TWAS hub - PPM1J

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0210	9.4e-03	0.011	0.008	-0.002	0.011	0.007	1.4e-02	3.2e-02	5.8e-01	0.016	3.7e-02
2	GTEx	Brain Cerebellar Hemisphere	0.4800	0.1520	5.5e-03	-0.003	NA	0.031	NA	0.066	3.8e-01	NA	5.5e-02	NA	9.1e-03
3	GTEx	Ovary	0.4790	0.1190	7.5e-03	-0.003	NA	0.011	NA	0.015	4.0e-01	NA	1.7e-01	NA	1.4e-01
4	GTEx	Pancreas	0.2030	0.0690	2.1e-03	0.015	NA	0.099	NA	0.048	7.2e-02	NA	5.6e-05	NA	4.5e-03
5	TCGA	Breast Invasive Carcinoma	0.0401	0.0176	8.0e-04	-0.001	0.006	0.007	NA	0.002	5.7e-01	1.5e-02	9.9e-03	NA	8.7e-02
6	TCGA	Esophageal Carcinoma	0.1820	0.0810	2.4e-03	0.016	0.088	0.010	NA	0.028	9.6e-02	9.6e-04	1.5e-01	NA	4.5e-02
7	TCGA	Liver Hepatocellular Carcinoma	0.0720	0.0410	4.9e-03	0.024	0.033	0.016	NA	0.029	2.5e-02	1.1e-02	5.5e-02	NA	1.5e-02
8	TCGA	Prostate Adenocarcinoma	0.0952	0.0414	8.5e-04	0.002	0.032	0.008	NA	0.012	1.7e-01	2.6e-04	4.1e-02	NA	1.6e-02
9	TCGA	Thyroid Carcinoma	0.1950	0.0570	3.3e-09	0.057	0.120	0.105	NA	0.096	2.9e-06	9.4e-12	2.0e-10	NA	1.4e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Medication: Blood pressure	4.1	7.8	19.5	4.4	-1.7	-0.2	0.3	3.3	-4.4	4.1	-1.0	0.1
Major Depression (MDD)	3.8	4.6	16.2	-0.0	-1.9	-0.6	-2.9	0.0	0.9	-0.4	-4.0	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	24.1	4.9	-0.5	2.3	-4.1	-1.1	0.4	-3.0	-0.9	-4.3
Chronic bronchitis/emphysema (mother)	3.2	3.8	11.4	0.8	-1.5	0.1	-1.9	-2.9	-0.3	-0.9	-2.6	-3.4
Medication: Amlodipine	3.1	4.3	14.0	1.9	-2.4	-0.3	-0.0	2.9	-2.2	3.7	-0.2	1.4
Diabetes (mother)	3.0	3.8	9.2	-0.7	-3.0	-2.3	-2.4	-0.9	1.1	0.2	-2.5	-2.3
Medication for cholesterol	3.0	4.5	11.7	-2.8	1.9	1.4	-0.6	-2.3	3.4	-3.1	0.5	-0.2
Blood Platelet Count	2.9	33.4	174.2	-0.9	5.2	2.1	-1.2	0.4	6.2	-13.2	3.6	-6.4
Heel T-Score	2.7	21.2	90.2	9.5	1.1	6.2	-4.4	-0.6	-0.5	-4.6	0.1	-4.5
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.0	21.2	4.6	-1.2	1.9	-3.3	-0.2	-0.2	-2.4	-0.6	-3.3
High blood pressure	2.4	6.6	17.0	3.9	-1.5	-0.3	0.9	3.5	-3.3	4.1	0.0	1.2
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	7.8	2.2	1.2	2.8	-0.9	0.4	2.6	-1.9	0.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	6.3	2.1	0.5	1.6	-2.2	-2.1	1.0	-0.4	-1.6	-2.5
Basal cell carcinoma (self-reported)	2.4	2.8	5.9	-0.3	-1.1	0.1	-2.3	-2.4	1.6	-1.4	-1.7	-2.4
Medication: Atenolol	2.2	2.7	8.3	1.0	-2.2	-1.1	0.2	1.4	-2.9	2.6	-0.3	0.4
Time employed in main current job	2.2	2.6	6.7	-1.6	-2.6	-0.4	0.9	-0.6	-1.9	2.4	-1.7	-0.1
Hypertension (Self-reported)	2.2	6.1	15.9	3.9	-1.7	-0.6	0.5	3.1	-3.1	4.0	-0.4	0.9
Myopia	2.2	3.2	13.6	-3.7	0.6	-2.0	1.2	-0.0	2.5	-1.0	1.0	0.9
Forced vital capacity (FVC), Best measure	2.1	7.8	25.7	-1.1	0.6	-0.7	-2.7	-2.1	4.7	-5.1	0.4	-3.0
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	7.7	2.8	-1.4	0.5	-1.0	-1.2	-1.3	1.0	-1.9	-1.7
Glaucoma (self-reported)	2.0	2.4	5.4	-0.1	1.1	0.1	-2.3	-0.9	2.3	-2.3	0.3	-1.9
Shortness of breath walking on level ground	2.0	2.4	9.9	1.4	-3.1	-0.7	-1.3	0.3	-1.0	1.5	-1.9	-0.8
Diastolic blood pressure, automated reading	2.0	6.2	23.5	4.8	2.7	0.1	1.0	2.9	-3.0	1.8	1.7	0.9
Ever used hormone-replacement therapy (HRT)	1.9	2.5	10.7	1.2	-0.9	0.3	1.6	0.2	-3.3	2.4	-0.9	0.1
Mouth/teeth dental problems	1.9	2.9	8.9	0.0	2.3	0.3	2.3	1.7	0.5	-1.2	3.0	1.5
Comparative body size at age 10	1.9	5.4	21.6	0.2	1.7	2.2	-2.0	-0.3	2.1	-4.7	1.0	-3.0
Chest pain or discomfort	1.9	2.8	10.2	1.7	-2.1	-0.9	-3.2	-0.7	1.3	0.1	-1.9	-1.0
Vascular/heart problems diagnosed by doctor	1.9	5.2	14.4	-3.5	1.5	0.2	-0.4	-3.0	2.8	-3.8	0.3	-0.8
HbA1C	1.8	2.0	4.8	-0.8	-1.5	-2.2	0.4	1.6	-1.6	2.0	-0.4	1.1
Number of children fathered	1.8	2.0	6.9	0.6	-0.6	0.2	1.4	2.6	-0.1	0.2	2.2	2.0
