Best TWAS P=6.8e-27 · Best GWAS P=2.02e-108 conditioned to 1.93e-100
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BNIP1 | 0.18 | 0.20 | lasso | 3 | 0.20 | 7.5e-24 | -5.7 | 5.7 | 1.3e-08 | -0.04 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | BNIP1 | 0.19 | 0.07 | enet | 10 | 0.12 | 2.5e-10 | -5.8 | 6.6 | 3.1e-11 | -0.04 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Aorta | BNIP1 | 0.18 | 0.17 | lasso | 5 | 0.14 | 4.3e-08 | -5.8 | 5.7 | 1.0e-08 | -0.04 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Tibial | BNIP1 | 0.18 | 0.08 | lasso | 5 | 0.13 | 2.1e-10 | -5.7 | 6.5 | 9.3e-11 | -0.03 | 1.00 | 0.00 | FALSE |
5 | GTEx | Brain Cortex | BNIP1 | 0.35 | 0.31 | lasso | 5 | 0.29 | 9.8e-09 | -5.7 | 5.7 | 1.3e-08 | -0.04 | 0.93 | 0.00 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | BNIP1 | 0.25 | 0.18 | enet | 12 | 0.18 | 2.0e-13 | -5.7 | 6.5 | 6.4e-11 | -0.04 | 1.00 | 0.00 | FALSE |
7 | GTEx | Colon Transverse | BNIP1 | 0.20 | 0.03 | enet | 27 | 0.00 | 4.5e-01 | -5.7 | 7.4 | 1.3e-13 | 0.02 | 0.22 | 0.04 | FALSE |
8 | GTEx | Esophagus Mucosa | BNIP1 | 0.24 | 0.14 | lasso | 8 | 0.14 | 1.2e-09 | -5.7 | 5.8 | 5.5e-09 | -0.05 | 1.00 | 0.00 | FALSE |
9 | GTEx | Esophagus Muscularis | BNIP1 | 0.23 | 0.18 | lasso | 6 | 0.18 | 7.1e-11 | -5.7 | 5.9 | 3.7e-09 | -0.04 | 1.00 | 0.00 | FALSE |
10 | GTEx | Lung | BNIP1 | 0.13 | 0.11 | lasso | 2 | 0.12 | 8.6e-10 | -5.8 | 7.6 | 2.7e-14 | -0.03 | 0.99 | 0.00 | FALSE |
11 | GTEx | Nerve Tibial | BNIP1 | 0.18 | 0.05 | lasso | 6 | 0.10 | 1.5e-07 | -5.7 | 8.5 | 2.1e-17 | -0.03 | 0.96 | 0.00 | TRUE |
12 | GTEx | Pancreas | SH3PXD2B | 0.19 | 0.00 | enet | 20 | 0.00 | 3.1e-01 | -6.7 | 6.5 | 1.1e-10 | -0.04 | 0.09 | 0.08 | TRUE |
13 | GTEx | Prostate | STK10 | 0.33 | -0.01 | enet | 77 | 0.04 | 2.8e-02 | 2.8 | -6.0 | 2.3e-09 | -0.01 | 0.07 | 0.05 | TRUE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | BNIP1 | 0.24 | 0.12 | lasso | 6 | 0.10 | 6.8e-06 | -5.8 | 6.0 | 1.8e-09 | -0.04 | 0.93 | 0.00 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | BNIP1 | 0.24 | 0.13 | lasso | 8 | 0.15 | 2.0e-12 | -5.8 | 5.9 | 3.0e-09 | -0.04 | 1.00 | 0.00 | TRUE |
16 | GTEx | Thyroid | BNIP1 | 0.18 | 0.11 | lasso | 7 | 0.10 | 5.1e-08 | -5.8 | 5.9 | 3.2e-09 | -0.04 | 1.00 | 0.00 | FALSE |
17 | GTEx | Whole Blood | BNIP1 | 0.09 | 0.05 | lasso | 4 | 0.04 | 1.9e-04 | -5.7 | 5.7 | 1.3e-08 | -0.04 | 0.51 | 0.10 | FALSE |
18 | METSIM | Adipose | BNIP1 | 0.08 | 0.05 | lasso | 15 | 0.07 | 6.8e-11 | -5.7 | 5.3 | 9.3e-08 | 0.00 | 1.00 | 0.00 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | BNIP1 | 0.28 | 0.29 | lasso | 9 | 0.29 | 3.3e-37 | -5.7 | 6.2 | 5.2e-10 | -0.04 | 1.00 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | BNIP1 | 0.10 | 0.09 | lasso | 4 | 0.06 | 3.6e-06 | -5.8 | 6.2 | 5.2e-10 | -0.03 | 0.96 | 0.03 | FALSE |
