Best TWAS P=8.01e-12 · Best GWAS P=4.22e-10 conditioned to 0.336
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | DAP | 0.25 | 0.09 | enet | 24 | 0.24 | 2.2e-19 | 3.4 | -6.0 | 2.2e-09 | 0.55 | 0.22 | 0.78 | FALSE |
2 | GTEx | Adipose Visceral Omentum | DAP | 0.21 | 0.07 | enet | 26 | 0.09 | 1.4e-05 | 3.4 | -6.4 | 1.8e-10 | 0.59 | 0.04 | 0.94 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | DAP | 0.34 | 0.14 | lasso | 8 | 0.26 | 6.5e-09 | 3.1 | -5.3 | 1.0e-07 | 0.55 | 0.04 | 0.96 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | DAP | 0.31 | 0.19 | lasso | 5 | 0.26 | 1.4e-19 | 3.7 | -6.3 | 2.8e-10 | 0.63 | 0.39 | 0.60 | FALSE |
5 | GTEx | Colon Transverse | DAP | 0.35 | 0.16 | lasso | 6 | 0.18 | 4.5e-09 | 3.4 | -6.0 | 1.8e-09 | 0.64 | 0.02 | 0.97 | FALSE |
6 | GTEx | Esophagus Mucosa | DAP | 0.16 | 0.05 | enet | 16 | 0.18 | 3.8e-12 | -6.2 | -6.5 | 6.4e-11 | 0.76 | 0.00 | 1.00 | FALSE |
7 | GTEx | Esophagus Muscularis | DAP | 0.27 | 0.15 | lasso | 8 | 0.24 | 5.6e-15 | 3.4 | -5.5 | 3.8e-08 | 0.70 | 0.01 | 0.99 | FALSE |
8 | GTEx | Heart Atrial Appendage | DAP | 0.26 | 0.08 | lasso | 4 | 0.17 | 4.0e-08 | -6.2 | -6.6 | 3.0e-11 | 0.79 | 0.00 | 1.00 | FALSE |
9 | GTEx | Lung | DAP | 0.32 | 0.21 | lasso | 3 | 0.26 | 1.2e-19 | -6.2 | -6.4 | 1.8e-10 | 0.89 | 0.00 | 1.00 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | DAP | 0.21 | 0.11 | lasso | 5 | 0.16 | 3.9e-13 | 3.4 | -5.9 | 2.8e-09 | 0.60 | 0.21 | 0.79 | FALSE |
11 | METSIM | Adipose | DAP | 0.13 | 0.03 | bslmm | 662 | 0.06 | 1.7e-09 | -6.2 | -6.4 | 1.5e-10 | 0.79 | 0.00 | 1.00 | FALSE |
12 | NTR | Blood | DAP | 0.03 | 0.01 | enet | 19 | 0.02 | 2.2e-06 | 3.1 | -5.6 | 2.4e-08 | 0.64 | 0.05 | 0.95 | FALSE |
13 | YFS | Blood | DAP | 0.35 | 0.19 | lasso | 8 | 0.27 | 1.3e-88 | -6.2 | -6.8 | 8.0e-12 | 0.84 | 0.00 | 1.00 | TRUE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | DAP | 0.03 | 0.02 | lasso | 3 | 0.02 | 6.0e-03 | 3.4 | -5.8 | 6.4e-09 | 0.55 | 0.05 | 0.89 | FALSE |