Medication: Lisinopril	1.8	2.3	5.0	1.9	-2.1	-0.8	0.6	1.6	-1.6	2.2	-0.8	1.0
Lung FVC	1.7	8.7	30.2	1.6	1.6	0.8	-3.1	-2.0	2.8	-5.5	0.2	-4.7
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	6.9	0.0	-1.9	1.0	0.4	-0.9	-1.5	1.8	-2.6	0.1
Chronic bronchitis/emphysema (father)	1.7	2.0	4.1	0.9	-1.1	1.9	-1.3	-1.5	0.8	-1.2	-2.0	-1.5
Forced vital capacity (FVC)	1.7	6.7	21.9	-1.5	1.4	-0.5	-1.4	-2.4	4.2	-4.7	0.3	-2.9
Breastfed as a baby	1.7	2.1	5.5	0.0	1.2	-1.2	1.9	1.2	-2.3	2.0	0.4	1.0
Eye problems/disorders: None of the above	1.7	2.0	4.3	1.4	-2.1	0.6	0.1	1.5	-1.5	1.6	-1.5	1.4
Medication: Bendroflumethiazide	1.7	2.6	6.2	2.5	0.3	-1.0	-1.0	1.8	-2.0	2.5	-1.1	0.7
Cardiovascular Disease	1.6	5.3	13.5	3.7	-1.0	-1.0	0.8	3.0	-2.6	3.7	0.1	1.5
Past tobacco smoking	1.6	2.9	7.5	-1.8	0.6	0.4	-1.5	-1.8	2.0	-2.3	-0.7	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	14.3	-1.3	0.3	-0.8	-2.2	-1.9	3.8	-3.7	0.3	-2.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	8.6	-2.9	-2.5	-2.4	-1.1	-1.3	1.8	-0.7	-0.3	-0.7
Medication: Omeprazole	1.6	1.9	4.3	1.7	0.1	1.3	-1.7	-1.6	1.1	-0.2	-1.4	-2.1
Age at last live birth	1.6	2.4	9.2	3.0	1.9	1.1	-1.6	-1.3	1.2	-1.0	0.9	-0.1
Leg pain on walking	1.6	2.0	8.4	0.9	-2.9	0.3	-0.2	-0.9	-1.4	1.5	-1.9	-0.2
Body Mass Index (BMI) (2010)	1.5	2.0	3.7	-1.5	-0.1	-1.6	0.7	1.6	1.8	-1.9	1.5	0.8
Systolic Blood Pressure	1.5	7.7	24.8	5.0	0.2	-1.3	0.6	4.0	-3.6	3.2	1.3	0.9
Hearing difficulty/problems with background noise	1.5	2.3	7.5	2.0	-2.7	0.2	-0.4	0.5	-1.6	2.1	-1.2	0.9
Impedance of arm (right)	1.5	6.8	19.8	-0.5	1.0	-0.3	4.0	2.0	-1.1	3.7	2.5	4.5
Number of full sisters	1.5	1.9	7.9	0.0	-0.3	0.2	1.2	2.2	-0.2	0.7	1.4	2.8
Had major operations	1.5	1.7	4.9	-1.2	0.6	-0.5	0.3	1.8	1.0	-0.6	2.2	2.0
Osteoarthritis (self-reported)	1.5	2.0	6.3	0.2	-2.1	0.5	1.3	2.5	-0.3	0.2	0.8	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	11.6	0.4	-0.6	0.7	-1.9	-1.9	1.6	-2.1	-1.1	-3.4
Ever smoked	1.5	2.6	6.1	2.0	-1.2	-0.2	1.0	1.2	-2.0	2.5	0.5	2.4
Ulcerative Colitis	1.4	2.0	6.4	-2.3	0.9	0.4	0.8	0.0	-0.0	-2.0	-0.7	-2.5
Hypothyroidism (self reported)	1.4	3.2	7.3	-2.5	-2.5	-2.7	-1.1	-1.2	1.8	-1.1	-0.8	-1.1
Chronotype (morning person)	1.4	3.2	11.7	-1.3	-0.4	0.6	-1.4	-0.8	3.4	-2.8	-0.3	-1.9
Hand grip strength (left)	1.4	3.8	10.3	-2.5	1.0	-0.5	-1.6	-2.2	3.2	-2.3	-0.5	-1.8
Pulse wave reflection index	1.4	1.7	6.5	2.5	0.4	1.7	-0.8	1.4	0.2	-1.3	1.4	0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	6.6	-0.5	-1.0	1.1	-1.6	-1.3	0.2	0.1	-2.6	-1.8
Exposure to tobacco smoke outside home	1.4	1.9	4.2	0.8	-0.9	-0.1	-1.4	-2.1	1.7	-0.8	-1.5	-1.9
Illnesses of father: High blood pressure	1.4	1.7	3.6	1.9	1.9	1.6	0.6	1.0	-1.3	1.7	-0.3	-0.1
Commuting to job workplace: Cycle	1.4	1.7	4.7	1.2	-1.6	-0.1	1.4	0.7	-2.2	1.6	-0.2	1.0
Neuroticism	1.3	3.3	12.3	-0.0	-1.6	-1.0	1.6	1.3	-2.1	3.5	-0.2	2.2
Hearing difficulty/problems: Yes	1.3	1.9	6.1	2.5	-1.5	-0.3	-0.4	1.5	-0.7	1.8	-0.2	1.7
Systolic blood pressure, automated reading	1.3	3.9	8.4	2.9	0.3	-0.9	1.3	2.9	-2.8	2.2	1.4	1.1
Trunk fat percentage	1.3	5.2	14.3	-2.7	-3.0	-2.9	1.1	1.1	0.7	2.4	-0.4	3.8
Hand grip strength (right)	1.3	3.6	8.4	-2.5	1.4	-0.1	-0.6	-2.2	2.9	-2.6	-0.6	-1.8
High blood pressure (mother)	1.3	1.8	9.8	3.1	-1.2	0.7	-1.2	1.3	0.3	0.7	-0.5	-0.3
Medication: Simvastatin	1.3	2.0	5.1	0.5	1.0	-0.2	1.6	1.2	-1.8	2.3	0.3	1.9
Falls in the last year	1.3	1.8	5.7	0.6	-1.1	0.3	-0.5	-1.7	-1.3	1.7	-2.4	-1.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	12.5	-2.0	1.4	-0.7	-1.0	-2.0	3.3	-3.5	0.3	-2.4
Illnesses of mother	1.3	1.6	5.0	-2.0	2.2	-0.6	1.1	-0.3	0.1	-0.7	1.1	1.3
High blood pressure (siblings)	1.3	1.9	4.2	1.8	-1.5	1.5	-1.1	2.1	-0.4	1.6	-0.8	0.2