21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | BNIP1 | 0.12 | 0.08 | lasso | 2 | 0.08 | 2.6e-15 | -5.7 | 5.7 | 1.1e-08 | -0.04 | 1.00 | 0.00 | FALSE |
22 | The Cancer Genome Atlas | Colon Adenocarcinoma | BNIP1 | 0.15 | 0.11 | blup | 49 | 0.11 | 5.6e-07 | -5.7 | 7.1 | 1.2e-12 | -0.03 | 0.69 | 0.21 | FALSE |
23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BNIP1 | 0.14 | 0.09 | lasso | 1 | 0.07 | 9.1e-09 | -5.7 | 5.7 | 1.5e-08 | -0.04 | 1.00 | 0.00 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BNIP1 | 0.13 | 0.11 | lasso | 8 | 0.10 | 9.7e-12 | -5.7 | 5.5 | 3.6e-08 | -0.04 | 1.00 | 0.00 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC285593 | 0.09 | 0.02 | blup | 85 | 0.04 | 9.0e-06 | -3.3 | -6.5 | 9.9e-11 | 0.05 | 0.63 | 0.05 | TRUE |
26 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BNIP1 | 0.07 | 0.05 | enet | 7 | 0.04 | 2.2e-03 | -5.7 | 5.9 | 4.1e-09 | -0.04 | 0.09 | 0.12 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BNIP1 | 0.25 | 0.13 | enet | 9 | 0.15 | 1.6e-16 | -5.7 | 5.2 | 2.4e-07 | -0.03 | 1.00 | 0.00 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC285593 | 0.18 | 0.13 | enet | 12 | 0.13 | 5.3e-15 | -9.9 | -10.7 | 6.8e-27 | 0.06 | 1.00 | 0.00 | TRUE |
29 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BNIP1 | 0.11 | 0.03 | blup | 49 | 0.09 | 3.3e-05 | -5.7 | 7.0 | 2.6e-12 | -0.01 | 0.03 | 0.93 | FALSE |
30 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BNIP1 | 0.11 | 0.09 | lasso | 2 | 0.08 | 1.1e-09 | -5.7 | 5.7 | 1.3e-08 | -0.04 | 1.00 | 0.00 | FALSE |
31 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ATP6V0E1 | 0.08 | 0.00 | blup | 59 | 0.02 | 2.4e-02 | 7.6 | -6.0 | 1.9e-09 | 0.01 | 0.01 | 0.36 | FALSE |
32 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NPM1 | 0.04 | 0.03 | blup | 50 | 0.03 | 2.6e-03 | -1.4 | 6.9 | 6.1e-12 | 0.00 | 0.15 | 0.03 | TRUE |
33 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BNIP1 | 0.32 | 0.18 | lasso | 4 | 0.16 | 4.5e-07 | -5.7 | 5.7 | 1.4e-08 | -0.04 | 0.96 | 0.00 | FALSE |
34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BNIP1 | 0.28 | 0.15 | lasso | 7 | 0.16 | 4.9e-16 | -5.7 | 5.3 | 1.1e-07 | -0.04 | 1.00 | 0.00 | FALSE |
35 | The Cancer Genome Atlas | Stomach Adenocarcinoma | BNIP1 | 0.06 | 0.04 | enet | 6 | 0.01 | 3.0e-02 | -5.7 | 5.3 | 1.1e-07 | -0.05 | 0.04 | 0.16 | FALSE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | BNIP1 | 0.32 | 0.24 | blup | 49 | 0.26 | 3.7e-25 | -5.7 | 6.9 | 6.6e-12 | -0.03 | 1.00 | 0.00 | FALSE |
37 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC285593 | 0.21 | 0.09 | lasso | 5 | 0.13 | 5.6e-13 | -9.9 | -8.1 | 7.7e-16 | 0.05 | 0.96 | 0.03 | TRUE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | NPM1 | 0.10 | 0.09 | blup | 50 | 0.10 | 4.1e-10 | -1.5 | 5.7 | 9.1e-09 | 0.00 | 1.00 | 0.00 | FALSE |