Best TWAS P=1.75e-42 · Best GWAS P=9.46e-119 conditioned to 2.4e-84
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NPR3 | 0.07 | 0.02 | bslmm | 470 | 0.02 | 2.2e-03 | -16.5 | 13.7 | 1.8e-42 | 0.36 | 0.07 | 0.60 | TRUE |
| 2 | GTEx | Artery Aorta | DROSHA | 0.35 | 0.06 | lasso | 8 | 0.10 | 6.2e-06 | 9.1 | -9.0 | 3.5e-19 | 0.05 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | DROSHA | 0.20 | 0.11 | lasso | 4 | 0.09 | 1.7e-07 | 9.1 | -9.1 | 6.1e-20 | 0.03 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Colon Transverse | DROSHA | 0.26 | 0.07 | enet | 3 | 0.03 | 8.9e-03 | -5.5 | -5.4 | 6.4e-08 | -0.03 | 0.12 | 0.57 | FALSE |
| 5 | GTEx | Esophagus Muscularis | DROSHA | 0.24 | 0.09 | enet | 44 | 0.13 | 1.9e-08 | 9.1 | -7.0 | 3.2e-12 | 0.01 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | CTD-2203K17.1 | 0.25 | 0.17 | enet | 47 | 0.20 | 1.4e-09 | 3.2 | -8.1 | 4.9e-16 | -0.06 | 0.92 | 0.01 | FALSE |
| 7 | GTEx | Nerve Tibial | DROSHA | 0.39 | 0.22 | enet | 34 | 0.22 | 7.9e-16 | -5.5 | -6.1 | 9.3e-10 | 0.01 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | DROSHA | 0.26 | 0.11 | enet | 15 | 0.09 | 8.1e-06 | -5.5 | -6.7 | 1.6e-11 | 0.00 | 0.08 | 0.92 | FALSE |
| 9 | GTEx | Thyroid | DROSHA | 0.27 | 0.23 | lasso | 5 | 0.22 | 4.5e-17 | -5.5 | -5.3 | 9.7e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Vagina | CTD-2203K17.1 | 0.27 | 0.22 | enet | 18 | 0.19 | 3.5e-05 | 3.2 | -7.0 | 1.9e-12 | -0.11 | 0.16 | 0.13 | FALSE |
| 11 | METSIM | Adipose | DROSHA | 0.26 | 0.14 | enet | 37 | 0.24 | 1.3e-35 | -5.5 | -5.8 | 5.2e-09 | -0.01 | 1.00 | 0.00 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | TARS | 0.10 | 0.05 | lasso | 6 | 0.08 | 3.7e-10 | -6.1 | 10.1 | 4.1e-24 | 0.03 | 1.00 | 0.00 | TRUE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C5orf22 | 0.09 | 0.03 | blup | 64 | 0.06 | 6.1e-07 | -3.2 | 5.6 | 2.2e-08 | -0.06 | 0.06 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MTMR12 | 0.10 | 0.00 | blup | 49 | 0.04 | 1.0e-04 | -4.9 | -6.6 | 3.5e-11 | 0.01 | 0.01 | 0.25 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNASEN | 0.06 | 0.01 | blup | 151 | 0.03 | 6.9e-04 | 9.1 | -5.7 | 1.1e-08 | 0.04 | 0.00 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | GOLPH3 | 0.05 | 0.03 | blup | 44 | 0.02 | 3.3e-03 | -6.7 | -7.1 | 1.6e-12 | -0.03 | 0.00 | 0.97 | TRUE |