Best TWAS P=6.51e-163 · Best GWAS P=2.5e-164 conditioned to 0.719
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | 26.88 | -27.2 | 6.5e-163 | -0.93 | 0.35 | 0.65 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | HEY2 | 0.15 | 0.20 | lasso | 10 | 0.21 | 6.7e-25 | -11.09 | -11.1 | 1.1e-28 | -0.09 | 0.00 | 1.00 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | HINT3 | 0.08 | 0.02 | enet | 17 | 0.03 | 2.0e-04 | -7.97 | 5.8 | 8.8e-09 | 0.23 | 0.69 | 0.01 | FALSE |
| 4 | GTEx | Artery Coronary | TPD52L1 | 0.31 | -0.01 | enet | 19 | 0.05 | 7.0e-03 | 0.26 | -8.6 | 7.2e-18 | -0.19 | 0.03 | 0.55 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | HINT3 | 0.39 | -0.01 | enet | 16 | 0.08 | 2.2e-03 | -3.68 | -8.4 | 4.6e-17 | -0.17 | 0.13 | 0.06 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | ECHDC1 | 0.22 | 0.07 | lasso | 5 | 0.08 | 1.2e-03 | -4.52 | 5.5 | 3.4e-08 | 0.07 | 0.52 | 0.03 | FALSE |
| 7 | GTEx | Esophagus Muscularis | HINT3 | 0.08 | 0.00 | enet | 14 | 0.00 | 2.9e-01 | 10.50 | -9.5 | 1.4e-21 | -0.13 | 0.07 | 0.04 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | 26.50 | -14.7 | 3.9e-49 | -0.66 | 0.04 | 0.24 | FALSE |
| 9 | GTEx | Pancreas | HEY2 | 0.28 | 0.11 | lasso | 3 | 0.10 | 3.5e-05 | -9.45 | -9.9 | 4.8e-23 | -0.07 | 0.14 | 0.86 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | HINT3 | 0.08 | 0.01 | lasso | 4 | 0.03 | 2.0e-03 | -8.12 | -10.9 | 1.1e-27 | -0.22 | 0.22 | 0.14 | FALSE |
| 11 | GTEx | Testis | NCOA7 | 0.18 | 0.03 | enet | 16 | 0.09 | 7.5e-05 | -6.03 | 6.4 | 1.2e-10 | -0.03 | 0.14 | 0.04 | FALSE |
| 12 | GTEx | Testis | HEY2 | 0.31 | 0.17 | lasso | 5 | 0.19 | 7.4e-09 | -10.74 | -10.7 | 1.6e-26 | -0.10 | 0.02 | 0.98 | FALSE |
| 13 | GTEx | Thyroid | HEY2 | 0.22 | 0.24 | lasso | 6 | 0.23 | 1.0e-17 | -10.74 | -11.1 | 1.2e-28 | -0.10 | 0.03 | 0.97 | FALSE |
| 14 | GTEx | Vagina | CENPW | 0.24 | -0.01 | lasso | 8 | -0.01 | 7.9e-01 | 9.05 | 11.4 | 5.5e-30 | 0.39 | 0.04 | 0.07 | FALSE |
| 15 | METSIM | Adipose | CENPW | 0.02 | 0.02 | blup | 189 | 0.01 | 8.3e-03 | 26.50 | -18.3 | 8.2e-75 | -0.71 | 0.07 | 0.26 | FALSE |
| 16 | METSIM | Adipose | HEY2 | 0.02 | 0.04 | lasso | 1 | 0.02 | 1.6e-04 | -9.37 | -9.4 | 7.1e-21 | -0.06 | 0.03 | 0.97 | FALSE |
| 17 | METSIM | Adipose | NCOA7 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.9e-07 | 9.73 | 13.9 | 1.1e-43 | 0.25 | 0.95 | 0.03 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | HEY2 | 0.10 | 0.12 | enet | 15 | 0.13 | 9.8e-17 | 10.39 | -10.8 | 5.3e-27 | -0.08 | 0.03 | 0.97 | FALSE |
| 19 | YFS | Blood | RNF146 | 0.01 | 0.00 | bslmm | 323 | 0.00 | 4.8e-02 | 4.19 | -6.7 | 2.1e-11 | 0.04 | 0.05 | 0.02 | TRUE |
| 20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf174 | 0.02 | 0.02 | lasso | 4 | 0.02 | 3.0e-05 | 5.40 | -5.7 | 9.4e-09 | 0.01 | 0.06 | 0.84 | FALSE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HINT3 | 0.04 | 0.02 | enet | 7 | 0.02 | 2.6e-05 | -6.03 | -8.5 | 2.3e-17 | -0.01 | 0.87 | 0.01 | TRUE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRMT11 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.3e-07 | -8.13 | 8.1 | 4.2e-16 | 0.25 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C6orf174 | 0.03 | 0.01 | blup | 79 | 0.02 | 4.1e-03 | -5.16 | -5.5 | 3.2e-08 | 0.05 | 0.03 | 0.37 | FALSE |
| 24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | 26.65 | -25.4 | 5.3e-142 | -0.90 | 0.02 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HEY2 | 0.05 | 0.05 | blup | 36 | 0.05 | 4.9e-06 | -9.45 | -7.6 | 2.8e-14 | -0.04 | 0.10 | 0.89 | FALSE |
| 26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | 26.55 | -25.6 | 1.1e-144 | -0.91 | 0.03 | 0.97 | FALSE |
| 27 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C6orf174 | 0.06 | 0.00 | blup | 78 | 0.02 | 3.0e-02 | 5.99 | -5.5 | 3.8e-08 | 0.00 | 0.01 | 0.78 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf174 | 0.03 | 0.01 | blup | 80 | 0.00 | 9.1e-02 | 4.03 | -5.2 | 2.3e-07 | 0.02 | 0.03 | 0.52 | FALSE |
| 29 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HEY2 | 0.09 | 0.06 | lasso | 8 | 0.06 | 2.3e-03 | -9.45 | -8.6 | 7.3e-18 | -0.05 | 0.03 | 0.80 | FALSE |
| 30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT11 | 0.03 | 0.00 | blup | 33 | 0.01 | 1.3e-02 | -8.22 | 7.3 | 2.5e-13 | 0.22 | 0.02 | 0.84 | TRUE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | HEY2 | 0.03 | 0.04 | lasso | 3 | 0.02 | 3.8e-03 | 8.59 | -9.0 | 1.5e-19 | -0.10 | 0.01 | 0.98 | FALSE |
| 32 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0408 | 0.07 | 0.08 | blup | 50 | 0.08 | 2.1e-08 | 5.40 | -5.7 | 1.6e-08 | -0.03 | 0.00 | 1.00 | FALSE |