8	0.6	-0.2	1.1	0.3	0.3	0.6
Arm predicted mass (right)	0.8	3.9	8.6	1.2	2.8	-2.9	-2.9	-0.1	2.3	-0.3	1.8	1.9	2.2	2.5	0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	3.5	-0.6	-1.2	0.7	0.7	0.0	-1.9	0.3	-1.3	-0.9	-1.6	-0.9	0.3	0.4
Whole body fat-free mass	0.8	4.7	10.0	1.0	2.6	-3.0	-3.0	0.3	2.8	0.0	2.3	2.3	2.5	3.2	0.7	-0.2
Medication for cholesterol	0.8	1.3	2.8	-1.6	-1.6	0.5	0.6	1.5	0.3	1.6	0.3	-0.7	0.4	-0.2	1.3	1.7
Osteoporosis (self-reported)	0.8	0.9	4.2	-1.1	-1.0	1.5	1.4	0.4	-2.1	0.4	-0.7	-0.3	-0.1	-0.5	-0.1	0.6
Crohns Disease (2012)	0.7	1.1	2.5	-1.5	-1.4	-0.6	-0.6	1.5	0.4	1.6	-0.1	-0.7	0.5	-0.6	1.0	1.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.8	1.6	1.6	0.1	0.1	-1.3	-0.6	-1.5	0.8	0.8	0.8	0.9	-1.4	-1.7
Average weekly spirits intake	0.7	0.8	2.3	-1.4	-0.6	-0.5	-0.5	1.4	0.3	1.5	-0.2	-0.3	-0.0	-0.1	1.2	1.5
Medication for hormone replacement therapy	0.7	0.8	3.8	-1.0	-1.4	0.7	0.7	0.7	-1.9	0.9	-0.3	-0.7	-0.0	-0.2	0.3	0.7
Hand grip strength (right)	0.7	2.0	5.7	1.1	0.9	0.4	0.4	-1.6	-0.7	-1.5	-1.1	-1.5	-2.4	-2.0	-1.7	-1.4
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.0	-0.4	-0.7	1.7	1.8	-0.1	-1.5	0.2	-0.8	-2.0	-1.5	-1.4	-0.5	0.0
Multivitamins +/- minerals	0.7	0.9	2.5	1.4	1.6	-0.5	-0.5	-1.1	0.0	-0.9	-1.1	-0.2	-0.5	-1.2	-1.0	-0.6
Diabetes (self-reported)	0.7	1.1	2.4	1.4	1.4	0.4	0.4	-1.1	-0.2	-1.3	1.2	0.7	0.7	0.8	-1.6	-1.4
Medication: Ramipril	0.7	0.9	3.6	0.2	0.6	-1.6	-1.6	-0.1	1.9	-0.0	-0.7	-1.0	-0.9	-0.6	0.4	-0.4
Loud music exposure frequency	0.7	0.7	1.9	-1.0	-1.0	-0.1	-0.2	1.2	0.8	1.4	-0.5	-0.8	-0.5	-0.4	0.9	1.1
Arm fat-free mass (right)	0.7	3.7	8.0	1.0	2.6	-2.8	-2.8	0.0	2.2	-0.2	1.9	1.9	2.3	2.6	0.4	-0.3
Pulse wave peak to peak time	0.7	0.9	1.7	0.9	0.8	1.1	1.0	-1.1	-0.9	-1.2	0.1	0.7	-0.5	0.2	-1.2	-1.3
Medication: Omeprazole	0.7	0.9	2.0	0.5	-0.0	0.6	0.6	-1.3	0.1	-1.2	-1.3	-0.7	-0.1	-1.3	-1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	-0.7	-0.5	-0.5	-0.5	0.9	0.9	0.9	1.3	1.0	1.0	1.1	1.1	0.6
Illnesses of siblings: Diabetes	0.7	0.9	3.0	-0.1	-0.5	0.8	0.8	-0.2	-1.4	-0.4	1.1	1.7	1.1	1.4	-0.5	0.0
Average weekly red wine intake	0.7	1.0	5.5	-0.1	-0.2	0.2	0.3	-0.1	-0.7	0.1	-1.4	-2.3	-1.4	-1.9	-0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	0.7	0.7	0.3	0.3	-0.9	0.8	-1.0	0.5	1.5	1.3	1.0	-0.9	-1.0
Number of operations (self-reported)	0.7	1.0	4.2	0.5	0.6	-2.1	-2.0	-0.3	0.6	-0.1	-1.0	-0.5	-1.0	-0.4	1.1	0.0
