Best TWAS P=7.36e-21 · Best GWAS P=9.25e-89 conditioned to 8.07e-78
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | RGS17 | 0.22 | 0.15 | lasso | 4 | 0.18 | 5.5e-12 | -5.20 | 6.3 | 3.4e-10 | -0.01 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Mucosa | RMND1 | 0.34 | 0.09 | lasso | 6 | 0.19 | 4.8e-13 | 8.34 | -9.0 | 1.9e-19 | -0.01 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Lung | RMND1 | 0.26 | 0.14 | lasso | 7 | 0.15 | 1.7e-11 | 7.99 | -7.9 | 3.1e-15 | -0.03 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Nerve Tibial | RMND1 | 0.25 | 0.04 | lasso | 7 | 0.04 | 4.3e-04 | 7.01 | 5.4 | 5.6e-08 | 0.00 | 0.54 | 0.03 | FALSE |
| 5 | GTEx | Thyroid | RMND1 | 0.17 | 0.12 | lasso | 4 | 0.13 | 2.4e-10 | 7.99 | -8.6 | 1.0e-17 | -0.02 | 0.99 | 0.00 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | SYNE1 | 0.12 | 0.01 | blup | 875 | 0.05 | 6.9e-07 | 0.68 | 6.3 | 2.1e-10 | 0.26 | 0.64 | 0.08 | TRUE |
| 7 | YFS | Blood | RMND1 | 0.06 | 0.06 | lasso | 12 | 0.05 | 6.5e-16 | 8.24 | -8.8 | 1.8e-18 | -0.01 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMND1 | 0.02 | 0.00 | blup | 57 | 0.01 | 3.1e-03 | 5.74 | -7.8 | 8.9e-15 | -0.02 | 0.00 | 0.62 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMND1 | 0.16 | 0.10 | lasso | 7 | 0.12 | 1.6e-06 | 8.24 | -9.0 | 1.5e-19 | -0.02 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMND1 | 0.11 | 0.09 | lasso | 4 | 0.10 | 2.9e-06 | 8.01 | -8.1 | 3.9e-16 | 0.01 | 0.69 | 0.22 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | RMND1 | 0.12 | 0.09 | enet | 9 | 0.10 | 4.2e-04 | 6.99 | -8.4 | 4.0e-17 | -0.03 | 0.08 | 0.28 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RMND1 | 0.07 | 0.06 | blup | 58 | 0.09 | 1.4e-10 | 8.24 | -8.6 | 7.8e-18 | 0.01 | 0.22 | 0.78 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMND1 | 0.09 | 0.10 | lasso | 4 | 0.10 | 1.6e-11 | 7.44 | -8.4 | 5.3e-17 | 0.03 | 0.74 | 0.26 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf211 | 0.05 | 0.03 | lasso | 3 | 0.04 | 6.3e-05 | 6.47 | -7.6 | 2.2e-14 | -0.01 | 0.17 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AKAP12 | 0.12 | 0.02 | blup | 141 | 0.04 | 5.8e-03 | 4.51 | -5.1 | 3.1e-07 | 0.04 | 0.34 | 0.11 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | RMND1 | 0.05 | 0.06 | lasso | 2 | 0.07 | 4.3e-08 | 9.19 | -9.4 | 7.4e-21 | -0.04 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RMND1 | 0.09 | 0.02 | lasso | 6 | 0.03 | 2.3e-04 | 7.99 | -7.8 | 5.4e-15 | 0.00 | 0.54 | 0.26 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RMND1 | 0.07 | 0.02 | enet | 7 | 0.05 | 2.7e-03 | 6.18 | -7.2 | 9.0e-13 | 0.01 | 0.03 | 0.38 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RMND1 | 0.22 | 0.21 | enet | 15 | 0.26 | 2.4e-27 | 7.99 | -7.7 | 2.0e-14 | -0.04 | 0.92 | 0.08 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RMND1 | 0.16 | 0.15 | enet | 7 | 0.09 | 2.7e-03 | 9.19 | -8.5 | 2.5e-17 | -0.04 | 0.00 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMND1 | 0.06 | 0.04 | blup | 57 | 0.06 | 4.9e-05 | 7.99 | -9.1 | 1.4e-19 | -0.03 | 0.03 | 0.88 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RMND1 | 0.19 | 0.06 | blup | 58 | 0.10 | 1.6e-04 | 7.19 | -5.2 | 2.4e-07 | 0.00 | 0.16 | 0.10 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | RMND1 | 0.13 | 0.13 | enet | 6 | 0.14 | 6.6e-14 | 8.15 | -7.8 | 6.1e-15 | 0.01 | 0.92 | 0.08 | FALSE |