Best TWAS P=5.6e-29 · Best GWAS P=9.79e-29 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRIG2 | 0.05 | 0.01 | bslmm | 358 | 0.03 | 1.0e-04 | 1.04 | -6.5 | 1.0e-10 | 0.23 | 0.15 | 0.11 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | -11.05 | -10.3 | 7.1e-25 | 0.93 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | ST7L | 0.33 | 0.32 | enet | 29 | 0.32 | 4.2e-17 | -3.50 | -6.4 | 1.3e-10 | 0.74 | 0.92 | 0.08 | FALSE |
| 4 | GTEx | Artery Aorta | WNT2B | 0.15 | 0.01 | enet | 7 | 0.01 | 1.0e-01 | 6.44 | 6.4 | 1.9e-10 | -0.36 | 0.24 | 0.06 | FALSE |
| 5 | GTEx | Brain Cortex | ST7L | 0.29 | 0.18 | lasso | 5 | 0.20 | 3.1e-06 | -3.50 | -6.8 | 1.4e-11 | 0.71 | 0.07 | 0.85 | FALSE |
| 6 | GTEx | Brain Cortex | WNT2B | 0.36 | 0.19 | lasso | 5 | 0.23 | 5.5e-07 | -11.01 | -10.4 | 2.4e-25 | 0.89 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | WNT2B | 0.29 | 0.28 | lasso | 3 | 0.29 | 2.6e-08 | -11.02 | -10.7 | 1.0e-26 | 0.93 | 0.01 | 0.99 | TRUE |
| 8 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 2.3e-02 | 6.22 | 6.0 | 2.6e-09 | -0.34 | 0.08 | 0.07 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | WNT2B | 0.01 | -0.01 | enet | 24 | 0.00 | 3.4e-01 | -0.19 | 5.8 | 5.9e-09 | -0.34 | 0.03 | 0.10 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | ST7L | 0.25 | 0.08 | enet | 18 | 0.11 | 1.1e-05 | -3.09 | -5.3 | 1.3e-07 | 0.67 | 0.25 | 0.75 | TRUE |
| 11 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 9.4e-04 | 6.26 | 5.9 | 4.1e-09 | -0.31 | 0.56 | 0.02 | TRUE |
| 12 | GTEx | Nerve Tibial | RP4-671G15.2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.9e-05 | 6.33 | -6.4 | 2.0e-10 | 0.36 | 0.92 | 0.03 | TRUE |
| 13 | GTEx | Pituitary | ST7L | 0.31 | 0.18 | lasso | 7 | 0.18 | 3.0e-05 | -7.79 | -9.5 | 3.0e-21 | 0.81 | 0.02 | 0.97 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | SLC16A1 | 0.12 | 0.00 | lasso | 5 | 0.04 | 5.0e-03 | -11.01 | 11.2 | 5.6e-29 | -0.80 | 0.02 | 0.89 | TRUE |
| 15 | GTEx | Skin Sun Exposed Lower leg | MOV10 | 0.05 | 0.02 | lasso | 5 | 0.02 | 1.1e-02 | -11.01 | -10.4 | 1.7e-25 | 0.80 | 0.02 | 0.93 | TRUE |
| 16 | GTEx | Testis | RLIMP2 | 0.35 | 0.00 | enet | 47 | 0.06 | 1.1e-03 | 1.24 | 5.3 | 1.3e-07 | -0.33 | 0.18 | 0.08 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | CAPZA1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.1e-07 | 6.46 | 6.5 | 1.1e-10 | -0.35 | 1.00 | 0.00 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | -11.01 | -10.1 | 3.8e-24 | 0.93 | 0.01 | 0.99 | FALSE |
| 19 | YFS | Blood | MOV10 | 0.07 | 0.04 | blup | 314 | 0.04 | 1.5e-12 | -11.11 | -7.5 | 9.4e-14 | 0.83 | 0.01 | 0.99 | TRUE |
| 20 | The Cancer Genome Atlas | Colon Adenocarcinoma | ST7L | 0.33 | 0.19 | lasso | 3 | 0.21 | 1.7e-12 | -3.50 | -6.5 | 1.1e-10 | 0.71 | 0.90 | 0.10 | FALSE |
| 21 | The Cancer Genome Atlas | Esophageal Carcinoma | PPM1J | 0.18 | 0.02 | blup | 39 | 0.09 | 9.6e-04 | -3.03 | 5.3 | 1.0e-07 | -0.02 | 0.02 | 0.05 | TRUE |
| 22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | 6.68 | 8.6 | 6.5e-18 | -0.60 | 0.03 | 0.44 | FALSE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ST7L | 0.11 | 0.13 | lasso | 7 | 0.12 | 1.5e-07 | -3.50 | -5.8 | 5.8e-09 | 0.70 | 0.42 | 0.58 | TRUE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | MOV10 | 0.06 | 0.06 | lasso | 7 | 0.05 | 9.4e-06 | -8.83 | -10.4 | 2.4e-25 | 0.94 | 0.01 | 0.99 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | 7.33 | 8.5 | 2.5e-17 | -0.43 | 0.23 | 0.09 | TRUE |