Schizophrenia (2018)	0.6	1.2	4.5	-0.7	-1.3	2.1	2.1	-0.1	-1.5	-0.3	0.9	0.0	0.7	0.4	-0.8	-0.1
Alzheimer’s Disease (in father)	0.6	0.7	3.8	-0.4	-1.0	1.1	1.1	0.4	-2.0	0.4	0.9	0.1	0.4	-0.1	-0.4	0.4
Breast Cancer	0.6	1.5	4.8	1.5	2.2	-1.4	-1.4	-0.9	1.3	-0.8	-1.2	1.3	-1.1	-0.3	-0.1	-0.7
Prostate Cancer	0.6	0.8	2.6	1.4	1.6	-1.1	-1.1	-1.0	0.2	-0.9	-0.8	0.4	-0.6	-0.3	0.0	-0.7
Neuroticism (2016)	0.6	0.8	2.0	1.0	0.6	0.7	0.6	-1.2	-0.1	-1.4	0.6	0.7	0.4	0.3	-1.3	-1.4
Blood Eosinophil Count	0.6	4.5	10.9	3.3	3.0	0.3	0.3	-2.6	-0.9	-3.0	1.2	1.0	0.4	0.9	-2.9	-3.1
Hypothyroidism (self reported)	0.6	1.3	5.1	1.9	2.2	-1.2	-1.2	-1.2	0.7	-1.1	-0.2	0.5	0.0	0.2	-0.7	-1.2
Number of treatments/medications taken	0.6	1.0	2.9	1.0	0.7	1.1	1.1	-1.5	0.3	-1.4	0.2	-0.2	0.3	0.1	-1.5	-1.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	-0.6	-0.7	0.8	0.9	0.6	-0.1	0.5	1.6	0.2	1.2	1.0	-0.4	0.3
Alcohol usually taken with meals	0.6	1.0	4.9	0.5	-0.3	-0.1	-0.1	-0.6	-0.2	-0.4	-1.5	-2.2	-1.2	-1.6	-0.6	-0.2
Had other major operations	0.6	0.7	2.5	0.5	1.0	-1.6	-1.5	-0.1	-0.4	-0.0	0.3	1.5	0.2	0.7	0.5	-0.0
Mouth/teeth dental problems	0.6	0.8	2.8	-0.9	-1.1	0.4	0.4	1.4	-0.2	1.3	0.3	-0.4	-1.7	-0.5	0.7	1.1
Heart attack	0.6	0.8	2.1	1.2	1.4	-0.7	-0.7	-1.2	-0.0	-1.1	-0.3	0.0	-0.2	0.3	-0.8	-1.5
Time employed in main current job	0.6	0.6	2.1	0.5	0.6	-0.3	-0.3	-0.5	-0.3	-0.6	0.7	1.5	1.4	1.3	-0.6	-0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-0.7	-0.5	-1.1	-1.1	1.0	1.0	1.1	-0.2	-0.5	0.4	-0.1	1.2	1.2
Exposure to tobacco smoke at home	0.6	0.7	1.7	-1.0	-1.0	-0.3	-0.2	0.7	0.1	0.8	-1.0	-1.1	-1.3	-0.4	1.0	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.4	0.3	0.0	0.5	0.5	-0.0	-1.0	-0.3	1.8	0.9	1.0	1.4	-0.5	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.7	-0.2	-0.6	1.2	1.2	-0.5	0.3	-0.3	-1.3	-1.6	-0.7	-1.4	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.6	-0.7	0.1	-1.3	-1.3	0.6	0.9	0.8	-0.9	-1.3	-0.6	-0.8	0.7	0.8
Shortness of breath walking on level ground	0.6	0.7	2.6	-0.6	0.9	-0.8	-0.8	0.8	1.6	0.8	0.5	0.8	-0.1	0.7	1.1	0.8
Medication: Allopurinol	0.6	0.8	2.0	1.4	1.3	-0.2	-0.2	-1.1	1.0	-1.2	0.2	0.5	0.6	0.4	-0.7	-1.4
Chest pain or discomfort	0.6	0.8	4.9	0.5	0.7	-0.0	-0.0	-0.2	2.2	-0.4	0.8	-1.8	0.5	0.3	-0.2	-0.3
