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chr6:129,235,633-134,100,937

Best TWAS P=3.71e-176 · Best GWAS P=1.28e-158 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARHGAP18	0.13	0.07	lasso	2	0.06	6.3e-08	-5.6	-5.7	9.6e-09	-0.11	0.99	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TMEM200A	0.04	0.03	lasso	3	0.03	9.4e-05	5.2	-5.2	2.5e-07	-0.24	0.81	0.01	TRUE
3	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	26.8	27.5	1.4e-166	0.94	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	26.8	27.9	9.9e-172	0.94	0.00	1.00	FALSE
5	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	26.8	27.6	8.5e-168	0.97	0.00	1.00	FALSE
6	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	26.8	27.4	1.0e-164	0.97	0.00	1.00	FALSE
7	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	26.8	27.2	3.2e-163	0.94	0.00	0.98	FALSE
8	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	26.8	26.9	2.6e-159	0.94	0.01	0.96	FALSE
9	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	20.3	27.1	1.5e-161	0.93	0.01	0.98	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	23.0	27.1	2.2e-161	0.90	0.01	0.97	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	26.8	26.8	4.0e-158	0.85	0.01	0.97	FALSE
12	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	26.8	27.1	6.8e-162	0.88	0.00	1.00	FALSE
13	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	26.8	27.4	4.6e-165	0.99	0.00	1.00	FALSE
14	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	23.0	26.9	8.3e-159	0.93	0.00	1.00	FALSE
15	GTEx	Esophagus Muscularis	MOXD1	0.22	0.08	lasso	5	0.15	2.8e-09	4.4	-7.2	6.7e-13	0.02	0.17	0.82	TRUE
16	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	26.8	28.0	5.7e-173	0.96	0.00	1.00	FALSE
17	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	26.8	27.8	2.1e-170	0.93	0.00	1.00	FALSE
18	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	26.8	27.8	9.7e-170	0.99	0.00	1.00	FALSE
19	GTEx	Ovary	MOXD1	0.57	-0.01	lasso	9	0.05	1.8e-02	2.5	6.1	1.0e-09	0.00	0.11	0.06	TRUE
20	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	26.8	27.9	2.0e-171	0.98	0.00	1.00	FALSE
21	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	20.3	24.0	2.9e-127	0.85	0.00	0.99	TRUE
22	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	20.3	20.5	2.7e-93	0.78	0.01	0.98	FALSE
23	GTEx	Prostate	SLC18B1	0.38	-0.01	enet	16	0.01	1.7e-01	-3.3	-6.2	6.4e-10	0.05	0.09	0.12	FALSE
24	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	26.8	27.1	5.1e-162	0.97	0.00	0.99	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	AKAP7	0.24	0.07	lasso	5	0.17	8.7e-10	-8.7	8.4	3.5e-17	-0.04	0.71	0.07	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	21.9	26.7	1.3e-157	0.92	0.00	1.00	TRUE
27	GTEx	Skin Sun Exposed Lower leg	AKAP7	0.25	0.08	enet	17	0.12	3.2e-10	-8.7	7.1	1.2e-12	-0.10	0.98	0.00	FALSE
28	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	26.8	26.9	1.4e-159	0.97	0.00	1.00	FALSE
29	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	26.8	27.7	1.5e-168	0.98	0.00	0.98	FALSE
30	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	23.0	27.3	1.3e-164	0.87	0.02	0.98	FALSE
31	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	23.0	25.5	4.6e-143	0.82	0.05	0.95	FALSE
32	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	26.1	25.9	5.9e-148	0.77	0.02	0.98	FALSE
33	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	26.1	24.8	4.4e-136	0.73	0.13	0.53	FALSE
34	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	26.8	26.0	6.4e-149	0.90	0.00	1.00	FALSE
35	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	26.8	28.3	3.7e-176	0.95	0.00	1.00	TRUE
36	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	24.2	27.8	1.7e-169	0.91	0.00	1.00	FALSE
37	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	26.8	27.6	8.8e-168	0.98	0.00	1.00	FALSE
38	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	26.8	27.4	1.2e-165	0.97	0.00	1.00	FALSE
39	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	23.0	20.9	3.5e-97	0.72	0.99	0.01	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	EPB41L2	0.12	0.12	blup	522	0.10	6.5e-13	6.0	8.8	1.0e-18	0.00	1.00	0.00	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	26.8	22.6	6.6e-113	0.72	0.00	1.00	TRUE
42	YFS	Blood	ENPP1	0.02	0.00	lasso	1	0.01	3.9e-03	-5.1	5.1	3.0e-07	0.08	0.04	0.02	TRUE
43	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	23.0	22.5	2.9e-112	0.74	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	EYA4	0.03	0.03	enet	8	0.02	5.5e-05	9.4	-9.2	4.7e-20	-0.01	0.01	0.99	TRUE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	L3MBTL3	0.05	0.00	blup	114	0.01	1.0e-02	16.6	8.6	7.5e-18	0.33	0.03	0.22	TRUE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	23.0	20.9	1.3e-96	0.77	0.02	0.87	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC285733	0.22	0.19	enet	9	0.19	3.9e-11	5.4	5.8	6.4e-09	0.00	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	AKAP7	0.23	0.02	enet	16	0.07	3.7e-07	5.6	5.8	6.5e-09	-0.02	0.02	0.86	TRUE