Neck or shoulder pain in last month	1.3	1.9	4.0	-0.6	-1.0	-0.6	2.0	0.3	-2.0	1.7	-0.8	2.0
Medication: Blood pressure	1.3	2.4	7.6	2.1	-1.7	-0.8	-0.9	1.4	-1.0	2.8	-0.9	1.0
Medication: Allopurinol	1.3	1.8	4.5	-0.7	0.3	0.9	-1.1	1.7	1.9	-1.3	2.1	0.8
Illnesses of siblings: Diabetes	1.3	1.6	5.7	-0.7	-2.1	-2.4	-1.2	-0.4	-0.0	0.9	-0.4	-1.1
Taking other prescription medications	1.2	1.8	5.3	-1.0	-0.6	-0.9	-1.5	0.5	2.3	-2.3	1.0	-0.1
Age when periods started (menarche)	1.2	2.9	8.5	-1.6	-0.2	-1.9	1.2	0.4	-2.0	2.9	-0.8	2.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.0	2.0	1.1	1.8	-0.7	-0.0	0.7	-1.7	0.9	-0.9
Impedance of arm (left)	1.2	5.4	15.1	-0.6	0.6	-1.0	3.5	1.4	-0.9	3.2	2.5	3.9
Ever highly irritable/argumentative for 2 days	1.2	1.4	5.8	0.2	-2.2	-0.4	-0.7	0.5	2.4	-0.1	-0.9	0.7
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	7.9	-2.0	0.6	-0.1	0.1	-1.2	1.2	-2.8	0.6	-1.3
Emphysema/chronic bronchitis	1.2	1.3	4.3	0.1	0.7	-1.1	-1.4	0.1	2.1	-1.8	-0.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.8	1.4	1.9	1.0	1.4	1.2	-0.6	0.4	0.1	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.1	1.4	-0.2	1.6	1.0	0.5	-1.8	1.3	-0.3	1.6
Mineral and other dietary supplements	1.2	1.7	7.4	-2.7	-1.0	-1.6	1.5	-0.6	-0.3	0.4	-0.8	-0.8
Alcohol drinker status: Previous	1.2	1.3	3.6	-1.9	-1.2	-1.8	-0.9	-0.6	1.5	0.1	-0.3	0.3
Pack years of smoking	1.2	1.7	5.2	-1.0	-1.8	-1.2	-0.1	-0.8	-1.0	1.6	-2.3	-0.4
Alzheimer’s Disease (in father)	1.1	1.2	7.6	2.8	-0.4	1.0	-0.9	0.8	0.3	0.4	0.4	0.2
Coronary Artery Disease (CAD)	1.1	1.3	5.1	1.4	-0.2	-1.2	0.4	0.0	0.8	0.5	1.5	2.2
Fasting Glucose	1.1	1.3	3.2	-0.8	-1.3	-1.0	-0.3	-1.8	-0.5	0.1	-1.8	-1.2
Sensitivity / hurt feelings	1.1	1.9	6.0	0.5	-1.1	-0.2	-0.6	-1.6	-1.6	1.9	-2.4	-0.4
Pack years adult smoking proportion	1.1	1.6	6.1	-0.6	-1.9	-1.0	-0.5	-1.0	-0.8	1.2	-2.5	-0.7
Medication: Levothyroxine sodium	1.1	1.9	7.0	-2.3	-2.6	-1.9	-0.4	-0.2	0.6	0.4	-0.3	0.2
Trunk fat mass	1.1	4.5	10.1	-2.8	-3.2	-3.1	0.3	0.4	1.5	1.4	-0.9	2.9
Number of incorrect matches in round	1.1	1.9	5.8	1.6	-2.4	0.8	-2.3	0.2	0.5	-0.2	-1.1	-1.0
Medication: Lansoprazole	1.1	1.3	4.2	0.5	0.4	0.8	0.2	2.0	-0.3	-0.2	1.4	2.1
Gout (self-reported)	1.1	1.5	4.8	-0.5	-0.3	0.6	-1.4	1.3	2.2	-2.0	1.0	-0.0
Arm fat-free mass (right)	1.1	5.4	11.0	-1.6	-2.4	-2.1	-2.9	-1.4	3.3	-3.1	-1.7	-1.4
Worry too long after embarrassment	1.1	1.8	6.0	0.2	-0.1	-0.5	0.9	1.5	-2.4	2.5	-0.3	0.9
Ever taken oral contraceptive pill	1.1	1.2	3.9	-0.5	0.6	-0.9	0.8	2.0	-1.0	1.0	0.4	1.8
Medication: Paracetamol	1.1	1.7	5.1	1.8	-2.3	0.8	-0.0	1.8	-1.4	-0.1	0.4	1.1
Cholesterol lowering medication	1.1	1.6	4.1	0.8	-0.2	-1.0	1.2	2.0	-1.9	1.6	0.5	0.9
Irritable Bowel Disease (IBD)	1.0	2.4	8.8	-0.9	-0.3	1.2	-0.2	-1.5	0.1	-2.8	-0.6	-3.0
Ovarian Cancer	1.0	1.3	3.9	-0.1	-1.1	-0.5	-2.0	-0.9	0.5	-0.6	-1.4	-1.6
Financial difficulties in last 2 years	1.0	1.4	5.5	-0.1	-0.1	-1.3	-1.4	-0.7	2.3	-1.3	1.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	5.5	1.9	-2.4	-1.3	-0.2	-0.5	-0.5	0.7	-1.3	-0.6
Lung cancer (father)	1.0	1.2	2.4	-0.9	-0.8	-1.6	-0.5	-1.4	1.2	-1.4	-0.2	-1.0
Exposure to tobacco smoke at home	1.0	1.1	3.5	-0.8	-0.9	-1.0	-0.4	0.5	1.7	-1.9	0.3	-0.5
Hair/balding pattern: Pattern 4	1.0	2.4	8.5	-0.9	1.9	-0.3	1.8	-0.3	-2.2	2.9	0.2	0.9
Birth weight	1.0	2.1	7.7	-0.9	-2.8	-1.3	-2.1	-1.0	0.8	-0.8	-0.3	-1.3
Body fat percentage	1.0	4.1	10.8	-2.1	-2.8	-2.5	1.0	0.9	0.6	2.1	-0.7	3.3
Medication: Ibuprofen	1.0	1.2	4.6	0.1	1.3	0.3	2.1	1.3	-1.3	-0.4	0.5	0.8
Arm predicted mass (right)	1.0	5.0	8.8	-1.7	-2.5	-2.1	-2.7	-1.4	3.0	-2.8	-1.9	-1.3
Pulse rate, automated reading	1.0	3.1	12.6	-3.5	1.2	-2.3	1.7	-1.8	-0.4	-0.9	-1.2	-0.4