Long-standing illness, disability or infirmity	0.6	1.0	3.2	0.2	1.0	-1.2	-1.1	0.2	1.2	-0.0	1.1	1.6	0.7	1.8	-0.0	-0.3
Fractured/broken bones in last 5 years	0.6	0.7	1.7	1.1	1.3	-1.1	-1.2	-0.8	0.7	-0.9	0.2	-0.3	-0.2	0.6	0.0	-1.2
Age started oral contraceptive pill	0.6	0.8	2.6	0.9	1.4	-1.5	-1.6	-0.6	1.1	-0.5	-0.7	0.4	0.2	-0.1	0.4	-0.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.2	-0.8	-1.5	0.5	0.4	0.7	-0.8	0.7	0.8	-0.5	1.3	0.9	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	1.1	1.4	-0.8	-0.7	-1.1	-0.1	-1.1	-0.3	0.1	-0.4	0.3	-0.8	-1.4
Rheumatoid Arthritis	0.5	0.7	2.1	1.1	1.5	-1.0	-1.0	-0.5	1.1	-0.3	-0.6	1.1	0.3	-0.0	0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.9	0.2	1.1	-1.4	-1.3	-0.0	0.9	-0.4	0.6	0.5	0.9	0.6	0.2	-0.5
Chronotype (morning person)	0.5	1.1	3.6	-0.5	-0.4	-0.5	-0.6	0.9	0.4	1.1	-1.1	-1.9	-1.2	-1.8	0.7	1.0
Sensitivity / hurt feelings	0.5	0.8	1.4	0.4	-0.4	1.2	1.2	-0.6	-0.4	-1.0	0.9	1.0	1.1	0.9	-1.0	-0.8
Diabetes (mother)	0.5	0.6	1.8	0.8	0.6	1.0	1.0	-1.0	0.2	-1.0	0.5	0.1	0.3	0.1	-1.4	-0.8
Pack years adult smoking proportion	0.5	0.8	2.3	0.1	1.1	-1.5	-1.5	0.3	0.9	0.2	0.2	1.1	0.8	1.1	0.7	0.2
Qualifications: CSEs or equivalent	0.5	0.6	2.7	0.5	0.7	0.2	0.1	-0.2	1.7	-0.3	0.9	0.9	1.0	1.0	-0.5	-0.4
Trunk fat-free mass	0.5	3.0	7.0	1.4	2.6	-2.6	-2.6	-0.2	2.4	-0.4	1.3	1.3	1.4	2.0	0.3	-0.5
Alcohol intake versus 10 years previously	0.5	0.7	2.0	-1.4	-0.8	-0.5	-0.4	1.1	-0.3	1.2	0.2	0.1	-0.5	0.3	1.4	1.0
Happiness	0.5	0.6	3.1	-0.7	-0.5	0.9	0.9	0.5	-0.4	0.2	1.7	0.3	0.7	1.2	-0.1	0.1
Asthma	0.5	0.9	2.3	-1.4	-1.1	0.1	0.2	1.4	1.0	1.5	0.3	-0.7	0.1	-0.0	1.0	1.4
Prospective memory result	0.5	0.6	1.4	0.7	0.8	0.4	0.4	-1.1	0.2	-1.1	-0.9	-0.4	-0.7	-0.9	-0.9	-1.2
Trunk predicted mass	0.5	2.9	7.2	1.4	2.6	-2.7	-2.7	-0.1	2.3	-0.3	1.3	1.3	1.4	2.0	0.4	-0.5
Heart disease (mother)	0.5	0.7	1.8	-0.2	-0.1	-1.1	-1.1	0.2	1.4	0.3	0.0	0.2	1.2	0.9	1.2	0.5
Illnesses of father: Heart disease	0.5	0.6	2.0	0.7	1.0	-0.9	-1.0	-0.4	1.4	-0.5	0.5	0.8	0.8	0.8	-0.5	-0.5
Asthma (self-reported)	0.5	1.1	2.6	-1.6	-1.2	0.1	0.1	1.5	1.1	1.6	0.4	-0.7	0.1	0.1	1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	1.3	1.2	-0.4	-0.4	-1.4	0.1	-1.4	-1.2	-0.9	-0.9	-1.1	-1.1	-1.3
High cholesterol (Self-reported)	0.5	0.9	2.9	1.3	1.7	-0.8	-0.9	-1.1	1.3	-1.1	-0.3	0.5	-0.2	-0.1	-0.4	-1.2
Alcohol drinker status: Never	0.5	0.5	1.5	-1.2	-0.7	0.1	0.1	1.1	0.3	1.1	-0.1	-0.7	-0.1	-0.2	1.0	1.0
