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chr6:154,878,398-156,330,580

Best TWAS P=2.66e-25 · Best GWAS P=3.33e-24 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TFB1M	0.29	0.36	lasso	4	0.37	9.1e-47	-7.38	-7.9	2.8e-15	0.68	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-477D19.2	0.10	0.07	lasso	2	0.05	3.0e-05	-10.06	-10.1	7.9e-24	1.00	0.01	0.99	FALSE
3	GTEx	Adrenal Gland	TFB1M	0.42	0.23	lasso	7	0.28	8.4e-11	-9.25	-8.8	2.1e-18	0.80	0.53	0.47	FALSE
4	GTEx	Adrenal Gland	RP11-477D19.2	0.36	0.34	lasso	6	0.35	2.5e-13	-9.87	-10.2	2.3e-24	0.94	0.01	0.99	FALSE
5	GTEx	Artery Aorta	TFB1M	0.11	0.06	enet	8	0.04	4.5e-03	6.28	-5.8	7.0e-09	0.49	0.18	0.44	FALSE
6	GTEx	Artery Aorta	RP11-477D19.2	0.20	0.00	lasso	10	0.02	2.3e-02	-0.78	-6.6	3.7e-11	0.55	0.02	0.83	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP11-477D19.2	0.56	0.48	lasso	7	0.50	8.6e-15	-9.68	-10.3	1.0e-24	0.97	0.01	0.99	FALSE
8	GTEx	Brain Cerebellum	RP11-477D19.2	0.60	0.52	lasso	5	0.53	3.0e-18	-10.06	-10.1	8.2e-24	1.00	0.01	0.99	FALSE
9	GTEx	Brain Frontal Cortex BA9	TFB1M	0.34	0.23	lasso	8	0.15	7.8e-05	-7.46	-7.5	5.5e-14	0.69	0.13	0.60	FALSE
10	GTEx	Brain Hypothalamus	RP11-477D19.2	0.52	0.26	lasso	6	0.31	6.0e-08	-9.95	-10.1	3.8e-24	0.98	0.02	0.98	FALSE
11	GTEx	Brain Putamen basal ganglia	TFB1M	0.41	0.07	enet	45	0.02	1.3e-01	7.99	-5.6	2.8e-08	0.58	0.04	0.80	FALSE
12	GTEx	Breast Mammary Tissue	RP11-477D19.2	0.19	0.15	lasso	7	0.12	1.3e-06	-10.15	-9.9	3.9e-23	0.99	0.01	0.99	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	TFB1M	0.27	0.19	lasso	2	0.17	3.1e-06	7.77	-8.2	2.7e-16	0.74	0.10	0.83	FALSE
14	GTEx	Cells Transformed fibroblasts	TFB1M	0.17	0.07	enet	21	0.10	6.3e-08	-10.00	-9.8	6.7e-23	0.89	0.01	0.99	FALSE
15	GTEx	Cells Transformed fibroblasts	RP11-477D19.2	0.13	0.07	lasso	2	0.07	1.2e-05	-10.11	-10.2	2.8e-24	1.00	0.01	0.99	FALSE
16	GTEx	Colon Transverse	TFB1M	0.21	0.11	enet	14	0.17	1.6e-08	-9.25	-8.9	4.1e-19	0.79	0.03	0.97	FALSE
17	GTEx	Colon Transverse	RP11-477D19.2	0.21	0.24	lasso	11	0.21	2.3e-10	-10.06	-10.0	1.9e-23	0.94	0.01	0.99	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	TFB1M	0.20	0.05	lasso	3	0.08	1.1e-03	-8.47	-8.5	1.6e-17	0.73	0.03	0.82	FALSE
19	GTEx	Esophagus Mucosa	TFB1M	0.18	0.17	lasso	6	0.14	8.8e-10	-7.38	-7.8	4.5e-15	0.67	0.97	0.03	FALSE
20	GTEx	Esophagus Mucosa	RP11-477D19.2	0.15	0.11	enet	10	0.09	6.9e-07	-10.06	-10.2	3.2e-24	0.98	0.01	0.99	FALSE
21	GTEx	Heart Atrial Appendage	RP11-477D19.2	0.15	0.12	lasso	1	0.10	2.1e-05	-9.25	-9.2	2.2e-20	0.85	0.02	0.96	FALSE
22	GTEx	Heart Left Ventricle	TFB1M	0.27	0.22	lasso	10	0.23	1.4e-12	-7.38	-9.3	1.0e-20	0.80	0.71	0.29	FALSE
23	GTEx	Heart Left Ventricle	RP11-477D19.2	0.19	0.13	lasso	2	0.12	1.0e-06	-9.68	-9.7	2.3e-22	0.91	0.02	0.98	FALSE
24	GTEx	Lung	RP11-477D19.2	0.15	0.01	enet	33	0.01	5.8e-02	-1.90	-6.2	6.1e-10	0.56	0.02	0.93	FALSE
25	GTEx	Nerve Tibial	RP11-477D19.2	0.28	0.17	lasso	6	0.16	1.2e-11	-10.06	-9.5	2.1e-21	0.98	0.01	0.99	FALSE
26	GTEx	Pituitary	RP11-477D19.2	0.45	0.29	lasso	8	0.20	8.4e-06	-10.06	-10.1	4.3e-24	1.00	0.01	0.99	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	RP11-477D19.2	0.24	0.21	enet	21	0.19	7.1e-11	-9.17	-9.8	1.8e-22	0.90	0.02	0.98	FALSE
28	GTEx	Skin Sun Exposed Lower leg	RP11-477D19.2	0.23	0.25	lasso	4	0.25	1.2e-20	-9.96	-10.1	6.4e-24	0.98	0.01	0.99	FALSE
29	GTEx	Spleen	RP11-477D19.2	0.53	0.09	lasso	8	0.17	3.0e-05	-9.25	-7.8	8.2e-15	0.76	0.02	0.88	FALSE
30	GTEx	Stomach	TFB1M	0.19	0.09	enet	14	0.09	2.8e-05	-8.04	-8.2	1.7e-16	0.64	0.23	0.74	FALSE
31	GTEx	Stomach	RP11-477D19.2	0.21	0.17	lasso	5	0.16	7.2e-08	-10.15	-10.4	2.7e-25	0.99	0.01	0.99	TRUE