Suffer from ‘nerves’	1.0	1.6	6.6	1.8	0.7	-0.5	0.1	2.6	-0.1	0.6	0.9	1.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.7	-0.9	0.1	0.7	-1.2	-1.4	1.6	-1.2	-0.8	-0.9
Loneliness, isolation	1.0	1.4	5.7	-0.5	-0.3	-0.4	0.9	1.0	1.1	1.1	1.6	2.4
Friendships satisfaction	1.0	1.3	3.3	-0.1	-0.7	-1.2	1.0	0.8	-0.6	1.7	1.2	1.8
Osteoporosis (self-reported)	1.0	1.2	2.8	-1.3	-0.5	-0.8	1.6	1.2	-0.2	0.6	1.0	1.7
Medication: Aspirin	1.0	1.3	3.6	0.5	-0.6	-1.9	0.4	1.7	-1.3	1.4	-0.3	0.9
Illnesses of father: None of the above (group 1)	1.0	1.3	4.2	-1.7	-0.7	-2.0	-0.7	0.2	1.4	0.1	0.9	0.7
Number of self-reported non-cancer illnesses	1.0	1.7	4.8	0.7	-1.1	-2.2	0.3	2.2	0.2	0.7	1.3	1.1
Guilty feelings	1.0	1.4	6.8	2.6	-0.9	1.2	-1.1	1.5	0.5	0.2	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.6	2.4	1.2	1.2	-1.0	0.7	0.0	-0.4	0.6	1.1
Average weekly beer plus cider intake	1.0	1.5	5.1	0.5	0.8	1.2	0.9	1.9	-0.3	1.3	-0.0	2.3
Ulcerative Colitis (UC)	0.9	1.7	5.7	-1.1	0.5	0.8	1.1	-1.1	0.2	-2.4	-0.1	-2.3
Crohns Disease (2012)	0.9	1.5	3.2	-0.8	-1.1	0.1	-1.6	-1.8	-0.3	-1.0	-1.6	-1.5
Mean Putamen Volume	0.9	1.0	3.9	2.0	-0.2	1.2	0.3	-0.8	-0.7	0.6	-1.5	-0.5
Medication: Co-codamol	0.9	1.0	3.2	0.5	-1.8	0.7	-1.6	-0.0	0.9	-0.7	-0.8	-1.0
Diabetes (father)	0.9	1.1	3.0	-1.3	0.4	-1.1	1.7	0.2	0.2	0.3	1.2	1.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.5	0.6	-1.5	1.6	-0.9	0.5	-0.1	0.8	-1.3	-0.1
Multivitamins +/- minerals	0.9	1.2	4.5	1.3	0.9	2.1	-0.8	-1.3	0.5	-0.2	-0.7	-0.3
Hair/balding pattern: Pattern 2	0.9	1.1	2.4	-0.6	-1.1	-1.6	-1.1	-1.2	0.9	-1.2	-0.4	-0.9
Had menopause	0.9	1.2	3.8	0.1	-0.6	-0.4	1.4	0.6	-1.9	1.6	-0.6	0.9
Medication: Ramipril	0.9	1.2	5.2	1.6	0.8	0.5	-1.0	2.3	0.4	0.1	0.5	0.8
Illnesses of siblings	0.9	1.3	4.2	-1.2	2.0	-0.2	1.6	-1.2	0.4	-0.9	0.8	0.6
Pulse rate	0.9	1.4	6.4	-2.5	-0.7	-1.4	0.9	-1.1	0.4	-0.3	-1.3	-0.3
Mouth/teeth dental problems: Dentures	0.9	1.6	6.1	0.8	-2.5	-0.7	-1.7	-0.8	-0.5	1.1	-1.4	-0.3
Medication: Paracetamol	0.9	1.4	5.2	1.7	-2.3	0.9	-0.7	1.3	-1.2	0.0	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.1	-1.3	-1.0	0.4	-1.3	-0.0	1.8	-1.5	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.3	0.7	-0.7	-1.4	-0.2	0.7	-1.6	1.8	-0.6	0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.9	0.6	0.2	-0.5	0.6	-0.7	-1.2	1.1	-2.2	-1.0
Medication: Aspirin	0.9	1.1	3.2	0.9	-0.2	-1.6	0.4	1.8	-1.1	1.2	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.3	-1.1	0.6	-1.9	-0.8	-0.0	2.3	-1.3	1.8	1.0
Leg fat-free mass (right)	0.9	4.6	8.9	-2.2	-3.0	-3.0	-2.3	-0.3	3.0	-2.1	-0.8	-0.3
Ever had bowel cancer screening	0.9	1.0	4.0	0.9	-1.0	2.0	-0.1	-0.6	-0.5	0.0	-1.4	-1.1
Leg predicted mass (right)	0.9	4.6	9.1	-2.1	-3.0	-3.0	-2.3	-0.3	2.9	-2.1	-0.8	-0.3
Hearing aid user	0.9	1.0	5.3	-0.5	0.9	-2.3	0.2	0.4	0.1	0.2	1.2	1.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.2	0.3	-1.8	-0.0	-0.3	0.7	-0.8	1.8	0.4	1.5
High cholesterol (Self-reported)	0.9	1.6	5.8	1.3	0.3	-0.4	1.2	1.2	-1.3	2.4	-0.3	1.4
Ever depressed for a whole week	0.9	1.1	4.7	2.1	0.5	2.2	0.2	-0.1	0.7	-0.0	-0.5	-0.1
Pain experienced in last month	0.9	1.5	4.8	-0.6	2.2	0.8	0.0	-2.0	0.2	-0.6	0.4	-1.8
Crohns Disease (2017)	0.8	1.8	4.3	-0.3	-1.3	0.8	-1.6	-1.4	0.1	-1.8	-1.2	-2.1
Smoking Status	0.8	1.9	8.6	1.3	-2.9	0.1	-0.9	0.8	0.1	1.6	-0.8	1.6
Relative age of first facial hair	0.8	1.6	5.1	1.4	-2.0	-0.5	-2.3	-0.7	1.1	0.7	-0.9	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	-1.1	-1.1	-0.7	0.9	0.6	-0.9	1.1	-0.9	0.8
Vitamin and mineral supplements	0.8	1.1	4.0	-1.1	-1.9	-2.0	0.2	0.2	-0.6	0.8	-0.6	-0.2
Leg fat-free mass (left)	0.8	4.3	9.2	-2.1	-3.0	-2.6	-2.3	-0.4	2.8	-1.9	-1.2	-0.2
Relative age voice broke	0.8	1.2	3.4	0.8	-1.6	0.3	-1.3	-1.2	-0.2	0.8	-1.8	-0.9