Average weekly beer plus cider intake	0.5	0.7	1.9	0.4	0.4	0.1	0.1	-0.5	1.1	-0.8	1.4	1.3	1.0	1.2	-0.2	-0.7
Irritability	0.5	0.8	3.8	-0.4	-0.7	1.9	1.9	-0.2	-0.8	-0.2	0.7	0.9	-0.0	0.6	-0.5	0.2
Diastolic blood pressure, automated reading	0.5	1.6	4.1	1.5	1.4	0.2	0.2	-1.6	0.5	-1.5	-0.9	0.7	-2.0	-0.7	-1.6	-1.8
Pack years of smoking	0.5	0.8	2.2	-0.1	0.8	-1.2	-1.2	0.3	0.7	0.2	0.4	1.5	1.0	1.4	0.8	0.3
HDL Cholesterol	0.4	0.6	2.5	0.3	0.3	-1.0	-0.9	0.3	1.6	0.2	0.8	0.8	1.1	0.7	0.8	0.5
LDL Cholesterol	0.4	0.6	4.4	-0.2	0.0	0.1	0.1	0.5	-0.2	0.3	1.5	0.5	2.1	0.8	-0.2	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.3	-0.8	-0.9	-0.1	0.0	1.0	-0.4	1.1	0.7	-0.5	1.1	0.2	1.0	1.1
Blood Red Count	0.4	3.5	7.1	-0.6	0.7	-2.7	-2.7	1.5	2.0	1.4	1.0	2.3	2.3	2.0	2.0	1.5
Smoking Status	0.4	0.9	2.2	0.7	1.5	-1.4	-1.3	-0.2	1.5	-0.2	0.7	0.8	0.2	1.2	-0.5	0.1
Respiratory disease	0.4	0.9	2.0	-1.1	-0.4	0.1	0.2	1.4	0.9	1.4	1.4	0.3	0.6	1.2	0.6	1.2
Lung FVC	0.4	2.0	3.7	1.7	1.7	-1.4	-1.4	-1.0	1.7	-1.2	0.8	1.9	1.7	1.3	-0.8	-1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.1	0.2	0.5	-0.8	-0.7	0.1	1.4	-0.1	0.7	0.9	0.6	1.1	0.3	0.2
Severe depression (siblings)	0.4	0.4	2.6	0.2	0.3	-0.5	-0.5	0.1	-0.6	0.0	0.5	0.7	1.6	1.2	0.2	-0.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	0.6	0.8	-1.0	-1.1	-0.2	1.0	-0.2	0.2	-0.8	0.8	0.2	0.3	-0.4
Number of incorrect matches in round	0.4	0.6	1.4	-1.2	-1.2	0.2	0.3	0.8	-0.9	0.7	0.1	-0.7	0.5	-0.1	1.0	1.1
Had menopause	0.4	0.5	2.1	-0.3	-0.6	0.7	0.7	0.2	-0.6	0.1	1.4	0.9	0.2	1.4	0.2	-0.1
Financial difficulties in last 2 years	0.4	0.5	2.3	0.4	0.9	-0.5	-0.5	0.1	1.5	-0.2	0.9	0.5	0.8	1.1	-0.2	-0.2
Allergy	0.4	0.9	2.9	0.7	0.9	-1.7	-1.7	-0.4	1.2	-0.5	-0.3	1.3	0.9	0.5	0.5	-0.4
Number of live births	0.4	0.5	1.5	0.1	-0.4	0.2	0.2	-0.8	-1.2	-0.7	-1.2	-0.3	-0.2	-0.9	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.9	0.8	0.6	1.0	1.0	-0.5	-0.3	-0.8	1.3	1.6	2.0	1.0	-1.6	-0.8
Gout (self-reported)	0.4	0.6	1.2	1.1	0.8	-0.2	-0.2	-0.9	0.2	-1.1	0.6	0.7	1.0	0.7	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.6	0.8	0.4	0.3	0.3	-0.5	0.0	-0.6	1.2	1.5	1.1	1.6	-0.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.8	-1.2	0.7	0.7	0.8	-0.4	0.8	-0.3	-0.8	-0.8	-0.4	0.2	0.9
Birth weight	0.4	1.0	3.0	-0.0	-0.3	1.2	1.2	-0.0	0.3	-0.2	1.7	0.7	1.4	1.5	-1.2	-0.3
