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chr7:17,133,294-21,068,214

Best TWAS P=1.84e-27 · Best GWAS P=1.04e-64 conditioned to 3.11e-47

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM196	0.08	0.01	bslmm	554	0.02	1.5e-03	7.1	9.4	4.0e-21	0.05	0.15	0.35	TRUE
2	GTEx	Adipose Subcutaneous	SNX13	0.19	0.16	lasso	2	0.13	1.5e-10	5.8	6.2	4.5e-10	-0.02	0.67	0.33	FALSE
3	GTEx	Adipose Visceral Omentum	SNX13	0.23	0.10	enet	20	0.13	3.5e-07	5.8	5.4	6.8e-08	-0.05	0.76	0.20	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	CTA-293F17.1	0.32	0.26	lasso	5	0.27	7.4e-08	7.2	-7.9	2.1e-15	-0.26	0.13	0.49	TRUE
5	GTEx	Breast Mammary Tissue	SNX13	0.21	0.17	lasso	5	0.17	4.9e-09	5.1	5.2	2.1e-07	0.01	0.92	0.07	FALSE
6	GTEx	Breast Mammary Tissue (Male)	SNX13	0.12	0.06	lasso	2	0.02	9.0e-02	5.1	5.7	1.5e-08	-0.04	0.09	0.14	FALSE
7	GTEx	Breast Mammary Tissue (Female)	TWIST1	0.10	0.10	lasso	3	0.13	1.2e-04	7.3	7.4	1.1e-13	0.03	0.07	0.07	TRUE
8	GTEx	Colon Transverse	SNX13	0.14	0.07	lasso	5	0.07	3.8e-04	-5.8	-7.0	2.5e-12	0.00	0.07	0.84	TRUE
9	GTEx	Nerve Tibial	SNX13	0.11	0.09	lasso	3	0.06	4.8e-05	-6.3	6.2	4.4e-10	-0.02	0.28	0.71	FALSE
10	GTEx	Nerve Tibial	TWISTNB	0.20	0.01	enet	13	0.07	9.4e-06	7.6	10.8	3.1e-27	0.00	0.28	0.27	TRUE
11	GTEx	Skin Not Sun Exposed Suprapubic	CTA-293F17.1	0.21	0.13	lasso	9	0.12	6.5e-07	7.2	-7.8	8.9e-15	-0.24	0.73	0.04	FALSE
12	GTEx	Small Intestine Terminal Ileum	SNX13	0.29	-0.01	enet	33	0.02	1.3e-01	6.3	-5.9	3.2e-09	0.05	0.05	0.46	FALSE
13	GTEx	Testis	SNX13	0.21	0.14	enet	15	0.13	2.0e-06	-6.2	6.6	4.4e-11	-0.02	0.17	0.83	FALSE
14	METSIM	Adipose	SNX13	0.07	0.09	lasso	2	0.09	1.0e-13	5.8	6.5	7.4e-11	-0.03	0.49	0.51	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TWIST1	0.09	0.02	blup	618	0.02	8.5e-04	-7.3	-10.9	1.8e-27	-0.05	0.36	0.03	TRUE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	SNX13	0.15	0.16	lasso	3	0.18	1.7e-10	6.4	-6.6	5.1e-11	-0.02	0.06	0.94	FALSE