Supplements: Glucosamine	0.8	1.1	3.9	2.0	1.5	1.0	-1.3	-0.1	-0.6	0.3	0.3	0.4
Leg predicted mass (left)	0.8	4.2	8.8	-2.1	-3.0	-2.7	-2.2	-0.4	2.8	-1.9	-1.2	-0.2
Alcohol usually taken with meals	0.8	1.3	6.4	-0.2	0.5	-0.6	-0.4	-1.4	0.7	-1.6	-0.0	-2.5
Arm fat percentage (right)	0.8	3.3	8.1	-1.6	-2.7	-1.8	0.6	1.4	0.0	2.3	-0.5	2.8
Hair/balding pattern: Pattern 3	0.8	1.2	3.4	-0.5	-0.1	0.3	-0.1	1.9	1.6	-0.5	1.7	1.1
Noisy workplace	0.8	0.9	3.0	0.5	-1.2	0.4	-0.0	-0.4	-0.9	1.7	-0.7	1.5
Tense / ‘highly strung’	0.8	1.3	3.1	1.4	0.9	0.4	0.4	1.1	-1.3	1.4	0.7	1.8
Blood clot in the leg (DVT)	0.8	1.0	2.5	-1.1	-0.7	-1.4	0.1	-0.1	-1.1	1.1	-1.6	-0.7
Wheeze or whistling in the chest in last year	0.8	1.5	7.2	0.9	-2.7	0.7	-1.4	-0.5	0.3	0.2	-1.5	0.3
Age at first live birth	0.8	1.4	4.1	2.0	1.9	0.8	-0.9	-0.9	0.9	-0.2	1.4	0.2
Whole body fat mass	0.8	3.4	9.1	-2.3	-3.0	-2.6	0.1	0.3	1.3	1.1	-1.1	2.4
Overall health rating	0.8	1.8	7.5	1.0	-2.7	-1.2	-0.9	0.7	0.1	1.6	-1.2	1.0
Whole body fat-free mass	0.8	4.7	9.7	-2.1	-2.5	-2.5	-2.5	-0.9	3.1	-2.6	-1.3	-0.9
Breast cancer (self-reported)	0.8	1.0	6.4	1.4	0.2	2.5	-0.1	-0.0	-0.1	0.7	0.2	0.1
Whole body water mass	0.8	4.8	10.0	-2.0	-2.6	-2.3	-2.6	-0.9	3.2	-2.7	-1.3	-1.0
Wears glasses or contact lenses	0.8	0.9	2.2	-1.5	0.1	-0.4	1.1	-0.5	-1.5	1.2	-0.8	0.1
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-0.3	1.1	0.5	-1.2	-0.6	1.3	-1.3	0.9	-1.1
Alcohol drinker status: Never	0.8	1.0	3.0	1.0	-1.2	0.0	0.3	0.3	-1.7	1.4	-1.0	0.3
Basal metabolic rate	0.8	4.4	9.1	-2.3	-2.7	-2.6	-2.1	-0.6	3.0	-2.1	-1.3	-0.3
Irritability	0.8	1.4	4.3	0.4	-1.5	-0.3	1.1	0.8	-0.9	1.8	-0.1	2.1
Fractured/broken bones in last 5 years	0.8	1.0	3.4	-1.8	-0.0	0.4	1.2	-0.7	-0.7	1.0	-1.5	0.2
Supplements: Calcium	0.8	0.9	2.9	-1.0	1.1	-0.0	-0.8	-1.1	1.7	-1.0	-0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	-0.7	-0.6	-1.3	0.7	-0.0	-1.5	1.4	-1.4	-0.2
Impedance of whole body	0.8	4.1	12.0	-0.4	1.1	-0.8	3.5	0.7	-0.6	2.8	1.9	3.3
Bipolar Disorder (2018)	0.7	1.0	3.7	-0.6	0.9	1.1	1.2	0.6	-0.8	0.4	0.8	1.9
Neuroticism (Nagel 2018)	0.7	1.6	4.3	0.3	-0.5	-0.3	1.2	1.4	-1.7	2.1	0.2	1.8
Schizophrenia (2018)	0.7	1.5	7.8	-1.4	0.4	-0.8	0.5	-0.6	2.8	-1.4	0.7	-0.3
Alzheimer’s Disease (in mother)	0.7	0.9	2.4	-1.5	-0.8	-0.9	-0.7	-0.4	1.4	0.3	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-0.7	-1.3	-1.0	-0.6	0.0	1.1	0.1	-1.1	-1.0
Lung FEV1/FVC ratio	0.7	3.6	17.1	-4.1	0.3	-1.2	2.0	0.3	-1.7	2.2	-0.4	1.2
Number of treatments/medications taken	0.7	1.3	5.4	1.7	-0.4	-1.1	-0.6	2.3	-0.6	0.5	1.0	0.7
Medication for hormone replacement therapy	0.7	0.8	2.1	0.6	-1.0	-1.4	-0.1	-1.3	-0.3	-0.4	-0.2	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.7	1.6	-1.5	0.7	-0.9	0.2	0.8	0.7	-0.2	0.8
Qualifications: CSEs or equivalent	0.7	0.9	3.4	0.3	0.1	1.0	-1.0	-0.5	1.8	-1.3	-0.3	-0.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.8	2.6	-0.1	0.2	-0.2	0.6	-1.8	1.7	0.1	0.6
Stomach or abdominal pain in last month	0.7	0.8	2.4	0.6	1.0	1.6	0.8	-1.3	-0.5	0.3	-0.4	-0.9
Waist circumference	0.7	2.6	8.0	-1.9	-2.6	-2.8	0.2	0.6	0.3	0.9	-1.1	1.6
Nervous feelings	0.7	1.3	2.5	0.4	0.5	-1.0	0.9	1.6	-1.2	1.5	0.7	1.5
Pain all over the body in last month	0.7	0.8	1.5	0.7	-0.9	1.2	-0.9	-0.6	1.2	-1.1	-0.1	-0.4
Neuroticism score	0.7	1.5	5.8	0.8	-1.2	-0.3	0.1	1.3	-1.1	2.4	-0.5	1.4
Weight	0.7	3.7	9.8	-2.4	-3.1	-2.7	-1.1	-0.1	2.3	-0.4	-1.3	1.1
Trunk fat-free mass	0.7	4.3	8.8	-1.7	-2.0	-2.0	-2.4	-1.2	3.0	-2.8	-1.3	-1.4
Hip circumference	0.7	3.1	7.4	-2.7	-2.3	-2.6	0.1	1.5	1.5	-0.1	0.1	2.0
Trunk predicted mass	0.7	4.2	8.9	-1.8	-1.9	-2.0	-2.4	-1.1	3.0	-2.9	-1.3	-1.4