Alcohol intake frequency.	0.4	0.9	2.6	-1.6	-1.1	-0.1	-0.1	1.4	0.5	1.4	0.5	-0.5	0.9	0.6	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	-0.6	-1.3	1.0	0.9	0.6	-0.6	0.6	0.3	0.2	-1.3	-0.4	-0.1	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-0.4	-0.7	1.0	1.0	-0.4	-0.9	-0.4	-0.5	-0.2	-0.9	-1.0	-0.4	-0.3
Smoking status: Previous	0.4	0.6	2.0	-1.4	-1.1	0.3	0.3	0.9	-0.1	0.9	-0.2	0.0	0.8	0.4	0.8	1.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	1.2	0.5	0.4	0.4	-0.9	-1.2	-0.8	0.2	-0.7	-0.1	-0.0	-0.6	-0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.2	-0.7	-0.2	-0.9	-0.8	0.9	-0.1	0.8	0.4	0.6	1.1	0.5	0.2	0.9
Ever taken oral contraceptive pill	0.4	0.4	1.3	0.3	0.7	-0.4	-0.5	-0.4	1.1	-0.3	-0.7	-1.1	0.1	-0.9	-0.0	-0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.6	0.2	0.5	-0.8	-0.7	-0.1	1.9	-0.1	-0.6	-0.6	-1.0	0.1	0.5	-0.2
Cholesterol lowering medication	0.4	0.5	2.2	-0.3	0.6	-1.4	-1.5	0.2	0.7	0.1	0.3	0.6	0.7	0.6	0.7	-0.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	0.9	0.3	1.1	1.1	-1.2	-0.2	-0.7	-1.1	-0.9	-0.1	-1.2	-0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	1.3	1.0	-0.2	-0.2	-1.0	1.3	-0.8	-0.8	-0.3	0.0	-0.8	-0.5	-0.7
HbA1C	0.3	0.3	1.7	0.3	-0.1	-0.1	-0.4	-0.4	1.0	-0.3	-0.5	-1.3	-0.2	-0.5	-0.0	-0.3
Schizophrenia (2014)	0.3	0.8	3.1	-0.6	-1.2	1.7	1.7	0.1	-1.2	-0.0	0.4	-0.4	0.5	-0.2	-0.5	0.2
Triglycerides	0.3	0.5	1.4	-0.6	0.0	-0.6	-0.6	1.0	-0.0	1.1	0.3	-0.0	1.2	0.6	0.7	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	1.7	-0.7	-0.5	0.3	0.3	0.0	-0.1	0.2	-1.3	-0.9	-0.7	-0.7	0.5	0.1
Maternal smoking around birth	0.3	0.4	1.1	0.2	1.1	-0.7	-0.6	0.3	0.2	0.2	1.0	1.0	0.4	0.9	0.6	0.1
Medication: Levothyroxine sodium	0.3	0.5	1.3	0.9	0.4	0.0	0.0	-0.9	0.5	-0.9	0.0	1.0	0.5	0.6	-0.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.5	0.2	0.6	-0.4	-0.4	-0.2	-0.8	-0.5	0.6	0.7	1.2	1.2	0.1	-0.1
Medication: Simvastatin	0.3	0.4	1.3	0.8	1.1	-0.9	-1.0	-0.5	1.1	-0.4	-0.5	0.3	0.2	-0.1	-0.2	-0.3
Pulse wave reflection index	0.3	0.4	1.7	-0.7	-1.3	0.4	0.4	0.4	-0.2	0.5	-0.2	-0.9	-0.4	-0.5	0.1	0.6
Medication: Paracetamol	0.3	0.6	2.0	-1.4	-1.1	0.4	0.4	0.9	-0.8	0.9	0.4	-0.2	0.5	0.1	0.7	0.7
Glaucoma (self-reported)	0.3	0.3	0.7	0.9	0.5	-0.4	-0.5	-0.7	-0.2	-0.8	0.1	0.0	0.5	0.4	-0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.4	0.4	0.6	-0.3	-0.2	-0.8	0.1	-1.0	0.3	-0.2	0.8	0.7	-0.6	-1.2
