Best TWAS P=7.4e-14 · Best GWAS P=2.08e-18 conditioned to 2.52e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | USP53 | 0.16 | 0.13 | lasso | 11 | 0.20 | 3.5e-23 | 5.2 | 6.0 | 1.7e-09 | -0.18 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-33B1.1 | 0.23 | 0.10 | lasso | 12 | 0.18 | 4.7e-15 | 5.0 | 6.0 | 1.5e-09 | -0.24 | 0.99 | 0.01 | FALSE |
3 | GTEx | Adrenal Gland | RP11-33B1.1 | 0.13 | 0.07 | enet | 25 | 0.09 | 5.5e-04 | -3.9 | 5.2 | 2.1e-07 | -0.23 | 0.71 | 0.02 | FALSE |
4 | GTEx | Artery Coronary | RP11-33B1.4 | 0.10 | 0.02 | lasso | 2 | 0.01 | 1.5e-01 | -5.6 | -5.7 | 9.9e-09 | 0.40 | 0.22 | 0.10 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | USP53 | 0.13 | 0.01 | lasso | 5 | 0.02 | 8.8e-02 | -5.6 | 5.8 | 5.4e-09 | -0.37 | 0.12 | 0.09 | FALSE |
6 | GTEx | Liver | RP11-33B1.4 | 0.18 | 0.14 | lasso | 6 | 0.12 | 3.2e-04 | -5.9 | 5.3 | 1.3e-07 | -0.31 | 0.72 | 0.04 | FALSE |
7 | GTEx | Nerve Tibial | RP11-33B1.4 | 0.21 | 0.10 | lasso | 7 | 0.12 | 6.2e-09 | -5.8 | 7.1 | 1.2e-12 | -0.05 | 0.76 | 0.01 | TRUE |
8 | GTEx | Ovary | RP11-33B1.1 | 0.26 | 0.07 | enet | 33 | 0.16 | 1.2e-04 | 5.2 | 7.5 | 7.4e-14 | -0.41 | 0.21 | 0.29 | TRUE |
9 | GTEx | Pancreas | RP11-33B1.1 | 0.13 | 0.18 | lasso | 5 | 0.18 | 4.7e-08 | -3.9 | 5.2 | 2.4e-07 | -0.28 | 0.99 | 0.00 | FALSE |
10 | GTEx | Pancreas | RP11-33B1.4 | 0.20 | 0.05 | lasso | 16 | 0.05 | 3.8e-03 | -5.5 | 6.2 | 5.0e-10 | -0.45 | 0.68 | 0.04 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | RP11-33B1.4 | 0.12 | 0.01 | lasso | 6 | 0.01 | 4.7e-02 | -5.8 | 7.0 | 2.3e-12 | -0.05 | 0.20 | 0.03 | FALSE |
12 | GTEx | Small Intestine Terminal Ileum | RP11-33B1.1 | 0.15 | 0.10 | lasso | 19 | 0.09 | 5.4e-03 | -3.9 | 5.2 | 2.6e-07 | -0.26 | 0.22 | 0.06 | FALSE |
13 | GTEx | Spleen | RP11-33B1.1 | 0.22 | 0.03 | enet | 17 | 0.02 | 7.7e-02 | 5.2 | 5.2 | 1.5e-07 | -0.20 | 0.17 | 0.05 | FALSE |
14 | GTEx | Testis | RP11-33B1.4 | 0.23 | 0.31 | enet | 16 | 0.37 | 1.5e-17 | -3.9 | 5.8 | 5.6e-09 | -0.35 | 1.00 | 0.00 | FALSE |
15 | GTEx | Thyroid | PDE5A | 0.09 | 0.04 | lasso | 3 | 0.04 | 6.9e-04 | 6.2 | 5.9 | 4.1e-09 | 0.00 | 0.27 | 0.04 | FALSE |
16 | GTEx | Thyroid | RP11-33B1.4 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.8e-04 | -5.9 | 6.2 | 4.4e-10 | -0.28 | 0.72 | 0.10 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | FABP2 | 0.24 | 0.20 | lasso | 9 | 0.25 | 1.8e-14 | 5.3 | -6.0 | 1.4e-09 | 0.22 | 0.06 | 0.94 | FALSE |
18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SEC24D | 0.06 | 0.00 | blup | 86 | 0.02 | 3.1e-03 | -3.9 | -5.4 | 6.2e-08 | 0.05 | 0.01 | 0.67 | TRUE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | USP53 | 0.25 | 0.05 | lasso | 5 | 0.08 | 6.5e-09 | -4.6 | 6.1 | 1.1e-09 | 0.01 | 0.63 | 0.30 | FALSE |
20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SEC24D | 0.06 | 0.02 | enet | 9 | 0.03 | 8.9e-05 | -4.3 | -5.1 | 3.0e-07 | 0.05 | 0.02 | 0.84 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | USP53 | 0.11 | 0.03 | blup | 88 | 0.07 | 5.8e-07 | 5.1 | 6.2 | 4.4e-10 | -0.13 | 0.51 | 0.42 | FALSE |