Qualifications: College or University degree	0.7	2.3	5.2	1.6	2.2	-0.9	0.2	-0.0	1.8	-2.0	2.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	4.8	0.4	0.3	1.1	0.7	0.1	0.2	0.8	0.6	2.2
Angina (self-reported)	0.7	0.9	1.8	1.1	0.7	1.0	0.7	1.3	-0.7	1.0	-0.3	1.3
Leg fat mass (right)	0.7	2.7	8.2	-2.1	-2.9	-2.1	-0.3	-0.3	1.2	0.6	-1.8	1.5
Comparative height size at age 10	0.7	3.7	12.7	-1.8	-2.9	-3.6	-0.6	0.2	2.5	0.5	-0.0	1.6
Knee pain experienced in last month	0.7	1.1	3.5	1.9	-0.5	-0.6	-0.2	1.5	-0.3	1.1	-0.4	1.6
Arm fat percentage (left)	0.7	2.8	7.5	-1.5	-2.7	-2.1	0.4	1.0	0.3	1.8	-0.6	2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.6	-0.6	0.9	0.5	1.3	0.8	-0.9	-0.5	1.3	0.5
Back pain experienced in last month	0.7	1.1	2.8	-0.0	-1.3	-0.3	-0.4	-0.2	-0.4	1.7	-1.7	1.4
Miserableness	0.7	1.2	4.0	0.9	-1.6	-0.5	-0.1	2.0	0.2	1.4	0.3	1.0
Arm fat-free mass (left)	0.7	3.6	8.4	-2.0	-2.1	-1.8	-2.0	-0.5	2.9	-2.5	-1.3	-0.5
Leg fat mass (left)	0.7	2.7	7.4	-2.1	-2.7	-2.3	-0.2	-0.1	1.3	0.5	-1.6	1.5
Arm predicted mass (left)	0.7	3.8	8.3	-2.4	-2.0	-1.9	-1.9	-0.6	2.9	-2.6	-1.1	-0.5
Worry (Nagel 2018)	0.6	1.2	3.7	-0.0	1.1	-0.7	0.9	0.7	-1.9	1.8	0.1	1.0
Age at First Birth	0.6	0.8	1.7	1.1	0.9	-0.5	-0.4	1.2	0.7	-0.4	1.3	0.9
Allergy or Eczema	0.6	1.6	6.1	1.5	-0.5	-0.3	0.5	1.4	-2.5	1.7	0.3	0.9
Angina	0.6	0.7	1.3	1.1	0.8	0.9	0.6	1.1	-0.7	0.8	-0.4	1.0
Impedance of leg (right)	0.6	2.7	10.7	0.1	1.7	0.1	3.3	-0.2	-0.6	2.2	0.6	2.4
Current tobacco smoking	0.6	1.0	3.4	1.5	-1.9	0.4	-0.9	-0.0	-0.1	1.3	-0.9	0.4
Happiness	0.6	0.8	3.6	1.9	1.4	0.2	0.1	-0.3	0.8	0.4	0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.9	2.2	0.3	0.3	1.2	1.0	-0.3	-0.7	2.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	3.4	-0.5	0.1	-0.2	1.9	1.0	-1.2	-0.3	-0.0	0.8
Arm fat mass (right)	0.6	2.6	7.1	-2.2	-2.7	-1.9	-0.4	0.7	1.3	0.7	-0.9	1.9
Loud music exposure frequency	0.6	0.6	2.4	0.3	-1.6	-0.3	-0.6	-0.8	0.2	0.6	-1.2	0.2
Leg fat percentage (right)	0.6	2.1	4.0	-1.5	-2.0	-1.6	0.8	0.2	-0.1	1.7	-1.7	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.7	0.9	0.2	1.1	-0.9	-1.6	0.5	-0.1	-0.9	-0.8
Alcohol intake frequency.	0.6	1.5	4.2	-0.7	-1.8	-0.6	-1.5	-1.5	2.1	-0.4	-0.4	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	-1.2	-0.4	0.4	-0.2	-0.2	1.0	-1.4	1.0	-0.4
Smoking status: Current	0.6	0.9	4.0	1.2	-2.0	0.3	-0.7	0.2	0.2	1.2	-0.6	0.7
Arm fat mass (left)	0.6	2.4	7.2	-2.0	-2.7	-2.1	-0.3	0.5	1.1	0.7	-0.9	1.8
Leg fat percentage (left)	0.6	2.1	3.8	-1.6	-1.9	-1.9	1.0	0.2	0.1	1.6	-1.5	1.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	-1.6	1.4	0.6	0.4	-0.4	-0.8	0.2	0.1	-0.5
Age started oral contraceptive pill	0.6	0.7	2.1	1.5	-0.2	0.1	-0.2	0.3	-1.3	1.0	-1.1	0.0
Depression (Nagel 2018)	0.5	0.7	3.2	1.1	-1.8	-0.1	-0.8	0.2	0.7	0.6	-0.3	0.2
Prostate Cancer	0.5	0.6	2.3	1.5	0.5	0.1	0.9	0.2	0.1	0.6	0.7	1.2
HDL Cholesterol	0.5	0.8	2.5	1.2	0.1	-0.2	1.4	0.5	0.5	-0.4	1.6	0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.9	-0.3	-0.3	-1.7	0.4	-1.2	-0.2	1.6	-0.4	-0.4
Average weekly spirits intake	0.5	0.6	1.5	0.3	-0.7	-0.1	-0.8	-1.2	1.0	-0.3	-1.2	-0.5
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.7	0.6	-1.6	0.3	-0.1	0.8	1.0	0.1	0.5	0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	-0.1	0.8	-0.3	0.6	1.2	0.7	-0.2	1.4	1.0
Average weekly fortified wine intake	0.5	0.6	1.3	-0.4	0.8	0.9	0.4	1.0	0.7	-0.8	1.1	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-0.6	1.0	0.1	0.9	-0.0	0.2	0.6	1.2	1.1
Impedance of leg (left)	0.5	2.3	9.9	-0.1	1.5	-0.5	3.1	-0.3	-0.2	1.8	0.7	2.1
Father’s age at death	0.5	0.7	2.9	0.7	1.3	1.7	-0.0	0.3	-1.1	-0.0	0.0	0.2
Worrier / anxious feelings	0.5	0.9	1.7	0.9	-0.6	0.7	-1.3	-0.9	0.5	0.5	-1.3	-1.1
Medication: Cholesterol lowering	0.5	0.8	2.1	1.3	1.4	0.1	0.2	0.3	-0.3	1.4	-0.0	1.2
