Best TWAS P=1.22e-11 · Best GWAS P=8.92e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GAR1 | 0.08 | 0.07 | lasso | 5 | 0.06 | 1.9e-07 | 4.8 | -5.6 | 1.8e-08 | -0.88 | 0.02 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RRH | 0.09 | 0.06 | lasso | 8 | 0.07 | 2.0e-08 | 6.1 | -5.9 | 3.4e-09 | -0.93 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | GAR1 | 0.22 | 0.08 | lasso | 3 | 0.04 | 2.9e-02 | 6.6 | -6.5 | 9.6e-11 | -0.94 | 0.01 | 0.86 | FALSE |
| 4 | GTEx | Esophagus Mucosa | GAR1 | 0.17 | 0.16 | lasso | 3 | 0.15 | 1.9e-10 | 6.6 | 6.6 | 4.8e-11 | 0.99 | 0.01 | 0.99 | FALSE |
| 5 | NTR | Blood | GAR1 | 0.02 | 0.00 | bslmm | 400 | 0.00 | 1.8e-02 | 4.8 | -5.8 | 7.7e-09 | -0.72 | 0.02 | 0.86 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | GAR1 | 0.18 | 0.24 | enet | 17 | 0.24 | 2.2e-30 | 6.8 | -6.5 | 8.7e-11 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GAR1 | 0.04 | 0.02 | blup | 45 | 0.03 | 8.0e-03 | 3.4 | 5.5 | 3.5e-08 | 0.84 | 0.02 | 0.59 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GAR1 | 0.04 | 0.06 | lasso | 2 | 0.06 | 8.1e-07 | 6.8 | 6.8 | 1.2e-11 | 0.99 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LRIT3 | 0.07 | 0.03 | blup | 59 | 0.06 | 9.3e-08 | 6.6 | -5.2 | 1.6e-07 | -0.82 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RRH | 0.04 | 0.04 | blup | 51 | 0.03 | 4.4e-03 | 6.1 | -5.7 | 1.4e-08 | -0.88 | 0.02 | 0.69 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GAR1 | 0.04 | 0.00 | enet | 6 | 0.01 | 7.4e-03 | 6.0 | -6.2 | 4.3e-10 | -0.78 | 0.02 | 0.34 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | RRH | 0.02 | 0.02 | lasso | 4 | 0.03 | 4.8e-04 | 3.8 | -5.3 | 1.2e-07 | -0.78 | 0.10 | 0.46 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GAR1 | 0.03 | 0.01 | blup | 43 | 0.03 | 5.3e-04 | 6.0 | 5.8 | 6.2e-09 | 0.88 | 0.01 | 0.91 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GAR1 | 0.10 | 0.09 | lasso | 2 | 0.07 | 6.8e-04 | 6.8 | -6.8 | 1.5e-11 | -0.99 | 0.00 | 0.96 | FALSE |
| 15 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RRH | 0.05 | 0.04 | blup | 52 | 0.04 | 2.2e-03 | 4.0 | -5.3 | 1.2e-07 | -0.79 | 0.11 | 0.21 | FALSE |