32	GTEx	Testis	RP11-477D19.2	0.23	0.08	enet	17	0.13	2.5e-06	7.98	-8.9	3.8e-19	0.84	0.02	0.98	FALSE
33	GTEx	Thyroid	TFB1M	0.24	0.09	lasso	6	0.09	2.7e-07	-9.25	-9.2	2.7e-20	0.83	0.37	0.63	FALSE
34	GTEx	Thyroid	RP11-477D19.2	0.29	0.28	lasso	7	0.27	1.1e-20	-9.96	-9.9	2.5e-23	0.94	0.01	0.99	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	TFB1M	0.16	0.18	lasso	5	0.17	2.1e-21	-7.38	-7.3	2.1e-13	0.61	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	RP11-477D19.2	0.26	0.35	lasso	6	0.37	4.7e-50	-10.07	-9.7	2.3e-22	0.97	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TFB1M	0.18	0.12	enet	16	0.16	2.8e-13	-7.46	-6.3	2.4e-10	0.66	0.69	0.31	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLDN20	0.02	0.00	blup	79	0.01	8.0e-03	4.05	7.5	8.2e-14	-0.74	0.03	0.36	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	TFB1M	0.12	0.16	enet	12	0.16	1.4e-31	-7.41	-7.9	3.1e-15	0.67	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TFB1M	0.14	0.10	enet	8	0.09	5.1e-05	-7.46	-8.3	1.1e-16	0.68	0.48	0.33	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	TFB1M	0.22	0.24	enet	19	0.23	1.6e-13	-7.46	-8.7	3.1e-18	0.74	0.92	0.08	FALSE
42	The Cancer Genome Atlas	Esophageal Carcinoma	TFB1M	0.36	0.21	blup	98	0.26	7.6e-09	-7.46	-7.0	1.7e-12	0.55	0.52	0.33	FALSE
43	The Cancer Genome Atlas	Glioblastoma Multiforme	TFB1M	0.25	0.21	lasso	8	0.17	8.8e-06	-7.38	-8.2	3.1e-16	0.69	0.11	0.85	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TFB1M	0.16	0.17	lasso	6	0.19	1.3e-20	-7.38	-8.6	1.0e-17	0.75	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TFB1M	0.05	0.03	blup	96	0.02	7.9e-04	-9.18	-9.2	4.4e-20	0.78	0.04	0.94	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TIAM2	0.05	0.01	blup	265	0.01	7.3e-03	-9.07	-8.5	1.6e-17	0.75	0.03	0.71	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TFB1M	0.11	0.15	lasso	4	0.16	2.3e-09	-7.38	-8.3	1.1e-16	0.71	0.42	0.58	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TIAM2	0.13	0.08	blup	261	0.07	8.5e-05	-9.74	-8.0	1.7e-15	0.79	0.01	0.98	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	TFB1M	0.39	0.30	enet	22	0.34	4.6e-40	-7.38	-7.9	3.0e-15	0.68	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TFB1M	0.06	0.07	lasso	3	0.06	5.8e-04	-8.04	-8.8	1.4e-18	0.79	0.12	0.68	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	TFB1M	0.18	0.19	lasso	9	0.19	1.9e-21	-8.04	-8.1	5.2e-16	0.72	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TFB1M	0.13	0.13	lasso	8	0.11	8.6e-13	-7.38	-7.9	3.4e-15	0.67	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TFB1M	0.18	0.18	blup	96	0.19	4.0e-13	-7.38	-7.5	5.9e-14	0.61	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TFB1M	0.15	0.11	blup	94	0.08	3.2e-04	-9.17	-8.2	2.0e-16	0.75	0.25	0.47	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TFB1M	0.29	0.23	lasso	4	0.27	3.8e-11	-7.38	-7.4	1.5e-13	0.62	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TIAM2	0.13	0.01	blup	266	0.03	3.4e-02	-9.87	-7.7	1.0e-14	0.75	0.02	0.77	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	TFB1M	0.21	0.23	enet	11	0.26	1.8e-26	-7.38	-8.2	2.1e-16	0.69	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	TFB1M	0.28	0.22	lasso	8	0.18	4.1e-05	-7.38	-8.1	5.5e-16	0.69	0.07	0.68	FALSE
59	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TFB1M	0.14	0.04	blup	96	0.05	1.6e-02	-7.38	-7.7	1.0e-14	0.74	0.02	0.34	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	TFB1M	0.16	0.20	enet	9	0.20	1.5e-14	-7.38	-8.9	7.8e-19	0.77	0.96	0.04	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	TFB1M	0.27	0.33	enet	11	0.34	9.0e-34	-7.41	-8.5	2.2e-17	0.73	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TFB1M	0.11	0.00	blup	93	0.06	1.1e-02	-7.46	-9.9	6.0e-23	0.89	0.02	0.65	FALSE