Prospective memory result	0.5	0.6	1.5	0.9	-0.5	0.1	0.6	0.8	-0.5	0.4	1.2	1.1
Standing height	0.5	4.9	19.4	-2.4	-1.8	-3.0	-1.1	-1.3	4.4	-1.8	0.2	0.8
Birth weight of first child	0.5	1.0	5.3	-1.3	-2.3	-0.7	-0.3	-0.3	0.2	0.8	-0.5	0.2
Migraine (self-reported)	0.5	0.6	2.4	-0.7	-1.6	-1.0	-0.8	-0.4	-0.1	-0.2	0.2	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	0.9	-0.5	-0.9	-0.9	0.8	0.5	-0.9	0.9	0.6	0.8
Supplements: Vitamin C	0.5	0.6	1.6	-0.5	0.9	0.3	1.3	0.7	-0.7	-0.2	0.6	0.9
Smoking status: Previous	0.5	0.8	2.2	0.7	-0.1	-0.2	0.8	1.1	-1.2	1.2	0.3	1.5
Average weekly red wine intake	0.5	0.8	3.4	1.8	-0.3	-1.0	-1.1	-0.5	0.5	-0.5	-0.5	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	3.4	-1.4	0.1	-1.8	0.4	0.3	1.0	-0.1	0.6	0.1
Medication: Gliclazide	0.5	0.6	1.4	0.1	-1.0	-0.6	1.0	-0.4	-1.1	1.2	-0.4	0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.7	-1.5	0.9	0.1	1.1	0.0	1.6	-0.7	0.9	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.3	-0.4	-1.5	-0.5	0.7	0.8	-0.4	1.4	0.4	1.4
Reaction Time	0.4	0.8	2.9	-0.2	-0.2	-1.7	-0.5	0.7	0.9	-1.3	0.8	-0.1
Bipolar Disorder (2011)	0.4	0.4	2.7	0.7	0.0	0.6	-1.7	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.4	0.7	2.3	-0.7	0.1	-1.0	0.1	-0.1	1.5	-1.3	0.8	-0.2
Lupus	0.4	0.6	2.0	1.1	-0.1	-0.1	-0.2	-0.7	1.3	-1.4	0.3	-0.5
Primary Biliary Cirrhosis	0.4	0.5	2.3	-1.5	-1.1	-0.1	0.7	-0.1	0.2	-0.4	-0.6	-0.1
Rheumatoid Arthritis	0.4	0.5	1.0	0.9	0.7	0.0	0.7	1.0	-0.8	0.1	0.8	0.9
Triglycerides	0.4	0.7	2.2	-1.5	0.4	0.5	1.0	0.3	-0.9	0.9	-0.7	0.4
Blood White Count	0.4	2.7	13.3	-3.6	0.8	0.3	2.4	-0.7	-0.9	-1.5	-0.5	-0.6
BMI	0.4	2.1	6.1	-2.3	-2.5	-1.6	-1.0	0.5	1.3	-0.3	-1.3	0.4
Height	0.4	7.1	28.3	-3.4	-1.6	-2.5	-1.4	-3.0	5.3	-1.8	-0.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	0.1	0.9	-1.1	0.9	0.1	-1.1	0.1	-0.2	-0.2
Fed-up feelings	0.4	0.7	1.4	0.6	-1.2	1.1	-1.1	-0.2	0.0	0.5	-1.2	-0.4
Body mass index (BMI)	0.4	1.6	6.2	-1.5	-2.5	-1.4	-0.8	0.3	0.4	0.5	-1.6	0.7
Qualifications: None of the above	0.4	0.9	3.2	-0.6	-1.8	0.8	-0.3	0.7	0.0	1.2	-1.1	0.9
Alcohol intake versus 10 years previously	0.4	0.5	2.0	-0.5	0.5	-0.9	0.8	0.7	0.6	-0.2	1.4	0.4
Number of live births	0.4	0.5	1.8	-0.3	-0.7	-1.3	0.5	-0.8	-1.2	0.7	0.0	-0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.1	-0.4	-1.0	0.0	0.8	0.2	-0.9	1.2	0.3
Length of working week for main job	0.4	0.4	1.1	-0.3	0.4	-0.3	1.1	0.7	0.7	-1.0	0.4	-0.3
Headache pain in last month	0.4	0.6	2.4	-0.2	-0.9	-1.0	-1.5	-0.6	0.4	0.3	-0.0	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	2.8	-1.0	1.7	-0.5	0.2	-1.2	0.9	0.2	0.5	-0.4
Family relationship satisfaction	0.4	0.5	1.5	1.2	-1.0	0.8	-0.0	-0.1	0.1	0.8	-0.1	0.7
Mood swings	0.4	0.8	3.0	0.0	-1.5	-0.2	0.3	0.9	0.3	0.9	0.3	1.7
Diabetes diagnosed by doctor	0.4	0.7	3.9	-0.3	-0.7	-2.0	0.3	-0.5	0.2	0.8	-0.4	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	0.2	-1.1	-0.1	-1.2	0.3	1.0	-0.7	-0.5	0.0
Mother’s age at death	0.4	0.5	1.6	-0.0	0.5	-0.6	-0.6	-0.9	0.7	-1.3	0.5	-0.3
Financial situation satisfaction	0.4	0.5	1.9	0.2	-0.9	-0.1	-1.2	-0.3	1.4	0.1	-0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	0.1	-1.0	-0.8	-1.0	0.1	1.2	-0.2	-0.1	0.4
Number of operations (self-reported)	0.4	0.5	1.1	-1.1	-0.9	-1.0	-0.5	0.6	0.3	0.9	-0.1	0.7
Unable to work because of sickness or disability	0.4	0.5	0.7	-0.0	0.5	0.7	-0.8	-0.8	0.7	-0.8	-0.8	-0.8
Heart disease (siblings)	0.4	0.5	1.9	0.5	0.3	0.8	0.1	1.4	0.1	-0.7	0.8	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.1	-0.1	1.3	-0.0	1.5	-0.5	-1.2	1.1	0.4	0.2
Breast Cancer	0.3	0.6	1.7	-0.3	-0.6	0.2	-0.1	1.3	1.0	-1.0	1.1	0.6
Neuroticism (2016)	0.3	0.5	1.6	1.0	-0.3	-1.3	-0.4	0.2	-0.5	0.6	-0.7	-0.4
