Best TWAS P=7.49e-100 · Best GWAS P=9.07e-180 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HACE1 | 0.14 | 0.10 | enet | 28 | 0.11 | 8.9e-14 | 6.84 | -11.0 | 3.0e-28 | -0.42 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | 22.73 | 21.2 | 7.5e-100 | 0.74 | 0.16 | 0.83 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | POPDC3 | 0.06 | 0.03 | bslmm | 386 | 0.02 | 1.0e-03 | 6.04 | -12.1 | 1.3e-33 | -0.31 | 0.19 | 0.09 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | HACE1 | 0.36 | 0.43 | enet | 19 | 0.39 | 5.8e-11 | 6.65 | -7.6 | 2.9e-14 | -0.30 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | HACE1 | 0.28 | 0.28 | enet | 16 | 0.26 | 3.6e-08 | 6.65 | -7.8 | 4.5e-15 | -0.31 | 0.98 | 0.00 | TRUE |
| 6 | GTEx | Brain Frontal Cortex BA9 | HACE1 | 0.25 | 0.21 | enet | 22 | 0.18 | 1.7e-05 | 6.65 | -7.0 | 3.2e-12 | -0.31 | 0.52 | 0.08 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | BVES | 0.07 | 0.01 | lasso | 3 | 0.01 | 1.4e-01 | 3.60 | 7.2 | 4.5e-13 | 0.26 | 0.04 | 0.13 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | HACE1 | 0.40 | 0.15 | lasso | 8 | 0.22 | 1.1e-07 | 9.27 | -10.9 | 1.9e-27 | -0.43 | 0.76 | 0.14 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | HACE1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | 3.38 | -8.5 | 1.7e-17 | -0.34 | 0.09 | 0.44 | TRUE |
| 10 | GTEx | Esophagus Mucosa | HACE1 | 0.17 | 0.03 | lasso | 6 | 0.04 | 9.6e-04 | -2.40 | -7.4 | 1.8e-13 | -0.28 | 0.65 | 0.07 | TRUE |
| 11 | GTEx | Lung | HACE1 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.2e-01 | -0.99 | -15.3 | 7.0e-53 | -0.56 | 0.06 | 0.22 | TRUE |
| 12 | GTEx | Thyroid | HACE1 | 0.08 | 0.06 | lasso | 4 | 0.04 | 8.9e-04 | 9.27 | -10.0 | 1.2e-23 | -0.35 | 0.26 | 0.04 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | HACE1 | 0.16 | 0.16 | lasso | 5 | 0.16 | 1.4e-20 | 9.27 | -9.0 | 2.8e-19 | -0.36 | 1.00 | 0.00 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | BVES | 0.08 | 0.00 | enet | 26 | 0.05 | 7.3e-07 | 0.47 | 5.2 | 2.4e-07 | 0.26 | 0.15 | 0.10 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HACE1 | 0.05 | 0.01 | blup | 72 | 0.02 | 1.6e-03 | 6.81 | -6.9 | 4.2e-12 | -0.25 | 0.50 | 0.31 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HACE1 | 0.08 | 0.04 | blup | 72 | 0.05 | 1.1e-06 | 3.38 | -5.9 | 3.2e-09 | -0.26 | 0.62 | 0.30 | FALSE |
| 17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HACE1 | 0.17 | 0.03 | enet | 21 | 0.11 | 3.2e-05 | -2.40 | -7.3 | 4.0e-13 | -0.17 | 0.09 | 0.20 | TRUE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HACE1 | 0.04 | 0.03 | lasso | 7 | 0.03 | 3.8e-04 | 6.82 | -6.3 | 2.7e-10 | -0.26 | 0.43 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | HACE1 | 0.09 | 0.03 | enet | 18 | 0.06 | 1.9e-06 | 6.84 | -7.9 | 2.2e-15 | -0.28 | 0.52 | 0.35 | TRUE |