Migraine (self-reported)	0.3	0.4	1.1	0.0	-0.2	0.7	0.6	-0.4	-0.9	-0.4	-0.5	-0.6	-1.1	-1.0	-0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	-0.7	-0.6	-0.2	-0.2	0.6	0.3	0.6	0.6	0.7	0.9	0.0	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.0	-0.2	0.3	-1.0	-1.0	0.4	0.6	0.6	-0.5	0.4	-0.7	0.0	0.5	0.7
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.9	-0.6	-0.2	-0.3	0.7	-0.7	0.7	-0.2	0.5	-0.3	0.4	0.4	0.7
Mother’s age at death	0.3	0.4	1.9	0.8	1.4	-0.4	-0.3	-0.5	0.5	-0.6	0.2	0.8	0.4	0.0	-0.3	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	1.1	1.0	-0.1	-0.1	-0.7	0.8	-0.8	-0.1	0.1	-0.1	-0.2	-0.4	-0.8
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.7	-0.2	-0.7	-0.7	0.8	0.3	0.6	0.4	-0.7	-0.3	0.5	0.9	0.7
Supplements: Calcium	0.3	0.4	1.1	-0.5	-0.2	-0.6	-0.6	0.4	0.5	0.4	-0.4	-1.0	-1.1	-0.6	0.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.4	-0.5	-1.2	-0.7	-0.6	0.5	0.3	0.3	0.6	-0.3	0.1	0.7	0.2	0.7
Heel T-Score	0.2	1.6	5.3	-1.7	-1.1	-0.5	-0.5	1.6	1.1	1.8	-0.2	0.6	-0.3	-0.0	2.3	1.8
Angina	0.2	0.3	1.3	-0.3	0.4	-0.7	-0.6	0.6	0.5	0.5	0.0	0.0	0.1	0.1	1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.1	0.3	0.7	0.1	0.1	-0.5	0.0	-0.4	-1.4	-0.6	-0.9	-1.5	-0.2	-0.2
Past tobacco smoking	0.2	0.3	0.8	0.9	0.5	0.4	0.3	-0.6	-0.9	-0.7	0.5	0.1	-0.4	-0.1	-0.7	-0.7
Forced vital capacity (FVC)	0.2	0.7	3.2	-0.1	-0.0	0.5	0.6	0.7	0.1	0.4	1.5	1.1	1.8	1.2	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	-0.1	-0.0	0.7	0.8	-0.5	0.6	-0.4	-1.1	-0.6	-0.8	-1.3	-0.2	-0.4
Pain all over the body in last month	0.2	0.2	1.1	0.3	-0.4	0.5	0.5	-0.5	-1.0	-0.4	0.0	-0.4	0.1	-0.1	-0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.5	0.4	0.1	0.1	-0.8	0.6	-0.7	-0.7	-0.6	-0.2	-0.7	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	0.9	1.0	0.2	0.3	-0.7	0.1	-0.8	0.5	0.7	1.2	0.3	-1.2	-0.9
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-0.3	-0.3	1.1	1.1	-0.2	-1.4	-0.2	0.2	-0.2	0.9	-0.0	-0.6	-0.7
Blood clot in the leg (DVT)	0.2	0.3	0.7	-0.2	-0.9	-0.9	-0.8	0.3	0.3	0.1	0.5	-0.1	0.1	0.6	0.0	0.5
Neck or shoulder pain in last month	0.2	0.3	1.0	-0.8	-0.3	0.4	0.4	0.7	0.8	0.5	1.0	0.5	-0.1	0.3	-0.1	0.6
Angina (self-reported)	0.2	0.2	1.0	-0.2	0.5	-0.6	-0.6	0.3	0.5	0.4	-0.1	-0.1	-0.1	-0.0	1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	-0.5	0.2	-0.7	-0.7	1.1	0.5	1.0	1.0	-0.1	0.9	0.6	0.4	0.7