Schizophrenia (2014)	0.3	0.7	2.4	-1.1	0.5	-0.3	-0.0	-0.8	1.6	-0.8	-0.6	-0.5
Respiratory disease	0.3	0.6	1.5	-1.2	-0.6	-0.3	1.0	0.3	0.2	-0.8	1.2	0.6
Medication: Metformin	0.3	0.5	2.6	0.0	0.8	-1.6	0.2	-0.2	0.6	-0.1	0.5	-0.4
Severe depression (siblings)	0.3	0.3	1.0	0.9	-0.8	-0.2	-0.1	-0.0	1.0	-0.2	0.4	-0.5
Townsend deprivation index at recruitment	0.3	0.4	2.6	-0.0	-0.5	-0.1	-0.2	0.4	1.6	-0.3	0.8	0.4
Maternal smoking around birth	0.3	0.4	2.0	0.8	-0.5	1.4	-0.4	-0.1	0.4	-0.5	-0.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.9	-0.8	0.9	-0.8	-0.1	0.7	0.0	-0.7	0.4
Had other major operations	0.3	0.4	1.5	0.4	-1.2	0.1	-0.8	-0.3	0.1	-0.5	-0.3	-0.8
Diabetes (self-reported)	0.3	0.5	2.7	-0.0	0.4	-1.6	0.6	-0.1	-0.2	1.0	0.1	-0.3
Fluid intelligence score	0.3	0.7	2.9	0.4	1.7	0.3	1.3	0.1	-1.0	0.7	0.5	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.3	0.3	0.1	0.5	-0.8	0.1	0.4	-1.1	0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	1.3	-0.7	0.3	-0.3	0.4	0.0	0.5	0.4	1.3
Peak expiratory flow (PEF)	0.3	0.6	1.2	-0.7	-0.5	-0.9	-0.8	-0.6	1.1	-1.0	-0.5	-0.6
Number of full brothers	0.3	0.3	0.9	1.0	-0.9	-0.3	-0.0	0.4	0.5	0.3	0.5	0.8
Pulse wave peak to peak time	0.3	0.4	1.2	-0.1	0.2	0.8	-0.0	-0.8	0.1	0.7	-1.1	-0.2
Mean time to correctly identify matches	0.3	0.6	1.9	-0.7	-0.6	-0.3	0.6	1.4	-0.2	-0.5	1.1	0.7
Heart disease (mother)	0.3	0.3	1.3	0.3	-0.1	0.5	1.1	0.7	-0.0	-0.5	0.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	0.5	-0.2	-0.7	-0.5	-1.1	0.4	0.3	-0.4	-0.6
Qualifications: nursing, teaching	0.3	0.4	1.9	0.3	0.1	-1.4	-0.8	-0.7	-0.3	0.2	0.3	-0.5
Eye problems/disorders: Cataract	0.3	0.3	1.1	0.5	0.5	-0.5	-0.1	-1.1	-0.3	-0.0	0.3	-1.0
Medication: Atorvastatin	0.3	0.4	1.5	0.7	-0.3	-0.4	-1.2	0.8	0.5	0.4	-0.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.1	-0.5	-0.0	0.5	-0.2	-0.5	0.8	-0.7	-1.0	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.9	0.6	1.2	0.2	1.4	-1.1	-0.6	0.7	0.6	-0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	1.4	0.1	0.3	-0.1	-0.5	0.0	1.2	-0.1	-0.6	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.3	-1.0	0.3	-0.2	0.0	0.3	1.0	-0.6	-0.4
Blood Eosinophil Count	0.2	1.6	3.7	-1.0	-1.9	-0.5	1.4	1.8	0.3	0.4	0.5	1.9
Blood Red Count	0.2	2.1	9.9	-3.1	1.2	0.5	-0.3	-0.7	1.6	-2.0	0.3	0.1
Heart attack	0.2	0.2	0.7	-0.7	0.0	0.6	0.1	-0.3	0.5	-0.5	-0.9	0.0
Allergy	0.2	0.5	2.3	-1.5	0.6	-0.4	0.3	-0.6	0.7	-0.8	-0.2	-0.7
Asthma	0.2	0.4	1.3	-0.2	0.1	0.4	-0.2	0.1	1.1	-1.0	0.9	0.8
Depression (self-reported)	0.2	0.3	1.5	-0.1	1.2	0.4	0.2	-0.6	-0.2	0.4	-0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	1.0	-0.6	-0.1	-0.0	-0.6	-0.8	-0.1	0.3	-1.0
Health satisfaction	0.2	0.3	0.8	0.2	-0.3	-0.3	-0.9	-0.2	0.9	0.0	-0.7	0.4
Illnesses of father: Heart disease	0.2	0.3	1.3	-0.5	0.5	-0.0	1.1	0.0	-0.1	-0.5	0.3	0.7
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.0	-0.2	-0.1	0.9	-0.0	-0.6	0.7	-0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.2	0.2	-0.8	-0.9	-0.6	-0.4	0.2	-0.0	-1.0
Asthma (self-reported)	0.2	0.3	1.0	-0.1	-0.3	0.3	-0.0	0.4	0.7	-0.5	0.8	1.0
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.3	0.2	0.3	0.7	0.4	-0.7	0.3	1.1	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.7	-0.6	0.2	-0.3	0.3	-0.6	-0.3	0.5	-0.4	-0.9
Waist Hip Ratio (WHR)	0.1	0.6	1.7	-0.1	1.3	-0.7	1.1	-1.1	-0.2	0.1	-1.0	-0.1
Tanning	0.1	1.3	4.2	1.6	0.4	0.7	0.4	1.4	-0.3	0.8	1.0	2.0
Supplements: Zinc	0.1	0.1	0.2	-0.0	-0.2	0.5	-0.5	0.5	-0.2	-0.4	0.3	0.2
Sitting height	0.1	0.9	3.8	0.6	-0.7	-0.4	-0.7	-0.1	1.5	-1.9	0.2	0.4
Risk taking	0.1	0.2	1.1	1.1	0.0	0.5	-0.0	-0.1	-0.1	-0.5	0.4	-0.3
Hair Pigment	0.0	0.6	2.2	-1.5	-0.1	-1.3	-0.9	0.4	-0.1	0.2	-0.6	-0.3

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