Ever had bowel cancer screening	0.2	0.2	0.6	0.5	0.3	0.4	0.4	-0.7	-0.4	-0.8	0.2	0.0	0.4	0.1	-0.3	-0.6
Breast cancer (self-reported)	0.2	0.2	0.6	0.3	-0.0	0.8	0.8	-0.5	0.1	-0.5	0.0	-0.1	-0.3	-0.0	-0.5	-0.5
Risk taking	0.2	0.3	0.9	-0.6	-0.3	-0.3	-0.3	0.5	0.9	0.6	-0.8	-0.8	-0.4	-0.7	0.0	0.6
Ever depressed for a whole week	0.2	0.3	1.8	0.1	0.4	-0.1	-0.1	0.1	-1.3	-0.1	0.6	-0.5	0.9	0.0	-0.0	-0.0
Unable to work because of sickness or disability	0.2	0.2	0.9	-0.3	-1.0	0.6	0.7	-0.1	0.3	-0.2	0.2	-0.7	-0.8	0.1	-0.4	-0.1
Height	0.1	2.8	8.2	-0.8	-1.3	2.8	2.9	0.6	-1.8	0.3	2.4	1.7	1.1	1.6	-1.4	0.4
Tanning	0.1	0.8	2.7	-0.5	-1.0	1.6	1.6	0.2	-1.4	0.1	0.9	0.4	0.5	0.5	-0.5	0.0
Vitamin and mineral supplements	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.4	0.0	0.5	-0.1	0.0	0.2	-0.3	0.3	0.5	-0.2
Sitting height	0.1	0.5	1.8	0.7	1.2	-0.1	-0.1	-0.1	0.7	-0.3	1.4	0.7	0.9	0.9	-0.5	-0.3
Standing height	0.1	1.1	3.1	-0.7	-0.8	1.7	1.8	0.5	-1.3	0.4	1.6	1.0	0.0	0.9	-0.7	0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	1.3	0.0	0.2	0.2	0.2	0.4	0.1	0.2	1.1	0.6	1.1	0.8	-0.4	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	0.3	-0.0	-0.4	-0.3	0.1	0.8	0.2	-0.6	-1.0	-0.7	-0.3	0.2	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.2	-0.1	-0.1	-0.0	-0.2	0.2	-0.2	-0.1	0.5	0.7	0.7	0.3	-0.3
Had major operations	0.1	0.1	0.4	-0.0	-0.5	0.3	0.4	-0.2	-0.1	-0.2	-0.2	-0.3	-0.6	0.5	0.1	0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.6	0.1	-0.4	-0.4	-0.6	-0.7	-0.5	-0.1	0.0	0.3	0.2	-0.1	-0.6
Medication: Atorvastatin	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.3	0.3	0.4	0.2	-0.1	-0.4	-0.1	0.2	0.4	0.2
Ever smoked	0.1	0.2	1.0	0.2	0.5	-0.5	-0.5	-0.3	1.0	-0.2	-0.8	0.1	0.0	-0.3	-0.3	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.5	0.2	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.3	-0.7	0.3	0.0	-0.5	-0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.8	-0.3	-0.3	-0.4	-0.4	0.2	0.1	0.2	-0.6	-0.9	-0.2	-0.7	0.2	0.5
Hair Pigment	0.0	0.2	0.7	0.2	0.2	-0.7	-0.6	0.1	0.8	0.0	0.7	0.2	-0.5	0.2	-0.1	0.2
Age when periods started (menarche)	0.0	0.1	0.5	-0.2	-0.2	0.5	0.5	0.0	0.0	-0.0	0.1	0.0	-0.7	-0.4	-0.0	-0.2
Comparative height size at age 10	0.0	0.3	0.6	0.4	0.3	0.8	0.8	-0.6	-0.6	-0.4	-0.5	0.3	-0.1	-0.5	-0.4	-0.4

Hub : Genes

ADK

Models

Trait associations